Prss21 (serine protease 21) - Rat Genome Database

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Gene: Prss21 (serine protease 21) Rattus norvegicus
Analyze
Symbol: Prss21
Name: serine protease 21
RGD ID: 727870
Description: Predicted to enable serine-type endopeptidase activity. Involved in spermatogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human PRSS21 (serine protease 21); INTERACTS WITH bisphenol A; cadmium atom; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eosinophil serine protease-1; Esp-1; protease, serine, 21; Resp-1; testisin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,404,820 - 13,410,195 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,405,066 - 13,410,195 (+)EnsemblGRCr8
mRatBN7.21012,899,820 - 12,905,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,900,535 - 12,905,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,645,215 - 17,650,385 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,134,003 - 17,139,173 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,633,311 - 12,638,455 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,214,343 - 13,219,994 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,214,130 - 13,219,894 (+)Ensemblrn6Rnor6.0
Rnor_5.01013,033,616 - 13,038,855 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1012,593,436 - 12,599,094 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA)
spermatogenesis  (IBA,IEP)

Cellular Component
extracellular space  (IBA)
membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning, expression analysis, and tissue distribution of esp-1/testisin, a membrane-type serine protease from the rat. Nakamura Y, etal., J Med Invest 2003 Feb;50(1-2):78-86.
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11861648   PMID:23943622  


Genomics

Comparative Map Data
Prss21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,404,820 - 13,410,195 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,405,066 - 13,410,195 (+)EnsemblGRCr8
mRatBN7.21012,899,820 - 12,905,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,900,535 - 12,905,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,645,215 - 17,650,385 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,134,003 - 17,139,173 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,633,311 - 12,638,455 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,214,343 - 13,219,994 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,214,130 - 13,219,894 (+)Ensemblrn6Rnor6.0
Rnor_5.01013,033,616 - 13,038,855 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1012,593,436 - 12,599,094 (+)NCBICelera
Cytogenetic Map10q12NCBI
PRSS21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,817,237 - 2,821,719 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,817,180 - 2,826,304 (+)Ensemblhg38GRCh38
GRCh37162,867,238 - 2,871,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,807,165 - 2,811,721 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34162,807,164 - 2,811,717NCBI
Celera163,067,095 - 3,071,651 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,833,834 - 2,838,393 (+)NCBIHuRef
CHM1_1162,867,197 - 2,871,755 (+)NCBICHM1_1
T2T-CHM13v2.0162,837,810 - 2,842,292 (+)NCBIT2T-CHM13v2.0
Prss21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,087,046 - 24,092,087 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,087,030 - 24,092,088 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381723,867,883 - 23,873,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1723,868,056 - 23,873,114 (+)Ensemblmm10GRCm38
MGSCv371724,005,039 - 24,010,080 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361723,595,694 - 23,600,734 (+)NCBIMGSCv36mm8
Celera1724,362,209 - 24,367,220 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.11NCBI
PRSS21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,339,762 - 3,345,280 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1167,118,143 - 7,123,661 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,721,788 - 1,726,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC479874
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,339,066 - 38,343,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,333,024 - 38,343,470 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha639,578,707 - 39,582,704 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0638,649,314 - 38,653,329 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1638,334,707 - 38,338,701 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,306,155 - 38,311,358 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,783,348 - 38,787,361 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
PRSS21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,317,717 - 39,323,150 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1339,318,134 - 39,322,775 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,699,346 - 40,703,993 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,520,825 - 2,532,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,526,827 - 2,532,107 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606828,380,186 - 28,394,248 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prss21
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:110
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000073065
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
BF400120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21012,901,752 - 12,901,903 (+)MAPPERmRatBN7.2
Rnor_6.01013,216,031 - 13,216,181NCBIRnor6.0
Rnor_5.01013,034,996 - 13,035,146UniSTSRnor5.0
Celera1012,594,654 - 12,594,804UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
12 3 11 42 63 63 41 17 41 6 117 44 2 27 18 64 22

Sequence


Ensembl Acc Id: ENSRNOT00000073065   ⟹   ENSRNOP00000065300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1013,405,066 - 13,410,195 (+)Ensembl
mRatBN7.2 Ensembl1012,900,535 - 12,905,618 (+)Ensembl
Rnor_6.0 Ensembl1013,214,130 - 13,219,894 (+)Ensembl
RefSeq Acc Id: NM_181477   ⟹   NP_852142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,405,066 - 13,410,195 (+)NCBI
mRatBN7.21012,900,483 - 12,905,612 (+)NCBI
Rnor_6.01013,214,813 - 13,219,890 (+)NCBI
Rnor_5.01013,033,616 - 13,038,855 (+)NCBI
Celera1012,593,436 - 12,599,094 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245872   ⟹   XP_006245934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,410,190 (+)NCBI
mRatBN7.21012,900,093 - 12,905,608 (+)NCBI
Rnor_6.01013,214,343 - 13,219,994 (+)NCBI
Rnor_5.01013,033,616 - 13,038,855 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086242   ⟹   XP_038942170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,409,569 (+)NCBI
mRatBN7.21012,899,821 - 12,904,985 (+)NCBI
RefSeq Acc Id: XM_063269269   ⟹   XP_063125339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,407,239 (+)NCBI
RefSeq Acc Id: XR_005489876
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,409,976 (+)NCBI
mRatBN7.21012,900,100 - 12,905,398 (+)NCBI
RefSeq Acc Id: XR_005489878
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,409,976 (+)NCBI
mRatBN7.21012,900,111 - 12,905,398 (+)NCBI
RefSeq Acc Id: XR_010055198
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,409,976 (+)NCBI
RefSeq Acc Id: NP_852142   ⟸   NM_181477
- Peptide Label: precursor
- UniProtKB: Q80Z40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245934   ⟸   XM_006245872
- Peptide Label: isoform X1
- UniProtKB: M0R778 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065300   ⟸   ENSRNOT00000073065
RefSeq Acc Id: XP_038942170   ⟸   XM_039086242
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063125339   ⟸   XM_063269269
- Peptide Label: isoform X2
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80Z40-F1-model_v2 AlphaFold Q80Z40 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727870 AgrOrtholog
BioCyc Gene G2FUF-25893 BioCyc
Ensembl Genes ENSRNOG00000047969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073065 ENTREZGENE
  ENSRNOT00000073065.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:353251 UniProtKB/TrEMBL
NCBI Gene 353251 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss21 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047969 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt M0R778 ENTREZGENE, UniProtKB/TrEMBL
  Q80Z40 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss21  serine protease 21  Prss21  protease, serine, 21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Prss21  protease, serine, 21      Symbol and Name status set to approved 1299863 APPROVED