Cd2ap (CD2-associated protein) - Rat Genome Database

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Gene: Cd2ap (CD2-associated protein) Rattus norvegicus
Analyze
Symbol: Cd2ap
Name: CD2-associated protein
RGD ID: 727803
Description: Enables beta-catenin binding activity; cadherin binding activity; and vascular endothelial growth factor receptor binding activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of receptor-mediated endocytosis; and vesicle organization. Located in cell leading edge; endocytic vesicle; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 3. Orthologous to human CD2AP (CD2 associated protein); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CMS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,580,071 - 25,679,968 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl925,583,975 - 25,679,968 (+)EnsemblGRCr8
mRatBN7.2918,086,744 - 18,182,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,086,984 - 18,182,199 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx926,673,658 - 26,770,708 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0931,748,203 - 31,845,260 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0930,039,092 - 30,134,950 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0920,794,680 - 20,858,438 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,765,296 - 20,858,504 (+)Ensemblrn6Rnor6.0
Rnor_5.0919,659,503 - 19,720,953 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4913,827,015 - 13,888,338 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera915,825,287 - 15,886,480 (+)NCBICelera
RGSC_v3.1913,824,339 - 13,885,656 (+)NCBI
Cytogenetic Map9q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
celecoxib  (EXP)
chlordecone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lisinopril dihydrate  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-nitrosodiethylamine  (ISO)
oxidopamine  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
prednisone  (EXP)
puromycin  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IBA,ISO,ISS)
actin filament polymerization  (ISO)
adipose tissue development  (ISO)
apoptotic process  (ISO)
cell differentiation  (ISO)
cell division  (IEA)
cell migration  (IBA,IMP)
cell population proliferation  (ISO)
cell-cell adhesion  (IEA,IMP)
cell-cell adhesion mediated by cadherin  (ISO)
cell-cell junction organization  (ISO)
collateral sprouting  (ISO)
D-glucose import  (ISO)
endothelium development  (ISO)
ERK1 and ERK2 cascade  (ISO)
filopodium assembly  (ISO)
gene expression  (ISO)
glomerulus development  (ISO)
immunological synapse formation  (ISO)
inflammatory response  (ISO)
kidney development  (ISO)
lipid metabolic process  (ISO)
liver development  (ISO)
localization of cell  (ISO)
lymph node development  (ISO)
maintenance of blood-brain barrier  (ISO)
male gonad development  (ISO)
membrane organization  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of small GTPase mediated signal transduction  (ISO,ISS)
negative regulation of transforming growth factor beta1 production  (ISO)
nerve growth factor signaling pathway  (ISO)
neuron projection development  (ISO)
neurotrophin signaling pathway  (ISO)
neurotrophin TRK receptor signaling pathway  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
podocyte differentiation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein secretion  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IDA)
protein catabolic process  (ISO)
protein heterooligomerization  (ISO)
protein phosphorylation  (ISO)
protein secretion  (ISO)
protein transport  (ISO)
Rab protein signal transduction  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of receptor-mediated endocytosis  (IDA)
regulation of synaptic plasticity  (ISO)
renal albumin absorption  (ISO)
response to glial cell derived neurotrophic factor  (ISO)
response to insulin  (ISO)
response to oxidative stress  (ISO)
response to transforming growth factor beta  (ISO)
response to virus  (ISO)
response to wounding  (ISO)
stress-activated MAPK cascade  (ISO)
synapse organization  (ISO)
T cell receptor signaling pathway  (ISO)
vesicle organization  (IDA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Kim JM, etal., Science. 2003 May 23;300(5623):1298-300.
3. The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1). Kobayashi S, etal., FASEB J 2004 May;18(7):929-31. Epub 2004 Mar 04.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. CD2AP contributes to cell migration and adhesion in cultured gastric epithelium. Mustonen H, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):426-32.
6. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
7. CD2AP expression in a renal ischemia/reperfusion injury model and analysis of its related genes using overexpression and RNA interference technique. Nishimura S, etal., Am J Nephrol. 2005 Jul-Aug;25(4):373-81. Epub 2005 Jun 25.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
Additional References at PubMed
PMID:8889548   PMID:10339567   PMID:10913159   PMID:15331416   PMID:15924139   PMID:17020880   PMID:17667985   PMID:18753381   PMID:19056867   PMID:21911934   PMID:22809625   PMID:22891260  
PMID:23376485   PMID:23533145   PMID:23793062   PMID:24471428   PMID:25468996   PMID:27044754   PMID:27076424   PMID:28235806   PMID:31413325   PMID:35172672  


Genomics

Comparative Map Data
Cd2ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,580,071 - 25,679,968 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl925,583,975 - 25,679,968 (+)EnsemblGRCr8
mRatBN7.2918,086,744 - 18,182,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,086,984 - 18,182,199 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx926,673,658 - 26,770,708 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0931,748,203 - 31,845,260 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0930,039,092 - 30,134,950 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0920,794,680 - 20,858,438 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,765,296 - 20,858,504 (+)Ensemblrn6Rnor6.0
Rnor_5.0919,659,503 - 19,720,953 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4913,827,015 - 13,888,338 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera915,825,287 - 15,886,480 (+)NCBICelera
RGSC_v3.1913,824,339 - 13,885,656 (+)NCBI
Cytogenetic Map9q13NCBI
CD2AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38647,477,789 - 47,627,263 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl647,477,752 - 47,627,263 (+)Ensemblhg38GRCh38
GRCh37647,445,525 - 47,594,999 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,553,484 - 47,702,958 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34647,553,898 - 47,702,606NCBI
Celera649,001,627 - 49,151,084 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef647,172,874 - 47,322,780 (+)NCBIHuRef
CHM1_1647,448,327 - 47,597,835 (+)NCBICHM1_1
T2T-CHM13v2.0647,318,653 - 47,468,952 (+)NCBIT2T-CHM13v2.0
Cd2ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,059,857 - 43,187,593 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,103,842 - 43,187,556 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381742,748,887 - 42,876,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,792,951 - 42,876,665 (-)Ensemblmm10GRCm38
MGSCv371742,929,900 - 43,013,373 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361742,256,435 - 42,352,155 (-)NCBIMGSCv36mm8
Celera1746,201,889 - 46,261,450 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.67NCBI
Cd2ap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,983,311 - 12,091,100 (+)Ensembl
ChiLan1.0NW_00495543712,005,399 - 12,087,014 (+)NCBIChiLan1.0ChiLan1.0
CD2AP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2561,977,062 - 62,123,354 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1657,844,128 - 57,989,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0647,065,284 - 47,210,746 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1648,328,836 - 48,474,166 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl648,328,863 - 48,474,163 (+)EnsemblpanPan2panpan1.1
CD2AP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,538,215 - 15,683,619 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,538,356 - 15,681,011 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1215,569,237 - 15,714,616 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01216,041,717 - 16,186,523 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1216,041,451 - 16,186,100 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11215,549,899 - 15,695,706 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,642,957 - 15,788,194 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,789,659 - 15,935,714 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd2ap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,972,198 - 51,069,620 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647612,890,468 - 12,987,843 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647612,890,595 - 12,989,046 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD2AP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl742,218,290 - 42,332,518 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1742,218,016 - 42,332,523 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,870,223 - 48,952,250 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD2AP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11724,664,245 - 24,815,786 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1724,663,872 - 24,815,829 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604447,487,056 - 47,639,257 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd2ap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,420,603 - 13,511,523 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475413,420,594 - 13,511,672 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd2ap
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1486,959,708 - 87,022,245 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd2ap
853 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000016291
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
AI010435  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2918,182,419 - 18,182,545 (+)MAPPERmRatBN7.2
Rnor_6.0920,861,620 - 20,861,745NCBIRnor6.0
Rnor_5.0919,724,135 - 19,724,260UniSTSRnor5.0
RGSC_v3.4913,891,520 - 13,891,645UniSTSRGSC3.4
Celera915,889,662 - 15,889,787UniSTS
RH 3.4 Map9104.9UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_181475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY114147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY205155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA506385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA508086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA513011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB545525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK359466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO386882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN937610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV718887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV727927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY312051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016291   ⟹   ENSRNOP00000016291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl925,614,886 - 25,679,965 (+)Ensembl
mRatBN7.2 Ensembl918,117,462 - 18,180,673 (+)Ensembl
Rnor_6.0 Ensembl920,765,296 - 20,858,504 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107057   ⟹   ENSRNOP00000086646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl925,584,328 - 25,679,965 (+)Ensembl
mRatBN7.2 Ensembl918,087,097 - 18,180,673 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120136   ⟹   ENSRNOP00000088324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl925,583,975 - 25,679,968 (+)Ensembl
mRatBN7.2 Ensembl918,086,984 - 18,182,199 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000142796   ⟹   ENSRNOP00000103834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl925,587,374 - 25,679,962 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156635   ⟹   ENSRNOP00000107086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl925,583,975 - 25,676,328 (+)Ensembl
RefSeq Acc Id: NM_181475   ⟹   NP_852140
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,583,975 - 25,679,968 (+)NCBI
mRatBN7.2918,086,744 - 18,182,744 (+)NCBI
Rnor_6.0920,794,680 - 20,858,438 (+)NCBI
Rnor_5.0919,659,503 - 19,720,953 (+)NCBI
RGSC_v3.4913,827,015 - 13,888,338 (+)RGD
Celera915,825,287 - 15,886,480 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083538   ⟹   XP_038939466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,580,071 - 25,679,963 (+)NCBI
mRatBN7.2918,086,766 - 18,182,739 (+)NCBI
RefSeq Acc Id: XM_039083539   ⟹   XP_038939467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,587,343 - 25,679,963 (+)NCBI
mRatBN7.2918,090,113 - 18,182,739 (+)NCBI
RefSeq Acc Id: XM_039083540   ⟹   XP_038939468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,613,192 - 25,679,963 (+)NCBI
mRatBN7.2918,115,986 - 18,182,739 (+)NCBI
RefSeq Acc Id: XM_039083541   ⟹   XP_038939469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,580,071 - 25,657,444 (+)NCBI
mRatBN7.2918,086,765 - 18,160,195 (+)NCBI
RefSeq Acc Id: XR_005488895
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,580,071 - 25,663,997 (+)NCBI
mRatBN7.2918,086,766 - 18,166,769 (+)NCBI
RefSeq Acc Id: NP_852140   ⟸   NM_181475
- UniProtKB: F1LRS8 (UniProtKB/Swiss-Prot),   Q7TSS5 (UniProtKB/Swiss-Prot),   A6JJ47 (UniProtKB/TrEMBL),   A0A8L2Q7T7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016291   ⟸   ENSRNOT00000016291
RefSeq Acc Id: XP_038939469   ⟸   XM_039083541
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038939466   ⟸   XM_039083538
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A6A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939467   ⟸   XM_039083539
- Peptide Label: isoform X2
- UniProtKB: A6JJ48 (UniProtKB/TrEMBL),   A0A8L2Q7T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939468   ⟸   XM_039083540
- Peptide Label: isoform X2
- UniProtKB: A6JJ48 (UniProtKB/TrEMBL),   A0A8L2Q7T7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088324   ⟸   ENSRNOT00000120136
Ensembl Acc Id: ENSRNOP00000086646   ⟸   ENSRNOT00000107057
Ensembl Acc Id: ENSRNOP00000107086   ⟸   ENSRNOT00000156635
Ensembl Acc Id: ENSRNOP00000103834   ⟸   ENSRNOT00000142796
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LRS8-F1-model_v2 AlphaFold F1LRS8 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727803 AgrOrtholog
BioCyc Gene G2FUF-28096 BioCyc
Ensembl Genes ENSRNOG00000011987 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016291 ENTREZGENE
  ENSRNOT00000120136 ENTREZGENE
  ENSRNOT00000142796 ENTREZGENE
Gene3D-CATH SH3 Domains UniProtKB/Swiss-Prot
InterPro CD2AP_SH3_1 UniProtKB/Swiss-Prot
  CD2AP_SH3_3 UniProtKB/Swiss-Prot
  CD2AP_SH_2 UniProtKB/Swiss-Prot
  Endophilin_SH3RF UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
NCBI Gene 316258 ENTREZGENE
PANTHER LD44138P UniProtKB/Swiss-Prot
  SH3 DOMAIN-CONTAINING UniProtKB/Swiss-Prot
Pfam SH3_1 UniProtKB/Swiss-Prot
  SH3_9 UniProtKB/Swiss-Prot
PhenoGen Cd2ap PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011987 RatGTEx
SMART SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
UniProt A0A8I6A6A6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GF65_RAT UniProtKB/TrEMBL
  A0A8L2Q7T7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQ34_RAT UniProtKB/TrEMBL
  A0ABK0LRG7_RAT UniProtKB/TrEMBL
  A6JJ47 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ48 ENTREZGENE, UniProtKB/TrEMBL
  CD2AP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TSS5 ENTREZGENE
  Q80ZE7_RAT UniProtKB/TrEMBL
UniProt Secondary Q7TSS5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cd2ap  CD2-associated protein      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein contains three SH3 domains 1302417
gene_homology rat sequence shows 84% homology to the human sequence and 92% homology to the mouse sequence 1302417
gene_physical_interaction the second SH3 domain is responsible for binding c-Cbl and Flt-1 in rat sinusoidal endothelial cells 1302417