Cd2ap (CD2-associated protein) - Rat Genome Database

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Gene: Cd2ap (CD2-associated protein) Rattus norvegicus
Analyze
Symbol: Cd2ap
Name: CD2-associated protein
RGD ID: 727803
Description: Enables beta-catenin binding activity; cadherin binding activity; and vascular endothelial growth factor receptor binding activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of receptor-mediated endocytosis; and vesicle organization. Located in cell leading edge; endocytic vesicle; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 3. Orthologous to human CD2AP (CD2 associated protein); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CMS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,580,071 - 25,679,968 (+)NCBIGRCr8
mRatBN7.2918,086,744 - 18,182,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,086,984 - 18,182,199 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx926,673,658 - 26,770,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0931,748,203 - 31,845,260 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0930,039,092 - 30,134,950 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0920,794,680 - 20,858,438 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,765,296 - 20,858,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,659,503 - 19,720,953 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,827,015 - 13,888,338 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,824,339 - 13,885,656 (+)NCBI
Celera915,825,287 - 15,886,480 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Cd2apRatCOVID-19  ISOCD2AP (Homo sapiens)9068941mRNA:increased expression:bronchoalveolar lavage (human)RGDPMID:32407669 and REF_RGD_ID:30296672
Cd2apRatfocal segmental glomerulosclerosis  ISOCD2AP (Homo sapiens)1600628FSGS3 more ...RGD 
Cd2apRatReperfusion Injury  IEP 1581187 RGD 
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Original Reference(s)
Cd2apRatfocal segmental glomerulosclerosis  ISOCD2AP (Homo sapiens)8554872ClinVar Annotator: match by term: Focal segmental glomerulosclerosisClinVarPMID:25741868 and PMID:28492532
Cd2apRatfocal segmental glomerulosclerosis 1  ISOCD2AP (Homo sapiens)8554872ClinVar Annotator: match by term: Focal sclerosis with hyalinosisClinVarPMID:25741868
Cd2apRatfocal segmental glomerulosclerosis 3  ISOCD2AP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10514378 more ...
Cd2apRatgenetic disease  ISOCD2AP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Cd2apRatkidney disease  ISOCD2AP (Homo sapiens)8554872ClinVar Annotator: match by term: renal diseaseClinVarPMID:25741868 and PMID:28492532
Cd2apRatprostate cancer  ISOCD2AP (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:28492532
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Cd2apRatAlzheimer's disease  ISOCD2AP (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21460840 more ...
Cd2apRatfocal segmental glomerulosclerosis  ISOCD2AP (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Original Reference(s)
Cd2apRatend stage renal disease  ISSCd2ap (Mus musculus)13592920 MouseDO 
Cd2apRatfocal segmental glomerulosclerosis 3  ISSCd2ap (Mus musculus)13592920OMIM:607832MouseDO 
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Original Reference(s)
Cd2apRatfocal segmental glomerulosclerosis 3  ISOCD2AP (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Cd2apRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CD2AP mRNA]CTDPMID:31150632
Cd2apRat(-)-epigallocatechin 3-gallate multiple interactionsISOCD2AP (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CD2AP mRNACTDPMID:22079256
Cd2apRat1,2-dimethylhydrazine decreases expressionISOCd2ap (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CD2AP mRNACTDPMID:22206623
Cd2apRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of CD2AP mRNACTDPMID:32145629
Cd2apRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOCd2ap (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of CD2AP mRNACTDPMID:19770486
Cd2apRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CD2AP mRNACTDPMID:34747641
Cd2apRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCd2ap (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CD2AP mRNACTDPMID:21570461 and PMID:24680724
Cd2apRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of CD2AP mRNACTDPMID:21346803
Cd2apRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of CD2AP mRNACTDPMID:21346803
Cd2apRat3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactionsEXP 6480464celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA]CTDPMID:19194550
Cd2apRat3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine decreases expressionEXP 6480464Puromycin Aminonucleoside results in decreased expression of CD2AP mRNACTDPMID:19194550
Cd2apRat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of CD2AP proteinCTDPMID:34915118
Cd2apRat4,4'-sulfonyldiphenol increases expressionISOCd2ap (Mus musculus)6480464bisphenol S results in increased expression of CD2AP mRNACTDPMID:39298647
Cd2apRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of CD2AP mRNACTDPMID:30047161
Cd2apRatacrylamide decreases expressionISOCD2AP (Homo sapiens)6480464Acrylamide results in decreased expression of CD2AP mRNACTDPMID:32763439
Cd2apRatall-trans-retinoic acid multiple interactionsEXP 6480464Tretinoin affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA] and Tretinoin inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]CTDPMID:16636307
Cd2apRatall-trans-retinoic acid increases expressionISOCD2AP (Homo sapiens)6480464Tretinoin results in increased expression of CD2AP mRNACTDPMID:33167477
Cd2apRatamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of CD2AP mRNACTDPMID:30047161
Cd2apRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of CD2AP mRNACTDPMID:16483693
Cd2apRatamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of CD2AP mRNACTDPMID:30779732

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Biological Process
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Original Reference(s)
Cd2apRatactin filament organization involved_inIBAFB:FBgn0027598 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cd2apRatactin filament organization involved_inISOCD2AP (Homo sapiens)1624291 PMID:22891260RGDPMID:22891260
Cd2apRatactin filament organization involved_inISSUniProtKB:Q9Y5K61600115GO_REF:0000024UniProtGO_REF:0000024
Cd2apRatactin filament polymerization acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:2664945 PMID:24218450RGDPMID:24218450
Cd2apRatadipose tissue development acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291 PMID:29729186RGDPMID:29729186
Cd2apRatapoptotic process acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:1333787 more ...RGDPMID:14512504 more ...
Cd2apRatcell differentiation acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:1330281 PMID:19013146RGDPMID:19013146
Cd2apRatcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Cd2apRatcell migration  IMP 1582380 RGD 
Cd2apRatcell migration involved_inIBAFB:FBgn0027598 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cd2apRatcell population proliferation acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:2664945 PMID:19679673RGDPMID:19679673
Cd2apRatcell-cell adhesion  IMP 1582382 RGD 
Cd2apRatcell-cell adhesion mediated by cadherin acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:1330281 PMID:19013146RGDPMID:19013146
Cd2apRatcell-cell junction organization acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:1330281 more ...RGDPMID:19013146 and PMID:25968128
Cd2apRatcollateral sprouting acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291 PMID:27076424RGDPMID:27076424
Cd2apRatD-glucose import acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:2664945 PMID:26546360RGDPMID:26546360
Cd2apRatendothelium development acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:2664945 PMID:25968128RGDPMID:25968128
Cd2apRatERK1 and ERK2 cascade acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:1333787 PMID:28878342RGDPMID:28878342
Cd2apRatfilopodium assembly acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291 PMID:27076424RGDPMID:27076424
Cd2apRatgene expression acts_upstream_of_or_withinISOCd2ap (Mus musculus)1624291MGI:1333787 more ...RGDPMID:15213232 more ...
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Cellular Component
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Original Reference(s)
Cd2apRatactin filament is_active_inISOCd2ap (Mus musculus)1624291 PMID:17606992RGDPMID:17606992
Cd2apRatanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Cd2apRatanchoring junction located_inIEAUniProtKB-SubCell:SL-00381600115GO_REF:0000044UniProtGO_REF:0000044
Cd2apRataxon located_inISOCd2ap (Mus musculus)1624291 PMID:32552912RGDPMID:32552912
Cd2apRatcell leading edge  IDA 1582380 RGD 
Cd2apRatcell leading edge is_active_inIBAPANTHER:PTN002680703 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cd2apRatcell periphery is_active_inISOCd2ap (Mus musculus)1624291 PMID:16501493RGDPMID:16501493
Cd2apRatcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Cd2apRatcell-cell junction located_inISOCd2ap (Mus musculus)1624291 PMID:23793062RGDPMID:23793062
Cd2apRatcentriolar satellite located_inISOCD2AP (Homo sapiens)1624291 RGDGO_REF:0000052
Cd2apRatcytoplasm is_active_inIBAMGI:1330281 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cd2apRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cd2apRatcytoplasm located_inISOCd2ap (Mus musculus)1624291 PMID:10913159RGDPMID:10913159
Cd2apRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Cd2apRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Cd2apRatdendrite located_inISOCd2ap (Mus musculus)1624291 PMID:32552912RGDPMID:32552912
Cd2apRatendocytic vesicle  IDA 1302417 RGD 
Cd2apRatfibrillar center located_inISOCD2AP (Homo sapiens)1624291 RGDGO_REF:0000052
Cd2apRatfilamentous actin part_ofISOCD2AP (Homo sapiens)1624291 PMID:10339567RGDPMID:10339567
Cd2apRatgrowth cone is_active_inISOCd2ap (Mus musculus)1624291 PMID:27076424RGDPMID:27076424
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Molecular Function
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Original Reference(s)
Cd2apRatactin binding enablesISOCd2ap (Mus musculus)1624291 PMID:15956777 more ...RGDPMID:15956777 more ...
Cd2apRatactin filament binding enablesISOCd2ap (Mus musculus)1624291 PMID:17606992RGDPMID:17606992
Cd2apRatbeta-catenin binding  IDA 1582382 RGD 
Cd2apRatcadherin binding  IPICdh2 (Rattus norvegicus)1582382 RGD 
Cd2apRatcadherin binding  IPICdh1 (Rattus norvegicus)1582380 RGD 
Cd2apRatclathrin binding enablesISOCd2ap (Mus musculus)1624291 PMID:26546360RGDPMID:26546360
Cd2apRatidentical protein binding enablesISOCD2AP (Homo sapiens)1624291UniProtKB:Q9Y5K6 more ...RGDPMID:17020880 and PMID:31413325
Cd2apRatphosphatidylinositol 3-kinase regulatory subunit binding enablesISOCd2ap (Mus musculus)1624291 PMID:27076424RGDPMID:27076424
Cd2apRatprotein binding  IPICBLC (Homo sapiens)1302417protein C-terminus bindingRGD 
Cd2apRatprotein binding enablesISOCd2ap (Mus musculus)1624291PR:O35245 more ...RGDPMID:10913159 more ...
Cd2apRatprotein binding enablesISOCD2AP (Homo sapiens)1624291UniProtKB:P06241 more ...RGDPMID:10339567 more ...
Cd2apRatprotein binding  IPITjp1 (Rattus norvegicus)1582382 RGD 
Cd2apRatprotein binding  IPIF11r (Rattus norvegicus)1582382 RGD 
Cd2apRatprotein-containing complex binding  IPITgfbr1 (Rattus norvegicus) and Tab1 (Rattus norvegicus)1582382 RGD 
Cd2apRatSH3 domain binding enablesISOCD2AP (Homo sapiens)1624291UniProtKB:P56945 and PMID:10339567RGDPMID:10339567
Cd2apRatSH3 domain binding enablesIEAUniProtKB-KW:KW-07291600115GO_REF:0000043UniProtGO_REF:0000043
Cd2apRatvascular endothelial growth factor receptor binding  IDA 1302417Flt-1RGD 
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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Kim JM, etal., Science. 2003 May 23;300(5623):1298-300.
3. The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1). Kobayashi S, etal., FASEB J 2004 May;18(7):929-31. Epub 2004 Mar 04.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. CD2AP contributes to cell migration and adhesion in cultured gastric epithelium. Mustonen H, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):426-32.
6. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
7. CD2AP expression in a renal ischemia/reperfusion injury model and analysis of its related genes using overexpression and RNA interference technique. Nishimura S, etal., Am J Nephrol. 2005 Jul-Aug;25(4):373-81. Epub 2005 Jun 25.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
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PMID:8889548   PMID:10339567   PMID:10913159   PMID:15331416   PMID:15924139   PMID:17020880   PMID:17667985   PMID:18753381   PMID:19056867   PMID:21911934   PMID:22809625   PMID:22891260  
PMID:23376485   PMID:23533145   PMID:23793062   PMID:24471428   PMID:25468996   PMID:27044754   PMID:27076424   PMID:28235806   PMID:31413325   PMID:35172672  



Cd2ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,580,071 - 25,679,968 (+)NCBIGRCr8
mRatBN7.2918,086,744 - 18,182,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,086,984 - 18,182,199 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx926,673,658 - 26,770,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0931,748,203 - 31,845,260 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0930,039,092 - 30,134,950 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0920,794,680 - 20,858,438 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,765,296 - 20,858,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,659,503 - 19,720,953 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,827,015 - 13,888,338 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1913,824,339 - 13,885,656 (+)NCBI
Celera915,825,287 - 15,886,480 (+)NCBICelera
Cytogenetic Map9q13NCBI
CD2AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38647,477,789 - 47,627,263 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl647,477,789 - 47,627,263 (+)EnsemblGRCh38hg38GRCh38
GRCh37647,445,525 - 47,594,999 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,553,484 - 47,702,958 (+)NCBINCBI36Build 36hg18NCBI36
Build 34647,553,898 - 47,702,606NCBI
Celera649,001,627 - 49,151,084 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef647,172,874 - 47,322,780 (+)NCBIHuRef
CHM1_1647,448,327 - 47,597,835 (+)NCBICHM1_1
T2T-CHM13v2.0647,318,653 - 47,468,952 (+)NCBIT2T-CHM13v2.0
Cd2ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,059,857 - 43,187,593 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,103,842 - 43,187,556 (-)EnsemblGRCm39 Ensembl
GRCm381742,748,887 - 42,876,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,792,951 - 42,876,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371742,929,900 - 43,013,373 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361742,256,435 - 42,352,155 (-)NCBIMGSCv36mm8
Celera1746,201,889 - 46,261,450 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.67NCBI
Cd2ap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,983,311 - 12,091,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543712,005,399 - 12,087,014 (+)NCBIChiLan1.0ChiLan1.0
CD2AP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2561,977,062 - 62,123,354 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1657,844,128 - 57,989,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0647,065,284 - 47,210,746 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1648,328,836 - 48,474,166 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl648,328,863 - 48,474,163 (+)Ensemblpanpan1.1panPan2
CD2AP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,538,215 - 15,683,619 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,538,356 - 15,681,011 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1215,569,237 - 15,714,616 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01216,041,717 - 16,186,523 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1216,041,451 - 16,186,100 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11215,549,899 - 15,695,706 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,642,957 - 15,788,194 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,789,659 - 15,935,714 (+)NCBIUU_Cfam_GSD_1.0
Cd2ap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,972,198 - 51,069,620 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647612,890,468 - 12,987,843 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647612,890,595 - 12,989,046 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD2AP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl742,218,290 - 42,332,518 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1742,218,016 - 42,332,523 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,870,223 - 48,952,250 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD2AP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11724,664,245 - 24,815,786 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1724,663,872 - 24,815,829 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604447,487,056 - 47,639,257 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd2ap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,420,603 - 13,511,523 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475413,420,594 - 13,511,672 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cd2ap
391 total Variants

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000016291
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat

1 to 10 of 19 rows
AI010435  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2918,182,419 - 18,182,545 (+)MAPPERmRatBN7.2
Rnor_6.0920,861,620 - 20,861,745NCBIRnor6.0
Rnor_5.0919,724,135 - 19,724,260UniSTSRnor5.0
RGSC_v3.4913,891,520 - 13,891,645UniSTSRGSC3.4
Celera915,889,662 - 15,889,787UniSTS
RH 3.4 Map9104.9UniSTS
Cytogenetic Map9q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 20 of 20 rows
RefSeq Transcripts NM_181475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY114147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY205155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA506385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA508086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA513011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB545525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK359466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO386882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN937610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV718887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV727927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY312051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000016291   ⟹   ENSRNOP00000016291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl918,117,462 - 18,180,673 (+)Ensembl
Rnor_6.0 Ensembl920,765,296 - 20,858,504 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107057   ⟹   ENSRNOP00000086646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl918,087,097 - 18,180,673 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120136   ⟹   ENSRNOP00000088324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl918,086,984 - 18,182,199 (+)Ensembl
RefSeq Acc Id: NM_181475   ⟹   NP_852140
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,583,975 - 25,679,968 (+)NCBI
mRatBN7.2918,086,744 - 18,182,744 (+)NCBI
Rnor_6.0920,794,680 - 20,858,438 (+)NCBI
Rnor_5.0919,659,503 - 19,720,953 (+)NCBI
RGSC_v3.4913,827,015 - 13,888,338 (+)RGD
Celera915,825,287 - 15,886,480 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083538   ⟹   XP_038939466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,580,071 - 25,679,963 (+)NCBI
mRatBN7.2918,086,766 - 18,182,739 (+)NCBI
RefSeq Acc Id: XM_039083539   ⟹   XP_038939467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,587,343 - 25,679,963 (+)NCBI
mRatBN7.2918,090,113 - 18,182,739 (+)NCBI
RefSeq Acc Id: XM_039083540   ⟹   XP_038939468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,613,192 - 25,679,963 (+)NCBI
mRatBN7.2918,115,986 - 18,182,739 (+)NCBI
RefSeq Acc Id: XM_039083541   ⟹   XP_038939469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,580,071 - 25,657,444 (+)NCBI
mRatBN7.2918,086,765 - 18,160,195 (+)NCBI
RefSeq Acc Id: XR_005488895
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,580,071 - 25,663,997 (+)NCBI
mRatBN7.2918,086,766 - 18,166,769 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_852140 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939466 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939467 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939468 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939469 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM47029 (Get FASTA)   NCBI Sequence Viewer  
  AAO46043 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016291
  ENSRNOP00000088324
  ENSRNOP00000103834
GenBank Protein F1LRS8 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_852140   ⟸   NM_181475
- UniProtKB: F1LRS8 (UniProtKB/Swiss-Prot),   Q7TSS5 (UniProtKB/Swiss-Prot),   A6JJ47 (UniProtKB/TrEMBL),   A0A8L2Q7T7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016291   ⟸   ENSRNOT00000016291
RefSeq Acc Id: XP_038939469   ⟸   XM_039083541
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038939466   ⟸   XM_039083538
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A6A6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939467   ⟸   XM_039083539
- Peptide Label: isoform X2
- UniProtKB: A6JJ48 (UniProtKB/TrEMBL),   A0A8L2Q7T7 (UniProtKB/TrEMBL)
SH3

Name Modeler Protein Id AA Range Protein Structure
AF-F1LRS8-F1-model_v2 AlphaFold F1LRS8 1-637 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-28096 BioCyc
Ensembl Genes ENSRNOG00000011987 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016291 ENTREZGENE
  ENSRNOT00000120136 ENTREZGENE
  ENSRNOT00000142796 ENTREZGENE
Gene3D-CATH SH3 Domains UniProtKB/Swiss-Prot
InterPro CD2AP_SH3_1 UniProtKB/Swiss-Prot
  CD2AP_SH3_3 UniProtKB/Swiss-Prot
  CD2AP_SH_2 UniProtKB/Swiss-Prot
  Endophilin_SH3RF UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
NCBI Gene 316258 ENTREZGENE
PANTHER LD44138P UniProtKB/Swiss-Prot
  SH3 DOMAIN-CONTAINING UniProtKB/Swiss-Prot
Pfam SH3_1 UniProtKB/Swiss-Prot
  SH3_9 UniProtKB/Swiss-Prot
PhenoGen Cd2ap PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011987 RatGTEx
SMART SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
UniProt A0A8I6A6A6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GF65_RAT UniProtKB/TrEMBL
  A0A8L2Q7T7 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ47 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ48 ENTREZGENE, UniProtKB/TrEMBL
  CD2AP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TSS5 ENTREZGENE
  Q80ZE7_RAT UniProtKB/TrEMBL
UniProt Secondary Q7TSS5 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cd2ap  CD2-associated protein      Symbol and Name status set to approved 1299863 APPROVED

Note Type Note Reference
gene_domains protein contains three SH3 domains 1302417
gene_homology rat sequence shows 84% homology to the human sequence and 92% homology to the mouse sequence 1302417
gene_physical_interaction the second SH3 domain is responsible for binding c-Cbl and Flt-1 in rat sinusoidal endothelial cells 1302417