Krtdap (keratinocyte differentiation associated protein) - Rat Genome Database

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Gene: Krtdap (keratinocyte differentiation associated protein) Rattus norvegicus
Analyze
Symbol: Krtdap
Name: keratinocyte differentiation associated protein
RGD ID: 71086
Description: Involved in epidermis development. Predicted to be located in lamellar body. Predicted to be active in extracellular space. Orthologous to human KRTDAP (keratinocyte differentiation associated protein); INTERACTS WITH benzo[a]pyrene; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kdap; Keratinocyte differentiation-associated protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,165,844 - 95,169,025 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl195,165,862 - 95,169,012 (+)EnsemblGRCr8
mRatBN7.2186,038,296 - 86,041,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,038,437 - 86,041,455 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,453,978 - 91,457,145 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,920,148 - 99,923,315 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,212,270 - 93,215,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,234,689 - 89,235,610 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,232,439 - 89,235,598 (+)Ensemblrn6Rnor6.0
Celera180,409,596 - 80,411,828 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Gene Data Set MGD Curation, June 12, 2002
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Kdap, a novel gene associated with the stratification of the epithelium. Oomizu S, etal., Gene 2000 Oct 3;256(1-2):19-27.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15140226  


Genomics

Comparative Map Data
Krtdap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,165,844 - 95,169,025 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl195,165,862 - 95,169,012 (+)EnsemblGRCr8
mRatBN7.2186,038,296 - 86,041,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,038,437 - 86,041,455 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,453,978 - 91,457,145 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,920,148 - 99,923,315 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,212,270 - 93,215,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,234,689 - 89,235,610 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,232,439 - 89,235,598 (+)Ensemblrn6Rnor6.0
Celera180,409,596 - 80,411,828 (+)NCBICelera
Cytogenetic Map1q21NCBI
KRTDAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,487,324 - 35,490,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,487,324 - 35,495,558 (-)Ensemblhg38GRCh38
GRCh371935,978,226 - 35,981,366 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,670,068 - 40,673,196 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1932,691,750 - 32,694,878 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,483,746 - 32,486,953 (-)NCBIHuRef
CHM1_11935,979,853 - 35,983,059 (-)NCBICHM1_1
T2T-CHM13v2.01938,032,044 - 38,038,270 (-)NCBIT2T-CHM13v2.0
Krtdap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,487,330 - 30,490,514 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,487,321 - 30,490,522 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38730,787,905 - 30,791,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,787,896 - 30,791,097 (+)Ensemblmm10GRCm38
MGSCv37731,572,924 - 31,576,102 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36730,496,665 - 30,499,843 (+)NCBIMGSCv36mm8
Celera725,370,739 - 25,373,917 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.24NCBI
Krtdap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,713,043 - 4,716,372 (-)Ensembl
ChiLan1.0NW_0049554684,713,332 - 4,716,212 (-)NCBIChiLan1.0ChiLan1.0
KRTDAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,450,127 - 41,508,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,433,487 - 43,491,758 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,434,016 - 32,437,611 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,170,227 - 41,173,441 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,170,227 - 41,173,441 (-)EnsemblpanPan2panpan1.1
KRTDAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,167,456 - 117,170,647 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,167,456 - 117,170,645 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1116,570,316 - 116,573,507 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01117,767,121 - 117,770,312 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,767,121 - 117,770,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,330,438 - 117,333,629 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,955,801 - 116,958,992 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,011,132 - 118,014,323 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Krtdap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,776,603 - 10,779,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570866,301 - 869,281 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936570866,334 - 869,279 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRTDAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,932,195 - 44,935,353 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1644,932,195 - 44,935,921 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,249,974 - 40,253,368 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRTDAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,412,518 - 30,417,957 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,412,526 - 30,415,611 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660738,204,929 - 8,208,111 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krtdap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,109,771 - 8,113,277 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247948,109,752 - 8,112,586 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Krtdap
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12165,224,817 - 165,227,794 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Krtdap
7 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
10 14 5 5 2 1 2 6 14 12 9 24 3

Sequence


Ensembl Acc Id: ENSRNOT00000093173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl189,235,033 - 89,235,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,165,862 - 95,168,886 (+)Ensembl
mRatBN7.2 Ensembl186,038,437 - 86,041,455 (+)Ensembl
Rnor_6.0 Ensembl189,232,439 - 89,232,497 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123644   ⟹   ENSRNOP00000106350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,165,869 - 95,169,012 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144610   ⟹   ENSRNOP00000100576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,165,869 - 95,169,012 (+)Ensembl
RefSeq Acc Id: NM_001399867   ⟹   NP_001386796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,165,862 - 95,169,025 (+)NCBI
mRatBN7.2186,038,430 - 86,041,594 (+)NCBI
RefSeq Acc Id: XM_039093979   ⟹   XP_038949907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,165,844 - 95,169,013 (+)NCBI
mRatBN7.2186,038,296 - 86,041,594 (+)NCBI
RefSeq Acc Id: XM_063272956   ⟹   XP_063129026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,165,865 - 95,169,013 (+)NCBI
RefSeq Acc Id: XM_063272964   ⟹   XP_063129034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,165,844 - 95,169,013 (+)NCBI
RefSeq Acc Id: XP_038949907   ⟸   XM_039093979
- Peptide Label: isoform X1
- UniProtKB: P85411 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001386796   ⟸   NM_001399867
- Peptide Label: precursor
RefSeq Acc Id: XP_063129034   ⟸   XM_063272964
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063129026   ⟸   XM_063272956
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000106350   ⟸   ENSRNOT00000123644
Ensembl Acc Id: ENSRNOP00000100576   ⟸   ENSRNOT00000144610

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P85411-F1-model_v2 AlphaFold P85411 1-98 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71086 AgrOrtholog
BioCyc Gene G2FUF-60077 BioCyc
Ensembl Genes ENSRNOG00000062262 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000123644 ENTREZGENE
  ENSRNOT00000144610 ENTREZGENE
InterPro KRTDAP UniProtKB/Swiss-Prot
NCBI Gene 65186 ENTREZGENE
PANTHER KERATINOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
  PTHR36463 UniProtKB/Swiss-Prot
Pfam KRTDAP UniProtKB/Swiss-Prot
PhenoGen Krtdap PhenoGen
RatGTEx ENSRNOG00000062262 RatGTEx
UniProt A0A8I6A1L3_RAT UniProtKB/TrEMBL
  KTDAP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Krtdap  keratinocyte differentiation associated protein      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contained two putative N-myristoylation sites and two casein kinase II phosphorylation sites 70785
gene_expression expressed exclusively in the suprabasal cell layers of the embryonic epidermis 70785