Fcgr2a (Fc gamma receptor 2A) - Rat Genome Database

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Gene: Fcgr2a (Fc gamma receptor 2A) Rattus norvegicus
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Symbol: Fcgr2a
Name: Fc gamma receptor 2A
RGD ID: 71069
Description: Enables immunoglobulin receptor binding activity. Involved in several processes, including regulation of Fc receptor mediated stimulatory signaling pathway; regulation of antibody-dependent cellular cytotoxicity; and regulation of tumor necrosis factor production. Located in cell surface. Used to study crescentic glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc gamma receptor IIa); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fc fragment of IgG low affinity IIa receptor for (CD32); Fc fragment of IgG receptor IIa; Fc fragment of IgG, low affinity IIa, receptor; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIa, receptor for (CD32); Fc gamma receptor IIa; Fc receptor, IgG, low affinity III; fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII; igG Fc receptor III; LOC360876; low affinity immunoglobulin gamma Fc region receptor III
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Fcgr2a-ps1  
Candidate Gene For: Glom15 Glom27
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,813,516 - 85,830,269 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1385,855,437 - 85,864,394 (-)EnsemblGRCr8
GRCr8 Ensembl1385,813,516 - 85,931,597 (-)EnsemblGRCr8
mRatBN7.21383,280,782 - 83,297,535 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,280,784 - 83,295,967 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1385,900,776 - 85,913,853 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,194,261 - 87,207,344 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,432,186 - 84,445,276 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,146,878 - 91,163,691 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,146,876 - 91,229,066 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1391,168,973 - 91,198,036 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,665,044 - 95,682,068 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41386,898,651 - 86,911,743NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1382,933,510 - 83,125,911 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IMP)
Anaphylaxis  (ISO)
arthus reaction  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
chronic myeloid leukemia  (ISO)
common variable immunodeficiency  (ISO)
coronary artery disease  (ISO)
crescentic glomerulonephritis  (IAGP)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
dengue disease  (ISO)
dengue hemorrhagic fever  (ISO)
diffuse large B-cell lymphoma  (ISO)
diffuse scleroderma  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
factor VIII deficiency  (ISO)
glomerulonephritis  (ISO)
haemophilus meningitis  (ISO)
hemolytic anemia  (ISO)
hemolytic disease of the fetus  (ISO)
Heparin-induced Thrombocytopenia  (ISO)
Kawasaki disease  (ISO)
lupus nephritis  (ISO)
lymphoid leukemia  (ISO)
lymphopenia  (ISO)
malaria  (ISO)
Meningococcal Infections  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
neutropenia  (ISO)
non-Hodgkin lymphoma  (ISO)
osteoarthritis  (ISO)
Plasmodium falciparum malaria  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
respiratory system disease  (ISO)
rheumatoid arthritis  (ISO)
Sjogren's syndrome  (ISO)
stroke  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Wallerian Degeneration  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-nitrofluorene  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
Fast green FCF  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
heparin  (ISO)
hexachlorobenzene  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SCH 23390  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulpiride  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
undecane  (EXP)
ursolic acid  (ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. Abboud G, etal., J Immunol. 2009 May 15;182(10):6517-26.
2. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Aitman TJ, etal., Nature. 2006 Feb 16;439(7078):851-5.
3. Expression of Fc gamma and complement receptors in monocytes of X-linked agammaglobulinaemia and common variable immunodeficiency patients. Amoras AL, etal., Clin Exp Immunol. 2007 Dec;150(3):422-8. Epub 2007 Sep 27.
4. FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis. Andren M, etal., Scand J Immunol. 2006 Apr;63(4):282-9.
5. Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis. Arepally G, etal., Blood. 1997 Jan 15;89(2):370-5.
6. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Asano K, etal., Nat Genet. 2009 Dec;41(12):1325-9. Epub 2009 Nov 15.
7. Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa (CD32A) R131 allele. Balada E, etal., Tissue Antigens. 2006 Nov;68(5):432-8.
8. Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. Baudino L, etal., J Immunol. 2008 Feb 1;180(3):1948-53.
9. Fc gamma RIIa polymorphism: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients. Bazilio AP, etal., Nephrol Dial Transplant. 2004 Jun;19(6):1427-31. Epub 2004 Mar 5.
10. Specificity and class distribution of Fc gamma R-specific autoantibodies in patients with autoimmune disease. Boros P, etal., J Immunol. 1994 Jan 1;152(1):302-6.
11. Destructive arthritis in the absence of both FcgammaRI and FcgammaRIII. Boross P, etal., J Immunol. 2008 Apr 1;180(7):5083-91.
12. On the role of platelet Fc gamma RIIa phenotype in heparin-induced thrombocytopenia. Brandt JT, etal., Thromb Haemost. 1995 Dec;74(6):1564-72.
13. No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS. Breij EC, etal., J Neuroimmunol. 2003 Jul;140(1-2):210-5.
14. Common variants in genes that mediate immunity and risk of multiple myeloma. Brown EE, etal., Int J Cancer. 2007 Jun 15;120(12):2715-22.
15. Fcgamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis. De Rose V, etal., Eur J Hum Genet. 2005 Jan;13(1):96-101.
16. C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo. Devaraj S, etal., Atherosclerosis. 2009 Mar;203(1):67-74. Epub 2008 Jun 13.
17. Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease. Domingo P, etal., Am J Med. 2002 Jan;112(1):19-25.
18. Effect of FCGR2A and FCGR3A variants on CLL outcome. Dornan D, etal., Blood. 2010 Nov 18;116(20):4212-22. doi: 10.1182/blood-2010-03-272765. Epub 2010 Aug 12.
19. The Fc gamma receptor IIa R131H polymorphism is associated with inhibitor development in severe hemophilia A. Eckhardt CL, etal., J Thromb Haemost. 2014 Aug;12(8):1294-301. doi: 10.1111/jth.12631. Epub 2014 Jul 16.
20. FcgammaRIIa and FcgammaRIIIa genetic polymorphisms in a group of pediatric immune thrombocytopenic purpura in Egypt. Eyada TK, etal., Blood Coagul Fibrinolysis. 2012 Jan;23(1):64-8. doi: 10.1097/MBC.0b013e32834ddf2f.
21. Rat CD16 is defined by a family of class III Fc gamma receptors requiring co-expression of heteroprotein subunits. Farber DL and Sears DW, J Immunol 1991 Jun 15;146(12):4352-61.
22. Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding specificity and fail to associate productively with rat CD3 zeta. Farber DL, etal., J Immunol 1993 May 15;150(10):4364-75.
23. The role of Fcgamma receptor polymorphisms and C3 in the immune defence against Neisseria meningitidis in complement-deficient individuals. Fijen CA, etal., Clin Exp Immunol. 2000 May;120(2):338-45.
24. [Low-affinity Fcgamma receptor IIa gene polymorphism and dengue bleeding disorder]. Garcia G, etal., Enferm Infecc Microbiol Clin. 2012 Dec;30(10):621-3. doi: 10.1016/j.eimc.2012.05.011. Epub 2012 Jul 18.
25. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
26. FCGR3A/2A polymorphisms and diffuse large B-cell lymphoma outcome treated with immunochemotherapy: a meta-analysis on 1134 patients from two prospective cohorts. Ghesquieres H, etal., Hematol Oncol. 2016 Jun 10. doi: 10.1002/hon.2305.
27. Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies. Giorgini A, etal., J Immunol. 2008 Dec 15;181(12):8745-52.
28. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
29. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Harley JB, etal., Nat Genet. 2008 Feb;40(2):204-10. Epub 2008 Jan 20.
30. Expression of Fcgamma and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis. Hepburn AL, etal., Rheumatology (Oxford). 2004 May;43(5):547-54. Epub 2004 Jan 27.
31. Dendritic cells modulate platelet activity in IVIg-mediated amelioration of ITP in mice. Huang HS, etal., Blood. 2010 Dec 2;116(23):5002-9. doi: 10.1182/blood-2010-03-275123. Epub 2010 Aug 10.
32. Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice. Inoue Y, etal., J Immunol. 2007 Jul 15;179(2):764-74.
33. Association between SLE nephritis and polymorphic variants of the CRP and FcgammaRIIIa genes. Jonsen A, etal., Rheumatology (Oxford). 2007 Sep;46(9):1417-21. Epub 2007 Jun 27.
34. Decreased expression of both Fc gamma RII and Fc gamma RIII mRNA in leukemic granulocytes. Kant A, etal., Leuk Res. 1995 Dec;19(12):997-1000.
35. Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the Fc gamma receptor IIA. Kim YS, etal., Blood Coagul Fibrinolysis. 2009 Jul;20(5):353-7.
36. The association between a common FCGR2A polymorphism and C-reactive protein and coronary artery disease revisited. Kroupis C, etal., Genet Test Mol Biomarkers. 2010 Dec;14(6):839-46. Epub 2010 Oct 25.
37. Inhibition of hyperacute transplant rejection by soluble proteins with the functional domains of CD46 and FcgammaRII. Lanteri MB, etal., Transplantation. 2000 Mar 27;69(6):1128-36.
38. Susceptibility for ischemic stroke in four constitution medicine is associated with polymorphisms of FCGR2A and IL1RN genes. Lee BC, etal., Neurol Res. 2010 Feb;32 Suppl 1:43-7.
39. FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia. Lin TS, etal., Blood. 2005 Jan 1;105(1):289-91. Epub 2004 Jun 24.
40. High-dose dexamethasone shifts the balance of stimulatory and inhibitory Fcgamma receptors on monocytes in patients with primary immune thrombocytopenia. Liu XG, etal., Blood. 2011 Feb 10;117(6):2061-9. doi: 10.1182/blood-2010-07-295477. Epub 2010 Dec 3.
41. The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. McKenzie SE, etal., J Immunol. 1999 Apr 1;162(7):4311-8.
42. FcgammaRIII (CD16)-deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia. Meyer D, etal., Blood. 1998 Dec 1;92(11):3997-4002.
43. CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice. Meyer T, etal., Blood. 2015 Nov 5;126(19):2230-8. doi: 10.1182/blood-2015-04-638684. Epub 2015 Sep 22.
44. Bevacizumab immune complexes activate platelets and induce thrombosis in FCGR2A transgenic mice. Meyer T, etal., J Thromb Haemost. 2009 Jan;7(1):171-81. doi: 10.1111/j.1538-7836.2008.03212.x. Epub 2008 Oct 30.
45. Gene Data Set MGD Curation, June 12, 2002
46. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
47. Association of Fc¿RIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan. Mohsin SN, etal., Am J Trop Med Hyg. 2015 Oct;93(4):691-6. doi: 10.4269/ajtmh.15-0199. Epub 2015 Aug 3.
48. Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis. Morgan AW, etal., Arthritis Res Ther. 2006;8(4):R109.
49. Relationships between eosinophil-associated parameters and disease severity in atopic dermatitis. Nakama T Kurume Med J. 1995;42(2):95-106.
50. [The diagnostic of defects of inborn immunity under B-cell tumors of lymphatic system]. Nazarova EL, etal., Klin Lab Diagn. 2014 Nov;59(11):39-42.
51. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
52. Relationship between Fc receptor IIA polymorphism and infection in children with sickle cell disease. Norris CF, etal., J Pediatr. 1996 Jun;128(6):813-9.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. Fc gamma RIIa, IIIa and IIIb polymorphisms in Turkish children susceptible to recurrent infectious diseases. Ozturk C, etal., Clin Exp Med. 2006 Mar;6(1):27-32.
55. Role of novel rat-specific Fc receptor in macrophage activation associated with crescentic glomerulonephritis. Page TH, etal., J Biol Chem. 2012 Feb 17;287(8):5710-9. doi: 10.1074/jbc.M111.260695. Epub 2011 Dec 19.
56. FcgammaRIIa and FcgammaRIIIa polymorphisms in childhood primary immune thrombocytopenia: implications for disease pathogenesis and outcome. Papagianni A, etal., Blood Coagul Fibrinolysis. 2013 Jan;24(1):35-9. doi: 10.1097/MBC.0b013e328359bc3b.
57. FC gamma RIIa polymorphism in patients with rheumatoid arthritis. Pawlik A, etal., Clin Exp Rheumatol. 2002 Nov-Dec;20(6):841-4.
58. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination. Pedotti R, etal., Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1867-72. Epub 2003 Feb 7.
59. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
60. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
61. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
62. Comprehensive gene review and curation RGD comprehensive gene curation
63. FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia. Rhein LM, etal., Am J Respir Cell Mol Biol. 2008 Apr;38(4):401-6. Epub 2007 Nov 1.
64. Anti-CD40L immune complexes potently activate platelets in vitro and cause thrombosis in FCGR2A transgenic mice. Robles-Carrillo L, etal., J Immunol. 2010 Aug 1;185(3):1577-83. Epub 2010 Jun 28.
65. Early atherosclerosis and IgG2 to bacteria are associated with FcgammaRIIa genotype in non-smokers. Sampi M, etal., Eur J Clin Invest. 2009 Jun;39(6):517-26.
66. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Sanchez E, etal., Ann Rheum Dis. 2011 Jun 30.
67. Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. Sarvari M, etal., J Neuroinflammation. 2012 Dec 3;9:264. doi: 10.1186/1742-2094-9-264.
68. FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children. Schuldt K, etal., J Med Genet. 2010 Jul;47(7):471-5. Epub 2009 Dec 3.
69. Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population. Sinha S, etal., Malar J. 2008 Jan 14;7:13.
70. The Fcgamma receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia. Sole-Violan J, etal., Crit Care Med. 2011 Jun;39(6):1388-93.
71. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
72. A single-nucleotide polymorphism of the Fcgamma receptor type IIIA gene in the recipient predicts transplant outcomes after HLA fully matched unrelated BMT for myeloid malignancies. Takami A, etal., Bone Marrow Transplant. 2011 Feb;46(2):238-43. doi: 10.1038/bmt.2010.88. Epub 2010 Apr 19.
73. FcgammaRIII b and FcgammaRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy. Taniuchi S, etal., Hum Immunol. 2001 Apr;62(4):408-13.
74. A novel splice variant of FcgammaRIIa: a risk factor for anaphylaxis in patients with hypogammaglobulinemia. van der Heijden J, etal., J Allergy Clin Immunol. 2013 May;131(5):1408-16.e5. doi: 10.1016/j.jaci.2013.02.009. Epub 2013 Mar 29.
75. A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice. van Royen-Kerkhof A, etal., Br J Haematol. 2005 Jul;130(1):130-7.
76. Expression of genes encoding receptors for IgG (FcRIII) and for C3b/C4b (Crry) in rat sciatic nerve during development and Wallerian degeneration. Vedeler CA, etal., J Neurosci Res. 1992 Apr;31(4):654-61.
77. Phenotypic analysis of alveolar macrophages and monocytes in allergic airway inflammation. I. Evidence for activation of alveolar macrophages, but not peripheral blood monocytes, in subjects with allergic rhinitis and asthma. Viksman MY, etal., Am J Respir Crit Care Med. 1997 Mar;155(3):858-63.
78. Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients. Villarreal J, etal., Rheumatology (Oxford). 2001 Sep;40(9):1009-12.
79. Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations. Weersma RK, etal., Inflamm Bowel Dis. 2010 Dec;16(12):2080-9. doi: 10.1002/ibd.21342.
80. Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32). Werwitzke S, etal., Ann Rheum Dis. 2008 Feb;67(2):154-61. Epub 2007 Jun 8.
81. Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. Wu CL, etal., Shock. 2009 Sep;32(3):276-85.
82. Correlation of Fc(gamma)RIIa (CD32) Polymorphism and IgG Antibody Subclasses in Hemolytic Disease of Newborn. Wu Q, etal., Neonatology. 2009;96(1):1-5. doi: 10.1159/000189239. Epub 2009 Jan 8.
83. Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis. Zaba LC, etal., J Allergy Clin Immunol. 2010 Jun;125(6):1261-1268.e9. Epub 2010 May 14.
84. Characterization and expression of an Fc gamma receptor cDNA cloned from rat natural killer cells. Zeger DL, etal., Proc Natl Acad Sci U S A 1990 May;87(9):3425-9.
Additional References at PubMed
PMID:8552190   PMID:8769481   PMID:9743367   PMID:10229794   PMID:11420040   PMID:11911824   PMID:17558411   PMID:19360001   PMID:23376485   PMID:38544414  


Genomics

Comparative Map Data
Fcgr2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,813,516 - 85,830,269 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1385,855,437 - 85,864,394 (-)EnsemblGRCr8
GRCr8 Ensembl1385,813,516 - 85,931,597 (-)EnsemblGRCr8
mRatBN7.21383,280,782 - 83,297,535 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,280,784 - 83,295,967 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1385,900,776 - 85,913,853 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,194,261 - 87,207,344 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,432,186 - 84,445,276 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,146,878 - 91,163,691 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,146,876 - 91,229,066 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1391,168,973 - 91,198,036 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,665,044 - 95,682,068 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41386,898,651 - 86,911,743NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1382,933,510 - 83,125,911 (-)NCBICelera
Cytogenetic Map13q24NCBI
FCGR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,505,457 - 161,524,048 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,505,415 - 161,524,013 (+)Ensemblhg38GRCh38
GRCh371161,475,247 - 161,489,619 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,741,844 - 159,755,984 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341158,288,274 - 158,302,415NCBI
Celera1134,591,741 - 134,592,404 (-)NCBICelera
Celera1134,682,428 - 134,687,972 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,800,353 - 132,814,372 (+)NCBIHuRef
CHM1_11162,897,042 - 162,911,192 (+)NCBICHM1_1
T2T-CHM13v2.01160,768,080 - 160,786,676 (+)NCBIT2T-CHM13v2.0
Fcgr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,878,738 - 170,893,477 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,878,743 - 170,892,504 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381171,051,169 - 171,065,915 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,051,174 - 171,064,935 (-)Ensemblmm10GRCm38
MGSCv371172,981,300 - 172,989,534 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361172,887,870 - 172,896,073 (-)NCBIMGSCv36mm8
Celera1173,499,171 - 173,507,755 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.8NCBI
LOC100991644
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,268,426 - 88,282,501 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,936,861 - 87,950,937 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,892,311 - 136,906,450 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Fcgr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,496,110 - 7,502,712 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493713115,542 - 22,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCGR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,480,710 - 2,512,429 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,557,192 - 1,570,636 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcgr2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482623,930 - 34,735 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fcgr2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11050,227,521 - 50,236,874 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fcgr2a
113 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:119
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000045427, ENSRNOT00000058496, ENSRNOT00000074149
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 1 30 108 68 60 36 79 36 12 254 143 11 83 56 70 24 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000004204   ⟹   ENSRNOP00000004204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,813,516 - 85,822,733 (-)Ensembl
mRatBN7.2 Ensembl1383,280,790 - 83,295,956 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096805   ⟹   ENSRNOP00000095599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,280,788 - 83,295,967 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096873   ⟹   ENSRNOP00000089656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,922,751 - 85,931,597 (-)Ensembl
mRatBN7.2 Ensembl1383,280,968 - 83,293,719 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118185   ⟹   ENSRNOP00000086950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,280,784 - 83,295,956 (-)Ensembl
RefSeq Acc Id: NM_001419015   ⟹   NP_001405944
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,813,516 - 85,828,685 (-)NCBI
mRatBN7.21383,280,782 - 83,295,951 (-)NCBI
RefSeq Acc Id: NM_001419016   ⟹   NP_001405945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,813,516 - 85,828,685 (-)NCBI
mRatBN7.21383,280,782 - 83,295,951 (-)NCBI
RefSeq Acc Id: NM_053843   ⟹   NP_446295
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,813,516 - 85,826,732 (-)NCBI
mRatBN7.21383,280,782 - 83,293,998 (-)NCBI
Rnor_6.01391,146,997 - 91,160,089 (-)NCBI
Rnor_5.01395,665,044 - 95,682,068 (-)NCBI
RGSC_v3.41386,898,651 - 86,911,743 (-)RGD
Celera1382,933,510 - 83,125,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250305   ⟹   XP_006250367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,813,524 - 85,830,269 (-)NCBI
mRatBN7.21383,280,785 - 83,297,535 (-)NCBI
Rnor_6.01391,146,878 - 91,163,691 (-)NCBI
Rnor_5.01395,665,044 - 95,682,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090269   ⟹   XP_038946197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,813,524 - 85,828,645 (-)NCBI
mRatBN7.21383,280,782 - 83,295,919 (-)NCBI
RefSeq Acc Id: XM_039090270   ⟹   XP_038946198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,813,524 - 85,828,686 (-)NCBI
mRatBN7.21383,281,481 - 83,295,915 (-)NCBI
RefSeq Acc Id: XM_039090273   ⟹   XP_038946201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,816,341 - 85,828,686 (-)NCBI
mRatBN7.21383,283,612 - 83,295,913 (-)NCBI
RefSeq Acc Id: XM_063271962   ⟹   XP_063128032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,813,524 - 85,823,983 (-)NCBI
RefSeq Acc Id: XM_063271963   ⟹   XP_063128033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,813,524 - 85,826,838 (-)NCBI
RefSeq Acc Id: NP_446295   ⟸   NM_053843
- Peptide Label: isoform 1
- UniProtKB: A0A8L2Q236 (UniProtKB/TrEMBL),   A0A8I6AAT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250367   ⟸   XM_006250305
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q236 (UniProtKB/TrEMBL),   A0A8I6AAT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038946197   ⟸   XM_039090269
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AP20 (UniProtKB/TrEMBL),   A0A8I6AAT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946198   ⟸   XM_039090270
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946201   ⟸   XM_039090273
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001405945   ⟸   NM_001419016
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001405944   ⟸   NM_001419015
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AAT3 (UniProtKB/TrEMBL),   A0A8L2Q236 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089656   ⟸   ENSRNOT00000096873
Ensembl Acc Id: ENSRNOP00000086950   ⟸   ENSRNOT00000118185
Ensembl Acc Id: ENSRNOP00000004204   ⟸   ENSRNOT00000004204
Ensembl Acc Id: ENSRNOP00000095599   ⟸   ENSRNOT00000096805
RefSeq Acc Id: XP_063128033   ⟸   XM_063271963
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AAT3 (UniProtKB/TrEMBL),   A0A8L2Q236 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128032   ⟸   XM_063271962
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AAT3 (UniProtKB/TrEMBL),   A0A8L2Q236 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27645-F1-model_v2 AlphaFold P27645 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71069 AgrOrtholog
BioCyc Gene G2FUF-17450 BioCyc
Ensembl Genes ENSRNOG00000046663 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000049422 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000004204 ENTREZGENE
  ENSRNOT00000047349.7 UniProtKB/Swiss-Prot
  ENSRNOT00000073643.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6886727 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_Fc_receptor UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
KEGG Report rno:116591 UniProtKB/Swiss-Prot
  rno:498276 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72645 IMAGE-MGC_LOAD
NCBI Gene 116591 ENTREZGENE
PANTHER IMMUNOGLOBULIN FC RECEPTOR UniProtKB/Swiss-Prot
  LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-A-RELATED UniProtKB/Swiss-Prot
Pfam Ig_2 UniProtKB/Swiss-Prot
PharmGKB FCGR2A RGD
PhenoGen Fcgr2a PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046663 RatGTEx
  ENSRNOG00000049422 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A8I6AAT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP20 ENTREZGENE
  A0A8I6GJ50_RAT UniProtKB/TrEMBL
  A0A8L2Q236 ENTREZGENE, UniProtKB/TrEMBL
  FCGR3_RAT UniProtKB/Swiss-Prot
  M0RCJ0_RAT UniProtKB/TrEMBL
  P27645 ENTREZGENE
UniProt Secondary Q04798 UniProtKB/Swiss-Prot
  Q63204 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-05 Fcgr2a  Fc gamma receptor 2A  Fcgr2a  Fc gamma receptor 2a  Name changed 629549 APPROVED
2022-05-05 Fcgr2a  Fc gamma receptor 2a  Fcgr2a  Fc gamma receptor IIa  Name changed 629549 APPROVED
2021-11-11 Fcgr2a  Fc gamma receptor IIa  Fcgr2a  Fc fragment of IgG receptor IIa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 Fcgr2a  Fc fragment of IgG receptor IIa  Fcgr2a  Fc fragment of IgG, low affinity IIa, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-22 Fcgr2a  Fc fragment of IgG, low affinity IIa, receptor  Fcgr2a  Fc fragment of IgG, low affinity IIa, receptor (CD32)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-16 Fcgr2a  Fc fragment of IgG, low affinity IIa, receptor (CD32)  Fcgr3  Fc receptor, IgG, low affinity III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Fcgr3  Fc receptor, IgG, low affinity III  Fcgr2a_predicted  Fc fragment of IgG, low affinity IIa, receptor for (CD32) (predicted)  Data merged from RGD:1307628 737654 APPROVED
2005-01-12 Fcgr2a_predicted  Fc fragment of IgG, low affinity IIa, receptor for (CD32) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Fcgr3  Fc receptor, IgG, low affinity III      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference