Lman1 (lectin, mannose-binding, 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lman1 (lectin, mannose-binding, 1) Rattus norvegicus
Analyze
Symbol: Lman1
Name: lectin, mannose-binding, 1
RGD ID: 71020
Description: Enables identical protein binding activity. Predicted to be involved in Golgi organization and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within endoplasmic reticulum organization; gene expression; and in utero embryonic development. Located in endoplasmic reticulum-Golgi intermediate compartment. Is active in glutamatergic synapse and postsynaptic Golgi apparatus. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to human LMAN1 (lectin, mannose binding 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; protein secretory pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endoplasmic reticulum-golgi intermediate compartment protein 53; ER-Golgi intermediate compartment 53 kDa protein; lectin mannose-binding 1; p58; protein ERGIC-53
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,778,971 - 61,800,960 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1861,772,917 - 61,800,820 (-)EnsemblGRCr8
mRatBN7.21859,508,996 - 59,530,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,508,996 - 59,530,851 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1861,604,527 - 61,624,705 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,303,213 - 62,323,391 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,131,092 - 60,151,186 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01861,683,377 - 61,707,344 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,685,117 - 61,707,317 (-)Ensemblrn6Rnor6.0
Rnor_5.01860,880,943 - 60,901,877 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41862,504,296 - 62,524,151 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1857,631,372 - 57,651,369 (-)NCBICelera
RGSC_v3.11862,577,496 - 62,597,352 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
dimethylarsinic acid  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexachlorobenzene  (EXP)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naled  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Synaptic activity and strength are reflected by changes in the post-synaptic secretory pathway. Gürth CM, etal., Sci Rep. 2020 Nov 25;10(1):20576. doi: 10.1038/s41598-020-77260-2.
4. Molecular cloning and expression of a 58-kDa cis-Golgi and intermediate compartment protein. Lahtinen U, etal., J Biol Chem 1996 Feb 23;271(8):4031-7.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Oligomerization and interacellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds. Neve EP, etal., J Mol Biol. 2005 Dec 2;354(3):556-68. Epub 2005 Oct 12.
9. ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families. Nichols WC, etal., Blood 1999 Apr 1;93(7):2261-6.
10. Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Nichols WC, etal., Cell. 1998 Apr 3;93(1):61-70.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Rezvani K, etal., J Neurosci. 2009 May 27;29(21):6883-96. doi: 10.1523/JNEUROSCI.4723-08.2009.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Lectin control of protein folding and sorting in the secretory pathway. Schrag JD, etal., Trends Biochem Sci 2003 Jan;28(1):49-57.
18. Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum. Velloso LM, etal., J Biol Chem 2002 May 3;277(18):15979-84.
Additional References at PubMed
PMID:9472029   PMID:10787428   PMID:11784862   PMID:14645249   PMID:14728599   PMID:15308636   PMID:15452145   PMID:18287528   PMID:19199708   PMID:19401338   PMID:19946888   PMID:19966784  
PMID:21187406   PMID:21525244   PMID:21795745   PMID:24270810  


Genomics

Comparative Map Data
Lman1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,778,971 - 61,800,960 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1861,772,917 - 61,800,820 (-)EnsemblGRCr8
mRatBN7.21859,508,996 - 59,530,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,508,996 - 59,530,851 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1861,604,527 - 61,624,705 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,303,213 - 62,323,391 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,131,092 - 60,151,186 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01861,683,377 - 61,707,344 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,685,117 - 61,707,317 (-)Ensemblrn6Rnor6.0
Rnor_5.01860,880,943 - 60,901,877 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41862,504,296 - 62,524,151 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1857,631,372 - 57,651,369 (-)NCBICelera
RGSC_v3.11862,577,496 - 62,597,352 (+)NCBI
Cytogenetic Map18q12.1NCBI
LMAN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381859,327,823 - 59,359,265 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1859,327,823 - 59,359,265 (-)Ensemblhg38GRCh38
GRCh371856,995,055 - 57,026,497 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361855,148,088 - 55,177,463 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341855,148,087 - 55,177,461NCBI
Celera1853,712,874 - 53,744,326 (-)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1853,704,319 - 53,735,757 (-)NCBIHuRef
CHM1_11856,990,302 - 57,021,756 (-)NCBICHM1_1
T2T-CHM13v2.01859,529,314 - 59,560,731 (-)NCBIT2T-CHM13v2.0
Lman1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,113,810 - 66,135,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,113,809 - 66,155,651 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381865,980,739 - 66,002,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,980,738 - 66,022,580 (-)Ensemblmm10GRCm38
MGSCv371866,140,393 - 66,162,289 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361866,106,123 - 66,127,980 (-)NCBIMGSCv36mm8
Celera1867,256,677 - 67,278,706 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.08NCBI
Lman1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540243,464,722 - 43,496,048 (-)Ensembl
ChiLan1.0NW_00495540243,465,556 - 43,495,789 (-)NCBIChiLan1.0ChiLan1.0
LMAN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21776,873,237 - 76,904,670 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11862,565,851 - 62,597,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01852,722,735 - 52,754,013 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11856,049,292 - 56,080,531 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1856,049,292 - 56,080,533 (-)EnsemblpanPan2panpan1.1
LMAN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1116,869,106 - 16,897,911 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,869,121 - 16,894,786 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha117,844,723 - 17,873,524 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0116,746,349 - 16,775,132 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,746,354 - 16,773,529 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,781,955 - 16,810,766 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0116,702,460 - 16,731,329 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0116,964,186 - 16,993,012 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lman1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,144,591 - 30,169,193 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364975,383,524 - 5,408,452 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364975,383,636 - 5,409,347 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMAN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1161,607,143 - 161,631,651 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11161,607,122 - 161,631,650 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,184,985 - 179,209,552 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LMAN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11820,377,259 - 20,409,565 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1820,377,255 - 20,409,741 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660605,179,049 - 5,212,921 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lman1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247924,732,446 - 4,776,041 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247924,732,476 - 4,775,946 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lman1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11565,264,161 - 65,285,572 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lman1
246 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:78
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000032047
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032047   ⟹   ENSRNOP00000035966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1861,685,117 - 61,707,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085784   ⟹   ENSRNOP00000070215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1861,781,960 - 61,800,820 (-)Ensembl
mRatBN7.2 Ensembl1859,508,996 - 59,530,851 (-)Ensembl
Rnor_6.0 Ensembl1861,686,401 - 61,707,307 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131067   ⟹   ENSRNOP00000107593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1861,772,917 - 61,800,820 (-)Ensembl
RefSeq Acc Id: NM_053886   ⟹   NP_446338
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,780,711 - 61,800,820 (-)NCBI
mRatBN7.21859,510,736 - 59,530,848 (-)NCBI
Rnor_6.01861,685,117 - 61,707,317 (-)NCBI
Rnor_5.01860,880,943 - 60,901,877 (-)NCBI
RGSC_v3.41862,504,296 - 62,524,151 (+)RGD
Celera1857,631,372 - 57,651,369 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096545   ⟹   XP_038952473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,778,971 - 61,800,960 (-)NCBI
mRatBN7.21859,508,996 - 59,530,873 (-)NCBI
RefSeq Acc Id: XM_039096546   ⟹   XP_038952474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,778,971 - 61,800,869 (-)NCBI
mRatBN7.21859,508,996 - 59,530,873 (-)NCBI
RefSeq Acc Id: NP_446338   ⟸   NM_053886
- Peptide Label: precursor
- Sequence:
Ensembl Acc Id: ENSRNOP00000070215   ⟸   ENSRNOT00000085784
Ensembl Acc Id: ENSRNOP00000035966   ⟸   ENSRNOT00000032047
RefSeq Acc Id: XP_038952474   ⟸   XM_039096546
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952473   ⟸   XM_039096545
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107593   ⟸   ENSRNOT00000131067
Protein Domains
L-type lectin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62902-F1-model_v2 AlphaFold Q62902 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700836
Promoter ID:EPDNEW_R11360
Type:multiple initiation site
Name:Lman1_1
Description:lectin, mannose-binding, 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01861,707,317 - 61,707,377EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71020 AgrOrtholog
BioCyc Gene G2FUF-7197 BioCyc
Ensembl Genes ENSRNOG00000024470 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000085784 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Intracellular_Lectin-GPT UniProtKB/Swiss-Prot
  Lectin_leg UniProtKB/Swiss-Prot
KEGG Report rno:116666 UniProtKB/Swiss-Prot
NCBI Gene 116666 ENTREZGENE
PANTHER PTHR12223:SF32 UniProtKB/Swiss-Prot
  VESICULAR MANNOSE-BINDING LECTIN UniProtKB/Swiss-Prot
Pfam Lectin_leg-like UniProtKB/Swiss-Prot
PhenoGen Lman1 PhenoGen
PROSITE L_LECTIN_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024470 RatGTEx
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt A0A0G2JXC1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LPD3_RAT UniProtKB/TrEMBL
  A6IXS1_RAT UniProtKB/TrEMBL
  A6IXS2 ENTREZGENE, UniProtKB/TrEMBL
  A6IXS4_RAT UniProtKB/TrEMBL
  LMAN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Lman1  lectin, mannose-binding, 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum (ER) and the Golgi complex 727344
gene_disease contains a carbohydrate recognition domain 727344