Sncg (synuclein, gamma) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sncg (synuclein, gamma) Rattus norvegicus
Analyze
Symbol: Sncg
Name: synuclein, gamma
RGD ID: 70996
Description: Enables alpha-tubulin binding activity and beta-tubulin binding activity. Involved in several processes, including cellular response to hydrostatic pressure; response to cocaine; and response to desipramine. Located in axon terminus; neuronal cell body; and perinuclear region of cytoplasm. Biomarker of depressive disorder and glaucoma. Human ortholog(s) of this gene implicated in Lewy body dementia. Orthologous to human SNCG (synuclein gamma); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gamma-synuclein; persyn; sensory neuron synuclein; synuclein, gamma (breast cancer-specific protein 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,706,765 - 9,712,072 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl169,706,753 - 9,712,076 (-)EnsemblGRCr8
mRatBN7.2169,700,513 - 9,705,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,700,514 - 9,705,368 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx169,720,641 - 9,725,221 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,865,356 - 10,869,935 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,715,722 - 9,720,302 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,722,110 - 10,726,648 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,722,106 - 10,726,707 (-)Ensemblrn6Rnor6.0
Rnor_5.0169,049,950 - 9,054,488 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41610,025,978 - 10,030,516 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera165,511,856 - 5,516,394 (+)NCBICelera
RGSC_v3.11610,025,976 - 10,030,511 (-)NCBI
Cytogenetic Map16p15NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Bufotalin  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
cisplatin  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
diuron  (EXP)
epoxiconazole  (ISO)
fenvalerate  (EXP)
furan  (EXP)
furfural  (ISO)
genistein  (EXP,ISO)
ketoconazole  (EXP)
mercaptopurine  (EXP)
methimazole  (EXP)
methylparaben  (ISO)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
purine-6-thiol  (EXP)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrahydropalmatine  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
axon terminus  (IBA,IDA)
centrosome  (IEA,ISO)
cytoplasm  (IBA,ISO)
cytosol  (ISO)
neuronal cell body  (IBA,IDA,ISO)
perinuclear region of cytoplasm  (IDA,IEA)
spindle  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Peripheral nervous system-specific genes identified by subtractive cDNA cloning. Akopian AN and Wood JN, J Biol Chem 1995 Sep 8;270(36):21264-70.
2. A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat. Boyer F, etal., Addict Biol. 2011 Jan;16(1):120-3. doi: 10.1111/j.1369-1600.2010.00232.x.
3. Distribution of alpha- and gamma-synucleins in the adult rat brain and their modification by high-dose cocaine treatment. Brenz Verca MS, etal., Eur J Neurosci. 2003 Oct;18(7):1923-38.
4. Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. Galvin JE, etal., Am J Pathol. 2000 Aug;157(2):361-8.
5. Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Galvin JE, etal., Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13450-5.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons. Giasson BI, etal., Exp Neurol. 2001 Dec;172(2):354-62.
8. Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression. Jeannotte AM, etal., Neuropsychopharmacology. 2009 Mar;34(4):987-98. Epub 2008 Sep 17.
9. Desipramine induced changes in the norepinephrine transporter, alpha- and gamma-synuclein in the hippocampus, amygdala and striatum. Jeannotte AM, etal., Neurosci Lett. 2009 Dec 25;467(2):86-9. doi: 10.1016/j.neulet.2009.10.010. Epub 2009 Oct 8.
10. Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS. Li JY, etal., Neuroscience. 2002;113(2):463-78.
11. Overexpression of synuclein-gamma in pancreatic adenocarcinoma. Li Z, etal., Cancer. 2004 Jul 1;101(1):58-65.
12. Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers. Liu H, etal., Cancer Res. 2005 Sep 1;65(17):7635-43.
13. Gene Data Set MGD Curation, June 12, 2002
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. Mukaetova-Ladinska EB, etal., Dement Geriatr Cogn Disord. 2008;26(1):32-42. Epub 2008 Jun 25.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein. Ninkina N, etal., Hum Mol Genet. 2009 May 15;18(10):1779-94. Epub 2009 Feb 26.
18. Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease. Nishioka K, etal., Arch Neurol. 2010 Aug;67(8):970-5.
19. Different levels of gamma-synuclein mRNA in the cerebral cortex of dominant, neutral and submissive rats selected in the competition test. Pinhasov A, etal., Genes Brain Behav. 2005 Feb;4(1):60-4.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. Robertson DC, etal., J Neurochem. 2004 Jun;89(5):1126-36.
24. Effect of gamma-synuclein silencing on apoptotic pathways in retinal ganglion cells. Surgucheva I, etal., J Biol Chem. 2008 Dec 26;283(52):36377-85. doi: 10.1074/jbc.M806660200. Epub 2008 Oct 20.
25. Synucleins in glaucoma: implication of gamma-synuclein in glaucomatous alterations in the optic nerve. Surgucheva I, etal., J Neurosci Res. 2002 Apr 1;68(1):97-106.
26. Gamma-synuclein as a marker of retinal ganglion cells. Surgucheva I, etal., Mol Vis. 2008 Aug 22;14:1540-8.
27. Age-dependent synuclein pathology following traumatic brain injury in mice. Uryu K, etal., Exp Neurol. 2003 Nov;184(1):214-24.
28. Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis. Wu K, etal., Breast Cancer Res Treat. 2007 Mar;101(3):259-67. Epub 2006 Jul 4.
Additional References at PubMed
PMID:9801372   PMID:10195122   PMID:14585981   PMID:15691713   PMID:16392033   PMID:17085784   PMID:17222866   PMID:18333965   PMID:18588534   PMID:19056867   PMID:19692427   PMID:20974939  
PMID:37487948  


Genomics

Comparative Map Data
Sncg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,706,765 - 9,712,072 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl169,706,753 - 9,712,076 (-)EnsemblGRCr8
mRatBN7.2169,700,513 - 9,705,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,700,514 - 9,705,368 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx169,720,641 - 9,725,221 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,865,356 - 10,869,935 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,715,722 - 9,720,302 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,722,110 - 10,726,648 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,722,106 - 10,726,707 (-)Ensemblrn6Rnor6.0
Rnor_5.0169,049,950 - 9,054,488 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41610,025,978 - 10,030,516 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera165,511,856 - 5,516,394 (+)NCBICelera
RGSC_v3.11610,025,976 - 10,030,511 (-)NCBI
Cytogenetic Map16p15NCBI
SNCG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381086,955,759 - 86,963,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1086,955,771 - 86,963,261 (+)Ensemblhg38GRCh38
GRCh371088,715,516 - 88,723,015 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,708,395 - 88,712,995 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341088,708,392 - 88,712,995NCBI
Celera1082,721,288 - 82,726,017 (+)NCBICelera
Cytogenetic Map10q23.2NCBI
HuRef1082,572,080 - 82,576,806 (+)NCBIHuRef
CHM1_11089,000,021 - 89,004,751 (+)NCBICHM1_1
T2T-CHM13v2.01087,839,472 - 87,846,971 (+)NCBIT2T-CHM13v2.0
Sncg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,092,231 - 34,096,626 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1434,092,231 - 34,096,746 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381434,370,274 - 34,374,669 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,370,274 - 34,374,789 (-)Ensemblmm10GRCm38
MGSCv371435,183,460 - 35,187,855 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361433,199,367 - 33,203,742 (-)NCBIMGSCv36mm8
Celera1430,636,519 - 30,640,914 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.81NCBI
Sncg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,958,276 - 5,961,719 (+)Ensembl
ChiLan1.0NW_0049555105,958,276 - 5,961,719 (+)NCBIChiLan1.0ChiLan1.0
SNCG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2898,953,010 - 98,957,933 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11098,958,333 - 98,963,252 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01083,383,566 - 83,391,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11086,940,295 - 86,947,770 (+)NCBIPanPan1.1PanPan1.1panPan2
SNCG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,604,867 - 34,608,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,605,091 - 34,608,842 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha434,596,074 - 34,600,277 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0434,965,024 - 34,969,227 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl434,964,991 - 34,969,222 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1434,811,241 - 34,814,866 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0434,980,171 - 34,983,796 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,486,039 - 35,489,664 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sncg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,906,537 - 43,911,351 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493680416,614 - 21,969 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493680416,869 - 21,684 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNCG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,904,659 - 87,922,095 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11487,916,353 - 87,922,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,191,841 - 95,197,607 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SNCG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,907,840 - 44,914,750 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,907,728 - 44,912,510 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660485,015,742 - 5,020,557 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sncg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624841192,398 - 196,064 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624841192,396 - 196,568 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sncg
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11310,142,247 - 10,146,667 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sncg
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:46
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000065516
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16423421216278352Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16423421216278352Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421216061395Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16423433317730812Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 51 59 6 314 151 11 141 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000080635   ⟹   ENSRNOP00000075051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,706,765 - 9,711,453 (-)Ensembl
mRatBN7.2 Ensembl169,700,514 - 9,705,368 (-)Ensembl
Rnor_6.0 Ensembl1610,722,111 - 10,726,648 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087150   ⟹   ENSRNOP00000071576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,706,765 - 9,711,254 (-)Ensembl
mRatBN7.2 Ensembl169,700,514 - 9,705,051 (-)Ensembl
Rnor_6.0 Ensembl1610,722,106 - 10,726,707 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131287   ⟹   ENSRNOP00000102366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,706,753 - 9,711,336 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143530   ⟹   ENSRNOP00000109611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,706,765 - 9,712,076 (-)Ensembl
RefSeq Acc Id: NM_031688   ⟹   NP_113876
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,706,765 - 9,711,336 (-)NCBI
mRatBN7.2169,700,513 - 9,705,084 (-)NCBI
Rnor_6.01610,722,110 - 10,726,648 (-)NCBI
Rnor_5.0169,049,950 - 9,054,488 (-)NCBI
RGSC_v3.41610,025,978 - 10,030,516 (-)RGD
Celera165,511,856 - 5,516,394 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094809   ⟹   XP_038950737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,706,765 - 9,712,072 (-)NCBI
mRatBN7.2169,700,513 - 9,705,751 (-)NCBI
RefSeq Acc Id: XM_063275691   ⟹   XP_063131761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,706,765 - 9,712,012 (-)NCBI
RefSeq Acc Id: NP_113876   ⟸   NM_031688
- UniProtKB: A0A0G2K0T6 (UniProtKB/TrEMBL),   A6KFS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075051   ⟸   ENSRNOT00000080635
Ensembl Acc Id: ENSRNOP00000071576   ⟸   ENSRNOT00000087150
RefSeq Acc Id: XP_038950737   ⟸   XM_039094809
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K0T6 (UniProtKB/TrEMBL),   A6KFS0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131761   ⟸   XM_063275691
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000109611   ⟸   ENSRNOT00000143530
Ensembl Acc Id: ENSRNOP00000102366   ⟸   ENSRNOT00000131287

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63544-F1-model_v2 AlphaFold Q63544 1-123 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699960
Promoter ID:EPDNEW_R10482
Type:initiation region
Name:Sncg_1
Description:synuclein, gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01610,726,642 - 10,726,702EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70996 AgrOrtholog
BioCyc Gene G2FUF-12062 BioCyc
Ensembl Genes ENSRNOG00000058006 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080635 ENTREZGENE
Gene3D-CATH Helix hairpin bin UniProtKB/Swiss-Prot
InterPro Synuclein UniProtKB/Swiss-Prot
  Synuclein_gamma UniProtKB/Swiss-Prot
KEGG Report rno:64347 UniProtKB/Swiss-Prot
NCBI Gene 64347 ENTREZGENE
PANTHER GAMMA-SYNUCLEIN UniProtKB/Swiss-Prot
  PTHR13820 UniProtKB/Swiss-Prot
Pfam Synuclein UniProtKB/Swiss-Prot
PhenoGen Sncg PhenoGen
PRINTS GSYNUCLEIN UniProtKB/Swiss-Prot
  SYNUCLEIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058006 RatGTEx
Superfamily-SCOP Synuclein UniProtKB/Swiss-Prot
UniProt A0A0G2K0T6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDL3_RAT UniProtKB/TrEMBL
  A0ABK0M4K4_RAT UniProtKB/TrEMBL
  A6KFR9_RAT UniProtKB/TrEMBL
  A6KFS0 ENTREZGENE, UniProtKB/TrEMBL
  A6KFS1_RAT UniProtKB/TrEMBL
  A6KFS2_RAT UniProtKB/TrEMBL
  F1LQ96_RAT UniProtKB/TrEMBL
  Q63544 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6R2I0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-01-30 Sncg  synuclein, gamma  Sncg  synuclein, gamma (breast cancer-specific protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Sncg  synuclein, gamma (breast cancer-specific protein 1)  Sncg  synuclein, gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Sncg  synuclein, gamma      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the neonatal rat dorsal root ganglia 70616