Sncb (synuclein, beta) - Rat Genome Database

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Gene: Sncb (synuclein, beta) Rattus norvegicus
Analyze
Symbol: Sncb
Name: synuclein, beta
RGD ID: 70992
Description: Enables alpha-tubulin binding activity and beta-tubulin binding activity. Predicted to be involved in chemical synaptic transmission; synapse organization; and synaptic vesicle endocytosis. Predicted to act upstream of or within dopamine metabolic process and negative regulation of neuron apoptotic process. Located in growth cone; neuronal cell body; and terminal bouton. Is active in presynaptic cytosol. Used to study uveitis. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-synuclein; phosphoneuroprotein 14; PNP 14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,851,825 - 9,860,143 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,840,019 - 9,860,142 (+)EnsemblGRCr8
mRatBN7.2179,846,802 - 9,855,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,846,802 - 9,855,012 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,860,708 - 9,869,180 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,394,284 - 11,402,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,857,117 - 9,865,594 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01710,384,472 - 10,392,776 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1710,384,511 - 10,392,843 (+)Ensemblrn6Rnor6.0
Rnor_5.01712,510,521 - 12,518,728 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,907,498 - 15,915,705 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,921,982 - 9,930,166 (+)NCBICelera
RGSC_v3.11715,907,640 - 15,915,194 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Beta-synuclein gene variants and Parkinson's disease: a preliminary case-control study. Brighina L, etal., Neurosci Lett. 2007 Jun 15;420(3):229-34. Epub 2007 May 21.
2. Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. Galvin JE, etal., Am J Pathol. 2000 Aug;157(2):361-8.
3. Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Galvin JE, etal., Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13450-5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons. Giasson BI, etal., Exp Neurol. 2001 Dec;172(2):354-62.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Hashimoto M, etal., Gene Ther. 2004 Dec;11(23):1713-23.
8. Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression. Jeannotte AM, etal., Neuropsychopharmacology. 2009 Mar;34(4):987-98. Epub 2008 Sep 17.
9. Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS. Li JY, etal., Neuroscience. 2002;113(2):463-78.
10. Alpha- and beta-synucleins are new diagnostic tools for acute erythroid leukemia and acute megakaryoblastic leukemia. Maitta RW, etal., Am J Hematol. 2011 Feb;86(2):230-4. doi: 10.1002/ajh.21932.
11. Gene Data Set MGD Curation, June 12, 2002
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein. Mor F, etal., J Immunol 2003 Jan 1;170(1):628-34.
14. Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus. Mori F, etal., Acta Neuropathol. 2002 Nov;104(5):455-61. Epub 2002 Jul 2.
15. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. Murphy DD, etal., J Neurosci 2000 May 1;20(9):3214-20.
16. Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA expression in rat brain determined by immunocytochemistry and in situ hybridization. Nakajo S, etal., Brain Res Mol Brain Res. 1994 Nov;27(1):81-6.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Beta-synuclein gene alterations in dementia with Lewy bodies. Ohtake H, etal., Neurology. 2004 Sep 14;63(5):805-11.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Localization of alpha-, beta-, and gamma-synuclein during neuronal development and alterations associated with the neuronal response to axonal trauma. Quilty MC, etal., Exp Neurol 2003 Jul;182(1):195-207.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease. Rockenstein E, etal., Brain Res. 2001 Sep 28;914(1-2):48-56.
25. Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model. Suzuki K, etal., Neuroreport. 2003 Mar 24;14(4):551-4.
26. Cloning and characterization of the cDNA encoding a novel brain-specific 14-kDa protein. Tobe T, etal., J Neurochem 1992 Nov;59(5):1624-9.
27. Age-dependent synuclein pathology following traumatic brain injury in mice. Uryu K, etal., Exp Neurol. 2003 Nov;184(1):214-24.
28. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
Additional References at PubMed
PMID:8223629   PMID:10964942   PMID:11312271   PMID:12477932   PMID:14651853   PMID:15465911   PMID:15489334   PMID:16269331   PMID:16483693   PMID:17085784   PMID:17222866   PMID:19692427  
PMID:20974939   PMID:21699177   PMID:22871113   PMID:25002582   PMID:25009269   PMID:25495902   PMID:28131823   PMID:29808713   PMID:30787438   PMID:33428933  


Genomics

Comparative Map Data
Sncb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,851,825 - 9,860,143 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,840,019 - 9,860,142 (+)EnsemblGRCr8
mRatBN7.2179,846,802 - 9,855,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,846,802 - 9,855,012 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,860,708 - 9,869,180 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,394,284 - 11,402,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,857,117 - 9,865,594 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01710,384,472 - 10,392,776 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1710,384,511 - 10,392,843 (+)Ensemblrn6Rnor6.0
Rnor_5.01712,510,521 - 12,518,728 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,907,498 - 15,915,705 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,921,982 - 9,930,166 (+)NCBICelera
RGSC_v3.11715,907,640 - 15,915,194 (+)NCBI
Cytogenetic Map17p14NCBI
SNCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385176,620,082 - 176,630,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5176,620,082 - 176,630,672 (-)Ensemblhg38GRCh38
GRCh375176,047,083 - 176,057,535 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365175,979,816 - 175,990,163 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345175,979,816 - 175,990,163NCBI
Celera5172,442,697 - 172,464,864 (+)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5170,970,990 - 170,981,256 (-)NCBIHuRef
CHM1_15175,479,633 - 175,489,981 (-)NCBICHM1_1
T2T-CHM13v2.05177,166,665 - 177,177,114 (-)NCBIT2T-CHM13v2.0
Sncb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,906,673 - 54,914,435 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,906,673 - 54,914,408 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381354,758,860 - 54,766,622 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,758,860 - 54,766,595 (-)Ensemblmm10GRCm38
MGSCv371354,860,221 - 54,867,801 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361354,768,482 - 54,776,062 (-)NCBIMGSCv36mm8
Celera1355,824,326 - 55,831,944 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.28NCBI
Sncb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,894,204 - 28,903,095 (-)Ensembl
ChiLan1.0NW_00495540828,894,204 - 28,903,095 (-)NCBIChiLan1.0ChiLan1.0
SNCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24171,700,736 - 171,711,148 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15169,840,275 - 169,850,687 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05171,918,297 - 171,928,672 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15178,988,314 - 178,998,805 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5178,988,439 - 178,998,800 (-)EnsemblpanPan2panpan1.1
SNCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,710,236 - 36,719,455 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,616,039 - 36,764,501 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha436,677,103 - 36,686,289 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0437,076,409 - 37,085,600 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,048,276 - 37,103,097 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,902,261 - 36,911,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,089,947 - 37,099,120 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0437,598,214 - 37,607,385 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sncb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213121,853,363 - 121,863,441 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936597878,286 - 888,331 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936597878,270 - 888,346 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl281,287,759 - 81,302,861 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1281,287,764 - 81,302,859 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2282,889,540 - 82,899,597 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12378,626,876 - 78,637,337 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2378,627,479 - 78,636,287 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660759,760,600 - 9,770,954 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sncb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473313,506,180 - 13,513,712 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473313,506,181 - 13,513,979 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sncb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11473,102,206 - 73,110,343 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sncb
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:185
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000024357
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
Sncb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,846,751 - 9,846,962 (+)MAPPERmRatBN7.2
Rnor_6.01710,384,519 - 10,384,729NCBIRnor6.0
Rnor_5.01712,510,471 - 12,510,681UniSTSRnor5.0
RGSC_v3.41715,907,448 - 15,907,658UniSTSRGSC3.4
Celera179,921,932 - 9,922,142UniSTS
Cytogenetic Map17p14UniSTS
AI145381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,854,698 - 9,854,918 (+)MAPPERmRatBN7.2
Rnor_6.01710,392,462 - 10,392,681NCBIRnor6.0
Rnor_5.01712,518,414 - 12,518,633UniSTSRnor5.0
RGSC_v3.41715,915,391 - 15,915,610UniSTSRGSC3.4
Celera179,929,852 - 9,930,071UniSTS
RH 3.4 Map1794.3UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 6 49 142 47 42 19 17 19 4 134 83 128 12 74 23 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024357   ⟹   ENSRNOP00000024357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,851,875 - 9,860,142 (+)Ensembl
mRatBN7.2 Ensembl179,846,802 - 9,855,012 (+)Ensembl
Rnor_6.0 Ensembl1710,384,511 - 10,392,843 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108686   ⟹   ENSRNOP00000096826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,843,926 - 9,860,142 (+)Ensembl
mRatBN7.2 Ensembl179,847,041 - 9,855,012 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000166923   ⟹   ENSRNOP00000111323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,840,019 - 9,860,142 (+)Ensembl
RefSeq Acc Id: NM_080777   ⟹   NP_542955
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,851,934 - 9,860,143 (+)NCBI
mRatBN7.2179,846,802 - 9,855,013 (+)NCBI
Rnor_6.01710,384,569 - 10,392,776 (+)NCBI
Rnor_5.01712,510,521 - 12,518,728 (+)NCBI
RGSC_v3.41715,907,498 - 15,915,705 (+)RGD
Celera179,921,982 - 9,930,166 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253594   ⟹   XP_006253656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,851,835 - 9,860,143 (+)NCBI
mRatBN7.2179,847,279 - 9,855,013 (+)NCBI
Rnor_6.01710,384,472 - 10,392,776 (+)NCBI
Rnor_5.01712,510,521 - 12,518,728 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063276013   ⟹   XP_063132083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,851,825 - 9,860,143 (+)NCBI
RefSeq Acc Id: XM_063276014   ⟹   XP_063132084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,851,845 - 9,860,143 (+)NCBI
RefSeq Acc Id: NP_542955   ⟸   NM_080777
- UniProtKB: Q63754 (UniProtKB/Swiss-Prot),   Q5PPN9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253656   ⟸   XM_006253594
- Peptide Label: isoform X2
- UniProtKB: Q63754 (UniProtKB/Swiss-Prot),   Q5PPN9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024357   ⟸   ENSRNOT00000024357
Ensembl Acc Id: ENSRNOP00000096826   ⟸   ENSRNOT00000108686
RefSeq Acc Id: XP_063132083   ⟸   XM_063276013
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132084   ⟸   XM_063276014
- Peptide Label: isoform X1
- UniProtKB: Q63754 (UniProtKB/Swiss-Prot),   Q5PPN9 (UniProtKB/Swiss-Prot),   A0A0G2JSQ1 (UniProtKB/TrEMBL),   A6KAX2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111323   ⟸   ENSRNOT00000166923

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63754-F1-model_v2 AlphaFold Q63754 1-137 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700317
Promoter ID:EPDNEW_R10841
Type:multiple initiation site
Name:Sncb_1
Description:synuclein, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01710,384,500 - 10,384,560EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70992 AgrOrtholog
BioCyc Gene G2FUF-10181 BioCyc
Ensembl Genes ENSRNOG00000018039 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024357 ENTREZGENE
  ENSRNOT00000108686 ENTREZGENE
Gene3D-CATH Helix hairpin bin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7314241 IMAGE-MGC_LOAD
InterPro Synuclein UniProtKB/Swiss-Prot
  Synuclein_beta UniProtKB/Swiss-Prot
KEGG Report rno:113893 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105340 IMAGE-MGC_LOAD
NCBI Gene 113893 ENTREZGENE
PANTHER PTHR13820 UniProtKB/Swiss-Prot
  PTHR13820:SF4 UniProtKB/Swiss-Prot
Pfam Synuclein UniProtKB/Swiss-Prot
PhenoGen Sncb PhenoGen
PRINTS BSYNUCLEIN UniProtKB/Swiss-Prot
  SYNUCLEIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018039 RatGTEx
Superfamily-SCOP Synuclein UniProtKB/Swiss-Prot
UniProt A0A0G2JSQ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATA5_RAT UniProtKB/TrEMBL
  A0ABK0M2D5_RAT UniProtKB/TrEMBL
  A6KAX2 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPN9 ENTREZGENE
  Q63754 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5PPN9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Sncb  synuclein, beta      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization found in the cellular cytosol and at the growth cones of developing axons early in development, but later distribution becomes punctate within axons and growth cones; after axonal injury, accumulates in the damaged axons, localizing to cytoskeletal abnormalities 1358136
gene_cellular_localization cortical neurons express both alpha- and beta-synuclein but distribution of the isoforms is nonoverlapping within individual neurons 1358136
gene_disease autoimmunity to sncb leads to encephalomyelitis 730073
gene_expression mRNA expressed specifically in brain 70615
gene_expression protein found in heavy myelin as well as neurons 730073
gene_protein 137 aa sequence codes for an acidic 14 kDa protein 70615