Klf15 (KLF transcription factor 15) - Rat Genome Database

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Gene: Klf15 (KLF transcription factor 15) Rattus norvegicus
Analyze
Symbol: Klf15
Name: KLF transcription factor 15
RGD ID: 70918
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to endothelin; negative regulation of collagen biosynthetic process; and negative regulation of transforming growth factor beta production. Predicted to be located in nucleus. Orthologous to human KLF15 (KLF transcription factor 15); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Krueppel-like factor 15; Kruppel-like factor 15; MGC108619
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84124,522,652 - 124,535,613 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4124,522,909 - 124,542,373 (+)EnsemblGRCr8
mRatBN7.24122,965,718 - 122,978,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4122,965,807 - 122,978,374 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4128,433,270 - 128,445,908 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04124,207,692 - 124,220,330 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04122,832,265 - 122,844,900 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04122,364,688 - 122,377,690 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,365,093 - 122,377,659 (+)Ensemblrn6Rnor6.0
Rnor_5.04186,905,687 - 186,918,647 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44124,714,395 - 124,726,991 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4111,889,901 - 111,902,497 (+)NCBICelera
RGSC_v3.14124,958,875 - 124,971,472 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylfuran  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
hexadecanoic acid  (EXP)
isoprenaline  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
LY294002  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
progesterone  (EXP)
propanal  (ISO)
prothioconazole  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tenofovir disoproxil fumarate  (EXP)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. Gray S, etal., J Biol Chem 2002 Sep 13;277(37):34322-8.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. Yamamoto J, etal., J Biol Chem 2004 Apr 23;279(17):16954-62. Epub 2004 Feb 10.
10. KLF15 is an essential negative regulatory factor for the cardiac remodeling response to pressure overload. Yu Y, etal., Cardiology. 2015;130(3):143-52. doi: 10.1159/000369382. Epub 2015 Jan 24.
Additional References at PubMed
PMID:12477932   PMID:17438289   PMID:19720047   PMID:19741146   PMID:19767294   PMID:20375365   PMID:20566642   PMID:22367544   PMID:22493483   PMID:22613989   PMID:24356553   PMID:24407292  
PMID:25907490   PMID:26600407   PMID:28064408   PMID:29127073   PMID:29179208   PMID:29970016   PMID:31822940   PMID:33949114   PMID:37308416   PMID:38513352  


Genomics

Comparative Map Data
Klf15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84124,522,652 - 124,535,613 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4124,522,909 - 124,542,373 (+)EnsemblGRCr8
mRatBN7.24122,965,718 - 122,978,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4122,965,807 - 122,978,374 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4128,433,270 - 128,445,908 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04124,207,692 - 124,220,330 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04122,832,265 - 122,844,900 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04122,364,688 - 122,377,690 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,365,093 - 122,377,659 (+)Ensemblrn6Rnor6.0
Rnor_5.04186,905,687 - 186,918,647 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44124,714,395 - 124,726,991 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4111,889,901 - 111,902,497 (+)NCBICelera
RGSC_v3.14124,958,875 - 124,971,472 (+)NCBI
Cytogenetic Map4q34NCBI
KLF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383126,288,125 - 126,357,408 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3126,342,635 - 126,357,458 (-)Ensemblhg38GRCh38
GRCh373126,061,478 - 126,076,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363127,544,168 - 127,558,926 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343127,544,176 - 127,558,935NCBI
Celera3124,486,052 - 124,501,056 (-)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3123,442,097 - 123,456,745 (-)NCBIHuRef
CHM1_13126,024,493 - 126,039,263 (-)NCBICHM1_1
T2T-CHM13v2.03129,020,460 - 129,089,956 (-)NCBIT2T-CHM13v2.0
Klf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39690,437,785 - 90,468,785 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl690,439,558 - 90,452,220 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38690,461,043 - 90,491,803 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl690,462,576 - 90,475,238 (+)Ensemblmm10GRCm38
MGSCv37690,412,620 - 90,425,203 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36690,428,130 - 90,440,713 (+)NCBIMGSCv36mm8
Celera692,350,733 - 92,363,315 (+)NCBICelera
Cytogenetic Map6D1NCBI
Klf15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542121,609,643 - 21,620,255 (-)Ensembl
ChiLan1.0NW_00495542121,609,709 - 21,618,920 (-)NCBIChiLan1.0ChiLan1.0
KLF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22124,276,383 - 124,290,991 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13124,281,164 - 124,295,988 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03123,395,678 - 123,410,514 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13130,712,599 - 130,724,530 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3130,712,599 - 130,724,530 (-)EnsemblpanPan2panpan1.1
KLF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.120513,649 - 524,873 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl20513,622 - 523,395 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha20549,887 - 563,042 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.020523,989 - 537,146 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl20522,954 - 537,258 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.120254,875 - 268,029 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.020581,895 - 595,033 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.020542,602 - 555,759 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klf15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494219,161,585 - 19,171,427 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936898519,572 - 529,319 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,877,818 - 53,889,144 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1753,877,813 - 53,890,558 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap7q13NCBI
KLF15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12254,659,406 - 54,674,321 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2254,659,703 - 54,674,368 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041111,622,080 - 111,636,842 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624773243,569 - 257,531 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624773243,599 - 256,786 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Klf15
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1656,445,069 - 56,457,768 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klf15
75 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir133brno-miR-133b-3pMirtarbaseexternal_infoWestern blotFunctional MTI19720047
Mir133a1rno-miR-133a-3pMirtarbaseexternal_infoWestern blotFunctional MTI19720047

Predicted Target Of
Summary Value
Count of predictions:396
Count of miRNA genes:211
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000024011
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
RH140732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24122,969,799 - 122,970,007 (+)MAPPERmRatBN7.2
Rnor_6.04122,369,086 - 122,369,293NCBIRnor6.0
Rnor_5.04186,910,043 - 186,910,250UniSTSRnor5.0
RGSC_v3.44124,718,388 - 124,718,595UniSTSRGSC3.4
Celera4111,893,894 - 111,894,101UniSTS
RH 3.4 Map4733.02UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 39 59 6 303 139 11 138 81 92 31 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB102791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB102792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024011   ⟹   ENSRNOP00000024011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4124,522,909 - 124,535,582 (+)Ensembl
mRatBN7.2 Ensembl4122,965,807 - 122,978,374 (+)Ensembl
Rnor_6.0 Ensembl4122,365,093 - 122,377,659 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151775   ⟹   ENSRNOP00000101293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4124,522,913 - 124,542,373 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000169602   ⟹   ENSRNOP00000110980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4124,522,920 - 124,538,187 (+)Ensembl
RefSeq Acc Id: NM_053536   ⟹   NP_445988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,523,015 - 124,535,611 (+)NCBI
mRatBN7.24122,965,807 - 122,978,403 (+)NCBI
Rnor_6.04122,365,093 - 122,377,688 (+)NCBI
Rnor_5.04186,905,687 - 186,918,647 (+)NCBI
RGSC_v3.44124,714,395 - 124,726,991 (+)RGD
Celera4111,889,901 - 111,902,497 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236882   ⟹   XP_006236944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,522,652 - 124,535,613 (+)NCBI
mRatBN7.24122,965,718 - 122,977,477 (+)NCBI
Rnor_6.04122,364,689 - 122,377,690 (+)NCBI
Rnor_5.04186,905,687 - 186,918,647 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236884   ⟹   XP_006236946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,525,275 - 124,535,613 (+)NCBI
mRatBN7.24122,968,065 - 122,978,397 (+)NCBI
Rnor_6.04122,367,310 - 122,377,682 (+)NCBI
Rnor_5.04186,905,687 - 186,918,647 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592934   ⟹   XP_017448423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,522,652 - 124,535,613 (+)NCBI
mRatBN7.24122,965,722 - 122,978,397 (+)NCBI
Rnor_6.04122,364,688 - 122,377,690 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108490   ⟹   XP_038964418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,522,652 - 124,535,613 (+)NCBI
mRatBN7.24122,965,896 - 122,977,477 (+)NCBI
RefSeq Acc Id: XM_063286783   ⟹   XP_063142853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,522,652 - 124,535,613 (+)NCBI
RefSeq Acc Id: XM_063286785   ⟹   XP_063142855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,523,395 - 124,535,613 (+)NCBI
RefSeq Acc Id: NP_445988   ⟸   NM_053536
- UniProtKB: Q5FVT6 (UniProtKB/TrEMBL),   A6IB85 (UniProtKB/TrEMBL),   Q9WTQ3 (UniProtKB/TrEMBL),   B2DBE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236944   ⟸   XM_006236882
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006236946   ⟸   XM_006236884
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448423   ⟸   XM_017592934
- Peptide Label: isoform X1
- UniProtKB: Q5FVT6 (UniProtKB/TrEMBL),   A6IB85 (UniProtKB/TrEMBL),   Q9WTQ3 (UniProtKB/TrEMBL),   B2DBE3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024011   ⟸   ENSRNOT00000024011
RefSeq Acc Id: XP_038964418   ⟸   XM_039108490
- Peptide Label: isoform X1
- UniProtKB: Q5FVT6 (UniProtKB/TrEMBL),   A6IB85 (UniProtKB/TrEMBL),   Q9WTQ3 (UniProtKB/TrEMBL),   B2DBE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142853   ⟸   XM_063286783
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063142855   ⟸   XM_063286785
- Peptide Label: isoform X1
- UniProtKB: Q9WTQ3 (UniProtKB/TrEMBL),   A6IB85 (UniProtKB/TrEMBL),   B2DBE3 (UniProtKB/TrEMBL),   Q5FVT6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110980   ⟸   ENSRNOT00000169602
Ensembl Acc Id: ENSRNOP00000101293   ⟸   ENSRNOT00000151775
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVT6-F1-model_v2 AlphaFold Q5FVT6 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693245
Promoter ID:EPDNEW_R3770
Type:initiation region
Name:Klf15_1
Description:Kruppel-like factor 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04122,365,016 - 122,365,076EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70918 AgrOrtholog
BioCyc Gene G2FUF-43732 BioCyc
Ensembl Genes ENSRNOG00000017808 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024011 ENTREZGENE
  ENSRNOT00000024011.7 UniProtKB/TrEMBL
  ENSRNOT00000151775.1 UniProtKB/TrEMBL
  ENSRNOT00000169602.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325036 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:85497 UniProtKB/TrEMBL
MGC_CLONE MGC:108619 IMAGE-MGC_LOAD
NCBI Gene 85497 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 15 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf15 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017808 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0ABK0L062_RAT UniProtKB/TrEMBL
  A0ABK0M619_RAT UniProtKB/TrEMBL
  A6IB85 ENTREZGENE
  B2DBE3 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVT6 ENTREZGENE, UniProtKB/TrEMBL
  Q9WTQ3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6IB85 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf15  KLF transcription factor 15  Klf15  Kruppel-like factor 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Klf15  Kruppel-like factor 15      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function mouse homolog involved in fasting-induced transcriptional activation of the Acas2l (AceCS2) gene; acts synergistically with Sp1 1304296
gene_physical_interaction interacts with MEF2A 724446