Acot1 (acyl-CoA thioesterase 1) - Rat Genome Database

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Gene: Acot1 (acyl-CoA thioesterase 1) Rattus norvegicus
Analyze
Symbol: Acot1
Name: acyl-CoA thioesterase 1
RGD ID: 70894
Description: Enables fatty acyl-CoA hydrolase activity. Involved in long-chain fatty acid metabolic process and negative regulation of cardiac muscle cell apoptotic process. Predicted to be located in cytosol. Orthologous to human ACOT1 (acyl-CoA thioesterase 1); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACH2; acyl-CoA thioesterase 1 cytosolic; acyl-CoA thioesterase 1, cytosolic; acyl-coenzyme A thioesterase 1; CTE-I; Cte1; cytosolic acyl-CoA thioesterase 1; inducible cytosolic acyl-coenzyme A thioester hydrolase; LACH2; long chain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase; palmitoyl-coenzyme A thioesterase
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,367,274 - 109,375,268 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6109,367,268 - 109,380,749 (+)EnsemblGRCr8
mRatBN7.26103,636,173 - 103,644,167 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6103,636,041 - 103,644,163 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6103,797,923 - 103,805,917 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,097,139 - 104,105,133 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,466,590 - 103,474,584 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06107,485,088 - 107,493,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6107,485,249 - 107,493,798 (+)Ensemblrn6Rnor6.0
Rnor_5.06118,051,121 - 118,059,101 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46108,042,050 - 108,050,044 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6101,466,169 - 101,474,163 (+)NCBICelera
RGSC_v3.16108,045,505 - 108,053,496 (+)NCBI
RH 3.4 Map6733.4RGD
Cytogenetic Map6q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
aspartame  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorothalonil  (ISO)
chlorotoluron  (ISO)
choline  (ISO)
chrysene  (ISO)
ciprofibrate  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
folic acid  (ISO)
fomesafen  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
graphene oxide  (ISO)
GW 4064  (ISO)
GW 6471  (EXP)
GW 7647  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
mifepristone  (EXP)
Monobutylphthalate  (EXP)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
Nivalenol  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
Oxyfluorfen  (ISO)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perflubutane  (EXP)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (ISO)
propiconazole  (ISO)
Rebamipide  (EXP)
rotenone  (EXP,ISO)
SCH 23390  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
streptozocin  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
mitochondrion  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
3. Molecular cloning of the peroxisome proliferator-induced 46-kDa cytosolic acyl-CoA thioesterase from mouse and rat liver--recombinant expression in Escherichia coli, tissue expression, and nutritional regulation. Lindquist PJ, etal., Eur J Biochem 1998 Feb 1;251(3):631-40.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver. Svensson LT, etal., Biochem J 1998 Feb 1;329 ( Pt 3):601-8.
11. Purification and properties of long-chain acyl-CoA hydrolases from the liver cytosol of rats treated with peroxisome proliferator. Yamada J, etal., Arch Biochem Biophys. 1994 Jan;308(1):118-25. doi: 10.1006/abbi.1994.1017.
12. cDNA cloning and genomic organization of peroxisome proliferator-inducible long-chain acyl-CoA hydrolase from rat liver cytosol. Yamada J, etal., Biochem Biophys Res Commun 1998 Jul 30;248(3):608-12.
13. Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling. Yang S, etal., PLoS One. 2012;7(11):e50376. doi: 10.1371/journal.pone.0050376. Epub 2012 Nov 30.
14. Reversal of obesity-induced hypertriglyceridemia by (R)-α-lipoic acid in ZDF (fa/fa) rats. Yi X, etal., Biochem Biophys Res Commun. 2013 Sep 27;439(3):390-5. doi: 10.1016/j.bbrc.2013.08.063. Epub 2013 Aug 29.
Additional References at PubMed
PMID:11694534   PMID:16103133   PMID:16940157   PMID:21094633   PMID:23385637   PMID:34800366  


Genomics

Comparative Map Data
Acot1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,367,274 - 109,375,268 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6109,367,268 - 109,380,749 (+)EnsemblGRCr8
mRatBN7.26103,636,173 - 103,644,167 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6103,636,041 - 103,644,163 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6103,797,923 - 103,805,917 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,097,139 - 104,105,133 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,466,590 - 103,474,584 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06107,485,088 - 107,493,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6107,485,249 - 107,493,798 (+)Ensemblrn6Rnor6.0
Rnor_5.06118,051,121 - 118,059,101 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46108,042,050 - 108,050,044 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6101,466,169 - 101,474,163 (+)NCBICelera
RGSC_v3.16108,045,505 - 108,053,496 (+)NCBI
RH 3.4 Map6733.4RGD
Cytogenetic Map6q31NCBI
ACOT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381473,490,933 - 73,543,796 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1473,537,143 - 73,543,796 (+)Ensemblhg38GRCh38
GRCh371474,003,847 - 74,010,500 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361473,073,681 - 73,080,251 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1433,178,727 - 33,185,623 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1454,170,795 - 54,177,365 (+)NCBIHuRef
CHM1_11473,943,328 - 73,949,898 (+)NCBICHM1_1
T2T-CHM13v2.01467,698,892 - 67,751,306 (+)NCBIT2T-CHM13v2.0
Acot1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,056,276 - 84,064,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,056,264 - 84,065,145 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381284,009,502 - 84,017,670 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,009,490 - 84,018,371 (+)Ensemblmm10GRCm38
MGSCv371285,350,452 - 85,358,620 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361284,899,250 - 84,907,418 (+)NCBIMGSCv36mm8
Celera1285,456,086 - 85,464,143 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.0NCBI

Variants

.
Variants in Acot1
73 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:7
Count of miRNA genes:7
Interacting mature miRNAs:7
Transcripts:ENSRNOT00000013729
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat

Markers in Region
RH142449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26103,643,979 - 103,644,142 (+)MAPPERmRatBN7.2
Rnor_6.06107,492,895 - 107,493,057NCBIRnor6.0
Rnor_5.06118,051,146 - 118,051,308UniSTSRnor5.0
RGSC_v3.46108,049,857 - 108,050,019UniSTSRGSC3.4
Celera6101,473,976 - 101,474,138UniSTS
RH 3.4 Map6733.4UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 10 67 142 85 84 53 46 53 6 297 141 7 125 81 91 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000080859   ⟹   ENSRNOP00000074406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6109,367,268 - 109,380,749 (+)Ensembl
mRatBN7.2 Ensembl6103,636,041 - 103,644,163 (+)Ensembl
Rnor_6.0 Ensembl6107,485,249 - 107,493,798 (+)Ensembl
RefSeq Acc Id: NM_031315   ⟹   NP_112605
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86109,367,274 - 109,375,268 (+)NCBI
mRatBN7.26103,636,173 - 103,644,167 (+)NCBI
Rnor_6.06107,485,088 - 107,493,082 (+)NCBI
Rnor_5.06118,051,121 - 118,059,101 (-)NCBI
RGSC_v3.46108,042,050 - 108,050,044 (+)RGD
Celera6101,466,169 - 101,474,163 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112605 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA32434 (Get FASTA)   NCBI Sequence Viewer  
  CAA70514 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074406
GenBank Protein O88267 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112605   ⟸   NM_031315
- UniProtKB: O88267 (UniProtKB/Swiss-Prot),   O55161 (UniProtKB/Swiss-Prot),   A6JDS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074406   ⟸   ENSRNOT00000080859
Protein Domains
Acyl-CoA thioester hydrolase/bile acid-CoA amino   BAAT/Acyl-CoA thioester hydrolase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88267-F1-model_v2 AlphaFold O88267 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70894 AgrOrtholog
BioCyc Gene G2FUF-36846 BioCyc
BioCyc Pathway PWY-5148 [acyl-CoA hydrolysis] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-5996 [oleate biosynthesis II (animals and fungi)] BioCyc
  PWY-8042 [acylceramide biosynthesis] BioCyc
  PWY3O-1801 [palmitoleate biosynthesis IV (fungi and animals)] BioCyc
BioCyc Pathway Image PWY-5148 BioCyc
  PWY-5972 BioCyc
  PWY-5996 BioCyc
  PWY-8042 BioCyc
  PWY3O-1801 BioCyc
Ensembl Genes ENSRNOG00000055221 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080859 ENTREZGENE
Gene3D-CATH 2.60.40.2240 UniProtKB/Swiss-Prot
  3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Acyl-CoA_thioEstase_long-chain UniProtKB/Swiss-Prot
  BAAT_C UniProtKB/Swiss-Prot
  Thio_Ohase/aa_AcTrfase UniProtKB/Swiss-Prot
  Thio_Ohase/BAAT_N UniProtKB/Swiss-Prot
KEGG Report rno:50559 UniProtKB/Swiss-Prot
NCBI Gene 50559 ENTREZGENE
PANTHER ACYL-COENZYME A THIOESTERASE 1-RELATED UniProtKB/Swiss-Prot
  ACYL-COENZYME A THIOESTERASE-RELATED UniProtKB/Swiss-Prot
Pfam BAAT_C UniProtKB/Swiss-Prot
  Bile_Hydr_Trans UniProtKB/Swiss-Prot
PhenoGen Acot1 PhenoGen
PIRSF Acyl-CoA_hydro UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055221 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A0G2K7Z3_RAT UniProtKB/TrEMBL
  A6JDS5 ENTREZGENE, UniProtKB/TrEMBL
  ACOT1_RAT UniProtKB/Swiss-Prot
  O55161 ENTREZGENE
  O88267 ENTREZGENE
UniProt Secondary O55161 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Acot1  acyl-CoA thioesterase 1  Cte1  cytosolic acyl-CoA thioesterase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cte1  cytosolic acyl-CoA thioesterase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression liver expression is induced by feeding clofibrate to rats 70703