Itih4 (inter-alpha-trypsin inhibitor heavy chain 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Itih4 (inter-alpha-trypsin inhibitor heavy chain 4) Rattus norvegicus
Analyze
Symbol: Itih4
Name: inter-alpha-trypsin inhibitor heavy chain 4
RGD ID: 70881
Description: Predicted to be involved in acute-phase response and response to cytokine. Located in extracellular space. Biomarker of amyotrophic lateral sclerosis and obesity. Human ortholog(s) of this gene implicated in intermediate coronary syndrome and myocardial infarction. Orthologous to human ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inter alpha-trypsin inhibitor, heavy chain 4; inter-alpha-inhibitor H4 heavy chain; inter-alpha-trypsin inhibitor heavy chain family, member 4; inter-alpha-trypsin inhibitor heavy chain H4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,086,985 - 6,102,162 (+)NCBIGRCr8
mRatBN7.2166,080,539 - 6,095,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,080,539 - 6,095,708 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,091,889 - 6,107,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,237,346 - 7,252,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,099,223 - 6,114,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,970,367 - 6,985,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,970,342 - 6,985,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,896,782 - 6,912,274 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,319,608 - 6,334,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,319,608 - 6,334,777 (+)NCBI
Celera169,093,866 - 9,109,046 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aluminium oxide  (ISO)
amiodarone  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
Evodiamine  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
icariin  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
olanzapine  (ISO)
omeprazole  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Profiling of gender-specific rat plasma proteins associated with susceptibility or resistance to diet-induced obesity. Choi JW, etal., J Proteomics. 2012 Feb 2;75(4):1386-400. doi: 10.1016/j.jprot.2011.11.012. Epub 2011 Nov 20.
2. Proteomic demonstration of the recurrent presence of inter-alpha-inhibitor H4 heavy-chain during aspergillosis induced in an animal model. Desoubeaux G, etal., Int J Med Microbiol. 2014 May;304(3-4):327-38. doi: 10.1016/j.ijmm.2013.11.015. Epub 2013 Dec 1.
3. Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene. Fujita Y, etal., J Hum Genet. 2004;49(1):24-8. Epub 2003 Dec 6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. Ivancic MM, etal., Cancer Prev Res (Phila). 2014 Nov;7(11):1160-9. doi: 10.1158/1940-6207.CAPR-14-0056. Epub 2014 Sep 8.
7. Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats. Lubieniecka JM, etal., PLoS One. 2011 Apr 29;6(4):e19247. doi: 10.1371/journal.pone.0019247.
8. ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection. Ma Y, etal., Cytokine. 2020 Dec 18;138:155377. doi: 10.1016/j.cyto.2020.155377.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma. Noh CK, etal., Clin Biochem. 2014 Sep;47(13-14):1257-61. doi: 10.1016/j.clinbiochem.2014.05.002. Epub 2014 May 14.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells. Pineiro M, etal., Biochem Biophys Res Commun. 1999 Sep 16;263(1):224-9.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human. Soury E, etal., Biochem Biophys Res Commun 1998 Feb 13;243(2):522-30.
20. ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis. Tanaka H, etal., J Neurol. 2013 Jul;260(7):1782-97. doi: 10.1007/s00415-013-6877-3. Epub 2013 Feb 23.
21. Identification of potential urine proteins and microRNA biomarkers for the diagnosis of pulmonary tuberculosis patients. Wang J, etal., Emerg Microbes Infect. 2018 Apr 11;7(1):63. doi: 10.1038/s41426-018-0066-5.
Additional References at PubMed
PMID:10712621   PMID:11803570   PMID:12477932   PMID:19056867   PMID:19263524   PMID:22516433   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Itih4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,086,985 - 6,102,162 (+)NCBIGRCr8
mRatBN7.2166,080,539 - 6,095,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,080,539 - 6,095,708 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,091,889 - 6,107,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,237,346 - 7,252,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,099,223 - 6,114,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,970,367 - 6,985,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,970,342 - 6,985,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,896,782 - 6,912,274 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,319,608 - 6,334,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,319,608 - 6,334,777 (+)NCBI
Celera169,093,866 - 9,109,046 (-)NCBICelera
Cytogenetic Map16p16NCBI
ITIH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,812,962 - 52,830,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,812,962 - 52,830,688 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,846,978 - 52,864,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,822,046 - 52,839,734 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,822,045 - 52,839,734NCBI
Celera352,825,723 - 52,843,435 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,908,665 - 52,926,377 (-)NCBIHuRef
CHM1_1352,799,205 - 52,816,916 (-)NCBICHM1_1
T2T-CHM13v2.0352,845,872 - 52,863,582 (-)NCBIT2T-CHM13v2.0
Itih4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,608,433 - 30,623,943 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,608,433 - 30,624,310 (+)EnsemblGRCm39 Ensembl
GRCm381430,886,476 - 30,901,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,886,476 - 30,902,353 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,699,678 - 31,715,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,715,522 - 29,730,858 (+)NCBIMGSCv36mm8
Celera1427,143,865 - 27,159,266 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Itih4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,770,373 - 2,789,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,772,064 - 2,787,912 (-)NCBIChiLan1.0ChiLan1.0
ITIH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,807,876 - 52,832,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,754,664 - 52,774,867 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,980,529 - 54,000,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensemblpanpan1.1panPan2
ITIH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,352,366 - 37,401,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,402,544 - 37,418,024 (+)NCBIUU_Cfam_GSD_1.0
Itih4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,434,701 - 170,450,834 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,573,384 - 3,589,345 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,573,282 - 3,589,345 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,928,439 - 34,948,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,928,455 - 34,948,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,197,507 - 38,209,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITIH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,194,979 - 14,216,180 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,195,701 - 14,213,603 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,684,251 - 152,702,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itih4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,397,744 - 4,411,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,397,704 - 4,411,562 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itih4
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:33
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000048344, ENSRNOT00000061294
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
RH128651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2166,095,503 - 6,095,686 (+)MAPPERmRatBN7.2
Rnor_6.0166,985,332 - 6,985,514NCBIRnor6.0
Rnor_5.0166,912,068 - 6,912,250UniSTSRnor5.0
RGSC_v3.4166,334,576 - 6,334,758UniSTSRGSC3.4
Celera169,093,890 - 9,094,072UniSTS
RH 3.4 Map1645.0UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 112 90 90 59 25 59 6 216 95 93 45 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000048344   ⟹   ENSRNOP00000048673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,080,539 - 6,095,708 (+)Ensembl
Rnor_6.0 Ensembl166,970,382 - 6,985,388 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061294   ⟹   ENSRNOP00000058007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,080,539 - 6,095,708 (+)Ensembl
Rnor_6.0 Ensembl166,970,342 - 6,985,579 (+)Ensembl
RefSeq Acc Id: NM_019369   ⟹   NP_062242
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,086,985 - 6,102,162 (+)NCBI
mRatBN7.2166,080,539 - 6,095,710 (+)NCBI
Rnor_6.0166,970,367 - 6,985,538 (+)NCBI
Rnor_5.0166,896,782 - 6,912,274 (+)NCBI
RGSC_v3.4166,319,608 - 6,334,782 (+)RGD
Celera169,093,866 - 9,109,046 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062242 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89806 (Get FASTA)   NCBI Sequence Viewer  
  CAA72155 (Get FASTA)   NCBI Sequence Viewer  
  EDL88978 (Get FASTA)   NCBI Sequence Viewer  
  EDL88979 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048673.5
  ENSRNOP00000058007.2
RefSeq Acc Id: NP_062242   ⟸   NM_019369
- Peptide Label: precursor
- UniProtKB: F7EYF5 (UniProtKB/TrEMBL),   D3ZFC6 (UniProtKB/TrEMBL),   Q5EBC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058007   ⟸   ENSRNOT00000061294
Ensembl Acc Id: ENSRNOP00000048673   ⟸   ENSRNOT00000048344
Protein Domains
VIT   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5EBC0-F1-model_v2 AlphaFold Q5EBC0 1-933 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699915
Promoter ID:EPDNEW_R10439
Type:multiple initiation site
Name:Itih4_1
Description:inter-alpha-trypsin inhibitor heavy chain family, member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0166,970,355 - 6,970,415EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70881 AgrOrtholog
BioCyc Gene G2FUF-12176 BioCyc
Ensembl Genes ENSRNOG00000017381 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048344.5 UniProtKB/TrEMBL
  ENSRNOT00000061294.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7326076 IMAGE-MGC_LOAD
InterPro ITIH UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:54404 UniProtKB/TrEMBL
MGC_CLONE MGC:108706 IMAGE-MGC_LOAD
NCBI Gene 54404 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4 UniProtKB/TrEMBL
Pfam VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PhenoGen Itih4 PhenoGen
PROSITE VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017381 RatGTEx
SMART VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A6KG22_RAT UniProtKB/TrEMBL
  D3ZFC6 ENTREZGENE, UniProtKB/TrEMBL
  F7EYF5 ENTREZGENE, UniProtKB/TrEMBL
  O35802_RAT UniProtKB/TrEMBL
  Q5EBC0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Itih4  inter-alpha-trypsin inhibitor heavy chain 4  Itih4  inter-alpha-trypsin inhibitor heavy chain family, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-17 Itih4  inter-alpha-trypsin inhibitor heavy chain family, member 4  Itih4  inter alpha-trypsin inhibitor, heavy chain 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Itih4  inter alpha-trypsin inhibitor, heavy chain 4      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains collagen-like pattern with 6 repeats of a Gly-X-Pro motifs 633094
gene_domains only member of inter-alpha-inhibitor family to have a Pro-rich region (PRR) in its C-terminal 633094
gene_regulation mRNA up-regulated by an acute, systemic inflammation in the liver 633094