Pnpla7 (patatin like domain 7, lysophospholipase) - Rat Genome Database

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Gene: Pnpla7 (patatin like domain 7, lysophospholipase) Rattus norvegicus
Analyze
Symbol: Pnpla7
Name: patatin like domain 7, lysophospholipase (Ensembl:patatin-like phospholipase domain containing 7)
RGD ID: 708466
Description: Predicted to enable phosphatidylcholine lysophospholipase activity. Predicted to be involved in phosphatidylcholine catabolic process. Predicted to be located in endoplasmic reticulum membrane and lipid droplet. Predicted to be active in endoplasmic reticulum. Orthologous to human PNPLA7 (patatin like phospholipase domain containing 7); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: liver NTE-related protein 1; LOC100911867; MGC108975; neuropathy target esterase like 1; Nte-related; NTE-related esterase; Ntel; Ntel1; patatin-like phospholipase domain containing 7; patatin-like phospholipase domain-containing protein 7; patatin-like phospholipase domain-containing protein 7-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,180,670 - 28,259,673 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,180,751 - 28,259,672 (+)EnsemblGRCr8
mRatBN7.237,782,572 - 7,861,504 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,782,572 - 7,861,497 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx310,887,331 - 10,966,646 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,473,561 - 19,552,873 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,663,405 - 17,742,723 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,182,191 - 2,261,890 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl34,730,990 - 4,772,154 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl32,182,957 - 2,261,878 (+)Ensemblrn6Rnor6.0
Rnor_5.032,164,205 - 2,243,127 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.435,122,212 - 5,201,139 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera32,611,803 - 2,690,723 (+)NCBICelera
RGSC_v3.135,163,825 - 5,201,138 (+)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
glafenine  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
leflunomide  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
propiconazole  (ISO)
rotenone  (EXP)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
endoplasmic reticulum  (IBA,IEA,ISO)
endoplasmic reticulum membrane  (IEA,ISO,ISS)
lipid droplet  (IEA,ISO,ISS)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Rat NTE-related esterase is a membrane-associated protein, hydrolyzes phenyl valerate, and interacts with diisopropylfluorophosphate through a serine catalytic machinery. Xie M, etal., Arch Biochem Biophys 2003 Aug 15;416(2):137-46.
Additional References at PubMed
PMID:12477932   PMID:12640454   PMID:18086666   PMID:22326266   PMID:28887301  


Genomics

Comparative Map Data
Pnpla7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,180,670 - 28,259,673 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,180,751 - 28,259,672 (+)EnsemblGRCr8
mRatBN7.237,782,572 - 7,861,504 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,782,572 - 7,861,497 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx310,887,331 - 10,966,646 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,473,561 - 19,552,873 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,663,405 - 17,742,723 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,182,191 - 2,261,890 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl34,730,990 - 4,772,154 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl32,182,957 - 2,261,878 (+)Ensemblrn6Rnor6.0
Rnor_5.032,164,205 - 2,243,127 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.435,122,212 - 5,201,139 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera32,611,803 - 2,690,723 (+)NCBICelera
RGSC_v3.135,163,825 - 5,201,138 (+)NCBI
Cytogenetic Map3p13NCBI
PNPLA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,459,952 - 137,550,402 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,459,952 - 137,550,431 (-)Ensemblhg38GRCh38
GRCh379140,354,404 - 140,444,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,474,226 - 139,564,807 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349137,630,241 - 137,720,673NCBI
Celera9110,879,193 - 110,969,453 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,818,540 - 109,909,455 (-)NCBIHuRef
CHM1_19140,501,929 - 140,594,079 (-)NCBICHM1_1
T2T-CHM13v2.09149,710,086 - 149,803,830 (-)NCBIT2T-CHM13v2.0
Pnpla7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,865,235 - 24,944,084 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,866,045 - 24,944,069 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38224,975,990 - 25,054,072 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,976,033 - 25,054,057 (+)Ensemblmm10GRCm38
MGSCv37224,831,553 - 24,909,592 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36224,798,097 - 24,876,064 (+)NCBIMGSCv36mm8
Celera224,699,962 - 24,781,158 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.88NCBI
Pnpla7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,376,699 - 5,434,581 (-)Ensembl
ChiLan1.0NW_0049555135,376,690 - 5,436,095 (-)NCBIChiLan1.0ChiLan1.0
PNPLA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,826,805 - 1,928,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan191,830,080 - 1,930,479 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,531,917 - 108,631,119 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,496,924 - 137,593,154 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,496,924 - 137,593,154 (-)EnsemblpanPan2panpan1.1
PNPLA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,221,754 - 48,286,352 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,221,514 - 48,286,352 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,408,962 - 47,473,587 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,083,836 - 49,148,496 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,083,916 - 49,148,495 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,860,228 - 47,924,866 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,159,209 - 48,223,845 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,205,678 - 48,270,340 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pnpla7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,769,065 - 202,840,510 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669535,796 - 605,710 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936669535,104 - 605,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA7
(Sus scrofa - pig)		 No map positions available.
PNPLA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112655,723 - 734,315 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660584,614,234 - 4,694,034 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624760521,145 - 575,431 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pnpla7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1512,135,923 - 12,214,944 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pnpla7
412 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:83
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000011633
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
D3Rat87  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8328,210,891 - 28,211,108 (+)Marker Load Pipeline
mRatBN7.237,812,714 - 7,812,933 (+)MAPPERmRatBN7.2
Rnor_6.032,213,097 - 2,213,313NCBIRnor6.0
Rnor_5.032,194,345 - 2,194,561UniSTSRnor5.0
RGSC_v3.435,152,357 - 5,152,573UniSTSRGSC3.4
RGSC_v3.435,152,356 - 5,152,573RGDRGSC3.4
RGSC_v3.135,152,356 - 5,152,573RGD
SHRSP x BN Map32.2599UniSTS
SHRSP x BN Map32.2599RGD
FHH x ACI Map30.0RGD
Cytogenetic Map3p13UniSTS
RH128428  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,780,818 - 7,781,002 (+)MAPPERmRatBN7.2
mRatBN7.2885,195,269 - 85,195,453 (+)MAPPERmRatBN7.2
Rnor_6.0891,820,974 - 91,821,157NCBIRnor6.0
Rnor_6.032,181,205 - 2,181,388NCBIRnor6.0
Rnor_5.0891,338,627 - 91,338,810UniSTSRnor5.0
Rnor_5.032,162,453 - 2,162,636UniSTSRnor5.0
RGSC_v3.435,120,460 - 5,120,643UniSTSRGSC3.4
RGSC_v3.4889,362,373 - 89,362,556UniSTSRGSC3.4
Celera884,840,039 - 84,840,222UniSTS
Celera32,610,050 - 2,610,233UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3p13UniSTS
RH132502  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,861,242 - 7,861,452 (+)MAPPERmRatBN7.2
Rnor_6.032,261,624 - 2,261,833NCBIRnor6.0
Rnor_5.032,242,872 - 2,243,081UniSTSRnor5.0
RGSC_v3.435,200,884 - 5,201,093UniSTSRGSC3.4
Celera32,690,468 - 2,690,677UniSTS
RH 3.4 Map1845.3UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011633   ⟹   ENSRNOP00000011633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,180,751 - 28,259,672 (+)Ensembl
mRatBN7.2 Ensembl37,782,572 - 7,861,497 (+)Ensembl
Rnor_6.0 Ensembl32,182,957 - 2,261,878 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,183,705 - 28,259,672 (+)Ensembl
mRatBN7.2 Ensembl37,785,526 - 7,861,497 (+)Ensembl
Rnor_6.0 Ensembl34,730,990 - 4,772,154 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,180,751 - 28,259,672 (+)Ensembl
mRatBN7.2 Ensembl37,782,572 - 7,861,497 (+)Ensembl
Rnor_6.0 Ensembl34,730,990 - 4,772,154 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141487   ⟹   ENSRNOP00000112741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,180,751 - 28,250,840 (+)Ensembl
RefSeq Acc Id: NM_144738   ⟹   NP_653339
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,180,751 - 28,259,673 (+)NCBI
mRatBN7.237,782,572 - 7,861,498 (+)NCBI
Rnor_6.032,182,957 - 2,261,879 (+)NCBI
Rnor_5.032,164,205 - 2,243,127 (+)NCBI
RGSC_v3.435,122,212 - 5,201,139 (+)RGD
Celera32,611,803 - 2,690,723 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104252   ⟹   XP_038960180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,180,670 - 28,250,842 (+)NCBI
mRatBN7.237,782,578 - 7,852,667 (+)NCBI
RefSeq Acc Id: XM_039104253   ⟹   XP_038960181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,180,670 - 28,247,575 (+)NCBI
mRatBN7.237,782,605 - 7,849,404 (+)NCBI
RefSeq Acc Id: XM_039104254   ⟹   XP_038960182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,180,670 - 28,243,870 (+)NCBI
mRatBN7.237,782,605 - 7,845,697 (+)NCBI
RefSeq Acc Id: XM_039104255   ⟹   XP_038960183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,216,430 - 28,259,673 (+)NCBI
mRatBN7.237,818,255 - 7,861,504 (+)NCBI
RefSeq Acc Id: XM_039104256   ⟹   XP_038960184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,220,777 - 28,259,673 (+)NCBI
mRatBN7.237,823,210 - 7,861,504 (+)NCBI
RefSeq Acc Id: XR_005501774
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,180,670 - 28,235,276 (+)NCBI
mRatBN7.237,782,605 - 7,837,102 (+)NCBI
RefSeq Acc Id: NP_653339   ⟸   NM_144738
- UniProtKB: Q8K3H9 (UniProtKB/Swiss-Prot),   Q5XIX2 (UniProtKB/Swiss-Prot),   Q5BK26 (UniProtKB/Swiss-Prot),   G3V745 (UniProtKB/TrEMBL),   A6JT00 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011633   ⟸   ENSRNOT00000011633
RefSeq Acc Id: XP_038960180   ⟸   XM_039104252
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960181   ⟸   XM_039104253
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960182   ⟸   XM_039104254
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038960183   ⟸   XM_039104255
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038960184   ⟸   XM_039104256
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000112741   ⟸   ENSRNOT00000141487
Protein Domains
Cyclic nucleotide-binding   PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK26-F1-model_v2 AlphaFold Q5BK26 1-1349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708466 AgrOrtholog
BioCyc Gene G2FUF-50490 BioCyc
Ensembl Genes ENSRNOG00000008190 Ensembl, ENTREZGENE
  ENSRNOG00000058862 Ensembl
Ensembl Transcript ENSRNOT00000011633 ENTREZGENE
  ENSRNOT00000141487 ENTREZGENE
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot
  Cytosolic phospholipase A2 catalytic domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132749 IMAGE-MGC_LOAD
  IMAGE:7321805 IMAGE-MGC_LOAD
InterPro Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot
  cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  NTE UniProtKB/Swiss-Prot
  NTE1_P-loop_dom UniProtKB/Swiss-Prot
  PNPLA_dom UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:246246 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108975 IMAGE-MGC_LOAD
  MGC:93152 IMAGE-MGC_LOAD
NCBI Gene 246246 ENTREZGENE
PANTHER NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER UniProtKB/Swiss-Prot
  PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 7 UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  NTE_Ploop UniProtKB/Swiss-Prot
  Patatin UniProtKB/Swiss-Prot
PhenoGen Pnpla7 PhenoGen
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PNPLA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008190 RatGTEx
  ENSRNOG00000058862 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  SSF52151 UniProtKB/Swiss-Prot
UniProt A0A8I6AQ73_RAT UniProtKB/TrEMBL
  A0A8I6AUA6_RAT UniProtKB/TrEMBL
  A0ABK0M1C2_RAT UniProtKB/TrEMBL
  A6JT00 ENTREZGENE, UniProtKB/TrEMBL
  G3V745 ENTREZGENE, UniProtKB/TrEMBL
  PLPL7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XIX2 ENTREZGENE
  Q8K3H9 ENTREZGENE
UniProt Secondary Q5XIX2 UniProtKB/Swiss-Prot
  Q8K3H9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Pnpla7  patatin like domain 7, lysophospholipase  Pnpla7  patatin-like phospholipase domain containing 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Pnpla7  patatin-like phospholipase domain containing 7  LOC100911867  patatin-like phospholipase domain-containing protein 7-like  Data merged from RGD:6490002 737654 PROVISIONAL
2012-07-05 LOC100911867  patatin-like phospholipase domain-containing protein 7-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-25 Pnpla7  patatin-like phospholipase domain containing 7  Ntel1  neuropathy target esterase like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ntel1  neuropathy target esterase like 1  Ntel  NTE-related protein  Symbol and Name updated 1299863 APPROVED
2005-09-30 Ntel        Symbol and Name status set to provisional 70820 PROVISIONAL