Negr1 (neuronal growth regulator 1) - Rat Genome Database

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Gene: Negr1 (neuronal growth regulator 1) Rattus norvegicus
Analyze
Symbol: Negr1
Name: neuronal growth regulator 1
RGD ID: 708416
Description: Involved in negative regulation of glial cell proliferation and negative regulation of synapse assembly. Located in dendrite and neuronal cell body. Is active in postsynaptic density. Orthologous to human NEGR1 (neuronal growth regulator 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kilon; kindred of IgLON; LOC59318
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82248,283,164 - 249,015,538 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2248,283,353 - 249,018,410 (+)EnsemblGRCr8
mRatBN7.22245,624,460 - 246,359,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2245,624,435 - 246,356,730 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2253,337,355 - 254,073,567 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02251,231,168 - 251,967,387 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02246,210,200 - 246,948,407 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02262,914,240 - 263,650,441 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2262,914,327 - 263,650,441 (+)Ensemblrn6Rnor6.0
Rnor_5.02281,586,109 - 282,319,649 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42254,666,633 - 255,426,378 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2237,443,428 - 238,169,037 (+)NCBICelera
RGSC_v3.12254,681,239 - 255,440,985 (+)NCBI
Cytogenetic Map2q45NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
obesity  (ISO)
scrapie  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fulvestrant  (ISO)
glyphosate  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
methapyrilene  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. IG-molecule Kilon shows differential expression pattern from LAMP in the developing and adult rat hippocampus. Bräuer AU, etal., Hippocampus. 2000;10(6):632-44. doi: 10.1002/1098-1063(2000)10:6<632::AID-HIPO1001>3.0.CO;2-6.
2. Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family. Funatsu N, etal., J Biol Chem 1999 Mar 19;274(12):8224-30.
3. IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons. Hashimoto T, etal., Brain Res. 2008 Aug 11;1224:1-11. doi: 10.1016/j.brainres.2008.05.069. Epub 2008 Jun 5.
4. IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons. Hashimoto T, etal., Cell Biochem Funct. 2009 Oct;27(7):496-8. doi: 10.1002/cbf.1600.
5. Proteomic Screen of Brain Glycoproteome Reveals Prion Specific Marker of Pathogenesis. Lamoureux L, etal., Proteomics. 2018 Jan;18(1). doi: 10.1002/pmic.201700296.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Biochemical and ultrastructural analyses of IgLON cell adhesion molecules, Kilon and OBCAM in the rat brain. Miyata S, etal., Neuroscience. 2003;117(3):645-58. doi: 10.1016/s0306-4522(02)00873-4.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Overexpression of IgLON cell adhesion molecules changes proliferation and cell size of cortical astrocytes. Sugimoto C, etal., Cell Biochem Funct. 2012 Jul;30(5):400-5. doi: 10.1002/cbf.2813. Epub 2012 Feb 28.
Additional References at PubMed
PMID:21700703   PMID:22627920   PMID:22844493   PMID:23376485  


Genomics

Comparative Map Data
Negr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82248,283,164 - 249,015,538 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2248,283,353 - 249,018,410 (+)EnsemblGRCr8
mRatBN7.22245,624,460 - 246,359,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2245,624,435 - 246,356,730 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2253,337,355 - 254,073,567 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02251,231,168 - 251,967,387 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02246,210,200 - 246,948,407 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02262,914,240 - 263,650,441 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2262,914,327 - 263,650,441 (+)Ensemblrn6Rnor6.0
Rnor_5.02281,586,109 - 282,319,649 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42254,666,633 - 255,426,378 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2237,443,428 - 238,169,037 (+)NCBICelera
RGSC_v3.12254,681,239 - 255,440,985 (+)NCBI
Cytogenetic Map2q45NCBI
NEGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,395,943 - 72,282,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,395,943 - 72,282,539 (-)Ensemblhg38GRCh38
GRCh37171,861,626 - 72,748,222 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,641,213 - 72,520,865 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34171,583,838 - 72,460,205NCBI
Celera170,157,555 - 71,037,580 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef169,978,580 - 70,860,342 (-)NCBIHuRef
CHM1_1171,983,975 - 72,863,635 (-)NCBICHM1_1
T2T-CHM13v2.0171,273,677 - 72,161,473 (-)NCBIT2T-CHM13v2.0
Negr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393156,266,082 - 157,022,101 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3156,267,431 - 157,022,082 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383156,561,790 - 157,316,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3156,561,794 - 157,316,445 (+)Ensemblmm10GRCm38
MGSCv373156,224,758 - 156,979,411 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363156,497,087 - 157,251,740 (+)NCBIMGSCv36mm8
Celera3163,010,595 - 163,778,314 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map380.6NCBI
Negr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542320,011,615 - 20,813,879 (+)Ensembl
ChiLan1.0NW_00495542320,011,488 - 20,816,686 (+)NCBIChiLan1.0ChiLan1.0
NEGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21154,602,246 - 155,488,935 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11153,764,106 - 154,647,525 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0170,628,093 - 71,503,114 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1172,609,803 - 73,484,442 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl172,613,516 - 73,484,240 (-)EnsemblpanPan2panpan1.1
NEGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1673,823,686 - 74,637,906 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl673,823,826 - 74,634,764 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha676,497,030 - 77,310,515 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0674,414,385 - 75,225,455 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl674,414,525 - 75,225,455 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1673,963,931 - 74,777,540 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0673,862,655 - 74,675,458 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0674,358,166 - 75,172,342 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Negr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505883,586,504 - 84,376,744 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936591113,013 - 899,271 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936591112,864 - 903,598 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6140,780,723 - 141,647,820 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16140,780,397 - 141,652,414 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26130,680,413 - 130,791,117 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12060,848,712 - 61,731,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603355,940,383 - 56,522,362 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Negr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474224,054,701 - 24,877,957 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474224,054,340 - 24,881,716 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Negr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v134,267,270 - 4,696,367 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Negr1
5306 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:65
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000029312
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat

Markers in Region
D2Rat70  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22245,889,653 - 245,889,826 (+)MAPPERmRatBN7.2
Rnor_6.02263,179,018 - 263,179,188NCBIRnor6.0
Rnor_5.02281,850,301 - 281,850,471UniSTSRnor5.0
RGSC_v3.42254,933,192 - 254,933,362UniSTSRGSC3.4
RGSC_v3.42254,933,191 - 254,933,362RGDRGSC3.4
Celera2237,707,980 - 237,708,150UniSTS
RGSC_v3.12254,947,787 - 254,948,141RGD
RH 3.4 Map21633.1RGD
RH 3.4 Map21633.1UniSTS
RH 2.0 Map21203.5RGD
SHRSP x BN Map2112.4798RGD
FHH x ACI Map2113.0199RGD
Cytogenetic Map2q45UniSTS
D2Got393  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22246,229,994 - 246,230,118 (+)MAPPERmRatBN7.2
Rnor_6.02263,518,807 - 263,518,932NCBIRnor6.0
Rnor_5.02282,187,965 - 282,188,090UniSTSRnor5.0
RGSC_v3.42255,287,754 - 255,287,879UniSTSRGSC3.4
Celera2238,047,903 - 238,048,029UniSTS
Cytogenetic Map2q45UniSTS
D2Got420  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82248,309,026 - 248,309,298 (+)Marker Load Pipeline
mRatBN7.22245,650,141 - 245,650,414 (+)MAPPERmRatBN7.2
Rnor_6.02262,939,797 - 262,940,069NCBIRnor6.0
Rnor_5.02281,611,213 - 281,611,485UniSTSRnor5.0
RGSC_v3.42254,692,741 - 254,693,013UniSTSRGSC3.4
Celera2237,468,995 - 237,469,267UniSTS
Cytogenetic Map2q45UniSTS
47.MMHAP35FRH11.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22245,624,799 - 245,624,965 (+)MAPPERmRatBN7.2
Rnor_6.02262,914,447 - 262,914,612NCBIRnor6.0
Rnor_5.02281,586,316 - 281,586,481UniSTSRnor5.0
RGSC_v3.42254,666,840 - 254,667,005UniSTSRGSC3.4
Celera2237,443,635 - 237,443,800UniSTS
Cytogenetic Map2q45UniSTS
AU048123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22245,728,032 - 245,728,291 (+)MAPPERmRatBN7.2
Rnor_6.02263,017,942 - 263,018,200NCBIRnor6.0
Rnor_5.02281,689,225 - 281,689,483UniSTSRnor5.0
RGSC_v3.42254,770,310 - 254,770,568UniSTSRGSC3.4
Celera2237,546,860 - 237,547,118UniSTS
Cytogenetic Map2q45UniSTS
RH138127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22245,935,228 - 245,935,366 (+)MAPPERmRatBN7.2
Rnor_6.02263,224,475 - 263,224,612NCBIRnor6.0
Rnor_5.02281,895,758 - 281,895,895UniSTSRnor5.0
RGSC_v3.42254,978,741 - 254,978,878UniSTSRGSC3.4
Celera2237,753,543 - 237,753,680UniSTS
RH 3.4 Map21635.6UniSTS
Cytogenetic Map2q45UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 67 165 91 90 59 38 59 6 294 137 11 144 78 90 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000029312   ⟹   ENSRNOP00000035271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2248,283,364 - 249,018,410 (+)Ensembl
mRatBN7.2 Ensembl2245,624,435 - 246,263,845 (+)Ensembl
Rnor_6.0 Ensembl2262,914,327 - 263,649,764 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089396   ⟹   ENSRNOP00000072152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2248,283,353 - 249,015,865 (+)Ensembl
mRatBN7.2 Ensembl2245,624,435 - 246,356,730 (+)Ensembl
Rnor_6.0 Ensembl2263,212,051 - 263,650,441 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101457   ⟹   ENSRNOP00000094089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2245,624,435 - 246,322,967 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116115   ⟹   ENSRNOP00000094558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2248,283,364 - 248,870,605 (+)Ensembl
mRatBN7.2 Ensembl2245,624,435 - 246,211,790 (+)Ensembl
RefSeq Acc Id: NM_021682   ⟹   NP_067714
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82248,283,476 - 249,015,538 (+)NCBI
mRatBN7.22245,624,593 - 246,356,730 (+)NCBI
Rnor_6.02262,914,240 - 263,650,441 (+)NCBI
Rnor_5.02281,586,109 - 282,319,649 (+)NCBI
RGSC_v3.42254,666,633 - 255,426,378 (+)RGD
Celera2237,443,428 - 238,169,037 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103007   ⟹   XP_038958935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82248,283,167 - 248,870,715 (+)NCBI
mRatBN7.22245,624,460 - 246,230,112 (+)NCBI
RefSeq Acc Id: XM_063282428   ⟹   XP_063138498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82248,283,164 - 248,926,288 (+)NCBI
RefSeq Acc Id: NP_067714   ⟸   NM_021682
- Peptide Label: precursor
- UniProtKB: Q9Z0J8 (UniProtKB/Swiss-Prot),   A6HWR8 (UniProtKB/TrEMBL),   A6HWR9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072152   ⟸   ENSRNOT00000089396
Ensembl Acc Id: ENSRNOP00000035271   ⟸   ENSRNOT00000029312
RefSeq Acc Id: XP_038958935   ⟸   XM_039103007
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AJV3 (UniProtKB/TrEMBL),   A6HWS0 (UniProtKB/TrEMBL),   A6HWR9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094089   ⟸   ENSRNOT00000101457
Ensembl Acc Id: ENSRNOP00000094558   ⟸   ENSRNOT00000116115
RefSeq Acc Id: XP_063138498   ⟸   XM_063282428
- Peptide Label: isoform X1
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0J8-F1-model_v2 AlphaFold Q9Z0J8 1-348 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708416 AgrOrtholog
BioCyc Gene G2FUF-50722 BioCyc
Ensembl Genes ENSRNOG00000021410 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029312 ENTREZGENE
  ENSRNOT00000089396.2 UniProtKB/Swiss-Prot
  ENSRNOT00000116115 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  IgLON_domain UniProtKB/Swiss-Prot
KEGG Report rno:59318 UniProtKB/Swiss-Prot
NCBI Gene 59318 ENTREZGENE
PANTHER IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED UniProtKB/Swiss-Prot
  NEURONAL GROWTH REGULATOR 1 UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
PhenoGen Negr1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021410 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A0G2K293_RAT UniProtKB/TrEMBL
  A0A8I6AJV3 ENTREZGENE, UniProtKB/TrEMBL
  A6HWR8 ENTREZGENE, UniProtKB/TrEMBL
  A6HWR9 ENTREZGENE, UniProtKB/TrEMBL
  A6HWS0 ENTREZGENE, UniProtKB/TrEMBL
  D4A2V0_RAT UniProtKB/TrEMBL
  NEGR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Negr1  neuronal growth regulator 1  LOC59318  kilon  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization glycosylphosphatidylinositol (GPI)-anchored to the membrane 1299429
gene_expression expression is restricted to brain 1299429