Cdk5rap1 (CDK5RAP1 mitochondrial tRNA methylthiotransferase) - Rat Genome Database

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Gene: Cdk5rap1 (CDK5RAP1 mitochondrial tRNA methylthiotransferase) Rattus norvegicus
Analyze
Symbol: Cdk5rap1
Name: CDK5RAP1 mitochondrial tRNA methylthiotransferase (Ensembl:CDK5 regulatory subunit associated protein 1)
RGD ID: 708387
Description: Predicted to enable tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity. Involved in regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytosol; mitochondrial matrix; and nucleoplasm. Orthologous to human CDK5RAP1 (CDK5 regulatory subunit associated protein 1); INTERACTS WITH 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDK5 activator-binding protein; CDK5 activator-binding protein C42; CDK5 regulatory subunit associated protein 1; CDK5 regulatory subunit-associated protein 1; LOC252827; mitochondrial tRNA methylthiotransferase CDK5RAP1; mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase; mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,189,435 - 163,333,003 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3163,191,056 - 163,332,908 (-)EnsemblGRCr8
mRatBN7.23142,838,081 - 142,872,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,708,028 - 142,872,677 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3146,703,769 - 146,740,020 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,321,928 - 155,358,184 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,061,296 - 153,097,549 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,835,953 - 149,870,429 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,703,848 - 149,870,413 (-)Ensemblrn6Rnor6.0
Rnor_5.03156,207,918 - 156,241,596 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43144,803,213 - 144,840,056 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3141,573,777 - 141,607,994 (-)NCBICelera
RGSC_v3.13144,542,380 - 144,745,686 (-)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning of three novel neuronal Cdk5 activator binding proteins. Ching YP, etal., Gene 2000 Jan 25;242(1-2):285-94.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Identification of a common protein association region in the neuronal Cdk5 activator. Wang X, etal., J Biol Chem 2000 Oct 13;275(41):31763-9.
Additional References at PubMed
PMID:11882646   PMID:15489334   PMID:25738458  


Genomics

Comparative Map Data
Cdk5rap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,189,435 - 163,333,003 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3163,191,056 - 163,332,908 (-)EnsemblGRCr8
mRatBN7.23142,838,081 - 142,872,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,708,028 - 142,872,677 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3146,703,769 - 146,740,020 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,321,928 - 155,358,184 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,061,296 - 153,097,549 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,835,953 - 149,870,429 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,703,848 - 149,870,413 (-)Ensemblrn6Rnor6.0
Rnor_5.03156,207,918 - 156,241,596 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43144,803,213 - 144,840,056 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3141,573,777 - 141,607,994 (-)NCBICelera
RGSC_v3.13144,542,380 - 144,745,686 (-)NCBI
Cytogenetic Map3q41NCBI
CDK5RAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,358,839 - 33,401,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,358,437 - 33,401,561 (-)Ensemblhg38GRCh38
GRCh372031,946,645 - 31,989,375 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,410,306 - 31,452,998 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2028,700,397 - 28,743,101 (-)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2028,734,002 - 28,776,702 (-)NCBIHuRef
CHM1_12031,847,728 - 31,890,453 (-)NCBICHM1_1
T2T-CHM13v2.02035,086,043 - 35,128,797 (-)NCBIT2T-CHM13v2.0
Cdk5rap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,063,931 - 154,216,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,177,300 - 154,214,930 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382154,222,011 - 154,373,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,335,380 - 154,373,010 (-)Ensemblmm10GRCm38
MGSCv372154,161,122 - 154,198,455 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362154,026,827 - 154,064,160 (-)NCBIMGSCv36mm8
Celera2160,245,246 - 160,276,980 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.46NCBI
Cdk5rap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,879,389 - 27,906,861 (+)Ensembl
ChiLan1.0NW_00495542227,878,048 - 27,907,157 (+)NCBIChiLan1.0ChiLan1.0
CDK5RAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,051,655 - 39,097,406 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,044,755 - 39,090,499 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,648,003 - 29,690,210 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12030,762,967 - 30,804,237 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2030,762,967 - 30,804,237 (-)EnsemblpanPan2panpan1.1
CDK5RAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,588,354 - 22,628,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,588,354 - 22,628,450 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2422,233,958 - 22,273,952 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02423,274,345 - 23,314,508 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,274,346 - 23,314,461 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,549,684 - 22,589,773 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,660,263 - 22,700,448 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,091,600 - 23,131,993 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdk5rap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,575,109 - 171,607,082 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365617,142,478 - 7,176,262 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365617,142,528 - 7,174,435 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK5RAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1736,877,650 - 36,908,019 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11736,877,570 - 36,911,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21741,827,904 - 41,861,614 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK5RAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,655,094 - 37,695,129 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,655,102 - 37,695,075 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605089,202,342 - 89,243,001 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk5rap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248425,834,709 - 5,887,254 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdk5rap1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15133,701,238 - 133,736,256 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdk5rap1
762 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:142
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000021418
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021418   ⟹   ENSRNOP00000021418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3163,303,212 - 163,331,052 (-)Ensembl
mRatBN7.2 Ensembl3142,708,028 - 142,872,677 (-)Ensembl
Rnor_6.0 Ensembl3149,703,848 - 149,870,413 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095276   ⟹   ENSRNOP00000080480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3163,322,796 - 163,331,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140954   ⟹   ENSRNOP00000105568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3163,191,056 - 163,331,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150058   ⟹   ENSRNOP00000110028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3163,298,308 - 163,332,877 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169885   ⟹   ENSRNOP00000100305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3163,305,626 - 163,332,908 (-)Ensembl
RefSeq Acc Id: NM_145721   ⟹   NP_663773
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,298,211 - 163,332,891 (-)NCBI
mRatBN7.23142,838,081 - 142,872,669 (-)NCBI
Rnor_6.03149,835,954 - 149,870,405 (-)NCBI
Rnor_5.03156,207,918 - 156,241,596 (-)NCBI
RGSC_v3.43144,803,213 - 144,840,056 (-)RGD
Celera3141,573,777 - 141,607,994 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283141   ⟹   XP_063139211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,298,211 - 163,332,273 (-)NCBI
RefSeq Acc Id: XM_063283142   ⟹   XP_063139212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,189,435 - 163,333,003 (-)NCBI
RefSeq Acc Id: XM_063283143   ⟹   XP_063139213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,298,211 - 163,333,003 (-)NCBI
RefSeq Acc Id: XR_010064566
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,298,433 - 163,333,003 (-)NCBI
RefSeq Acc Id: XR_010064567
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,306,449 - 163,331,052 (-)NCBI
RefSeq Acc Id: NP_663773   ⟸   NM_145721
- UniProtKB: Q9JLH6 (UniProtKB/Swiss-Prot),   A6KHY4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021418   ⟸   ENSRNOT00000021418
RefSeq Acc Id: XP_063139212   ⟸   XM_063283142
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139213   ⟸   XM_063283143
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063139211   ⟸   XM_063283141
- Peptide Label: isoform X1
- UniProtKB: Q9JLH6 (UniProtKB/Swiss-Prot),   A6KHY4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110028   ⟸   ENSRNOT00000150058
Ensembl Acc Id: ENSRNOP00000100305   ⟸   ENSRNOT00000169885
Ensembl Acc Id: ENSRNOP00000105568   ⟸   ENSRNOT00000140954
Ensembl Acc Id: ENSRNOP00000080480   ⟸   ENSRNOT00000095276
Protein Domains
MTTase N-terminal   Radical SAM core   TRAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLH6-F1-model_v2 AlphaFold Q9JLH6 1-586 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692571
Promoter ID:EPDNEW_R3096
Type:multiple initiation site
Name:Cdk5rap1_1
Description:CDK5 regulatory subunit associated protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03149,870,417 - 149,870,477EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708387 AgrOrtholog
BioCyc Gene G2FUF-47180 BioCyc
Ensembl Genes ENSRNOG00000015696 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000140954 ENTREZGENE
  ENSRNOT00000150058 ENTREZGENE
Gene3D-CATH 3.40.50.12160 UniProtKB/Swiss-Prot
  3.80.30.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623565 IMAGE-MGC_LOAD
InterPro Elp3/MiaB/NifB UniProtKB/Swiss-Prot
  Methylthiotransferase UniProtKB/Swiss-Prot
  Methylthiotransferase_CS UniProtKB/Swiss-Prot
  Methylthiotransferase_N UniProtKB/Swiss-Prot
  Methylthiotransferase_N_sf UniProtKB/Swiss-Prot
  MiaB_methiolase UniProtKB/Swiss-Prot
  rSAM UniProtKB/Swiss-Prot
  rSAM_horseshoe UniProtKB/Swiss-Prot
  TRAM_dom UniProtKB/Swiss-Prot
KEGG Report rno:252827 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72290 IMAGE-MGC_LOAD
NCBI Gene 252827 ENTREZGENE
PANTHER CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1 UniProtKB/Swiss-Prot
  MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1 UniProtKB/Swiss-Prot
Pfam Radical_SAM UniProtKB/Swiss-Prot
  TRAM UniProtKB/Swiss-Prot
  UPF0004 UniProtKB/Swiss-Prot
PhenoGen Cdk5rap1 PhenoGen
PROSITE MTTASE_N UniProtKB/Swiss-Prot
  MTTASE_RADICAL UniProtKB/Swiss-Prot
  RADICAL_SAM UniProtKB/Swiss-Prot
  TRAM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015696 RatGTEx
SMART Elp3 UniProtKB/Swiss-Prot
Superfamily-SCOP Radical SAM enzymes UniProtKB/Swiss-Prot
UniProt A0A8I5ZQ54_RAT UniProtKB/TrEMBL
  A0ABK0LHF9_RAT UniProtKB/TrEMBL
  A0ABK0LNN3_RAT UniProtKB/TrEMBL
  A0ABK0LP80_RAT UniProtKB/TrEMBL
  A0ABK0M4V6_RAT UniProtKB/TrEMBL
  A6KHY4 ENTREZGENE, UniProtKB/TrEMBL
  CK5P1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Cdk5rap1  CDK5RAP1 mitochondrial tRNA methylthiotransferase  Cdk5rap1  CDK5 regulatory subunit associated protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cdk5rap1  CDK5 regulatory subunit associated protein 1  LOC252827  CDK5 activator-binding protein  Symbol and Name updated 1299863 APPROVED