Cyp4f5 (cytochrome P450, family 4, subfamily f, polypeptide 5) - Rat Genome Database

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Gene: Cyp4f5 (cytochrome P450, family 4, subfamily f, polypeptide 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp4f5 (Ensembl: Cyp4f37)
Name: cytochrome P450, family 4, subfamily f, polypeptide 5 (Ensembl:cytochrome P450, family 4, subfamily f, polypeptide 37)
RGD ID: 708364
Description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in leukotriene metabolic process and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of congestive heart failure and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human CYP4F8 (cytochrome P450 family 4 subfamily F member 8); PARTICIPATES IN arachidonic acid metabolic pathway; INTERACTS WITH 1-nitropropane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYPIVF5; cytochrome P450 4F5; cytochrome P450 4F5-like; LOC691320; similar to cytochrome P450 4F1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,194,567 - 12,209,495 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl712,195,022 - 12,209,965 (+)EnsemblGRCr8
mRatBN7.2711,544,040 - 11,558,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,544,082 - 11,558,978 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx714,361,994 - 14,377,041 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,239,423 - 16,254,470 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0714,111,496 - 14,126,355 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,559,806 - 14,574,345 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,529,482 - 14,574,361 (+)Ensemblrn6Rnor6.0
Rnor_5.0714,712,613 - 14,727,091 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4713,119,551 - 13,134,015 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera79,652,973 - 9,667,356 (+)NCBICelera
RGSC_v3.1713,119,550 - 13,134,014 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
3. Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6. Bylund J, etal., Arch Biochem Biophys 2003 Apr 1;412(1):34-41.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily. Kawashima H and Strobel HW, Biochem Biophys Res Commun 1995 Dec 26;217(3):1137-44.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16182239  


Genomics

Variants

.
Variants in Cyp4f5
79 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:76
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000007428
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 91 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000007428   ⟹   ENSRNOP00000007428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,195,022 - 12,209,491 (+)Ensembl
mRatBN7.2 Ensembl711,544,120 - 11,558,978 (+)Ensembl
Rnor_6.0 Ensembl714,559,878 - 14,574,342 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000065282   ⟹   ENSRNOP00000062471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl713,881,583 - 13,887,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090844   ⟹   ENSRNOP00000072675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl714,529,482 - 14,574,361 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093545   ⟹   ENSRNOP00000076271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,195,022 - 12,209,965 (+)Ensembl
mRatBN7.2 Ensembl711,544,082 - 11,558,838 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000161370   ⟹   ENSRNOP00000100277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,198,127 - 12,209,965 (+)Ensembl
RefSeq Acc Id: NM_173124   ⟹   NP_775147
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,194,637 - 12,209,492 (+)NCBI
mRatBN7.2711,544,120 - 11,558,979 (+)NCBI
Rnor_6.0714,559,878 - 14,574,342 (+)NCBI
Rnor_5.0714,712,613 - 14,727,091 (+)NCBI
RGSC_v3.4713,119,551 - 13,134,015 (+)RGD
Celera79,652,973 - 9,667,356 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078523   ⟹   XP_038934451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,194,567 - 12,209,495 (+)NCBI
mRatBN7.2711,544,049 - 11,558,982 (+)NCBI
RefSeq Acc Id: XM_039078525   ⟹   XP_038934453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,195,092 - 12,209,495 (+)NCBI
mRatBN7.2711,544,568 - 11,558,982 (+)NCBI
RefSeq Acc Id: XM_039078527   ⟹   XP_038934455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,203,008 - 12,209,495 (+)NCBI
mRatBN7.2711,552,491 - 11,558,982 (+)NCBI
RefSeq Acc Id: XM_063263077   ⟹   XP_063119147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,194,567 - 12,209,495 (+)NCBI
RefSeq Acc Id: XM_063263078   ⟹   XP_063119148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,195,084 - 12,209,495 (+)NCBI
RefSeq Acc Id: NP_775147   ⟸   NM_173124
- UniProtKB: P51870 (UniProtKB/Swiss-Prot),   Q9EQ70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072675   ⟸   ENSRNOT00000090844
Ensembl Acc Id: ENSRNOP00000007428   ⟸   ENSRNOT00000007428
RefSeq Acc Id: XP_038934451   ⟸   XM_039078523
- Peptide Label: isoform X1
- UniProtKB: A2VD07 (UniProtKB/TrEMBL),   A6K954 (UniProtKB/TrEMBL),   Q9EQ70 (UniProtKB/TrEMBL),   F7FNW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934453   ⟸   XM_039078525
- Peptide Label: isoform X3
- UniProtKB: A0A1W2Q6H4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934455   ⟸   XM_039078527
- Peptide Label: isoform X4
- UniProtKB: A0A1W2Q6H4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000062471   ⟸   ENSRNOT00000065282
Ensembl Acc Id: ENSRNOP00000076271   ⟸   ENSRNOT00000093545
RefSeq Acc Id: XP_063119147   ⟸   XM_063263077
- Peptide Label: isoform X2
- UniProtKB: Q9EQ70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119148   ⟸   XM_063263078
- Peptide Label: isoform X3
- UniProtKB: A0A1W2Q6H4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100277   ⟸   ENSRNOT00000161370

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGC5-F1-model_v2 AlphaFold D3ZGC5 1-262 view protein structure
AF-P51870-F1-model_v2 AlphaFold P51870 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708364 AgrOrtholog
BioCyc Gene G2FUF-34822 BioCyc
Ensembl Genes ENSRNOG00000042496 Ensembl, ENTREZGENE
  ENSRNOG00000050888 Ensembl
Ensembl Transcript ENSRNOT00000007428 ENTREZGENE
  ENSRNOT00000093545 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7375658 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_Monoox UniProtKB/Swiss-Prot
KEGG Report rno:286905 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156578 IMAGE-MGC_LOAD
NCBI Gene 286905 ENTREZGENE
PANTHER CYTOCHROME P450 CYP4F16-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp4f5 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000042496 RatGTEx
  ENSRNOG00000050888 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A1W2Q6H4 ENTREZGENE
  A0ABK0LHD3_RAT UniProtKB/TrEMBL
  A0ABZ3NNI3_RAT UniProtKB/TrEMBL
  A2VD07 ENTREZGENE
  A6K954 ENTREZGENE, UniProtKB/TrEMBL
  CP4F5_RAT UniProtKB/Swiss-Prot
  F7FNW8 ENTREZGENE, UniProtKB/TrEMBL
  P51870 ENTREZGENE
  Q9EQ70 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cyp4f5  cytochrome P450, family 4, subfamily f, polypeptide 5  LOC691320  similar to cytochrome P450 4F1  Data merged from RGD:1585095 737654 PROVISIONAL
2010-04-19 Cyp4f5  cytochrome P450, family 4, subfamily f, polypeptide 5  Cyp4f5  cytochrome P450 4F5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691320  similar to cytochrome P450 4F1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-09-30 Cyp4f5        Symbol and Name status set to provisional 70820 PROVISIONAL