Ces2a (carboxylesterase 2A) - Rat Genome Database

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Gene: Ces2a (carboxylesterase 2A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces2a (Ensembl: Ces2j)
Name: carboxylesterase 2A (Ensembl:carboxylesterase 2J)
RGD ID: 708353
Description: Enables carboxylesterase activity and retinyl-palmitate esterase activity. Predicted to be involved in retinol metabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human CES2 (carboxylesterase 2); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxylesterase 6; carboxylesterase isoenzyme; carboxylesterase isoenzyme gene; carboxylic ester hydrolase; Ces6; LOC246252; pyrethroid hydrolase Ces2a
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819135,885 - 142,935 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl19135,885 - 142,935 (-)EnsemblGRCr8
mRatBN7.219129,428 - 136,480 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19129,428 - 136,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx19134,435 - 141,443 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.019868,131 - 875,141 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019143,363 - 150,371 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01959,110 - 64,378 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1959,197 - 64,303 (-)Ensemblrn6Rnor6.0
Rnor_5.019506,180 - 507,580 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01954,661 - 64,888 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41937,686 - 44,736 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera19125,426 - 132,478 (-)NCBICelera
RGSC_v3.11937,685 - 44,736 (-)NCBI
Cytogenetic Map19p14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.
Additional References at PubMed
PMID:19187434   PMID:34503976  


Genomics

Variants

.
Variants in Ces2a
60 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:8
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000015451
Prediction methods:Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
16 7 17 21 73 75 58 10 58 3 136 39 8 17 77 17

Sequence


Ensembl Acc Id: ENSRNOT00000015451   ⟹   ENSRNOP00000015451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl19135,885 - 142,935 (-)Ensembl
mRatBN7.2 Ensembl19129,428 - 136,480 (-)Ensembl
Rnor_6.0 Ensembl1959,197 - 64,303 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145622   ⟹   ENSRNOP00000101631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl19135,885 - 142,935 (-)Ensembl
RefSeq Acc Id: NR_171898
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819135,885 - 142,935 (-)NCBI
mRatBN7.219129,428 - 136,480 (-)NCBI
Protein Sequences
Protein RefSeqs NP_653344 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK61610 (Get FASTA)   NCBI Sequence Viewer  
  Q8K3R0 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000015451   ⟸   ENSRNOT00000015451
Ensembl Acc Id: ENSRNOP00000101631   ⟸   ENSRNOT00000145622
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3R0-F1-model_v2 AlphaFold Q8K3R0 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700902
Promoter ID:EPDNEW_R11426
Type:initiation region
Name:Ces2a_1
Description:carboxylesterase 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01964,334 - 64,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708353 AgrOrtholog
BioCyc Gene G2FUF-6675 BioCyc
Ensembl Genes ENSRNOG00000011330 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015451 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Type-B_Carboxylest/Lipase UniProtKB/Swiss-Prot
NCBI Gene 246252 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Ces2a PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011330 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A0G2K1L3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L0N6_RAT UniProtKB/TrEMBL
  EST2A_RAT UniProtKB/Swiss-Prot
  F7F3M3 ENTREZGENE
  Q8K3R0 ENTREZGENE
UniProt Secondary F7F3M3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces2a  carboxylesterase 2A  Ces6  carboxylesterase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Ces6  carboxylesterase 6  LOC246252  carboxylesterase isoenzyme gene  Symbol and Name updated 1299863 APPROVED