Tamalin (trafficking regulator and scaffold protein tamalin) - Rat Genome Database

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Gene: Tamalin (trafficking regulator and scaffold protein tamalin) Rattus norvegicus
Analyze
Symbol: Tamalin
Name: trafficking regulator and scaffold protein tamalin
RGD ID: 70554
Description: Enables PDZ domain binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to be involved in regulation of postsynaptic neurotransmitter receptor internalization and signal transduction. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human TAMALIN (trafficking regulator and scaffold protein tamalin); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein; general receptor for phosphoinositides 1 associated scaffold protein; general receptor for phosphoinositides 1-associated scaffold protein; Grasp; GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein; Grp1 (general receptor for phosphoinositides)-associated scaffold protein; GRP1-associated scaffold protein; LOC102556412; PSD-95 PDZ domain-containing protein; uncharacterized LOC102556412
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,217,612 - 134,225,378 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,217,065 - 134,225,378 (+)EnsemblGRCr8
mRatBN7.27132,338,900 - 132,359,519 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,338,900 - 132,346,666 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,140,744 - 134,148,514 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,370,258 - 136,378,028 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,280,692 - 136,288,521 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,869,785 - 142,877,551 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,869,752 - 142,878,347 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,670,666 - 140,678,432 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,970,173 - 139,977,939 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,804,534 - 128,812,273 (+)NCBICelera
RGSC_v3.17140,046,609 - 140,054,376 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association. Kitano J, etal., J Biol Chem 2003 Apr 25;278(17):14762-8. Epub 2003 Feb 13.
3. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. Kitano J, etal., J Neurosci 2002 Feb 15;22(4):1280-9.
4. Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation. Matosin N, etal., Acta Neuropathol. 2015 Jul;130(1):119-29. doi: 10.1007/s00401-015-1411-6. Epub 2015 Mar 17.
5. Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia. Matosin N, etal., Schizophr Res. 2015 Aug;166(1-3):212-8. doi: 10.1016/j.schres.2015.05.001. Epub 2015 Jun 2.id: 97053792 Error occurred: The following PMID is not available: 97053792
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation. Sugi T, etal., EMBO J. 2007 Apr 18;26(8):2192-205. Epub 2007 Mar 29.
Additional References at PubMed
PMID:10828067   PMID:15173175   PMID:22569042   PMID:22980744   PMID:28285821  


Genomics

Comparative Map Data
Tamalin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,217,612 - 134,225,378 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,217,065 - 134,225,378 (+)EnsemblGRCr8
mRatBN7.27132,338,900 - 132,359,519 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,338,900 - 132,346,666 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,140,744 - 134,148,514 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,370,258 - 136,378,028 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,280,692 - 136,288,521 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,869,785 - 142,877,551 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,869,752 - 142,878,347 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,670,666 - 140,678,432 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,970,173 - 139,977,939 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,804,534 - 128,812,273 (+)NCBICelera
RGSC_v3.17140,046,609 - 140,054,376 (+)NCBI
Cytogenetic Map7q36NCBI
TAMALIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,006,946 - 52,015,889 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,006,946 - 52,015,889 (+)Ensemblhg38GRCh38
GRCh371252,400,730 - 52,409,673 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,687,015 - 50,695,938 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341250,687,014 - 50,695,938NCBI
Celera1251,203,041 - 51,211,963 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,433,882 - 49,442,831 (+)NCBIHuRef
CHM1_11252,367,010 - 52,375,941 (+)NCBICHM1_1
T2T-CHM13v2.01251,970,517 - 51,979,459 (+)NCBIT2T-CHM13v2.0
Tamalin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,122,088 - 101,130,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,122,069 - 101,130,637 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,224,207 - 101,232,756 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,224,188 - 101,232,756 (+)Ensemblmm10GRCm38
MGSCv3715101,054,638 - 101,063,187 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,052,243 - 101,066,427 (+)NCBIMGSCv36mm8
Celera15103,372,533 - 103,381,084 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.57NCBI
Tamalin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,377,702 - 2,385,277 (+)Ensembl
ChiLan1.0NW_0049555472,377,612 - 2,385,918 (+)NCBIChiLan1.0ChiLan1.0
TAMALIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,179,596 - 42,188,252 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,176,359 - 42,185,012 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,747,159 - 36,755,812 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,523,542 - 37,531,996 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,524,232 - 37,531,927 (-)EnsemblpanPan2panpan1.1
TAMALIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,981,261 - 3,000,648 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,255,149 - 43,262,297 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,991,005 - 2,998,190 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,990,639 - 2,998,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,007,624 - 3,014,858 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,994,165 - 3,001,323 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,653,334 - 43,660,493 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tamalin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,697,480 - 63,706,368 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,458,444 - 9,467,351 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,458,549 - 9,467,350 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAMALIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,355,883 - 17,366,309 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1517,357,625 - 17,366,033 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,942,982 - 17,953,496 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAMALIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,176,394 - 48,184,985 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,176,413 - 48,184,981 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037197,905,422 - 197,914,003 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tamalin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816312,476 - 323,192 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624816314,841 - 322,696 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tamalin
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11261,858,159 - 261,866,395 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tamalin
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:47
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000009979
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009979   ⟹   ENSRNOP00000009979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,217,065 - 134,225,378 (+)Ensembl
mRatBN7.2 Ensembl7132,338,900 - 132,346,666 (+)Ensembl
Rnor_6.0 Ensembl7142,869,752 - 142,878,012 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088730   ⟹   ENSRNOP00000069285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7142,877,086 - 142,878,347 (+)Ensembl
RefSeq Acc Id: NM_138894   ⟹   NP_620249
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,217,612 - 134,225,378 (+)NCBI
mRatBN7.27132,338,900 - 132,346,666 (+)NCBI
Rnor_6.07142,869,785 - 142,877,551 (+)NCBI
Rnor_5.07140,670,666 - 140,678,432 (+)NCBI
RGSC_v3.47139,970,173 - 139,977,939 (+)RGD
Celera7128,804,534 - 128,812,273 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620249 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL87038 (Get FASTA)   NCBI Sequence Viewer  
  EDL86904 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009979
  ENSRNOP00000009979.1
GenBank Protein Q8R4T5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620249   ⟸   NM_138894
- UniProtKB: Q8R4T5 (UniProtKB/Swiss-Prot),   A6KCN8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009979   ⟸   ENSRNOT00000009979
Ensembl Acc Id: ENSRNOP00000069285   ⟸   ENSRNOT00000088730
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R4T5-F1-model_v2 AlphaFold Q8R4T5 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695666
Promoter ID:EPDNEW_R6190
Type:single initiation site
Name:Grasp_1
Description:general receptor for phosphoinositides 1 associated scaffoldprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,869,768 - 142,869,828EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70554 AgrOrtholog
BIND 144392
  144395
  144396
  144397
  144399
BioCyc Gene G2FUF-31994 BioCyc
Ensembl Genes ENSRNOG00000007346 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009979 ENTREZGENE
  ENSRNOT00000009979.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
InterPro Intracell_Traff_Signaling_Reg UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:192254 UniProtKB/Swiss-Prot
NCBI Gene Tamalin ENTREZGENE
PANTHER GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED UniProtKB/Swiss-Prot
  PROTEIN TAMALIN UniProtKB/Swiss-Prot
Pfam PDZ UniProtKB/Swiss-Prot
PhenoGen Tamalin PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007346 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot
UniProt A6KCN8 ENTREZGENE, UniProtKB/TrEMBL
  GRASP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tamalin  trafficking regulator and scaffold protein tamalin  LOC102556412  uncharacterized LOC102556412  Data merged from RGD:7689805 737654 PROVISIONAL
2020-02-24 Tamalin  trafficking regulator and scaffold protein tamalin  Grasp  general receptor for phosphoinositides 1 associated scaffold protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-22 Grasp  general receptor for phosphoinositides 1 associated scaffold protein  Grasp  GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102556412  uncharacterized LOC102556412      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Grasp  GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein    Grp1 (general receptor for phosphoinositides)-associated scaffold protein  Name updated 1299863 APPROVED
2002-06-10 Grasp  Grp1 (general receptor for phosphoinositides)-associated scaffold protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a 95-kDa postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain, a leucine-zipper region, and a carboxyl-terminal PDZ binding motif 1299234
gene_function scaffold protein that binds group 1 metabotropic glutamate receptors at its amino-terminal PDZ domain and ARF-specific GEF protein at its C-terminus 70394
gene_function forms a complex with PSD-95 and Mint2/X11beta/X11L 1299234
gene_process has a role in associating group 1 metabotropic glutamate receptors and ARF-specific GEF proteins to mediate intracellular trafficking 70394