Acsl6 (acyl-CoA synthetase long-chain family member 6) - Rat Genome Database

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Gene: Acsl6 (acyl-CoA synthetase long-chain family member 6) Rattus norvegicus
Analyze
Symbol: Acsl6
Name: acyl-CoA synthetase long-chain family member 6
RGD ID: 69403
Description: Enables arachidonate-CoA ligase activity and protein homodimerization activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of long-chain fatty acid import across plasma membrane; and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum membrane; mitochondrial outer membrane; and peroxisomal membrane. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arachidonate--CoA ligase; Facl6; fatty acid Coenzyme A ligase, long chain 6; LACS 6; Lacsl; long-chain acyl-CoA synthetase 6; long-chain acyl-CoA synthetase-like; long-chain-fatty-acid--CoA ligase 6; long-chain-fatty-acid--CoA ligase, brain isozyme
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,940,668 - 38,999,515 (+)NCBIGRCr8
mRatBN7.21038,439,914 - 38,501,182 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,440,080 - 38,498,757 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,136,726 - 43,184,107 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,626,824 - 42,674,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,130,538 - 38,177,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,654,771 - 39,717,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,655,455 - 39,719,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,430,561 - 39,491,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,729,805 - 39,778,106 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,743,427 - 39,791,726 (+)NCBI
Celera1037,792,002 - 37,839,268 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation. Benani A, etal., Eur J Neurosci. 2003 Oct;18(7):1904-14.
2. Transient maintenance in bioreactor improves health of neuronal cells. Di Loreto S, etal., In Vitro Cell Dev Biol Anim. 2006 May-Jun;42(5-6):134-42.
3. Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. Dillon JS, etal., Diabetes. 2000 Dec;49(12):2012-20.
4. Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. Durgan DJ, etal., Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2480-97. Epub 2006 Jan 20.
5. Cloning and functional expression of a novel long-chain acyl-CoA synthetase expressed in brain. Fujino T and Yamamoto T, J Biochem (Tokyo) 1992 Feb;111(2):197-203.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. Klett EL, etal., J Lipid Res. 2017 May;58(5):884-894. doi: 10.1194/jlr.M072512. Epub 2017 Feb 16.
9. Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. Marszalek JR, etal., J Biol Chem. 2004 Jun 4;279(23):23882-91. Epub 2004 Mar 29.
10. Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. Marszalek JR, etal., J Biol Chem. 2005 Mar 18;280(11):10817-26. Epub 2005 Jan 17.
11. Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet. Mashek DG, etal., J Lipid Res. 2006 Sep;47(9):2004-10. Epub 2006 Jun 13.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
20. Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains. Soupene E, etal., BMC Biochem. 2010 Apr 29;11:18. doi: 10.1186/1471-2091-11-18.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Fatty acid transport by vectorial acylation in mammals: roles played by different isoforms of rat long-chain acyl-CoA synthetases. Tong F, etal., Arch Biochem Biophys. 2006 Mar 1;447(1):46-52. Epub 2006 Jan 23.
23. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
24. Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). Yagasaki F, etal., Genes Chromosomes Cancer. 1999 Nov;26(3):192-202.
25. Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain. Yamakawa A, etal., J Biol Chem 1991 Sep 15;266(26):17580-3.
Additional References at PubMed
PMID:12767919   PMID:14651853   PMID:15683247   PMID:16834775   PMID:22205969   PMID:22633490   PMID:24269233   PMID:27647415   PMID:35976155  


Genomics

Comparative Map Data
Acsl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,940,668 - 38,999,515 (+)NCBIGRCr8
mRatBN7.21038,439,914 - 38,501,182 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,440,080 - 38,498,757 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,136,726 - 43,184,107 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,626,824 - 42,674,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,130,538 - 38,177,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,654,771 - 39,717,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,655,455 - 39,719,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,430,561 - 39,491,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,729,805 - 39,778,106 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,743,427 - 39,791,726 (+)NCBI
Celera1037,792,002 - 37,839,268 (+)NCBICelera
Cytogenetic Map10q22NCBI
ACSL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385131,949,973 - 132,012,213 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5131,949,973 - 132,012,243 (-)EnsemblGRCh38hg38GRCh38
GRCh375131,285,666 - 131,347,761 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,317,051 - 131,375,248 (-)NCBINCBI36Build 36hg18NCBI36
Build 345131,317,050 - 131,375,248NCBI
Celera5127,419,235 - 127,477,416 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5126,478,229 - 126,540,313 (-)NCBIHuRef
CHM1_15130,718,510 - 130,780,578 (-)NCBICHM1_1
T2T-CHM13v2.05132,469,856 - 132,532,085 (-)NCBIT2T-CHM13v2.0
Acsl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,194,580 - 54,255,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,194,624 - 54,255,582 (+)EnsemblGRCm39 Ensembl
GRCm381154,303,805 - 54,364,756 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,303,798 - 54,364,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,117,326 - 54,175,041 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,147,247 - 54,204,962 (+)NCBIMGSCv36mm8
Celera1158,892,926 - 58,950,070 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Acsl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,333,392 - 3,392,141 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,336,214 - 3,391,117 (-)NCBIChiLan1.0ChiLan1.0
ACSL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,268,577 - 127,330,482 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,408,140 - 125,470,045 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,373,306 - 127,434,954 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,537,292 - 133,599,093 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,537,292 - 133,586,711 (-)Ensemblpanpan1.1panPan2
ACSL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,226,877 - 20,284,919 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,227,268 - 20,285,631 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,022,424 - 19,080,475 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,004,617 - 21,062,652 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,003,713 - 21,062,951 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11119,731,639 - 19,789,658 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,579,269 - 19,637,509 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,220,723 - 20,279,041 (-)NCBIUU_Cfam_GSD_1.0
Acsl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,150,811 - 116,206,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,153,485 - 3,213,582 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,153,586 - 3,208,935 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,210,917 - 134,278,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,210,915 - 134,278,860 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,569,528 - 139,633,727 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,787,097 - 34,846,387 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2334,787,432 - 34,829,042 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603443,111,126 - 43,174,349 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,105,806 - 40,160,221 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473340,105,795 - 40,157,108 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acsl6
363 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:141
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000030760, ENSRNOT00000058817
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 11 64 11 8
Low 27 9 1 1 10 24 6
Below cutoff 3 16 18 10 19 10 27 6 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_130739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY625254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF490998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB881417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC938826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S56508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000030760   ⟹   ENSRNOP00000033248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,451,416 - 38,498,757 (+)Ensembl
Rnor_6.0 Ensembl1039,666,991 - 39,715,973 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000058817   ⟹   ENSRNOP00000055608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,440,326 - 38,498,757 (+)Ensembl
Rnor_6.0 Ensembl1039,655,455 - 39,719,312 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103397   ⟹   ENSRNOP00000096136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,440,080 - 38,498,757 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107770   ⟹   ENSRNOP00000080278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,456,634 - 38,498,757 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115137   ⟹   ENSRNOP00000081838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,456,361 - 38,498,757 (+)Ensembl
RefSeq Acc Id: NM_130739   ⟹   NP_570095
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,952,161 - 38,999,502 (+)NCBI
mRatBN7.21038,451,416 - 38,498,762 (+)NCBI
Rnor_6.01039,666,991 - 39,715,982 (+)NCBI
Rnor_5.01039,430,561 - 39,491,346 (+)NCBI
RGSC_v3.41039,729,805 - 39,778,106 (+)RGD
Celera1037,792,002 - 37,839,268 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246221   ⟹   XP_006246283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,940,813 - 38,999,515 (+)NCBI
mRatBN7.21038,440,234 - 38,501,182 (+)NCBI
Rnor_6.01039,655,298 - 39,717,592 (+)NCBI
Rnor_5.01039,430,561 - 39,491,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246222   ⟹   XP_006246284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,940,919 - 38,999,515 (+)NCBI
mRatBN7.21038,440,233 - 38,501,182 (+)NCBI
Rnor_6.01039,655,295 - 39,717,592 (+)NCBI
Rnor_5.01039,430,561 - 39,491,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246224   ⟹   XP_006246286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,940,668 - 38,999,515 (+)NCBI
mRatBN7.21038,439,914 - 38,501,182 (+)NCBI
Rnor_6.01039,654,771 - 39,717,426 (+)NCBI
Rnor_5.01039,430,561 - 39,491,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085077   ⟹   XP_038941005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,940,942 - 38,999,515 (+)NCBI
mRatBN7.21038,440,233 - 38,501,182 (+)NCBI
RefSeq Acc Id: XM_063268323   ⟹   XP_063124393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,940,942 - 38,974,011 (+)NCBI
RefSeq Acc Id: XM_063268324   ⟹   XP_063124394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,940,942 - 38,999,515 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_570095   ⟸   NM_130739
- UniProtKB: Q63835 (UniProtKB/Swiss-Prot),   P33124 (UniProtKB/Swiss-Prot),   Q6IU14 (UniProtKB/Swiss-Prot),   A6HEH5 (UniProtKB/TrEMBL),   A0A8I5ZSH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246286   ⟸   XM_006246224
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZSH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246283   ⟸   XM_006246221
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006246284   ⟸   XM_006246222
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000055608   ⟸   ENSRNOT00000058817
RefSeq Acc Id: ENSRNOP00000033248   ⟸   ENSRNOT00000030760
RefSeq Acc Id: XP_038941005   ⟸   XM_039085077
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000080278   ⟸   ENSRNOT00000107770
RefSeq Acc Id: ENSRNOP00000081838   ⟸   ENSRNOT00000115137
RefSeq Acc Id: ENSRNOP00000096136   ⟸   ENSRNOT00000103397
RefSeq Acc Id: XP_063124394   ⟸   XM_063268324
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063124393   ⟸   XM_063268323
- Peptide Label: isoform X5
Protein Domains
AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33124-F1-model_v2 AlphaFold P33124 1-697 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697195
Promoter ID:EPDNEW_R7712
Type:single initiation site
Name:Acsl6_1
Description:acyl-CoA synthetase long-chain family member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01039,655,427 - 39,655,487EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69403 AgrOrtholog
BioCyc Gene G2FUF-25116 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-5143 BioCyc
  PWY-5972 BioCyc
  PWY-6000 BioCyc
  PWY-7049 BioCyc
  PWY-8181 BioCyc
  PWY3DJ-11470 BioCyc
  PWY66-387 BioCyc
  PWY66-388 BioCyc
  PWY66-389 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000026745 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030760.5 UniProtKB/Swiss-Prot
  ENSRNOT00000058817.6 UniProtKB/TrEMBL
  ENSRNOT00000103397.1 UniProtKB/TrEMBL
  ENSRNOT00000107770 ENTREZGENE
  ENSRNOT00000107770.1 UniProtKB/TrEMBL
  ENSRNOT00000115137.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AMP-binding_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANL_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LC-FACS_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117243 UniProtKB/Swiss-Prot
NCBI Gene 117243 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LONG-CHAIN-FATTY-ACID--COA LIGASE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acsl6 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026745 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206202
UniProt A0A0A6YYM0_RAT UniProtKB/TrEMBL
  A0A8I5ZPS9_RAT UniProtKB/TrEMBL
  A0A8I5ZSH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B3S2_RAT UniProtKB/TrEMBL
  A6HEH3_RAT UniProtKB/TrEMBL
  A6HEH4_RAT UniProtKB/TrEMBL
  A6HEH5 ENTREZGENE, UniProtKB/TrEMBL
  A6HEH6_RAT UniProtKB/TrEMBL
  ACSL6_RAT UniProtKB/Swiss-Prot
  B2BET9_RAT UniProtKB/TrEMBL
  P33124 ENTREZGENE
  Q63835 ENTREZGENE
  Q6IU14 ENTREZGENE
UniProt Secondary Q63835 UniProtKB/Swiss-Prot
  Q6IU14 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acsl6  acyl-CoA synthetase long-chain family member 6  Facl6  fatty acid Coenzyme A ligase, long chain 6  Symbol and Name updated 1299863 APPROVED
2002-06-10 Facl6  fatty acid Coenzyme A ligase, long chain 6      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in intestine; also present in liver 69376
gene_expression mRNAs increases in liver by high sucrose refeeding and decreases with fasting 69376
gene_function catalyzes the ligation of long chain fatty acids with coenzyme A to produce long chain acyl-CoAs, has a broad substrate specificity for saturated fatty acids of 1218 carbon atoms and unsaturated fatty acids of 1620 carbon atoms 69376
gene_process involved in energy use via b-oxidation and the synthesis of triacylglycerol, phospholipids, cholesterol esters, and sphingomyelin 69376