Ech1 (enoyl-CoA hydratase 1) - Rat Genome Database

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Gene: Ech1 (enoyl-CoA hydratase 1) Rattus norvegicus
Analyze
Symbol: Ech1
Name: enoyl-CoA hydratase 1
RGD ID: 69353
Description: Predicted to enable delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Orthologous to human ECH1 (enoyl-CoA hydratase 1); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-bromopropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; enoyl CoA hydratase 1, peroxisomal; enoyl coenzyme A hydratase 1; enoyl coenzyme A hydratase 1, peroxisomal; enoyl hydratase-like protein peroxisomal; enoyl hydratase-like protein, peroxisomal; Peroxisomal enoyl hydratase-like protein; Pxel
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,241,076 - 93,248,314 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,241,734 - 93,248,440 (+)EnsemblGRCr8
mRatBN7.2184,114,494 - 84,120,788 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,112,751 - 84,120,795 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,524,636 - 89,530,833 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,983,698 - 97,989,944 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,280,494 - 91,286,691 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,009,798 - 87,015,996 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,009,730 - 87,016,005 (+)Ensemblrn6Rnor6.0
Rnor_5.0188,190,416 - 88,196,614 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,932,720 - 83,938,918 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,504,909 - 78,511,107 (+)NCBICelera
RGSC_v3.1184,010,830 - 84,017,029 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-aminobenzotriazole  (ISO)
1-bromopropane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium trinitrate  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
gliotoxin  (EXP)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
hydroxyurea  (ISO)
indometacin  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP)
Muraglitazar  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
nafenopin  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
nitric oxide  (ISO)
Nivalenol  (ISO)
Nutlin-3  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
quercetin  (EXP)
rac-1,2-dichloropropane  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP,ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IBA,IDA,IEA,ISO)
peroxisome  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization. Filppula SA, etal., J Biol Chem. 1998 Jan 2;273(1):349-55.
2. Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase. FitzPatrick DR, etal., Genomics 1995 Jun 10;27(3):457-66.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Enoyl coenzyme A hydratase 1 combats obesity and related metabolic disorders by promoting adipose tissue browning. Mao X, etal., Am J Physiol Endocrinol Metab. 2020 Mar 1;318(3):E318-E329. doi: 10.1152/ajpendo.00424.2019. Epub 2020 Jan 21.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9739087   PMID:14651853   PMID:15489334   PMID:18614015   PMID:19946888   PMID:20178365   PMID:20458337   PMID:23376485   PMID:26316108  


Genomics

Comparative Map Data
Ech1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,241,076 - 93,248,314 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,241,734 - 93,248,440 (+)EnsemblGRCr8
mRatBN7.2184,114,494 - 84,120,788 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,112,751 - 84,120,795 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,524,636 - 89,530,833 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,983,698 - 97,989,944 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,280,494 - 91,286,691 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,009,798 - 87,015,996 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,009,730 - 87,016,005 (+)Ensemblrn6Rnor6.0
Rnor_5.0188,190,416 - 88,196,614 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,932,720 - 83,938,918 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,504,909 - 78,511,107 (+)NCBICelera
RGSC_v3.1184,010,830 - 84,017,029 (+)NCBI
Cytogenetic Map1q21NCBI
ECH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,815,422 - 38,831,794 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,815,417 - 38,831,874 (-)Ensemblhg38GRCh38
GRCh371939,306,062 - 39,322,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,997,902 - 44,014,337 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341943,997,909 - 44,014,278NCBI
Celera1936,108,519 - 36,124,956 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,752,797 - 35,769,242 (-)NCBIHuRef
CHM1_11939,306,533 - 39,322,968 (-)NCBICHM1_1
T2T-CHM13v2.01941,619,465 - 41,635,846 (-)NCBIT2T-CHM13v2.0
Ech1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,524,763 - 28,531,664 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,524,642 - 28,531,672 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,825,338 - 28,832,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,825,217 - 28,832,247 (+)Ensemblmm10GRCm38
MGSCv37729,610,357 - 29,617,258 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36728,534,098 - 28,540,999 (+)NCBIMGSCv36mm8
Celera723,386,212 - 23,393,113 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
Ech1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955468686,171 - 692,737 (+)NCBIChiLan1.0ChiLan1.0
LOC100980944
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,106,270 - 45,122,592 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11946,976,768 - 46,993,103 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,909,348 - 35,925,686 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,479,555 - 44,489,355 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,479,561 - 44,489,355 (-)EnsemblpanPan2panpan1.1
ECH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,281,754 - 114,291,211 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ech1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,352,637 - 13,357,795 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,780,866 - 1,785,869 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,780,706 - 1,785,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ECH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,627,062 - 47,639,291 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1647,627,056 - 47,638,961 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,166,641 - 43,178,371 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q21NCBI
ECH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,439,490 - 33,449,349 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,439,682 - 33,449,272 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607311,451,944 - 11,461,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ech1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,195,385 - 12,203,606 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479412,196,402 - 12,203,674 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ech1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,170,420 - 167,177,304 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ech1
77 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:104
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000027537
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat

Markers in Region
D1Bda9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,120,602 - 84,120,731 (+)MAPPERmRatBN7.2
Rnor_6.0187,015,811 - 87,015,939NCBIRnor6.0
Rnor_5.0188,196,429 - 88,196,557UniSTSRnor5.0
RGSC_v3.4183,938,733 - 83,938,861UniSTSRGSC3.4
Celera178,510,922 - 78,511,050UniSTS
Cytogenetic Map1q21UniSTS
AI102822  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8193,247,852 - 93,248,198 (+)Marker Load Pipeline
mRatBN7.2184,120,336 - 84,120,682 (+)MAPPERmRatBN7.2
Rnor_6.0187,015,545 - 87,015,890NCBIRnor6.0
Rnor_5.0188,196,163 - 88,196,508UniSTSRnor5.0
RGSC_v3.4183,938,467 - 83,938,812UniSTSRGSC3.4
Celera178,510,656 - 78,511,001UniSTS
RH 3.4 Map1837.4UniSTS
Cytogenetic Map1q21UniSTS
RH124256  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8193,247,918 - 93,248,154 (+)Marker Load Pipeline
mRatBN7.2184,120,402 - 84,120,638 (+)MAPPERmRatBN7.2
Rnor_6.0187,015,611 - 87,015,846NCBIRnor6.0
Rnor_5.0188,196,229 - 88,196,464UniSTSRnor5.0
RGSC_v3.4183,938,533 - 83,938,768UniSTSRGSC3.4
Celera178,510,722 - 78,510,957UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027537   ⟹   ENSRNOP00000027537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,242,598 - 93,248,440 (+)Ensembl
mRatBN7.2 Ensembl184,115,082 - 84,120,795 (+)Ensembl
Rnor_6.0 Ensembl187,009,730 - 87,016,005 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096349   ⟹   ENSRNOP00000085027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,241,734 - 93,248,440 (+)Ensembl
mRatBN7.2 Ensembl184,112,751 - 84,120,794 (+)Ensembl
RefSeq Acc Id: NM_022594   ⟹   NP_072116
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,242,106 - 93,248,304 (+)NCBI
mRatBN7.2184,114,590 - 84,120,788 (+)NCBI
Rnor_6.0187,009,798 - 87,015,996 (+)NCBI
Rnor_5.0188,190,416 - 88,196,614 (+)NCBI
RGSC_v3.4183,932,720 - 83,938,918 (+)RGD
Celera178,504,909 - 78,511,107 (+)RGD
Sequence:
RefSeq Acc Id: XM_063272779   ⟹   XP_063128849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,241,076 - 93,248,314 (+)NCBI
Protein Sequences
Protein RefSeqs NP_072116 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128849 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA82008 (Get FASTA)   NCBI Sequence Viewer  
  AAH62226 (Get FASTA)   NCBI Sequence Viewer  
  EDM07870 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085027
  ENSRNOP00000085027.1
GenBank Protein Q62651 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_072116   ⟸   NM_022594
- Peptide Label: precursor
- UniProtKB: A0A8L2QF26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027537   ⟸   ENSRNOT00000027537
Ensembl Acc Id: ENSRNOP00000085027   ⟸   ENSRNOT00000096349
RefSeq Acc Id: XP_063128849   ⟸   XM_063272779
- Peptide Label: isoform X1
- UniProtKB: Q62651 (UniProtKB/Swiss-Prot),   A0A8L2QF26 (UniProtKB/TrEMBL),   A6J9L4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62651-F1-model_v2 AlphaFold Q62651 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689888
Promoter ID:EPDNEW_R411
Type:multiple initiation site
Name:Ech1_1
Description:enoyl-CoA hydratase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0187,009,796 - 87,009,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69353 AgrOrtholog
BioCyc Gene G2FUF-60213 BioCyc
BioCyc Pathway PWY-6837 [fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)] BioCyc
BioCyc Pathway Image PWY-6837 BioCyc
Ensembl Genes ENSRNOG00000020308 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000096349 ENTREZGENE
  ENSRNOT00000096349.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.12.10 UniProtKB/Swiss-Prot
  2-enoyl-CoA Hydratase, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6890529 IMAGE-MGC_LOAD
  IMAGE:6921895 IMAGE-MGC_LOAD
InterPro ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot
  Ech1-like UniProtKB/Swiss-Prot
  Enoyl-CoA_hyd/isom_CS UniProtKB/Swiss-Prot
  Enoyl-CoA_hydra/iso UniProtKB/Swiss-Prot
  Enoyl-CoA_hydra_C UniProtKB/Swiss-Prot
KEGG Report rno:64526 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72820 IMAGE-MGC_LOAD
  MGC:72821 IMAGE-MGC_LOAD
NCBI Gene 64526 ENTREZGENE
PANTHER DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR43149 UniProtKB/Swiss-Prot
Pfam ECH_1 UniProtKB/Swiss-Prot
PhenoGen Ech1 PhenoGen
PROSITE ENOYL_COA_HYDRATASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020308 RatGTEx
Superfamily-SCOP SSF52096 UniProtKB/Swiss-Prot
TIGR TC216608
UniProt A0A8L2QF26 ENTREZGENE, UniProtKB/TrEMBL
  A6J9L4 ENTREZGENE, UniProtKB/TrEMBL
  ECH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-06 Ech1  enoyl-CoA hydratase 1  Ech1  enoyl CoA hydratase 1, peroxisomal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ech1  enoyl CoA hydratase 1, peroxisomal  Ech1  enoyl coenzyme A hydratase 1, peroxisomal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ech1  enoyl coenzyme A hydratase 1, peroxisomal    enoyl coenzyme A hydratase 1  Name updated 1299863 APPROVED
2002-06-10 Ech1  enoyl coenzyme A hydratase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in liver 68827
gene_regulation mRNA expression upregulated by peroxisome proliferator 68827