Ndst1 (N-deacetylase and N-sulfotransferase 1) - Rat Genome Database

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Gene: Ndst1 (N-deacetylase and N-sulfotransferase 1) Rattus norvegicus
Analyze
Symbol: Ndst1
Name: N-deacetylase and N-sulfotransferase 1
RGD ID: 69303
Description: Enables heparan sulfate N-deacetylase activity and heparan sulfate N-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: [Heparan sulfate]-glucosamine N-sulfotransferase 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; Golgi heparan sulfate N-deacetylase/N-sulfotransferase; heparan sulfate-N-deacetylase/N-sulfotransferase; HSNST 1; Hsst; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; N-deacetylase/N-sulfotransferase 1; N-heparan sulfate sulfotransferase 1; N-HSST; N-HSST 1; NDST-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,407,308 - 56,470,007 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1856,411,200 - 56,448,612 (-)EnsemblGRCr8
mRatBN7.21854,136,887 - 54,199,545 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,140,779 - 54,178,191 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1856,229,512 - 56,266,941 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01856,944,111 - 56,981,540 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01854,764,697 - 54,802,107 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01855,951,497 - 56,014,107 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1855,955,389 - 55,992,885 (-)Ensemblrn6Rnor6.0
Rnor_5.01855,189,496 - 55,226,905 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41856,638,891 - 56,677,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1852,295,217 - 52,332,793 (-)NCBICelera
RGSC_v3.11856,711,122 - 56,750,063 (-)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
heparan sulfate  (ISO)
losartan  (EXP)
medroxyprogesterone acetate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. Aikawa J and Esko JD, J Biol Chem. 1999 Jan 29;274(5):2690-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase. Hashimoto Y, etal., J Biol Chem 1992 Aug 5;267(22):15744-50.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. A single protein catalyzes both N-deacetylation and N-sulfation during the biosynthesis of heparan sulfate. Wei Z, etal., Proc Natl Acad Sci U S A. 1993 May 1;90(9):3885-8. doi: 10.1073/pnas.90.9.3885.
Additional References at PubMed
PMID:9890952   PMID:10664446   PMID:10852901   PMID:11087757   PMID:11792394   PMID:15253930   PMID:15793251   PMID:16020517   PMID:21454625   PMID:25807483   PMID:28363469   PMID:36222339  


Genomics

Comparative Map Data
Ndst1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,407,308 - 56,470,007 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1856,411,200 - 56,448,612 (-)EnsemblGRCr8
mRatBN7.21854,136,887 - 54,199,545 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,140,779 - 54,178,191 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1856,229,512 - 56,266,941 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01856,944,111 - 56,981,540 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01854,764,697 - 54,802,107 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01855,951,497 - 56,014,107 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1855,955,389 - 55,992,885 (-)Ensemblrn6Rnor6.0
Rnor_5.01855,189,496 - 55,226,905 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41856,638,891 - 56,677,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1852,295,217 - 52,332,793 (-)NCBICelera
RGSC_v3.11856,711,122 - 56,750,063 (-)NCBI
Cytogenetic Map18q12.1NCBI
NDST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,497,779 - 150,558,211 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,485,648 - 150,558,211 (+)Ensemblhg38GRCh38
GRCh375149,877,341 - 149,937,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,880,623 - 149,917,966 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345149,880,622 - 149,917,966NCBI
Celera5145,968,756 - 146,018,856 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,034,217 - 145,084,242 (+)NCBIHuRef
CHM1_15149,320,110 - 149,370,203 (+)NCBICHM1_1
T2T-CHM13v2.05151,034,321 - 151,094,757 (+)NCBIT2T-CHM13v2.0
Ndst1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391860,817,566 - 60,907,465 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1860,817,566 - 60,881,722 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381860,684,494 - 60,749,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,684,494 - 60,748,650 (-)Ensemblmm10GRCm38
MGSCv371860,845,617 - 60,873,043 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361860,811,332 - 60,838,758 (-)NCBIMGSCv36mm8
Celera1861,969,670 - 61,997,089 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.38NCBI
Ndst1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554153,999,473 - 4,060,998 (-)Ensembl
ChiLan1.0NW_0049554154,017,142 - 4,078,927 (-)NCBIChiLan1.0ChiLan1.0
NDST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,713,778 - 145,787,281 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,854,440 - 143,926,827 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,910,993 - 145,982,933 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,918,667 - 151,986,668 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,936,357 - 151,986,668 (+)EnsemblpanPan2panpan1.1
NDST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,580,231 - 58,639,750 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,532,148 - 58,640,191 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha458,347,429 - 58,405,535 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0459,061,802 - 59,119,959 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,061,147 - 59,090,976 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,850,372 - 58,908,502 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,966,408 - 59,022,929 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,495,800 - 59,553,938 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ndst1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,839,583 - 142,921,891 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,413,549 - 4,454,109 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,413,549 - 4,495,933 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,489,521 - 151,522,749 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12151,433,925 - 151,525,909 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NDST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,109,806 - 53,159,880 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2353,123,222 - 53,155,016 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603424,554,718 - 24,627,309 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndst1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,758,809 - 9,821,309 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247749,758,459 - 9,821,309 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ndst1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11571,234,350 - 71,258,398 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ndst1
321 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:454
Count of miRNA genes:230
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000025881
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
Ndst1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,141,283 - 54,141,724 (+)MAPPERmRatBN7.2
Rnor_6.01855,955,894 - 55,956,334NCBIRnor6.0
Rnor_5.01855,190,001 - 55,190,441UniSTSRnor5.0
RGSC_v3.41856,639,396 - 56,639,836UniSTSRGSC3.4
Celera1852,295,722 - 52,296,162UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 90 59 6 354 190 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025881   ⟹   ENSRNOP00000025881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1856,411,200 - 56,448,612 (-)Ensembl
mRatBN7.2 Ensembl1854,140,779 - 54,178,191 (-)Ensembl
Rnor_6.0 Ensembl1855,955,389 - 55,992,885 (-)Ensembl
RefSeq Acc Id: NM_024361   ⟹   NP_077337
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,411,200 - 56,448,610 (-)NCBI
mRatBN7.21854,140,779 - 54,178,189 (-)NCBI
Rnor_6.01855,955,389 - 55,992,883 (-)NCBI
Rnor_5.01855,189,496 - 55,226,905 (-)NCBI
RGSC_v3.41856,638,891 - 56,677,831 (-)RGD
Celera1852,295,217 - 52,332,793 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772130   ⟹   XP_008770352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,407,308 - 56,424,497 (-)NCBI
mRatBN7.21854,136,887 - 54,154,075 (-)NCBI
Rnor_6.01855,951,497 - 55,968,635 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600929   ⟹   XP_017456418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,407,308 - 56,448,552 (-)NCBI
mRatBN7.21854,136,887 - 54,178,127 (-)NCBI
Rnor_6.01855,956,343 - 55,992,836 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600930   ⟹   XP_017456419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,407,308 - 56,469,741 (-)NCBI
mRatBN7.21854,136,887 - 54,199,322 (-)NCBI
Rnor_6.01855,956,343 - 56,013,962 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600931   ⟹   XP_017456420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,407,308 - 56,445,327 (-)NCBI
mRatBN7.21854,136,887 - 54,174,713 (-)NCBI
Rnor_6.01855,956,343 - 55,989,294 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600932   ⟹   XP_017456421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,407,308 - 56,469,955 (-)NCBI
mRatBN7.21854,136,887 - 54,199,542 (-)NCBI
Rnor_6.01855,956,343 - 56,014,107 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005496018
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,422,232 - 56,470,007 (-)NCBI
mRatBN7.21854,151,811 - 54,199,545 (-)NCBI
RefSeq Acc Id: NP_077337   ⟸   NM_024361
- UniProtKB: Q02353 (UniProtKB/Swiss-Prot),   A6IXC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770352   ⟸   XM_008772130
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456421   ⟸   XM_017600932
- Peptide Label: isoform X1
- UniProtKB: Q02353 (UniProtKB/Swiss-Prot),   A6IXC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456419   ⟸   XM_017600930
- Peptide Label: isoform X1
- UniProtKB: Q02353 (UniProtKB/Swiss-Prot),   A6IXC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456418   ⟸   XM_017600929
- Peptide Label: isoform X1
- UniProtKB: Q02353 (UniProtKB/Swiss-Prot),   A6IXC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456420   ⟸   XM_017600931
- Peptide Label: isoform X1
- UniProtKB: Q02353 (UniProtKB/Swiss-Prot),   A6IXC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025881   ⟸   ENSRNOT00000025881
Protein Domains
Heparan sulfate-N-deacetylase N-terminal   Heparan sulphate-N-deacetylase deacetylase   Sulfotransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02353-F1-model_v2 AlphaFold Q02353 1-882 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700806
Promoter ID:EPDNEW_R11330
Type:multiple initiation site
Name:Ndst1_1
Description:N-deacetylase and N-sulfotransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01855,992,891 - 55,992,951EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69303 AgrOrtholog
BioCyc Gene G2FUF-7358 BioCyc
BioCyc Pathway PWY-6558 [heparan sulfate biosynthesis] BioCyc
BioCyc Pathway Image PWY-6558 BioCyc
Ensembl Genes ENSRNOG00000019014 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025881 ENTREZGENE
  ENSRNOT00000025881.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro Heparan_SO4_deacetylase UniProtKB/Swiss-Prot
  HSNSD_N UniProtKB/Swiss-Prot
  NST/OST UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Sulfotransferase_dom UniProtKB/Swiss-Prot
KEGG Report rno:29633 UniProtKB/Swiss-Prot
NCBI Gene 29633 ENTREZGENE
PANTHER BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE 1 UniProtKB/Swiss-Prot
  PTHR10605 UniProtKB/Swiss-Prot
Pfam HSNSD UniProtKB/Swiss-Prot
  HSNSD_N UniProtKB/Swiss-Prot
  Sulfotransfer_1 UniProtKB/Swiss-Prot
PhenoGen Ndst1 PhenoGen
RatGTEx ENSRNOG00000019014 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A6IXC4 ENTREZGENE, UniProtKB/TrEMBL
  NDST1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Ndst1  N-deacetylase and N-sulfotransferase 1  Ndst1  N-deacetylase/N-sulfotransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Ndst1  N-deacetylase/N-sulfotransferase 1  Ndst1  N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ndst1  N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the membrane 68801