Slc16a8 (solute carrier family 16 member 8)

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Gene: Slc16a8 (solute carrier family 16 member 8) Rattus norvegicus

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Symbol:

Slc16a8

Name:

solute carrier family 16 member 8

RGD ID:

69282

Description:

Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in lactate transmembrane transport. Located in basal plasma membrane. Orthologous to human SLC16A8 (solute carrier family 16 member 8); INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MCT 3; Mct3; monocarboxylate transporter 3; solute carrier family 16 (monocarboxylate transporter), member 8; solute carrier family 16 (monocarboxylic acid transporters) member 8; solute carrier family 16 (monocarboxylic acid transporters), member 8; solute carrier family 16, member 8; solute carrier family 16, member 8 (monocarboxylic acid transporter 3)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC16A8 (solute carrier family 16 member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc16a8 (solute carrier family 16 (monocarboxylic acid transporters), member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc16a8 (solute carrier family 16 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC16A8 (solute carrier family 16 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC16A8 (solute carrier family 16 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc16a8 (solute carrier family 16 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC16A8 (solute carrier family 16 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC16A8 (solute carrier family 16 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc16a8 (solute carrier family 16 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SULT2A1 (sulfotransferase family 2A member 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLC16A8 (solute carrier family 16 member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc16a8 (solute carrier family 16 (monocarboxylic acid transporters), member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc16a8 (solute carrier family 16 member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	MCH2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mct-4	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MCH4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mct1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mct-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8468	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mct-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	112,698,701 - 112,702,496 (-)	NCBI		GRCr8
mRatBN7.2	7	110,818,274 - 110,822,069 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	110,818,274 - 110,822,069 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	112,566,396 - 112,570,216 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	114,789,932 - 114,793,752 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	114,759,292 - 114,763,112 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	120,486,266 - 120,490,192 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	120,486,266 - 120,490,061 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	120,479,912 - 120,483,773 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	117,234,094 - 117,237,887 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	117,268,373 - 117,272,117 (-)	NCBI
Celera	7	107,151,849 - 107,155,644 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

COVID-19 (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

macular degeneration (ISO)

myoclonic dystonia 26 (ISO)

neurodegeneration with brain iron accumulation 2A (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

choline (ISO)

cisplatin (ISO)

cocaine (EXP)

Cuprizon (EXP)

dextran sulfate (ISO)

dibutyl phthalate (ISO)

dimethylarsinic acid (ISO)

dorsomorphin (ISO)

fenvalerate (EXP)

folic acid (ISO)

glycidol (EXP)

L-methionine (ISO)

methylarsonic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (EXP)

PCB138 (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lactate transmembrane transport (IEA)

Cellular Component

apical plasma membrane (ISO)

basal plasma membrane (IDA)

basolateral plasma membrane (IBA,ISO)

plasma membrane (IBA)

Molecular Function

monocarboxylic acid transmembrane transporter activity (IBA)

secondary active monocarboxylate transmembrane transporter activity (TAS)

symporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE.	Philp NJ, etal., Am J Physiol 1998 Jun;274(6 Pt 2):R1824-8.
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15917240

Genomics

Comparative Map Data

Slc16a8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	112,698,701 - 112,702,496 (-)	NCBI		GRCr8
mRatBN7.2	7	110,818,274 - 110,822,069 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	110,818,274 - 110,822,069 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	112,566,396 - 112,570,216 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	114,789,932 - 114,793,752 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	114,759,292 - 114,763,112 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	120,486,266 - 120,490,192 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	120,486,266 - 120,490,061 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	120,479,912 - 120,483,773 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	117,234,094 - 117,237,887 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	117,268,373 - 117,272,117 (-)	NCBI
Celera	7	107,151,849 - 107,155,644 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

SLC16A8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	38,078,137 - 38,084,184 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	38,078,134 - 38,084,184 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	38,474,144 - 38,480,191 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	36,804,090 - 36,809,116 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	36,798,644 - 36,803,649	NCBI
Celera	22	22,275,893 - 22,280,919 (-)	NCBI		Celera
Cytogenetic Map	22	q13.1	NCBI
HuRef	22	21,438,822 - 21,443,842 (-)	NCBI		HuRef
CHM1_1	22	38,432,878 - 38,437,904 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	38,539,760 - 38,545,772 (-)	NCBI		T2T-CHM13v2.0

Slc16a8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	79,135,216 - 79,139,619 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	79,135,214 - 79,138,961 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	79,251,016 - 79,255,562 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	79,251,014 - 79,254,761 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	79,081,446 - 79,085,178 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	79,078,271 - 79,082,003 (-)	NCBI		MGSCv36	mm8
Celera	15	81,370,781 - 81,374,517 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.7	NCBI

Slc16a8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	24,400,826 - 24,405,208 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	24,400,621 - 24,406,754 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC16A8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	47,934,793 - 47,939,356 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	50,623,157 - 50,627,720 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	18,991,316 - 18,996,071 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	36,816,866 - 36,821,606 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	36,817,117 - 36,821,606 (-)	Ensembl	panpan1.1		panPan2

SLC16A8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	26,589,236 - 26,593,703 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	26,589,236 - 26,593,483 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	26,544,528 - 26,549,024 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	27,381,048 - 27,385,522 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	27,381,063 - 27,385,300 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	27,101,043 - 27,105,540 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	27,412,641 - 27,417,102 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	27,589,693 - 27,594,193 (+)	NCBI		UU_Cfam_GSD_1.0

Slc16a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,080,039 - 10,086,048 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	3,092,113 - 3,096,269 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	3,090,624 - 3,096,462 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC16A8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	9,800,397 - 9,806,543 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	9,799,830 - 9,806,550 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	7,201,563 - 7,206,416 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC16A8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	20,780,596 - 20,785,845 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	20,780,848 - 20,785,655 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	104,984,913 - 104,990,189 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc16a8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	9,874,740 - 9,878,909 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	9,874,740 - 9,879,280 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc16a8
20 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	111
Count of miRNA genes:	94
Interacting mature miRNAs:	102
Transcripts:	ENSRNOT00000016247
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	80221299	112308525	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Markers in Region

RH144644

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	110,818,326 - 110,818,479 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	120,486,319 - 120,486,471	NCBI	Rnor6.0
Rnor_5.0	7	120,479,965 - 120,480,117	UniSTS	Rnor5.0
RGSC_v3.4	7	117,234,146 - 117,234,298	UniSTS	RGSC3.4
Celera	7	107,151,902 - 107,152,054	UniSTS
RH 3.4 Map	7	840.9	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	47	97	46	45	14	25	14	6	160	95	77	34	47	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF059258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016247 ⟹ ENSRNOP00000016248

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	110,818,274 - 110,822,069 (-)	Ensembl
Rnor_6.0 Ensembl	7	120,486,266 - 120,490,061 (-)	Ensembl

RefSeq Acc Id:

NM_031744 ⟹ NP_113932

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	112,698,701 - 112,702,496 (-)	NCBI
mRatBN7.2	7	110,818,274 - 110,822,069 (-)	NCBI
Rnor_6.0	7	120,486,266 - 120,490,061 (-)	NCBI
Rnor_5.0	7	120,479,912 - 120,483,773 (-)	NCBI
RGSC_v3.4	7	117,234,094 - 117,237,887 (-)	RGD
Celera	7	107,151,849 - 107,155,644 (-)	NCBI

Sequence:

show sequence

TCAACAGGAGTGCAGCCACCAGAGTCAAGGCTGTTGGACACTCTCAGAGCTAGAGGCTGCCCCT
CCCGAAGGCCTCAGGAGATGTGAGGTTCAACCCTAAATCCAGAGTCAGGTCCAGGTCCCCAGAG
GAGAGGAGCCCTGGTGAGGAAACCTCAAAGTCAAGTCTCCATTCAGCCTTCACAGGCCTTTGCA
GGAAGCAGAAGCAGAGGCAATGGGTGCTGGCGGCCCGCGGCGGGGTGCTGGTCCTCCAGATGGT
GGCTGGGGCTGGGTGGTACTGGGCGCCTGCTTCGTGATCACTGGCTTCGCCTATGGCTTCCCTA
AGGCTGTGAGCGTCTTCTTCCGAGAGCTCAAGCGCGACTTCGGGGCAGGTTACAGTGACACAGC
CTGGGTGTCTTCCATCATGCTGGCTATGCTCTACGGCACGGGCCCCTTGTCCAGCATCCTCGTG
ACGCGCTTTGGCTGTCGCCCAGTGATGCTGGCTGGTGGACTGCTGGCTTCAGCGGGCATGATTC
TGGCTTCCTTTGCCTCGCGCCTCCTGGAGCTGTACCTGACGGCTGGGGTACTCACAGGCCTGGG
CCTGGCTCTCAACTTCCAGCCGTCGCTCATCATGCTGGGGCTCTACTTCGAGCGGCGACGGCCC
CTGGCCAACGGGCTGGCAGCAGCAGGCAGCCCGGTGTTTCTGTCCACGCTGTCGCCTCTCGGCC
AGCTGCTGGGGGAGCGCTTTGGCTGGCGCGGCGGCTTCCTGCTGTTTGGCGGTCTCCTGCTGCA
CTGTTGCGCCTGTGGGGCTGTCATGCGTCCGCCCCCTGGACCCCAGCCGCGCCCAGACCCTGCG
CCCCCCGGTGGCCGGGCTCGCCACAGGCAGCTGCTGGACTTGGCAGTGTGCACTGACCGCACTT
TCATGGTATACATGGTTACCAAGTTCCTGATGGCGCTCGGGCTCTTTGTGCCGGCTATCCTGCT
GGTGAACTACGCCAAGGACGCGGGTGTGCCTGATGCCGAGGCCGCCTTCTTGTTGTCTATCGTG
GGCTTTGTGGACATCGTGGCACGGCCAGCGTGTGGTGCTTTGGCGGGTCTGGGGCGACTGAGAC
CCCACGTCCCCTATCTCTTCAGCCTGGCCTTGTTGGCCAATGGGCTCACGGACCTGATTAGCGC
TCGTGCGCGCTCCTACGGCACCCTTGTGGCTTTCTGCATCGCCTTCGGCCTCTCCTATGGCATG
GTGGGCGCGCTGCAATTTGAGGTGCTCATGGCGACCGTGGGTGCGCCCCGCTTCCCTAGTGCCT
TGGGCCTAGTGCTGCTCGTGGAGGCCGTGGCTGTGCTCATAGGACCGCCTTCTGCCGGCCGCCT
GGTGGATGCTCTGAAGAACTATGAGATCATCTTCTACCTTGCTGGTTCTGAGGTGGTCTTGGCA
GGAGTCTTCATGGCAGTTACCACATACTGCTGCCAGCGCTGCTCTAAGGACATCCCACCAGGTC
CATCTGCTGAGGGAGGAACCAGCGACACAGAGGACGTGGAGGCTGAGAGGGACTCTGAGCCAAT
GCCTGCCAGCACTGAAGAGCCTGGCAGCCTGGAAGCTCTGGAGGTGCTGAGCCCCAGGGCTGGG
TCCCCAGAACCAGAGGAGGAGGCAGTGCCTGACCTGAGTCACGAGTCTGTAGGTGGCCATGAGG
CACATGGCCAAAACGCTTGAAAATGTGGCTTCCTCTCTGAGGGCCTGGTACGTGGGGAACCAGC
CTGGGGTGGTCCCTTGGGCACCCAATCTGTTAGGCCCTGTTCACAGTGAAGCTGCTGGGGGCTG
CCAGGAGCACACGTTGATAAAAGCCCCCTAAAAGATA

hide sequence

RefSeq Acc Id:

XM_017595102 ⟹ XP_017450591

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	112,698,701 - 112,701,574 (-)	NCBI
mRatBN7.2	7	110,818,274 - 110,821,147 (-)	NCBI
Rnor_6.0	7	120,486,266 - 120,489,262 (-)	NCBI

Sequence:

show sequence

TGACCTTCCTACCTTGCTGGCTCTATGAACCTGAAAAGGTTCAGTGGGTGTCTCAGGCTGTTCC
TCTTTCTCAATCCGTTCCCCTACAGCACCTACCACTGCCTTTTGTCCCCCTCTTCCCCAGCAGA
AGCAGAGGCAATGGGTGCTGGCGGCCCGCGGCGGGGTGCTGGTCCTCCAGATGGTGGCTGGGGC
TGGGTGGTACTGGGCGCCTGCTTCGTGATCACTGGCTTCGCCTATGGCTTCCCTAAGGCTGTGA
GCGTCTTCTTCCGAGAGCTCAAGCGCGACTTCGGGGCAGGTTACAGTGACACAGCCTGGGTGTC
TTCCATCATGCTGGCTATGCTCTACGGCACGGGCCCCTTGTCCAGCATCCTCGTGACGCGCTTT
GGCTGTCGCCCAGTGATGCTGGCTGGTGGACTGCTGGCTTCAGCGGGCATGATTCTGGCTTCCT
TTGCCTCGCGCCTCCTGGAGCTGTACCTGACGGCTGGGGTACTCACAGGCCTGGGCCTGGCTCT
CAACTTCCAGCCGTCGCTCATCATGCTGGGGCTCTACTTCGAGCGGCGACGGCCCCTGGCCAAC
GGGCTGGCAGCAGCAGGCAGCCCGGTGTTTCTGTCCACGCTGTCGCCTCTCGGCCAGCTGCTGG
GGGAGCGCTTTGGCTGGCGCGGCGGCTTCCTGCTGTTTGGCGGTCTCCTGCTGCACTGTTGCGC
CTGTGGGGCTGTCATGCGTCCGCCCCCTGGACCCCAGCCGCGCCCAGACCCTGCGCCCCCCGGT
GGCCGGGCTCGCCACAGGCAGCTGCTGGACTTGGCAGTGTGCACTGACCGCACTTTCATGGTAT
ACATGGTTACCAAGTTCCTGATGGCGCTCGGGCTCTTTGTGCCGGCTATCCTGCTGGTGAACTA
CGCCAAGGACGCGGGTGTGCCTGATGCCGAGGCCGCCTTCTTGTTGTCTATCGTGGGCTTTGTG
GACATCGTGGCACGGCCAGCGTGTGGTGCTTTGGCGGGTCTGGGGCGACTGAGACCCCACGTCC
CCTATCTCTTCAGCCTGGCCTTGTTGGCCAATGGGCTCACGGACCTGATTAGCGCTCGTGCGCG
CTCCTACGGCACCCTTGTGGCTTTCTGCATCGCCTTCGGCCTCTCCTATGGCATGGTGGGCGCG
CTGCAATTTGAGGTGCTCATGGCGACCGTGGGTGCGCCCCGCTTCCCTAGTGCCTTGGGCCTAG
TGCTGCTCGTGGAGGCCGTGGCTGTGCTCATAGGACCGCCTTCTGCCGGCCGCCTGGTGGATGC
TCTGAAGAACTATGAGATCATCTTCTACCTTGCTGGTTCTGAGGTGGTCTTGGCAGGAGTCTTC
ATGGCAGTTACCACATACTGCTGCCAGCGCTGCTCTAAGGACATCCCACCAGGTCCATCTGCTG
AGGGAGGAACCAGCGACACAGAGGACGTGGAGGCTGAGAGGGACTCTGAGCCAATGCCTGCCAG
CACTGAAGAGCCTGGCAGCCTGGAAGCTCTGGAGGTGCTGAGCCCCAGGGCTGGGTCCCCAGAA
CCAGAGGAGGAGGCAGTGCCTGACCTGAGTCACGAGTCTGTAGGTGGCCATGAGGCACATGGCC
AAAACGCTTGAAAATGTGGCTTCCTCTCTGAGGGCCTGGTACGTGGGGAACCAGCCTGGGGTGG
TCCCTTGGGCACCCAATCTGTTAGGCCCTGTTCACAGTGAAGCTGCTGGGGGCTGCCAGGAGCA
CACGTTGATAAAAGCCCCCTAAAAGATA

hide sequence

RefSeq Acc Id:

XM_063264226 ⟹ XP_063120296

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	112,698,701 - 112,701,514 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_113932	(Get FASTA)	NCBI Sequence Viewer
	XP_017450591	(Get FASTA)	NCBI Sequence Viewer
	XP_063120296	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC18120	(Get FASTA)	NCBI Sequence Viewer
	EDM15812	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016248.1
GenBank Protein	O70461	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113932 ⟸ NM_031744

- UniProtKB:

O70461 (UniProtKB/Swiss-Prot), G3V7K8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGAGGPRRGAGPPDGGWGWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIM
LAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLTAGVLTGLGLALNFQ
PSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGFLLFGGLLLHCCACGA
VMRPPPGPQPRPDPAPPGGRARHRQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKD
AGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYG
TLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKN
YEIIFYLAGSEVVLAGVFMAVTTYCCQRCSKDIPPGPSAEGGTSDTEDVEAERDSEPMPASTEE
PGSLEALEVLSPRAGSPEPEEEAVPDLSHESVGGHEAHGQNA

hide sequence

RefSeq Acc Id:	XP_017450591 ⟸ XM_017595102
- Peptide Label:	isoform X1
- UniProtKB:	O70461 (UniProtKB/Swiss-Prot), G3V7K8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNLKRFSGCLRLFLFLNPFPYSTYHCLLSPSSPAEAEAMGAGGPRRGAGPPDGGWGWVVLGACF VITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLA GGLLASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSP VFLSTLSPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARHRQL LDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPAC GALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMA TVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVTTYCC QRCSKDIPPGPSAEGGTSDTEDVEAERDSEPMPASTEEPGSLEALEVLSPRAGSPEPEEEAVPD LSHESVGGHEAHGQNA hide sequence

Ensembl Acc Id:

ENSRNOP00000016248 ⟸ ENSRNOT00000016247

RefSeq Acc Id:	XP_063120296 ⟸ XM_063264226
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O70461-F1-model_v2	AlphaFold	O70461	1-492	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69282	AgrOrtholog
BioCyc Gene	G2FUF-32767	BioCyc
Ensembl Genes	ENSRNOG00000012090	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000016247.4	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot
InterPro	MCT	UniProtKB/Swiss-Prot
	MFS	UniProtKB/Swiss-Prot
	MFS_dom	UniProtKB/Swiss-Prot
	MFS_trans_sf	UniProtKB/Swiss-Prot
	Proton-linked_MCT	UniProtKB/Swiss-Prot
KEGG Report	rno:65200	UniProtKB/Swiss-Prot
NCBI Gene	65200	ENTREZGENE
PANTHER	MONOCARBOXYLATE TRANSPORTER	UniProtKB/Swiss-Prot
	PTHR11360:SF26	UniProtKB/Swiss-Prot
Pfam	MFS_1	UniProtKB/Swiss-Prot
PhenoGen	Slc16a8	PhenoGen
PROSITE	MFS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000012090	RatGTEx
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot
UniProt	G3V7K8	ENTREZGENE
	MOT3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	G3V7K8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Slc16a8	solute carrier family 16 member 8	Slc16a8	solute carrier family 16 (monocarboxylate transporter), member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc16a8	solute carrier family 16 (monocarboxylate transporter), member 8	Slc16a8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-19	Slc16a8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	Slc16a8	solute carrier family 16, member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Slc16a8	solute carrier family 16, member 8			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the basal membrane of the retinal pigment epithelium	68849
gene_product	member of the monocarboxylate transporter family	68849

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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