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Gene: Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) Rattus norvegicus

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Symbol:

Entpd2

Name:

ectonucleoside triphosphate diphosphohydrolase 2

RGD ID:

69266

Description:

Enables identical protein binding activity and pyrophosphatase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to auditory stimulus. Located in cell body; cell projection membrane; and cell surface. Biomarker of hypertension. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CD39 antigen-like 1; Cd39l1; ecto-ATP diphosphohydrolase 2; ecto-ATPase 2; ecto-ATPDase 2; NTPDase 2; NTPDase2; nucleoside triphosphate diphosphohydrolase 2; testicular ecto-ATPase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,611,722 - 28,617,237 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	28,611,772 - 28,618,184 (+)	Ensembl				GRCr8
mRatBN7.2	3	8,213,575 - 8,219,094 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,213,663 - 8,226,866 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	11,318,790 - 11,324,211 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,905,020 - 19,910,441 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	18,094,862 - 18,100,283 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,617,795 - 2,623,818 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,617,805 - 2,623,445 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	2,599,211 - 2,605,231 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	3,564,380 - 3,569,801 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	3,038,775 - 3,044,196 (+)	NCBI		Celera
RGSC_v3.1	3	3,564,379 - 3,569,800 (+)	NCBI
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (IEP)

genetic disease (ISO)

high grade glioma (ISO)

hypertension (IEP)

liver cirrhosis (ISO)

primary biliary cholangitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (EXP)

aconitine (EXP)

acrylamide (EXP)

Aflatoxin B2 alpha (ISO)

alachlor (EXP)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

antimycin A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

butyric acid (EXP)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

coumestrol (ISO)

Cuprizon (EXP)

cyhalothrin (EXP)

decabromodiphenyl ether (EXP)

diethylstilbestrol (ISO)

diquat (ISO)

diuron (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

etoposide (ISO)

flavonoids (EXP)

folic acid (ISO)

fructose (EXP)

furan (EXP)

L-methionine (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (EXP,ISO)

nitrofen (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

pravastatin (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

raloxifene (EXP)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

Soman (EXP)

sotorasib (ISO)

sulforaphane (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triptonide (ISO)

valproic acid (ISO)

vincristine (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to interferon-alpha (IEA,IEP)

cellular response to interleukin-6 (IMP)

cellular response to lipopolysaccharide (IEA,IEP)

cellular response to tumor necrosis factor (IEA,IEP)

G protein-coupled receptor signaling pathway (ISO)

nucleoside diphosphate catabolic process (IBA)

platelet activation (ISO)

purine ribonucleoside diphosphate catabolic process (ISO)

response to auditory stimulus (IEA,IEP)

ribonucleoside triphosphate catabolic process (IDA,IEA,ISO)

Cellular Component

basement membrane (IEA,ISO)

cell body (IDA)

cell projection membrane (IDA)

cell surface (IDA)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

ADP phosphatase activity (IDA,IEA)

apyrase activity (IDA,IEA,ISO)

ATP binding (IEA)

ATP hydrolysis activity (IDA,IEA)

CDP phosphatase activity (IEA)

CTPase activity (IEA)

GDP phosphatase activity (IBA,IEA)

GTPase activity (IEA)

hydrolase activity (IEA)

identical protein binding (IPI)

IDP phosphatase activity (IEA)

ITPase activity (IEA)

nucleoside diphosphate phosphatase activity (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

ribonucleoside triphosphate phosphatase activity (IBA,IEA,ISO)

UDP phosphatase activity (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Selective NTPDase2 expression modulates in vivo rat glioma growth.	Braganhol E, etal., Cancer Sci. 2009 Aug;100(8):1434-42. doi: 10.1111/j.1349-7006.2009.01219.x. Epub 2009 May 18.
2.	Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3 (NTPDase1-3) by cortical astrocytes after exposure to pro-inflammatory factors in vitro.	Brisevac D, etal., J Mol Neurosci. 2013 Nov;51(3):871-9. doi: 10.1007/s12031-013-0088-3. Epub 2013 Aug 29.
3.	The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver.	Dranoff JA, etal., Hepatology 2002 Nov;36(5):1135-44.
4.	Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis.	Dranoff JA, etal., J Investig Med. 2004 Nov;52(7):475-82.
5.	Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes.	Failer BU, etal., Eur J Biochem. 2003 Apr;270(8):1802-9.
6.	L-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats.	Furstenau CR, etal., Life Sci. 2010 Aug 28;87(9-10):325-32. doi: 10.1016/j.lfs.2010.07.008. Epub 2010 Jul 23.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Functional characterization of rat ecto-ATPase and ecto-ATP diphosphohydrolase after heterologous expression in CHO cells.	Heine P, etal., Eur J Biochem. 1999 May;262(1):102-7. doi: 10.1046/j.1432-1327.1999.00347.x.
9.	An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain.	Kegel B, etal., Neuropharmacology 1997 Sep;36(9):1189-200.
10.	Ecto-ATPase mRNA is regulated by FSH in Sertoli cells.	Lu Q, etal., J Androl 2001 Mar-Apr;22(2):289-301.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18.	Evidence for alternative splicing of ecto-ATPase associated with termination of purinergic transmission.	Vlajkovic SM, etal., Brain Res Mol Brain Res 1999 Nov 10;73(1-2):85-92.
19.	Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea.	Vlajkovic SM, etal., Neuroscience. 2004;126(3):763-73.
20.	C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation.	Wang CJ, etal., Biochem J. 2005 Feb 1;385(Pt 3):729-36. doi: 10.1042/BJ20040852.
21.	Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes.	Wink MR, etal., Neuroscience. 2006;138(2):421-32. Epub 2006 Jan 18.
22.	IL-6 downregulates transcription of NTPDase2 via specific promoter elements.	Yu J, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G748-56. doi: 10.1152/ajpgi.00208.2007. Epub 2008 Jan 17.
23.	Crystallographic snapshots along the reaction pathway of nucleoside triphosphate diphosphohydrolases.	Zebisch M, etal., Structure. 2013 Aug 6;21(8):1460-75. doi: 10.1016/j.str.2013.05.016. Epub 2013 Jul 3.

Additional References at PubMed

PMID:10510450	PMID:11929769	PMID:12477932	PMID:12832497	PMID:14730706	PMID:14764443	PMID:15004436	PMID:15799977	PMID:17574764	PMID:17910474	PMID:18201730	PMID:18458329
PMID:19524108	PMID:21325440	PMID:22038661	PMID:23010799	PMID:23533145	PMID:23677997	PMID:26080748	PMID:35593054	PMID:38055119	PMID:38158780

Genomics

Comparative Map Data

Entpd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,611,722 - 28,617,237 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	28,611,772 - 28,618,184 (+)	Ensembl				GRCr8
mRatBN7.2	3	8,213,575 - 8,219,094 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,213,663 - 8,226,866 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	11,318,790 - 11,324,211 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,905,020 - 19,910,441 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	18,094,862 - 18,100,283 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,617,795 - 2,623,818 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,617,805 - 2,623,445 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	2,599,211 - 2,605,231 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	3,564,380 - 3,569,801 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	3,038,775 - 3,044,196 (+)	NCBI		Celera
RGSC_v3.1	3	3,564,379 - 3,569,800 (+)	NCBI
Cytogenetic Map	3	p13	NCBI

ENTPD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	137,048,107 - 137,054,061 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	137,048,107 - 137,054,061 (-)	Ensembl			hg38	GRCh38
GRCh37	9	139,942,559 - 139,948,513 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	139,062,374 - 139,068,326 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	137,218,389 - 137,224,342	NCBI
Celera	9	110,455,967 - 110,461,919 (-)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,402,078 - 109,408,246 (-)	NCBI		HuRef
CHM1_1	9	140,091,345 - 140,097,263 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,283,232 - 149,291,667 (-)	NCBI		T2T-CHM13v2.0

Entpd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,285,886 - 25,291,335 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,285,886 - 25,291,333 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	25,395,874 - 25,401,323 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,395,874 - 25,401,321 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	25,251,394 - 25,256,843 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,217,967 - 25,223,327 (+)	NCBI		MGSCv36	mm8
Celera	2	25,123,341 - 25,128,787 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.22	NCBI

Entpd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	5,068,875 - 5,075,098 (-)	Ensembl
ChiLan1.0	NW_004955513	5,070,050 - 5,075,098 (-)	NCBI	ChiLan1.0	ChiLan1.0

ENTPD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,344,532 - 2,350,408 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,346,687 - 2,352,742 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	108,108,780 - 108,114,806 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	137,077,207 - 137,083,031 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	137,077,207 - 137,083,031 (-)	Ensembl			panPan2	panpan1.1

ENTPD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,589,408 - 48,594,852 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,570,891 - 48,594,452 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,803,203 - 47,808,473 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,467,623 - 49,472,893 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,467,627 - 49,472,890 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,243,870 - 48,249,128 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,542,603 - 48,547,873 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,589,911 - 48,595,183 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Entpd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,468,293 - 202,475,008 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	901,104 - 906,782 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	901,192 - 906,765 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENTPD2
(Sus scrofa - pig)

No map positions available.

ENTPD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,137,500 - 1,142,798 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,137,495 - 1,143,231 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666058	4,159,835 - 4,165,592 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Entpd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	859,637 - 866,804 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624760	859,598 - 865,194 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Entpd2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	11,781,232 - 11,786,870 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Entpd2
47 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	199
Count of miRNA genes:	123
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000017829, ENSRNOT00000018560
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10450811	Scl73	Serum cholesterol level QTL 73	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat
10450808	Scl72	Serum cholesterol level QTL 72	4.4	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
10450806	Scl71	Serum cholesterol level QTL 71	5.8	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	6125437	51125437	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	36721849	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	6556347	51556347	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	3e-08	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	15272348	60272348	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	155	91	90	59	91	59	6	355	191	11	134	81	92	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001429439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_172030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF129103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF276940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086558	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF394323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Y11835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017829 ⟹ ENSRNOP00000017829

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,213,663 - 8,220,040 (+)	Ensembl
Rnor_6.0 Ensembl	3	2,617,805 - 2,623,445 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000018927 ⟹ ENSRNOP00000018927

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,220,678 - 8,226,866 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094013 ⟹ ENSRNOP00000086303

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,213,663 - 8,226,862 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102806 ⟹ ENSRNOP00000091377

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,214,833 - 8,220,040 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112091 ⟹ ENSRNOP00000096205

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,220,678 - 8,226,866 (+)	Ensembl

RefSeq Acc Id:

NM_172030 ⟹ NP_742027

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,611,816 - 28,617,237 (+)	NCBI
mRatBN7.2	3	8,213,673 - 8,219,094 (+)	NCBI
Rnor_6.0	3	2,617,895 - 2,623,316 (+)	NCBI
Rnor_5.0	3	2,599,211 - 2,605,231 (+)	NCBI
RGSC_v3.4	3	3,564,380 - 3,569,801 (+)	RGD
Celera	3	3,038,775 - 3,044,196 (+)	RGD

Sequence:

show sequence

CATGGCTGGAAAGTTGGTGTCACTGGTGCCACCCCTGCTGCTGGCTGCCGCGGGCCTCGCCGGC
CTTCTGCTACTTTGCGTCCCTACCCAAGACGTCCGGGAGCCGCCCGCCCTCAAGTACGGCATTG
TCCTGGATGCGGGCTCTTCACACACATCCATGTTTGTCTACAAGTGGCCAGCGGACAAGGAGAA
TGACACAGGCATCGTGGGCCAGCACAGCTCTTGTGATGTTCAAGGTGGTGGCATCTCCAGCTAT
GCAAATGACCCCTCTAAGGCAGGCCAGAGTCTGGTCCGATGCCTTGAGCAGGCCCTTCGGGATG
TACCCAGAGACAGACATGCTAGCACACCACTCTACCTGGGAGCTACAGCAGGCATGCGCCTGCT
CAACCTGACCAGCCCAGAGGCCACAGCCAGGGTGCTTGAGGCAGTGACACAGACGCTCACACAG
TACCCCTTTGACTTCCGTGGTGCTCGCATCCTCTCGGGACAGGATGAAGGGGTGTTTGGCTGGG
TGACTGCCAACTACCTGCTGGAGAACTTCATCAAGTATGGCTGGGTGGGCCGGTGGATACGGCC
AAGGAAGGGAACACTGGGGGCCATGGACCTTGGGGGTGCTTCGACACAGATCACCTTTGAGACA
ACCAGTCCCTCTGAAGATCCAGGCAACGAGGTTCATTTGCGACTCTATGGCCAGCATTACCGCG
TTTACACACATAGCTTCCTCTGCTATGGCCGAGACCAGATTCTCCTGAGGCTTCTGGCCAGTGC
CCTCCAGATCCATCGCTTCCACCCCTGCTGGCCAAAGGGCTACTCTACCCAAGTGCTGCTCCAG
GAAGTCTACCAGTCGCCATGCACGATGGGTCAGCGTCCCCGGGCCTTCAATGGCAGTGCCATCG
TCAGCCTGTCAGGAACCAGCAATGCTACCCTGTGTCGTGACCTCGTCTCTCGGCTCTTCAACAT
CTCCTCCTGCCCCTTTTCCCAATGCTCCTTCAATGGGGTCTTCCAGCCTCCCGTGACTGGAAAC
TTCATAGCCTTTTCTGCTTTCTACTATACTGTGGACTTCCTGACAACAGTGATGGGGCTGCCTG
TGGGAACCCTGAAGCAGCTGGAGGAAGCCACAGAGATCACCTGCAACCAGACATGGACTGAACT
TCAGGCCCGAGTGCCAGGACAAAAGACCCGCCTGGCTGACTACTGTGCTGTAGCCATGTTCATA
CATCAGCTTCTGAGCCGTGGTTACCACTTCGATGAGCGCTCCTTCAGAGAAGTGGTCTTCCAAA
AGAAGGCTGCAGACACGGCTGTCGGCTGGGCGCTGGGCTACATGCTGAATTTCACTAACCTGAT
TCCTGCCGACCTCCCCGGACTACGCAAGGGCACCCACTTCAGCTCCTGGGTCGCTCTCCTGCTG
CTCTTCACAGTCCTGATCTTGGCGGCGCTGGTCCTGCTCCTGCGCCAGGTGCGTTCTGCCAAGT
CTCCAGGCGCCCTCTAGGGGTGAACTGGGAGCCTCTCCCAACTCCCTACTATCCCTCCCTTCCA
GAGGGCATCTCTGACCCTGAAGCAGCCTGGAAACCAACGTTCCCTATCTACATTCACAGAAAGC
CTACGTGGGCAGCCCTGAGTTCTCAATTAATCCTCCTCTCTCTTCCTAGGATGTCAGGTCTCAG
CCTGTGACTCAGGGTGAGGTCCATTCGGAGTGGGACTTTTGTTCTGATCTTCAGGGCCCTGGGA
ACTTTCTGTCTGGGCCTTTAGAAAGGCAGGCACCAGAGCCTACAGGCTGGGAGTCAGTTCCATG
CCTACTTGTAAAAACTTTTGTAATAAAAGATTTCTCCTAGAGCAGCGAAGTGTTCCTAGGGCGG
GGCACCCTTGGTCGCCTGTTCTGCCTTCCAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006233644 ⟹ XP_006233706

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,611,722 - 28,617,237 (+)	NCBI
mRatBN7.2	3	8,213,576 - 8,219,041 (+)	NCBI
Rnor_6.0	3	2,617,796 - 2,623,818 (+)	NCBI
Rnor_5.0	3	2,599,211 - 2,605,231 (+)	NCBI

Sequence:

show sequence

ACTCCGGCCCCGCCCCCGCGTCTAACTCTGGGGCCCCGGCCACCCGGGCCTCCCCGCTGCCTGC
TGTCCGGGGTCCCGCTGTGTTCTCCCACGCGTTCTCATGGCTGGAAAGTTGGTGTCACTGGTGC
CACCCCTGCTGCTGGCTGCCGCGGGCCTCGCCGGCCTTCTGCTACTTTGCGTCCCTACCCAAGA
CGTCCGGGAGCCGCCCGCCCTCAAGTACGGCATTGTCCTGGATGCGGGCTCTTCACACACATCC
ATGTTTGTCTACAAGTGGCCAGCGGACAAGGAGAATGACACAGGCATCGTGGGCCAGCACAGCT
CTTGTGATGTTCAAGGTGGTGGCATCTCCAGCTATGCAAATGACCCCTCTAAGGCAGGCCAGAG
TCTGGTCCGATGCCTTGAGCAGGCCCTTCGGGATGTACCCAGAGACAGACATGCTAGCACACCA
CTCTACCTGGGAGCTACAGCAGGCATGCGCCTGCTCAACCTGACCAGCCCAGAGGCCACAGCCA
GGGTGCTTGAGGCAGTGACACAGACGCTCACACAGTACCCCTTTGACTTCCGTGGTGCTCGCAT
CCTCTCGGGACAGGATGAAGGGGTGTTTGGCTGGGTGACTGCCAACTACCTGCTGGAGAACTTC
ATCAAGTATGGCTGGGTGGGCCGGTGGATACGGCCAAGGAAGGGAACACTGGGGGCCATGGACC
TTGGGGGTGCTTCGACACAGATCACCTTTGAGACAACCAGTCCCTCTGAAGATCCAGGCAACGA
GGTTCATTTGCGACTCTATGGCCAGCATTACCGCGTTTACACACATAGCTTCCTCTGCTATGGC
CGAGACCAGATTCTCCTGAGGCTTCTGGCCAGTGCCCTCCAGATCCATCGCTTCCACCCCTGCT
GGCCAAAGGGCTACTCTACCCAAGTGCTGCTCCAGGAAGTCTACCAGTCGCCATGCACGATGGG
TCAGCGTCCCCGGGCCTTCAATGGCAGTGCCATCGTCAGCCTGTCAGGAACCAGCAATGCTACC
CTGTGTCGTGACCTCGTCTCTCGGCTCTTCAACATCTCCTCCTGCCCCTTTTCCCAATGCTCCT
TCAATGGGGTCTTCCAGCCTCCCGTGGCTGGAAACTTCATAGCCTTTTCTGCTTTCTACTATAC
TGTGGACTTCCTGACAACAGTGATGGGGCTGCCTGTGGGAACCCTGAAGCAGCTGGAGGAAGCC
ACAGAGATCACCTGCAACCAGACATGGACTGAACTTCAGGCCCGAGTGCCAGGACAAAAGACCC
GCCTGGCTGACTACTGTGCTGTAGCCATGTTCATACATCAGCTTCTGAGCCGTGGTTACCACTT
CGATGAGCGCTCCTTCAGAGAAGTGGTCTTCCAAAAGAAGGCTGCAGACACGGCTGTCGGCTGG
GCGCTGGGCTACATGCTGAATTTGACTAACCTGATTCCTGCCGACCTCCCCGGACTACGCAAGG
GCACCCACTTCAGCTCCTGGGTCGCTCTCCTGCTGCTCTTCACAGTCCTGATCTTGGCGGCGCT
GGTCCTGCTCCTGCGCCAGGATGTCAGGTCTCAGCCTGTGACTCAGGGTGAGGTCCATTCGGAG
TGGGACTTTTGTTCTGATCTTCAGGGCCCTGGGAACTTTCTGTCTGGGCCTTTAGAAAGGCAGG
CACCAGAGCCTACAGGCTGGGAGTCAGTTCCATGCCTACTTGTAAAAACTTTTGTAATAAAAGA
TTTTTCCTAGAGCAGCGAAGTGTTCCTAGGGCGGGGCACCCTTGGTCGCCTGTTCTGCCTTCCA
GCTGTGTTGTTGGTTATTTGGGTGAAACCTGGTTCCAAGATACTGACTTTTCTTGCTTCCTCCC
TTTTTGTACCAGGCCTGAGGCAATGGAGGCACTCCTACCTACTCTGCTCTGGGGTTGTCCCTGA
GTCTGAGTTTTCTCTGACAGACAGAACCCTAACAAACCGCAGGTCCCCCTCGAATGACATCCAC
AGGAATTGAGGCTGCACTCCCAAGCTGTTTTTTCCAACTGATACTTGAGATATTAGTAGGCCTG
AAGGTCAGAGGCACCTGCATCCGCAGCCTAAGTCTCTGTGTTCTCTAGGTGGGAAAGTGTGACC
CGAGTATGGGACTCTCTTGCCTCTTTCATGGGAAATTAGCTCAGACTCTATTTCTGTGCAGTCA
ATGCCTTAAGGGCTGGGTTGGGATGGTAGCTCGAGTGCATGCGTGCGCGACACACACACACACA
CACACACACACACACACACACACAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA

hide sequence

RefSeq Acc Id:

XM_017592023 ⟹ XP_017447512

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,611,723 - 28,617,237 (+)	NCBI
mRatBN7.2	3	8,213,575 - 8,219,041 (+)	NCBI
Rnor_6.0	3	2,617,795 - 2,623,818 (+)	NCBI

Sequence:

show sequence

TACTCCGGCCCCGCCCCCGCGTCTAACTCTGGGGCCCCGGCCACCCGGGCCTCCCCGCTGCCTG
CTGTCCGGGGTCCCGCTGTGTTCTCCCACGCGTTCTCATGGCTGGAAAGTTGGTGTCACTGGTG
CCACCCCTGCTGCTGGCTGCCGCGGGCCTCGCCGGCCTTCTGCTACTTTGCGTCCCTACCCAAG
ACGTCCGGGAGCCGCCCGCCCTCAAGTACGGCATTGTCCTGGATGCGGGCTCTTCACACACATC
CATGTTTGTCTACAAGTGGCCAGCGGACAAGGAGAATGACACAGGCATCGTGGGCCAGCACAGC
TCTTGTGATGTTCAAGGTGGTGGCATCTCCAGCTATGCAAATGACCCCTCTAAGGCAGGCCAGA
GTCTGGTCCGATGCCTTGAGCAGGCCCTTCGGGATGTACCCAGAGACAGACATGCTAGCACACC
ACTCTACCTGGGAGCTACAGCAGGCATGCGCCTGCTCAACCTGACCAGCCCAGAGGCCACAGCC
AGGGTGCTTGAGGCAGTGACACAGACGCTCACACAGTACCCCTTTGACTTCCGTGGTGCTCGCA
TCCTCTCGGGACAGGATGAAGGGGTGTTTGGCTGGGTGACTGCCAACTACCTGCTGGAGAACTT
CATCAAGTATGGCTGGGTGGGCCGGTGGATACGGCCAAGGAAGGGAACACTGGGGGCCATGGAC
CTTGGGGGTGCTTCGACACAGATCACCTTTGAGACAACCAGTCCCTCTGAAGATCCAGGCAACG
AGGTTCATTTGCGACTCTATGGCCAGCATTACCGCGTTTACACACATAGCTTCCTCTGCTATGG
CCGAGACCAGATTCTCCTGAGGCTTCTGGCCAGTGCCCTCCAGATCCATCGCTTCCACCCCTGC
TGGCCAAAGGGCTACTCTACCCAAGTGCTGCTCCAGGAAGTCTACCAGTCGCCATGCACGATGG
GTCAGCGTCCCCGGGCCTTCAATGGCAGTGCCATCGTCAGCCTGTCAGGAACCAGCAATGCTAC
CCTGTGTCGTGACCTCGTCTCTCGGCTCTTCAACATCTCCTCCTGCCCCTTTTCCCAATGCTCC
TTCAATGGGGTCTTCCAGCCTCCCGTGGCTGGAAACTTCATAGCCTTTTCTGCTTTCTACTATA
CTGTGGACTTCCTGACAACAGTGATGGGGCTGCCTGTGGGAACCCTGAAGCAGCTGGAGGAAGC
CACAGAGATCACCTGCAACCAGACATGGACTGAATGGCCATCTTTGCTGTCCTCTCCATCCAGC
TGTTGGAAGGGGAGAACACAAGGTTCCAGCAGTCACGAGCTTCAGGCCCGAGTGCCAGGACAAA
AGACCCGCCTGGCTGACTACTGTGCTGTAGCCATGTTCATACATCAGCTTCTGAGCCGTGGTTA
CCACTTCGATGAGCGCTCCTTCAGAGAAGTGGTCTTCCAAAAGAAGGCTGCAGACACGGCTGTC
GGCTGGGCGCTGGGCTACATGCTGAATTTGACTAACCTGATTCCTGCCGACCTCCCCGGACTAC
GCAAGGGCACCCACTTCAGCTCCTGGGTCGCTCTCCTGCTGCTCTTCACAGTCCTGATCTTGGC
GGCGCTGGTCCTGCTCCTGCGCCAGGATGTCAGGTCTCAGCCTGTGACTCAGGGTGAGGTCCAT
TCGGAGTGGGACTTTTGTTCTGATCTTCAGGGCCCTGGGAACTTTCTGTCTGGGCCTTTAGAAA
GGCAGGCACCAGAGCCTACAGGCTGGGAGTCAGTTCCATGCCTACTTGTAAAAACTTTTGTAAT
AAAAGATTTTTCCTAGAGCAGCGAAGTGTTCCTAGGGCGGGGCACCCTTGGTCGCCTGTTCTGC
CTTCCAGCTGTGTTGTTGGTTATTTGGGTGAAACCTGGTTCCAAGATACTGACTTTTCTTGCTT
CCTCCCTTTTTGTACCAGGCCTGAGGCAATGGAGGCACTCCTACCTACTCTGCTCTGGGGTTGT
CCCTGAGTCTGAGTTTTCTCTGACAGACAGAACCCTAACAAACCGCAGGTCCCCCTCGAATGAC
ATCCACAGGAATTGAGGCTGCACTCCCAAGCTGTTTTTTCCAACTGATACTTGAGATATTAGTA
GGCCTGAAGGTCAGAGGCACCTGCATCCGCAGCCTAAGTCTCTGTGTTCTCTAGGTGGGAAAGT
GTGACCCGAGTATGGGACTCTCTTGCCTCTTTCATGGGAAATTAGCTCAGACTCTATTTCTGTG
CAGTCAATGCCTTAAGGGCTGGGTTGGGATGGTAGCTCGAGTGCATGCGTGCGCGACACACACA
CACACACACACACACACACACACACACACAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA

hide sequence

RefSeq Acc Id:

XM_017592024 ⟹ XP_017447513

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,611,725 - 28,617,184 (+)	NCBI
mRatBN7.2	3	8,213,576 - 8,219,041 (+)	NCBI
Rnor_6.0	3	2,617,796 - 2,623,818 (+)	NCBI

Sequence:

show sequence

ACTCCGGCCCCGCCCCCGCGTCTAACTCTGGGGCCCCGGCCACCCGGGCCTCCCCGCTGCCTGC
TGTCCGGGGTCCCGCTGTGTTCTCCCACGCGTTCTCATGGCTGGAAAGTTGGTGTCACTGGTGC
CACCCCTGCTGCTGGCTGCCGCGGGCCTCGCCGGCCTTCTGCTACTTTGCGTCCCTACCCAAGA
CGTCCGGGAGCCGCCCGCCCTCAAGTACGGCATTGTCCTGGATGCGGGCTCTTCACACACATCC
ATGTTTGTCTACAAGTGGCCAGCGGACAAGGAGAATGACACAGGCATCGTGGGCCAGCACAGCT
CTTGTGATGTTCAAGGTGGTGGCATCTCCAGCTATGCAAATGACCCCTCTAAGGCAGGCCAGAG
TCTGGTCCGATGCCTTGAGCAGGCCCTTCGGGATGTACCCAGAGACAGACATGCTAGCACACCA
CTCTACCTGGGAGCTACAGCAGGCATGCGCCTGCTCAACCTGACCAGCCCAGAGGCCACAGCCA
GGGTGCTTGAGGCAGTGACACAGACGCTCACACAGTACCCCTTTGACTTCCGTGGTGCTCGCAT
CCTCTCGGGACAGGATGAAGGGGTGTTTGGCTGGGTGACTGCCAACTACCTGCTGGAGAACTTC
ATCAAGTATGGCTGGGTGGGCCGGTGGATACGGCCAAGGAAGGGAACACTGGGGGCCATGGACC
TTGGGGGTGCTTCGACACAGATCACCTTTGAGACAACCAGTCCCTCTGAAGATCCAGGCAACGA
GGTTCATTTGCGACTCTATGGCCAGCATTACCGCGTTTACACACATAGCTTCCTCTGCTATGGC
CGAGACCAGATTCTCCTGAGGCTTCTGGCCAGTGCCCTCCAGATCCATCGCTTCCACCCCTGCT
GGCCAAAGGGCTACTCTACCCAAGTGCTGCTCCAGGAAGTCTACCAGTCGCCATGCACGATGGG
TCAGCGTCCCCGGGCCTTCAATGGCAGTGCCATCGTCAGCCTGTCAGGAACCAGCAATGCTACC
CTGTGTCGTGACCTCGTCTCTCGGCTCTTCAACATCTCCTCCTGCCCCTTTTCCCAATGCTCCT
TCAATGGGGTCTTCCAGCCTCCCGTGGCTGGAAACTTCATAGCCTTTTCTGCTTTCTACTATAC
TGTGGACTTCCTGACAACAGTGATGGGGCTGCCTGTGGGAACCCTGAAGCAGCTGGAGGAAGCC
ACAGAGATCACCTGCAACCAGACATGGACTGAATGGCCATCTTTGCTGTCCTCTCCATCCAGCT
GTTGGAAGGGGAGAACACAAGGTTCCAGCAGTCACGAGCTTCAGGCCCGAGTGCCAGGACAAAA
GACCCGCCTGGCTGACTACTGTGCTGTAGCCATGTTCATACATCAGCTTCTGAGCCGTGGTTAC
CACTTCGATGAGCGCTCCTTCAGAGAAGTGGTCTTCCAAAAGAAGGCTGCAGACACGGCTGTCG
GCTGGGCGCTGGGCTACATGCTGAATTTGACTAACCTGATTCCTGCCGACCTCCCCGGACTACG
CAAGGGCACCCACTTCAGCTCCTGGGTCGCTCTCCTGCTGCTCTTCACAGTCCTGATCTTGGCG
GCGCTGGTCCTGCTCCTGCGCCAGGTGCGTTCTGCCAAGTCTCCAGGCGCCCTCTAGGGGTGAA
CTGGGAGCCTCTCCCAACTCCCTACTATCCCTCCCTTCCAGAGGGCATCTCTGACCCTGAAGCA
GCCTGGAAACCAACGTTCCCTATCTACATTCACAGAAAGCCTACGTGGGCAGCCCTGAGTTCTC
AATTAATCCTCCTCTCTCTTCCTAGGATGTCAGGTCTCAGCCTGTGACTCAGGGTGAGGTCCAT
TCGGAGTGGGACTTTTGTTCTGATCTTCAGGGCCCTGGGAACTTTCTGTCTGGGCCTTTAGAAA
GGCAGGCACCAGAGCCTACAGGCTGGGAGTCAGTTCCATGCCTACTTGTAAAAACTTTTGTAAT
AAAAGATTTTTCCTAGAGCAGCGAAGTGTTCCTAGGGCGGGGCACCCTTGGTCGCCTGTTCTGC
CTTCCAGCTGTGTTGTTGGTTATTTGGGTGAAACCTGGTTCCAAGATACTGACTTTTCTTGCTT
CCTCCCTTTTTGTACCAGGCCTGAGGCAATGGAGGCACTCCTACCTACTCTGCTCTGGGGTTGT
CCCTGAGTCTGAGTTTTCTCTGACAGACAGAACCCTAACAAACCGCAGGTCCCCCTCGAATGAC
ATCCACAGGAATTGAGGCTGCACTCCCAAGCTGTTTTTTCCAACTGATACTTGAGATATTAGTA
GGCCTGAAGGTCAGAGGCACCTGCATCCGCAGCCTAAGTCTCTGTGTTCTCTAGGTGGGAAAGT
GTGACCCGAGTATGGGACTCTCTTGCCTCTTTCATGGGAAATTAGCTCAGACTCTATTTCTGTG
CAGTCAATGCCTTAAGGGCTGGGTTGGGATGGTAGCTCGAGTGCATGCGTGCGCGACACACACA
CACACACACACACACACACACACACACACAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA

hide sequence

RefSeq Acc Id:

XM_039105790 ⟹ XP_038961718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,611,724 - 28,617,184 (+)	NCBI
mRatBN7.2	3	8,213,576 - 8,219,041 (+)	NCBI

RefSeq Acc Id:

XM_063284518 ⟹ XP_063140588

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,611,726 - 28,617,184 (+)	NCBI

RefSeq Acc Id:

XM_063284519 ⟹ XP_063140589

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,613,238 - 28,617,237 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001416368	(Get FASTA)	NCBI Sequence Viewer
	NP_742027	(Get FASTA)	NCBI Sequence Viewer
	XP_006233706	(Get FASTA)	NCBI Sequence Viewer
	XP_017447512	(Get FASTA)	NCBI Sequence Viewer
	XP_017447513	(Get FASTA)	NCBI Sequence Viewer
	XP_038961718	(Get FASTA)	NCBI Sequence Viewer
	XP_063140588	(Get FASTA)	NCBI Sequence Viewer
	XP_063140589	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD42303	(Get FASTA)	NCBI Sequence Viewer
	AAF87740	(Get FASTA)	NCBI Sequence Viewer
	AAH86558	(Get FASTA)	NCBI Sequence Viewer
	ABN58479	(Get FASTA)	NCBI Sequence Viewer
	CAA72533	(Get FASTA)	NCBI Sequence Viewer
	EDL93594	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017829
	ENSRNOP00000086303
	ENSRNOP00000101840
GenBank Protein	O35795	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_742027 ⟸ NM_172030
- Peptide Label:	precursor
- UniProtKB:	Q9WVE7 (UniProtKB/Swiss-Prot), Q9JHY5 (UniProtKB/Swiss-Prot), O35795 (UniProtKB/Swiss-Prot), Q5RJP4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGKLVSLVPPLLLAAAGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKEN DTGIVGQHSSCDVQGGGISSYANDPSKAGQSLVRCLEQALRDVPRDRHASTPLYLGATAGMRLL NLTSPEATARVLEAVTQTLTQYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRP RKGTLGAMDLGGASTQITFETTSPSEDPGNEVHLRLYGQHYRVYTHSFLCYGRDQILLRLLASA LQIHRFHPCWPKGYSTQVLLQEVYQSPCTMGQRPRAFNGSAIVSLSGTSNATLCRDLVSRLFNI SSCPFSQCSFNGVFQPPVTGNFIAFSAFYYTVDFLTTVMGLPVGTLKQLEEATEITCNQTWTEL QARVPGQKTRLADYCAVAMFIHQLLSRGYHFDERSFREVVFQKKAADTAVGWALGYMLNFTNLI PADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQVRSAKSPGAL hide sequence

RefSeq Acc Id:	XP_006233706 ⟸ XM_006233644
- Peptide Label:	isoform X2
- UniProtKB:	F1M7N2 (UniProtKB/TrEMBL), A0A8I6AFG9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGKLVSLVPPLLLAAAGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKEN DTGIVGQHSSCDVQGGGISSYANDPSKAGQSLVRCLEQALRDVPRDRHASTPLYLGATAGMRLL NLTSPEATARVLEAVTQTLTQYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRP RKGTLGAMDLGGASTQITFETTSPSEDPGNEVHLRLYGQHYRVYTHSFLCYGRDQILLRLLASA LQIHRFHPCWPKGYSTQVLLQEVYQSPCTMGQRPRAFNGSAIVSLSGTSNATLCRDLVSRLFNI SSCPFSQCSFNGVFQPPVAGNFIAFSAFYYTVDFLTTVMGLPVGTLKQLEEATEITCNQTWTEL QARVPGQKTRLADYCAVAMFIHQLLSRGYHFDERSFREVVFQKKAADTAVGWALGYMLNLTNLI PADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQDVRSQPVTQGEVHSEWDFCSDLQGPGN FLSGPLERQAPEPTGWESVPCLLVKTFVIKDFS hide sequence

RefSeq Acc Id:	XP_017447512 ⟸ XM_017592023
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AFG9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGKLVSLVPPLLLAAAGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKEN DTGIVGQHSSCDVQGGGISSYANDPSKAGQSLVRCLEQALRDVPRDRHASTPLYLGATAGMRLL NLTSPEATARVLEAVTQTLTQYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRP RKGTLGAMDLGGASTQITFETTSPSEDPGNEVHLRLYGQHYRVYTHSFLCYGRDQILLRLLASA LQIHRFHPCWPKGYSTQVLLQEVYQSPCTMGQRPRAFNGSAIVSLSGTSNATLCRDLVSRLFNI SSCPFSQCSFNGVFQPPVAGNFIAFSAFYYTVDFLTTVMGLPVGTLKQLEEATEITCNQTWTEW PSLLSSPSSCWKGRTQGSSSHELQARVPGQKTRLADYCAVAMFIHQLLSRGYHFDERSFREVVF QKKAADTAVGWALGYMLNLTNLIPADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQDVRS QPVTQGEVHSEWDFCSDLQGPGNFLSGPLERQAPEPTGWESVPCLLVKTFVIKDFS hide sequence

RefSeq Acc Id:

XP_017447513 ⟸ XM_017592024

- Peptide Label:

isoform X4

- Sequence:

show sequence

MAGKLVSLVPPLLLAAAGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKEN
DTGIVGQHSSCDVQGGGISSYANDPSKAGQSLVRCLEQALRDVPRDRHASTPLYLGATAGMRLL
NLTSPEATARVLEAVTQTLTQYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRP
RKGTLGAMDLGGASTQITFETTSPSEDPGNEVHLRLYGQHYRVYTHSFLCYGRDQILLRLLASA
LQIHRFHPCWPKGYSTQVLLQEVYQSPCTMGQRPRAFNGSAIVSLSGTSNATLCRDLVSRLFNI
SSCPFSQCSFNGVFQPPVAGNFIAFSAFYYTVDFLTTVMGLPVGTLKQLEEATEITCNQTWTEW
PSLLSSPSSCWKGRTQGSSSHELQARVPGQKTRLADYCAVAMFIHQLLSRGYHFDERSFREVVF
QKKAADTAVGWALGYMLNLTNLIPADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQVRSA
KSPGAL

hide sequence

Ensembl Acc Id:

ENSRNOP00000017829 ⟸ ENSRNOT00000017829

RefSeq Acc Id:	XP_038961718 ⟸ XM_039105790
- Peptide Label:	isoform X3
- UniProtKB:	Q9WVE7 (UniProtKB/Swiss-Prot), Q9JHY5 (UniProtKB/Swiss-Prot), O35795 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000091377 ⟸ ENSRNOT00000102806

Ensembl Acc Id:

ENSRNOP00000096205 ⟸ ENSRNOT00000112091

Ensembl Acc Id:

ENSRNOP00000086303 ⟸ ENSRNOT00000094013

Ensembl Acc Id:

ENSRNOP00000018927 ⟸ ENSRNOT00000018927

RefSeq Acc Id:	XP_063140588 ⟸ XM_063284518
- Peptide Label:	isoform X5
- UniProtKB:	Q9WVE7 (UniProtKB/Swiss-Prot), Q9JHY5 (UniProtKB/Swiss-Prot), O35795 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063140589 ⟸ XM_063284519
- Peptide Label:	isoform X6

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35795-F1-model_v2	AlphaFold	O35795	1-495	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691875

Promoter ID:

EPDNEW_R2400

Type:

initiation region

Name:

Entpd2_1

Description:

ectonucleoside triphosphate diphosphohydrolase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	2,617,851 - 2,617,911	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69266	AgrOrtholog
BioCyc Gene	G2FUF-50457	BioCyc
Ensembl Genes	ENSRNOG00000013102	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000017829	ENTREZGENE
	ENSRNOT00000094013	ENTREZGENE
	ENSRNOT00000167123	ENTREZGENE
Gene3D-CATH	3.30.420.40	UniProtKB/Swiss-Prot
	Exopolyphosphatase. Domain 2	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7302083	IMAGE-MGC_LOAD
InterPro	GDA1_CD39_NTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:64467	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105301	IMAGE-MGC_LOAD
NCBI Gene	64467	ENTREZGENE
PANTHER	ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2	UniProtKB/Swiss-Prot
	PTHR11782	UniProtKB/Swiss-Prot
Pfam	GDA1_CD39	UniProtKB/Swiss-Prot
PhenoGen	Entpd2	PhenoGen
PROSITE	GDA1_CD39_NTPASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013102	RatGTEx
TIGR	TC230447
UniProt	A0A8I6A5S8_RAT	UniProtKB/TrEMBL
	A0A8I6AFG9	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LNF4_RAT	UniProtKB/TrEMBL
	A3FKJ7_RAT	UniProtKB/TrEMBL
	ENTP2_RAT	UniProtKB/Swiss-Prot
	F1M7N2	ENTREZGENE, UniProtKB/TrEMBL
	O35795	ENTREZGENE
	Q5RJP4	ENTREZGENE, UniProtKB/TrEMBL
	Q9JHY5	ENTREZGENE
	Q9WVE7	ENTREZGENE
UniProt Secondary	Q9JHY5	UniProtKB/Swiss-Prot
	Q9WVE7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Entpd2	ectonucleoside triphosphate diphosphohydrolase 2			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in portal fibroblasts near hepatic bile duct epithelial basolateral membranes	728486

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)