Impa1 (inositol monophosphatase 1) - Rat Genome Database

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Gene: Impa1 (inositol monophosphatase 1) Rattus norvegicus
Analyze
Symbol: Impa1
Name: inositol monophosphatase 1
RGD ID: 69254
Description: Enables inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in phosphatidylinositol biosynthetic process. Located in axon and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59 and intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: D-galactose 1-phosphate phosphatase; IMP 1; Impa1-L; IMPase 1; Inositol (myo)-1(or 4)-monophosphatase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,370,200 - 93,391,474 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl293,370,299 - 93,391,468 (+)EnsemblGRCr8
mRatBN7.2291,462,781 - 91,484,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl291,462,799 - 91,484,313 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx297,953,286 - 97,974,472 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,074,274 - 96,095,454 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,131,126 - 91,152,304 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0293,675,203 - 93,696,355 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl293,675,203 - 93,696,232 (+)Ensemblrn6Rnor6.0
Rnor_5.02113,430,723 - 113,453,209 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4293,415,958 - 93,438,247 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera287,065,842 - 87,086,646 (+)NCBICelera
RGSC_v3.1293,360,919 - 93,383,209 (+)NCBI
Cytogenetic Map2q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
clofibrate  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
inositol  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
PCB138  (EXP)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (IEA,ISO)
neuronal cell body  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons. Andreassi C, etal., Nat Neurosci. 2010 Mar;13(3):291-301. doi: 10.1038/nn.2486. Epub 2010 Jan 31.
3. A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability. Figueiredo T, etal., Mol Psychiatry. 2016 Aug;21(8):1125-9. doi: 10.1038/mp.2015.150. Epub 2015 Sep 29.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Molecular characterization of coding and untranslated regions of rat cortex lithium-sensitive myo-inositol monophosphatase cDNA. Parthasarathy L, etal., Gene 1997 May 20;191(1):81-7.
10. Regional changes in rat brain inositol monophosphatase 1 (IMPase 1) activity with chronic lithium treatment. Parthasarathy LK, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):55-60.
11. Brain inositol monophosphatase identified as a galactose 1-phosphatase. Parthasarathy R, etal., Brain Res. 1997 Dec 5;778(1):99-106.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Inositol monophosphatase 1 as a novel interacting partner of RAGE in pulmonary hypertension. Rafikov R, etal., Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L428-L444. doi: 10.1152/ajplung.00393.2018. Epub 2019 Jan 3.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Intracerebroventricular antisense to inositol monophosphatase-1 reduces enzyme activity but does not affect Li-sensitive behavior. Shamir A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jan;26(1):103-6.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1377913   PMID:16189514   PMID:17068342   PMID:19447967   PMID:21516116   PMID:22082260   PMID:23027737   PMID:23376485   PMID:25416956   PMID:31897490   PMID:33626357  


Genomics

Comparative Map Data
Impa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,370,200 - 93,391,474 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl293,370,299 - 93,391,468 (+)EnsemblGRCr8
mRatBN7.2291,462,781 - 91,484,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl291,462,799 - 91,484,313 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx297,953,286 - 97,974,472 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,074,274 - 96,095,454 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,131,126 - 91,152,304 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0293,675,203 - 93,696,355 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl293,675,203 - 93,696,232 (+)Ensemblrn6Rnor6.0
Rnor_5.02113,430,723 - 113,453,209 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4293,415,958 - 93,438,247 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera287,065,842 - 87,086,646 (+)NCBICelera
RGSC_v3.1293,360,919 - 93,383,209 (+)NCBI
Cytogenetic Map2q23NCBI
IMPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38881,656,914 - 81,686,325 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl881,656,914 - 81,686,848 (-)Ensemblhg38GRCh38
GRCh37882,569,149 - 82,598,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36882,732,751 - 82,761,115 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34882,732,750 - 82,761,115NCBI
Celera878,574,122 - 78,603,090 (-)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef878,058,964 - 78,088,484 (-)NCBIHuRef
CHM1_1882,620,772 - 82,650,210 (-)NCBICHM1_1
T2T-CHM13v2.0882,088,505 - 82,118,041 (-)NCBIT2T-CHM13v2.0
Impa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39310,377,016 - 10,396,499 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl310,377,016 - 10,396,499 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38310,311,956 - 10,331,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl310,311,956 - 10,331,439 (-)Ensemblmm10GRCm38
MGSCv37310,313,540 - 10,331,439 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36310,296,072 - 10,313,904 (-)NCBIMGSCv36mm8
Celera310,347,693 - 10,365,549 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.61NCBI
Impa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541712,504 - 40,902 (-)Ensembl
ChiLan1.0NW_00495541714,114 - 40,128 (-)NCBIChiLan1.0ChiLan1.0
IMPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2797,392,378 - 97,423,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1873,019,820 - 73,053,140 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0878,177,200 - 78,209,901 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1879,800,265 - 79,829,713 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl879,800,257 - 79,829,935 (-)EnsemblpanPan2panpan1.1
IMPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12928,772,044 - 28,799,170 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2928,771,853 - 28,799,077 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2929,050,877 - 29,078,089 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02928,903,802 - 28,931,360 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2928,902,020 - 28,931,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12928,973,370 - 29,000,580 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02928,987,403 - 29,014,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02929,344,086 - 29,371,303 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Impa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530350,407,891 - 50,427,696 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366562,598,413 - 2,618,396 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366562,598,454 - 2,616,643 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IMPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl454,935,860 - 54,984,238 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1454,935,838 - 54,968,672 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103237047
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1877,073,577 - 77,100,418 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl877,074,805 - 77,100,862 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603964,094,905 - 64,121,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Impa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247449,817,004 - 9,839,760 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247449,817,723 - 9,839,186 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Impa1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13144,359,473 - 144,381,208 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Impa1
345 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:656
Count of miRNA genes:283
Interacting mature miRNAs:360
Transcripts:ENSRNOT00000014274
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH128298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2291,483,624 - 91,483,818 (+)MAPPERmRatBN7.2
Rnor_6.0293,695,923 - 93,696,116NCBIRnor6.0
Rnor_5.02113,451,106 - 113,451,299UniSTSRnor5.0
RGSC_v3.4293,437,940 - 93,438,133UniSTSRGSC3.4
Celera287,086,339 - 87,086,532UniSTS
RH 3.4 Map2572.0UniSTS
Cytogenetic Map2q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014274   ⟹   ENSRNOP00000014274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl293,370,299 - 93,391,468 (+)Ensembl
mRatBN7.2 Ensembl291,462,799 - 91,484,313 (+)Ensembl
Rnor_6.0 Ensembl293,675,203 - 93,696,232 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132949   ⟹   ENSRNOP00000110780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl293,372,535 - 93,391,468 (+)Ensembl
RefSeq Acc Id: NM_032057   ⟹   NP_114446
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8293,370,200 - 93,391,349 (+)NCBI
mRatBN7.2291,462,781 - 91,483,932 (+)NCBI
Rnor_6.0293,675,203 - 93,696,230 (+)NCBI
Rnor_5.02113,430,723 - 113,453,209 (+)NCBI
RGSC_v3.4293,415,958 - 93,438,247 (+)RGD
Celera287,065,842 - 87,086,646 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232151   ⟹   XP_006232213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8293,370,268 - 93,391,474 (+)NCBI
mRatBN7.2291,462,908 - 91,484,057 (+)NCBI
Rnor_6.0293,675,291 - 93,696,355 (+)NCBI
Rnor_5.02113,430,723 - 113,453,209 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_114446 (Get FASTA)   NCBI Sequence Viewer  
  XP_006232213 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB19106 (Get FASTA)   NCBI Sequence Viewer  
  AAB63338 (Get FASTA)   NCBI Sequence Viewer  
  EDM00988 (Get FASTA)   NCBI Sequence Viewer  
  EDM00989 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014274
  ENSRNOP00000110780
GenBank Protein P97697 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114446   ⟸   NM_032057
- UniProtKB: P97697 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232213   ⟸   XM_006232151
- Peptide Label: isoform X1
- UniProtKB: P97697 (UniProtKB/Swiss-Prot),   F1M978 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014274   ⟸   ENSRNOT00000014274
Ensembl Acc Id: ENSRNOP00000110780   ⟸   ENSRNOT00000132949

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97697-F1-model_v2 AlphaFold P97697 1-277 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691234
Promoter ID:EPDNEW_R1758
Type:initiation region
Name:Impa1_1
Description:inositol monophosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0293,675,195 - 93,675,255EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69254 AgrOrtholog
BioCyc Gene G2FUF-53757 BioCyc
BioCyc Pathway PWY-2301 [myo-inositol biosynthesis] BioCyc
BioCyc Pathway Image PWY-2301 BioCyc
Ensembl Genes ENSRNOG00000010482 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014274 ENTREZGENE
  ENSRNOT00000132949 ENTREZGENE
Gene3D-CATH 3.40.190.80 UniProtKB/Swiss-Prot
  Fructose-1,6-Bisphosphatase, subunit A, domain 1 UniProtKB/Swiss-Prot
InterPro IMPase UniProtKB/Swiss-Prot
  Inositol_monoP_metal-BS UniProtKB/Swiss-Prot
  Inositol_monoPase_Li-sen UniProtKB/Swiss-Prot
  Inositol_monophosphatase-like UniProtKB/Swiss-Prot
  Inositol_monophosphatase_CS UniProtKB/Swiss-Prot
KEGG Report rno:83523 UniProtKB/Swiss-Prot
NCBI Gene 83523 ENTREZGENE
PANTHER INOSITOL MONOPHOSPHATASE UniProtKB/Swiss-Prot
  INOSITOL MONOPHOSPHATASE 1 UniProtKB/Swiss-Prot
Pfam Inositol_P UniProtKB/Swiss-Prot
PhenoGen Impa1 PhenoGen
PRINTS IMPHPHTASES UniProtKB/Swiss-Prot
  LIIMPHPHTASE UniProtKB/Swiss-Prot
PROSITE IMP_1 UniProtKB/Swiss-Prot
  IMP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010482 RatGTEx
Superfamily-SCOP Carbohydrate phosphatase UniProtKB/Swiss-Prot
TIGR TC220636
UniProt A0ABK0LIU5_RAT UniProtKB/TrEMBL
  A6IH41_RAT UniProtKB/TrEMBL
  F1M978 ENTREZGENE, UniProtKB/TrEMBL
  IMPA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Impa1  inositol monophosphatase 1  Impa1  Inositol (myo)-1(or 4)-monophosphatase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Impa1  Inositol (myo)-1(or 4)-monophosphatase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs sensitive to lithium 68803
gene_process has a role in inositol-based cell signaling and cell volume control 68803