Ctsj (cathepsin J) - Rat Genome Database

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Gene: Ctsj (cathepsin J) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ctsj
Name: cathepsin J
RGD ID: 69241
Description: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L); INTERACTS WITH ammonium chloride; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cathepsin L-related protein; cathepsin P; catlrp-p; Ctsp
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,744,340 - 3,748,988 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,744,340 - 3,748,988 (+)EnsemblGRCr8
mRatBN7.2173,738,729 - 3,743,381 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,738,729 - 3,743,377 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx173,758,268 - 3,762,918 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0175,299,906 - 5,304,556 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,754,709 - 3,759,361 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,105,890 - 4,110,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,105,890 - 4,110,538 (+)Ensemblrn6Rnor6.0
Rnor_5.0176,333,162 - 6,337,810 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera173,867,624 - 3,872,272 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of a rat placental cDNA encoding a novel cathepsin L-related protein. Conliffe PR, etal., Mol Reprod Dev 1995 Feb;40(2):146-56.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Expression of cathepsin P mRNA, protein and activity in the rat choriocarcinoma cell line, Rcho-1, during giant cell transformation. Hassanein M, etal., Placenta. 2007 Aug-Sep;28(8-9):912-9. Epub 2007 Jan 10.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:19346238  


Genomics

Variants

.
Variants in Ctsj
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:126
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000038758
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat

Markers in Region
BI285782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,743,110 - 3,743,327 (+)MAPPERmRatBN7.2
Rnor_6.0174,110,272 - 4,110,488NCBIRnor6.0
Rnor_5.0176,337,544 - 6,337,760UniSTSRnor5.0
Celera173,872,006 - 3,872,222UniSTS
RH 3.4 Map1747.9UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
1 15 20 8 10 3 7 3 26 23 20 18 7

Sequence


Ensembl Acc Id: ENSRNOT00000038758   ⟹   ENSRNOP00000035908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl173,744,340 - 3,748,988 (+)Ensembl
mRatBN7.2 Ensembl173,738,729 - 3,743,377 (+)Ensembl
Rnor_6.0 Ensembl174,105,890 - 4,110,538 (+)Ensembl
RefSeq Acc Id: NM_017121   ⟹   NP_058817
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,744,340 - 3,748,988 (+)NCBI
mRatBN7.2173,738,729 - 3,743,377 (+)NCBI
Rnor_6.0174,105,890 - 4,110,538 (+)NCBI
Rnor_5.0176,333,162 - 6,337,810 (+)NCBI
Celera173,867,624 - 3,872,272 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058817 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC42066 (Get FASTA)   NCBI Sequence Viewer  
  AAH97263 (Get FASTA)   NCBI Sequence Viewer  
  AAL26793 (Get FASTA)   NCBI Sequence Viewer  
  EDL93852 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035908
  ENSRNOP00000035908.3
GenBank Protein Q63088 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058817   ⟸   NM_017121
- Peptide Label: precursor
- UniProtKB: Q920D9 (UniProtKB/Swiss-Prot),   Q63088 (UniProtKB/Swiss-Prot),   A6KAE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035908   ⟸   ENSRNOT00000038758
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63088-F1-model_v2 AlphaFold Q63088 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69241 AgrOrtholog
BioCyc Gene G2FUF-10476 BioCyc
Ensembl Genes ENSRNOG00000046476 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038758 ENTREZGENE
  ENSRNOT00000038758.5 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7460052 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_asp_AS UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Pept_his_AS UniProtKB/Swiss-Prot
  Peptidase_C1A UniProtKB/Swiss-Prot
  Peptidase_C1A_C UniProtKB/Swiss-Prot
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot
  Prot_inhib_I29 UniProtKB/Swiss-Prot
KEGG Report rno:29174 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114232 IMAGE-MGC_LOAD
NCBI Gene 29174 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot
  Peptidase_C1 UniProtKB/Swiss-Prot
PhenoGen Ctsj PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046476 RatGTEx
SMART Inhibitor_I29 UniProtKB/Swiss-Prot
  Pept_C1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
TIGR TC205466
UniProt A6KAE4 ENTREZGENE, UniProtKB/TrEMBL
  CATJ_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q920D9 ENTREZGENE
UniProt Secondary Q920D9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ctsj  cathepsin J      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in rat placenta 68768
gene_protein 237 amino acids 68768