Gpx4 (glutathione peroxidase 4) - Rat Genome Database

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Pathways
Gene: Gpx4 (glutathione peroxidase 4) Rattus norvegicus
Analyze
Symbol: Gpx4
Name: glutathione peroxidase 4
RGD ID: 69226
Description: Enables phospholipid-hydroperoxide glutathione peroxidase activity and selenium binding activity. Involved in response to estradiol. Is active in cytosol and mitochondrion. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4); PARTICIPATES IN glutathione metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Gpx-4; Gshpx-4; Phgpx; phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; snGpx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gpx4-ps1   Gpx4-ps2   Gpx4-ps3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,300,833 - 10,303,629 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,300,832 - 10,303,629 (-)EnsemblGRCr8
mRatBN7.279,650,186 - 9,652,982 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,533,042 - 12,535,860 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,408,380 - 14,411,198 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,269,509 - 12,272,287 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)Ensemblrn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,826,041 - 7,828,838 (-)NCBICelera
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-voacangine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-ropivacaine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-nitropyrene  (ISO)
12(S)-HPETE  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrophenol  (EXP)
2-bromohexadecanoic acid  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
25-hydroxycholesterol  (ISO)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
Angoline  (ISO)
antimony(0)  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
Arenobufagin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
astaxanthin  (EXP,ISO)
astemizole  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
baicalein  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
benzoates  (ISO)
beryllium sulfate  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
boric acid  (EXP)
busulfan  (ISO)
butan-1-ol  (ISO)
butein  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carvacrol  (ISO)
cerium trichloride  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
DDE  (EXP)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicyclanil  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethyl fumarate  (EXP,ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
diuron  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP,ISO)
empagliflozin  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erastin  (EXP,ISO)
eriodictyol  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethylene glycol dimethacrylate  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
ferrostatin-1  (EXP,ISO)
finasteride  (EXP)
flumequine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
galactose  (EXP)
gallium nitrate  (ISO)
Gastrodin  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
ginkgolide B  (ISO)
Ginsenoside Rh4  (ISO)
glucose  (EXP,ISO)
glycine betaine  (EXP)
GSK-J4  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hypochlorous acid  (ISO)
imidacloprid  (EXP)
indoline  (ISO)
inulin  (ISO)
Iodine aqueous  (ISO)
iron atom  (EXP)
iron dextran  (ISO)
iron(0)  (EXP)
isobavachalcone  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
KN-93  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
Leonurine  (EXP,ISO)
limonene  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
microcystin-LR  (ISO)
MitoTEMPO  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalene  (ISO)
naphthalenes  (EXP)
nefazodone  (EXP)
nerolidol  (EXP)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nitrogen dioxide  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylhydrazine  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Picein  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pirinixic acid  (EXP,ISO)
polymyxin B2  (ISO)
potassium dichromate  (EXP)
propiconazole  (ISO)
protosappanin A  (EXP,ISO)
pyrazinecarboxamide  (EXP)
Pyridostigmine bromide  (EXP)
pyrimethamine  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
sclareol  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
sevoflurane  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
solasodine  (ISO)
sorafenib  (EXP,ISO)
stavudine  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (EXP,ISO)
thiazoles  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tolterodine tartrate  (ISO)
toluene  (EXP)
toosendanin  (ISO)
trabectedin  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
Valtratum  (ISO)
verteporfin  (EXP,ISO)
wedelolactone  (ISO)
zinc atom  (EXP)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IDA,IEA,ISO,ISS)
mitochondrion  (IBA,IDA,IEA,ISO)
nuclear envelope  (IEA,ISO)
nucleolus  (IEA)
nucleus  (IBA,IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Import into mitochondria of phospholipid hydroperoxide glutathione peroxidase requires a leader sequence. Arai M, etal., Biochem Biophys Res Commun. 1996 Oct 14;227(2):433-9.
2. Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Bermano G, etal., Genes Nutr. 2007 Nov;2(2):225-32. doi: 10.1007/s12263-007-0052-3. Epub 2007 Oct 13.
3. Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress. Briones-Herrera A, etal., Food Chem Toxicol. 2018 May;115:185-197. doi: 10.1016/j.fct.2018.03.016. Epub 2018 Mar 13.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Impaired glomerular and tubular antioxidative defense mechanisms in nephrotic syndrome. Granqvist A, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F898-904. doi: 10.1152/ajprenal.00124.2010. Epub 2010 Aug 4.
7. Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Holley A, etal., J Investig Med. 2017 Jun;65(5):919-925. doi: 10.1136/jim-2016-000361. Epub 2017 Mar 15.
8. Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression. Imai H, etal., J Biochem (Tokyo) 1995 Nov;118(5):1061-7.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans. Lan X, etal., Biol Trace Elem Res. 2017 Jul;178(1):22-28. doi: 10.1007/s12011-016-0908-8. Epub 2016 Dec 13.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Mistry HD, etal., Hypertension. 2008 Nov;52(5):881-8. doi: 10.1161/HYPERTENSIONAHA.108.116103. Epub 2008 Oct 13.
13. Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Mistry HD, etal., Placenta. 2010 May;31(5):401-8. doi: 10.1016/j.placenta.2010.02.011. Epub 2010 Mar 19.
14. Genetic variants in selenoprotein genes increase risk of colorectal cancer. Méplan C, etal., Carcinogenesis. 2010 Jun;31(6):1074-9. doi: 10.1093/carcin/bgq076. Epub 2010 Apr 8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Binge drinking during adolescence disrupts Se homeostasis and its main hepatic selenoprotein expression. Ojeda ML, etal., Alcohol Clin Exp Res. 2015 May;39(5):818-26. doi: 10.1111/acer.12707. Epub 2015 Apr 10.
17. Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation. Pfeifer H, etal., FASEB J 2001 May;15(7):1236-8.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Rat phospholipid-hydroperoxide glutathione peroxidase. cDNA cloning and identification of multiple transcription and translation start sites. Pushpa-Rekha TR, etal., J Biol Chem 1995 Nov 10;270(45):26993-9.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. Sakamoto H, etal., J Biol Chem 2002 Dec 27;277(52):50431-8.
24. Dietary selenium requirements based on glutathione peroxidase-1 activity and mRNA levels and other Se-dependent parameters are not increased by pregnancy and lactation in rats. Sunde RA, etal., J Nutr. 2005 Sep;135(9):2144-50.
25. Spermatozoa have decreased antioxidant enzymatic capacity and increased reactive oxygen species production during aging in the Brown Norway rat. Weir CP and Robaire B, J Androl. 2007 Mar-Apr;28(2):229-40. Epub 2006 Oct 4.
26. Expression of selenium-containing proteins in human colon carcinoma tissue. Yagublu V, etal., Anticancer Res. 2011 Sep;31(9):2693-8.
27. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Yant LJ, etal., Free Radic Biol Med 2003 Feb 15;34(4):496-502.
28. Effect of oestrogen on reactive oxygen species production in the aortas of ovariectomized Dahl salt-sensitive rats. Zhang L, etal., J Hypertens. 2007 Feb;25(2):407-14.
Additional References at PubMed
PMID:1556123   PMID:2386798   PMID:8135530   PMID:9988735   PMID:10464096   PMID:11115402   PMID:11903656   PMID:12533403   PMID:12724282   PMID:12819198   PMID:12865426   PMID:14575705  
PMID:14583338   PMID:14651853   PMID:15670826   PMID:15757501   PMID:15821744   PMID:15888450   PMID:15901730   PMID:16159880   PMID:17603929   PMID:17630701   PMID:17997296   PMID:18614015  
PMID:19056867   PMID:19398061   PMID:19723078   PMID:19890015   PMID:21630459   PMID:22614831   PMID:23376485   PMID:23816523   PMID:25402683   PMID:25922076   PMID:26071777   PMID:26163004  
PMID:28709976   PMID:29290465   PMID:30205109   PMID:31685805   PMID:32376803   PMID:33415582   PMID:34699317   PMID:35076866   PMID:35320827   PMID:35653908   PMID:37391124   PMID:37506966  
PMID:37552043   PMID:37710183   PMID:37968154   PMID:38029583   PMID:38494855   PMID:38686488   PMID:38871197   PMID:38943181   PMID:39175261   PMID:39354361  


Genomics

Comparative Map Data
Gpx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,300,833 - 10,303,629 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,300,832 - 10,303,629 (-)EnsemblGRCr8
mRatBN7.279,650,186 - 9,652,982 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,533,042 - 12,535,860 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,408,380 - 14,411,198 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,269,509 - 12,272,287 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)Ensemblrn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,826,041 - 7,828,838 (-)NCBICelera
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Cytogenetic Map7q11NCBI
GPX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,103,994 - 1,106,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,103,982 - 1,106,791 (+)Ensemblhg38GRCh38
GRCh37191,103,993 - 1,106,778 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,054,936 - 1,057,787 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34191,054,965 - 1,057,778NCBI
Celera191,036,910 - 1,039,761 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19877,428 - 880,271 (+)NCBIHuRef
CHM1_1191,103,529 - 1,106,380 (+)NCBICHM1_1
T2T-CHM13v2.0191,068,660 - 1,071,445 (+)NCBIT2T-CHM13v2.0
Gpx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,883,000 - 79,892,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,883,000 - 79,892,273 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381080,047,166 - 80,056,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,047,166 - 80,056,439 (+)Ensemblmm10GRCm38
MGSCv371079,516,255 - 79,519,184 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,456,617 - 79,459,567 (+)NCBIMGSCv36mm8
Celera1081,068,319 - 81,071,248 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gpx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,767,975 - 6,772,178 (-)Ensembl
ChiLan1.0NW_0049554956,767,969 - 6,772,256 (-)NCBIChiLan1.0ChiLan1.0
GPX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,439,232 - 5,443,396 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,675,807 - 4,679,965 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01920,904 - 23,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,082,917 - 1,085,538 (+)NCBIPanPan1.1PanPan1.1panPan2
GPX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2057,443,525 - 57,445,796 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02058,383,449 - 58,385,704 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,383,450 - 58,385,689 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,438,781 - 57,441,040 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,918,275 - 57,920,554 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,121,304 - 58,123,564 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,324,770 - 217,328,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588506,147 - 508,101 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936588506,101 - 508,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,320,464 - 77,323,931 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,673,720 - 77,676,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16873,867 - 876,225 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660817,991,488 - 7,994,293 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,534,449 - 7,536,586 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248287,534,251 - 7,536,675 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpx4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11154,819,107 - 154,821,897 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpx4
89 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000018691
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH137289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,338,433 - 35,338,615 (+)MAPPERmRatBN7.2
mRatBN7.279,650,550 - 9,651,548 (+)MAPPERmRatBN7.2
Rnor_6.0712,516,723 - 12,517,720NCBIRnor6.0
Rnor_6.01437,904,806 - 37,904,987NCBIRnor6.0
Rnor_5.01437,715,064 - 37,715,245UniSTSRnor5.0
Rnor_5.0712,686,826 - 12,687,823UniSTSRnor5.0
RGSC_v3.41437,742,061 - 37,742,242UniSTSRGSC3.4
RGSC_v3.4711,162,887 - 11,163,884UniSTSRGSC3.4
Celera77,826,407 - 7,827,404UniSTS
Celera1434,593,349 - 34,593,530UniSTS
Cytogenetic Map14p11UniSTS
Cytogenetic Map7q11UniSTS
RH143516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,652,690 - 9,652,829 (+)MAPPERmRatBN7.2
Rnor_6.0712,518,863 - 12,519,001NCBIRnor6.0
Rnor_5.0712,688,966 - 12,689,104UniSTSRnor5.0
RGSC_v3.4711,165,027 - 11,165,165UniSTSRGSC3.4
Celera77,828,547 - 7,828,685UniSTS
RH 3.4 Map740.6UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:237712  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8710,301,048 - 10,301,218 (+)Marker Load Pipeline
mRatBN7.279,650,401 - 9,650,571 (+)MAPPERmRatBN7.2
Rnor_6.0712,516,574 - 12,516,743NCBIRnor6.0
Rnor_5.0712,686,677 - 12,686,846UniSTSRnor5.0
RGSC_v3.4711,162,738 - 11,162,907UniSTSRGSC3.4
Celera77,826,258 - 7,826,427UniSTS
Cytogenetic Map7q11UniSTS
Gpx4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,338,112 - 35,338,614 (+)MAPPERmRatBN7.2
Rnor_6.01437,904,485 - 37,904,986NCBIRnor6.0
Rnor_5.01437,714,743 - 37,715,244UniSTSRnor5.0
RGSC_v3.41437,741,740 - 37,742,241UniSTSRGSC3.4
Celera1434,593,028 - 34,593,529UniSTS
Cytogenetic Map14p11UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF274028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ537598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY570513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB582508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ087247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000018691   ⟹   ENSRNOP00000018691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,357 - 12,518,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077681   ⟹   ENSRNOP00000072552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,357 - 12,519,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,359 - 12,517,335 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093376   ⟹   ENSRNOP00000076198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,300,832 - 10,303,629 (-)Ensembl
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)Ensembl
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093426   ⟹   ENSRNOP00000076309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,300,832 - 10,303,629 (-)Ensembl
mRatBN7.2 Ensembl79,650,186 - 9,652,512 (-)Ensembl
Rnor_6.0 Ensembl712,516,363 - 12,518,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,358 - 12,517,901 (-)Ensembl
RefSeq Acc Id: NM_001039849   ⟹   NP_001034938
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,300,833 - 10,303,159 (-)NCBI
mRatBN7.279,650,186 - 9,652,512 (-)NCBI
Rnor_6.0712,516,357 - 12,518,684 (-)NCBI
Rnor_5.0712,686,460 - 12,689,257 (-)NCBI
RGSC_v3.4711,162,521 - 11,165,318 (-)RGD
Celera77,826,041 - 7,828,368 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368043   ⟹   NP_001354972
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,300,833 - 10,303,537 (-)NCBI
mRatBN7.279,650,186 - 9,652,890 (-)NCBI
RefSeq Acc Id: NM_017165   ⟹   NP_058861
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,300,833 - 10,303,629 (-)NCBI
mRatBN7.279,650,186 - 9,652,982 (-)NCBI
Rnor_6.0712,516,357 - 12,519,154 (-)NCBI
Rnor_5.0712,686,460 - 12,689,257 (-)NCBI
RGSC_v3.4711,162,521 - 11,165,318 (-)RGD
Celera77,826,041 - 7,828,838 (-)RGD
Sequence:
RefSeq Acc Id: NP_058861   ⟸   NM_017165
- Peptide Label: isoform A precursor
- UniProtKB: Q76LU9 (UniProtKB/Swiss-Prot),   Q6PZ55 (UniProtKB/Swiss-Prot),   Q91XR8 (UniProtKB/Swiss-Prot),   P36970 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001034938   ⟸   NM_001039849
- Peptide Label: isoform B
- UniProtKB: P36970 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018691   ⟸   ENSRNOT00000018691
Ensembl Acc Id: ENSRNOP00000072552   ⟸   ENSRNOT00000077681
Ensembl Acc Id: ENSRNOP00000076198   ⟸   ENSRNOT00000093376
Ensembl Acc Id: ENSRNOP00000076309   ⟸   ENSRNOT00000093426
RefSeq Acc Id: NP_001354972   ⟸   NM_001368043
- Peptide Label: isoform C

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695040
Promoter ID:EPDNEW_R5561
Type:initiation region
Name:Gpx4_2
Description:glutathione peroxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5562  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,518,684 - 12,518,744EPDNEW
RGD ID:13695039
Promoter ID:EPDNEW_R5562
Type:initiation region
Name:Gpx4_1
Description:glutathione peroxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5561  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,519,059 - 12,519,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69226 AgrOrtholog
BioCyc Gene G2FUF-34914 BioCyc
BioCyc Pathway PWY-4081 [glutathione-peroxide redox reactions] BioCyc
BioCyc Pathway Image PWY-4081 BioCyc
Ensembl Genes ENSRNOG00000013604 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000093376 ENTREZGENE
  ENSRNOT00000093376.2 UniProtKB/Swiss-Prot
  ENSRNOT00000093426.2 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:29328 UniProtKB/Swiss-Prot
NCBI Gene 29328 ENTREZGENE
PANTHER PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE UniProtKB/Swiss-Prot
  PTHR11592 UniProtKB/Swiss-Prot
Pfam GSHPx UniProtKB/Swiss-Prot
PhenoGen Gpx4 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013604 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A6K8S0_RAT UniProtKB/TrEMBL
  A6K8S1_RAT UniProtKB/TrEMBL
  A6K8S2_RAT UniProtKB/TrEMBL
  GPX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PZ55 ENTREZGENE
  Q76LU9 ENTREZGENE
  Q91XR8 ENTREZGENE
UniProt Secondary Q6PZ55 UniProtKB/Swiss-Prot
  Q76LU9 UniProtKB/Swiss-Prot
  Q91XR8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gpx4  glutathione peroxidase 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression inhibits synthesis of platelet activating factor 728699