Qsox1 (quiescin sulfhydryl oxidase 1) - Rat Genome Database

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Gene: Qsox1 (quiescin sulfhydryl oxidase 1) Rattus norvegicus
Analyze
Symbol: Qsox1
Name: quiescin sulfhydryl oxidase 1
RGD ID: 68957
Description: Enables FAD binding activity and flavin-dependent sulfhydryl oxidase activity. Predicted to be involved in extracellular matrix assembly; negative regulation of macroautophagy; and protein folding. Located in extracellular space. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FAD-dependent sulfhydryl oxidase-2; Qscn6; Qsox; quiescin Q6; quiescin Q6 sulfhydryl oxidase 1; rQSOX; rSOx; Sox-2; sulfhydryl oxidase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,500,060 - 70,537,711 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1370,500,060 - 70,537,733 (-)EnsemblGRCr8
mRatBN7.21367,949,780 - 67,987,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1367,949,780 - 67,987,459 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1370,529,544 - 70,566,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01371,844,987 - 71,881,834 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,106,470 - 69,143,317 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01373,423,396 - 73,460,890 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,423,397 - 73,460,935 (-)Ensemblrn6Rnor6.0
Rnor_5.01378,351,222 - 78,388,703 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41370,739,793 - 70,777,526 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1367,815,702 - 67,852,956 (-)NCBICelera
RGSC_v3.11370,753,873 - 70,791,628 (-)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetochlor  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
graphene oxide  (ISO)
herbicide  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methoxyacetic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (EXP)
promegestone  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular exosome  (IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO,ISS)
Golgi apparatus  (IEA,ISO)
Golgi membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat seminal vesicle fad-dependent sulfhydryl oxidase. biochemical characterization and molecular cloning of a member of the new sulfhydryl oxidase/quiescin q6 gene family. Benayoun B, etal., J Biol Chem 2001 Apr 27;276(17):13830-7.
2. Enzyme structure captures four cysteines aligned for disulfide relay. Gat Y, etal., Protein Sci. 2014 Aug;23(8):1102-12. doi: 10.1002/pro.2496. Epub 2014 Jun 18.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Expression of SOx-2, a member of the FAD-dependent sulfhydryl oxidase/quiescin Q6 gene family, in rat brain. Mairet-Coello G, etal., Neuroreport 2002 Nov 15;13(16):2049-51.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10708601   PMID:12354420   PMID:16502470   PMID:16806532   PMID:17331072   PMID:17927979   PMID:18393449   PMID:20211621   PMID:21082674   PMID:23376485   PMID:23533145  
PMID:23867277   PMID:24006456   PMID:24475161   PMID:25766108   PMID:29757379  


Genomics

Comparative Map Data
Qsox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,500,060 - 70,537,711 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1370,500,060 - 70,537,733 (-)EnsemblGRCr8
mRatBN7.21367,949,780 - 67,987,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1367,949,780 - 67,987,459 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1370,529,544 - 70,566,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01371,844,987 - 71,881,834 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,106,470 - 69,143,317 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01373,423,396 - 73,460,890 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,423,397 - 73,460,935 (-)Ensemblrn6Rnor6.0
Rnor_5.01378,351,222 - 78,388,703 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41370,739,793 - 70,777,526 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1367,815,702 - 67,852,956 (-)NCBICelera
RGSC_v3.11370,753,873 - 70,791,628 (-)NCBI
Cytogenetic Map13q21NCBI
QSOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381180,154,869 - 180,204,030 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1180,154,869 - 180,204,030 (+)Ensemblhg38GRCh38
GRCh371180,124,004 - 180,173,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361178,390,591 - 178,433,792 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341176,855,624 - 176,898,826NCBI
Celera1153,231,536 - 153,274,744 (+)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1151,355,443 - 151,398,518 (+)NCBIHuRef
CHM1_11181,547,697 - 181,590,889 (+)NCBICHM1_1
T2T-CHM13v2.01179,510,604 - 179,559,769 (+)NCBIT2T-CHM13v2.0
Qsox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,653,901 - 155,688,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,651,775 - 155,688,635 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381155,778,155 - 155,812,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,776,029 - 155,812,889 (-)Ensemblmm10GRCm38
MGSCv371157,625,285 - 157,660,029 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361157,540,373 - 157,575,117 (-)NCBIMGSCv36mm8
Celera1158,211,715 - 158,246,555 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.64NCBI
Qsox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540619,363,938 - 19,402,134 (+)NCBIChiLan1.0ChiLan1.0
QSOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2169,563,559 - 69,606,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1169,221,823 - 69,265,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01155,641,793 - 155,687,231 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,289,932 - 159,358,675 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,313,245 - 159,358,672 (+)EnsemblpanPan2panpan1.1
QSOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1713,718,799 - 13,754,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl713,718,799 - 13,754,114 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha713,297,965 - 13,333,390 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0713,446,573 - 13,482,007 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl713,446,567 - 13,482,619 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1713,357,448 - 13,392,875 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0713,463,885 - 13,499,332 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0713,588,279 - 13,623,755 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Qsox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,129,070 - 91,166,948 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364818,975,790 - 9,013,723 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364818,975,818 - 9,013,684 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QSOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9121,779,792 - 121,822,825 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19121,779,072 - 121,822,829 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29133,595,396 - 133,638,610 (+)NCBISscrofa10.2Sscrofa10.2susScr3
QSOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12549,180,365 - 49,223,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2549,181,365 - 49,223,741 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605550,571,837 - 50,617,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qsox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624771449,992 - 489,693 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624771449,761 - 490,372 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Qsox1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11035,189,589 - 35,227,365 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Qsox1
165 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:299
Count of miRNA genes:140
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000005052, ENSRNOT00000068044
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH139452  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21367,949,798 - 67,949,941 (+)MAPPERmRatBN7.2
Rnor_6.01373,423,415 - 73,423,557NCBIRnor6.0
Rnor_5.01378,351,241 - 78,351,383UniSTSRnor5.0
RGSC_v3.41370,739,812 - 70,739,954UniSTSRGSC3.4
Celera1367,815,721 - 67,815,863UniSTS
RH 3.4 Map13344.6UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005052   ⟹   ENSRNOP00000005052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1370,500,061 - 70,537,733 (-)Ensembl
mRatBN7.2 Ensembl1367,949,782 - 67,987,459 (-)Ensembl
Rnor_6.0 Ensembl1373,423,397 - 73,460,912 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068044   ⟹   ENSRNOP00000061072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1370,500,060 - 70,537,711 (-)Ensembl
mRatBN7.2 Ensembl1367,949,780 - 67,987,434 (-)Ensembl
Rnor_6.0 Ensembl1373,424,027 - 73,460,935 (-)Ensembl
RefSeq Acc Id: NM_001109898   ⟹   NP_001103368
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,500,060 - 70,537,711 (-)NCBI
mRatBN7.21367,949,780 - 67,987,434 (-)NCBI
Rnor_6.01373,423,396 - 73,460,890 (-)NCBI
Rnor_5.01378,351,222 - 78,388,703 (-)NCBI
RGSC_v3.41370,739,793 - 70,777,526 (-)RGD
Celera1367,815,702 - 67,852,956 (-)RGD
Sequence:
RefSeq Acc Id: NM_053431   ⟹   NP_445883
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,500,060 - 70,537,711 (-)NCBI
mRatBN7.21367,949,780 - 67,987,434 (-)NCBI
Rnor_6.01373,423,396 - 73,460,890 (-)NCBI
Rnor_5.01378,351,222 - 78,388,703 (-)NCBI
RGSC_v3.41370,739,793 - 70,777,526 (-)RGD
Celera1367,815,702 - 67,852,956 (-)RGD
Sequence:
RefSeq Acc Id: NP_445883   ⟸   NM_053431
- Peptide Label: isoform B precursor
- UniProtKB: A6ICZ3 (UniProtKB/TrEMBL),   A6ICZ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103368   ⟸   NM_001109898
- Peptide Label: isoform A precursor
- UniProtKB: Q8K4M2 (UniProtKB/Swiss-Prot),   Q99J80 (UniProtKB/Swiss-Prot),   Q6IUU3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005052   ⟸   ENSRNOT00000005052
Ensembl Acc Id: ENSRNOP00000061072   ⟸   ENSRNOT00000068044
Protein Domains
ERV/ALR sulfhydryl oxidase   Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IUU3-F1-model_v2 AlphaFold Q6IUU3 1-750 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698909
Promoter ID:EPDNEW_R9434
Type:initiation region
Name:Qsox1_1
Description:quiescin sulfhydryl oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01373,460,961 - 73,461,021EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68957 AgrOrtholog
BioCyc Gene G2FUF-17831 BioCyc
Ensembl Genes ENSRNOG00000003649 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005052 ENTREZGENE
  ENSRNOT00000005052.10 UniProtKB/Swiss-Prot
  ENSRNOT00000068044 ENTREZGENE
  ENSRNOT00000068044.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.1960 UniProtKB/Swiss-Prot
  1.20.120.310 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
InterPro ERV/ALR_sulphydryl_oxid_sf UniProtKB/Swiss-Prot
  ERV/ALR_sulphydryl_oxidase UniProtKB/Swiss-Prot
  QSOX_FAD-bd_dom UniProtKB/Swiss-Prot
  QSOX_FAD-bd_sf UniProtKB/Swiss-Prot
  QSOX_Trx1 UniProtKB/Swiss-Prot
  Sulfhydryl_oxidase UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:84491 UniProtKB/Swiss-Prot
NCBI Gene 84491 ENTREZGENE
PANTHER PTHR22897 UniProtKB/Swiss-Prot
  SULFHYDRYL OXIDASE 1 UniProtKB/Swiss-Prot
Pfam Evr1_Alr UniProtKB/Swiss-Prot
  FAD_SOX UniProtKB/Swiss-Prot
  QSOX_Trx1 UniProtKB/Swiss-Prot
  Thioredoxin UniProtKB/Swiss-Prot
PhenoGen Qsox1 PhenoGen
PROSITE ERV_ALR UniProtKB/Swiss-Prot
  THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003649 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
  SSF69000 UniProtKB/Swiss-Prot
UniProt A6ICZ2 ENTREZGENE, UniProtKB/TrEMBL
  A6ICZ3 ENTREZGENE, UniProtKB/TrEMBL
  Q6IUU3 ENTREZGENE
  Q8K4M2 ENTREZGENE
  Q99J80 ENTREZGENE
  QSOX1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K4M2 UniProtKB/Swiss-Prot
  Q99J80 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Qsox1  quiescin sulfhydryl oxidase 1  Qsox1  quiescin Q6 sulfhydryl oxidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Qsox1  quiescin Q6 sulfhydryl oxidase 1  Qscn6  quiescin Q6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Qscn6  quiescin Q6      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in diencephalon and telencephalon 1299176
gene_function converts alkyl thiols and oxygen to their dialkyl disulfides and hydrogen peroxide 67932
gene_protein 570 amino acids 67932
gene_transcript 2472 nucleotide cDNA with an open reading frame of 1710 base pairs 67932