Dlg3 (discs large MAGUK scaffold protein 3) - Rat Genome Database

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Gene: Dlg3 (discs large MAGUK scaffold protein 3) Rattus norvegicus
Analyze
Symbol: Dlg3
Name: discs large MAGUK scaffold protein 3
RGD ID: 68423
Description: Enables PDZ domain binding activity; ionotropic glutamate receptor binding activity; and protein phosphatase binding activity. A structural constituent of postsynaptic density. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to synapse; and receptor clustering. Predicted to act upstream of or within establishment of planar polarity. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: discs large homolog 3; discs, large homolog 3; discs, large homolog 3 (Drosophila); disks large homolog 3; Dlgh3; PSD-95/SAP90-related protein 1; SAP-102; SAP102; synapse-associated protein 102
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,899,694 - 69,951,928 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX69,900,003 - 69,950,696 (+)EnsemblGRCr8
mRatBN7.2X65,859,653 - 65,911,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,860,172 - 65,910,322 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX67,343,327 - 67,394,012 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,843,724 - 70,894,417 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,404,631 - 68,455,321 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,596,246 - 70,648,529 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,596,576 - 70,648,532 (+)Ensemblrn6Rnor6.0
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X88,777,585 - 88,828,504 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX66,218,231 - 66,268,819 (+)NCBICelera
RGSC_v3.1X88,851,017 - 88,901,937 (+)NCBI
Cytogenetic MapXq22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folpet  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
propylparaben  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. Chen BS, etal., J Biol Chem. 2006 Jun 16;281(24):16583-90. Epub 2006 Apr 10.
2. Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. DeMarco SJ and Strehler EE, J Biol Chem. 2001 Jun 15;276(24):21594-600. Epub 2001 Mar 26.
3. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. Karnak D, etal., J Biol Chem 2002 Nov 29;277(48):46730-5. Epub 2002 Sep 25.
7. Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. Kim K, etal., EMBO J. 2009 Apr 22;28(8):1170-9. doi: 10.1038/emboj.2009.44. Epub 2009 Feb 19.
8. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. Lau LF, etal., J Biol Chem. 1996 Aug 30;271(35):21622-8.
9. The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic. Lee HW, etal., J Neurosci. 2010 Apr 21;30(16):5508-18. doi: 10.1523/JNEUROSCI.4283-09.2010.
10. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
11. Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. Lim IA, etal., J Biol Chem. 2002 Jun 14;277(24):21697-711. Epub 2002 Apr 5.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Muller BM, etal., Neuron. 1996 Aug;17(2):255-65.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones. Rockliffe N and Gawler D, FEBS Lett. 2006 Feb 6;580(3):831-8. Epub 2006 Jan 18.
19. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Sans N, etal., Nat Cell Biol. 2003 Jun;5(6):520-30.
20. DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1. Stathakis DG, etal., Genomics 1998 Apr 15;49(2):310-3.
21. Pursuit auditory tracking of dichotically presented tonal amplitudes. Sussman HM, etal., J Speech Hear Res. 1975 Mar;18(1):74-81.
22. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. Takeuchi M, etal., J Biol Chem 1997 May 2;272(18):11943-51.
23. Mutations in the DLG3 Gene Cause Nonsyndromic X-Linked Mental Retardation. Tarpey P, etal., Am J Hum Genet 2004 Jun 7;75(2).
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. Tobaben S, etal., J Biol Chem 2000 Nov 17;275(46):36204-10.
26. A novel family of adhesion-like molecules that interacts with the NMDA receptor. Wang CY, etal., J Neurosci. 2006 Feb 22;26(8):2174-83.
27. Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. Wu HY, etal., J Biol Chem. 2007 Jul 13;282(28):20075-87. doi: 10.1074/jbc.M700624200. Epub 2007 May 25.
28. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
29. SAP102 is a highly mobile MAGUK in spines. Zheng CY, etal., J Neurosci. 2010 Mar 31;30(13):4757-66. doi: 10.1523/JNEUROSCI.6108-09.2010.
Additional References at PubMed
PMID:9581761   PMID:14596909   PMID:15458844   PMID:15992371   PMID:17046693   PMID:17670980   PMID:17938206   PMID:19104036   PMID:19389623   PMID:21209193   PMID:21920314   PMID:22632720  
PMID:22664934   PMID:22871113   PMID:23486974   PMID:23946397   PMID:24509856   PMID:25429150   PMID:25555912   PMID:29574717   PMID:30053369   PMID:30067114   PMID:31682872   PMID:31745231  


Genomics

Comparative Map Data
Dlg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,899,694 - 69,951,928 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX69,900,003 - 69,950,696 (+)EnsemblGRCr8
mRatBN7.2X65,859,653 - 65,911,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,860,172 - 65,910,322 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX67,343,327 - 67,394,012 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,843,724 - 70,894,417 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,404,631 - 68,455,321 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,596,246 - 70,648,529 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,596,576 - 70,648,532 (+)Ensemblrn6Rnor6.0
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X88,777,585 - 88,828,504 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX66,218,231 - 66,268,819 (+)NCBICelera
RGSC_v3.1X88,851,017 - 88,901,937 (+)NCBI
Cytogenetic MapXq22NCBI
DLG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,444,835 - 70,505,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,444,835 - 70,505,490 (+)Ensemblhg38GRCh38
GRCh37X69,664,685 - 69,725,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,581,449 - 69,642,062 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X69,447,839 - 69,505,554NCBI
CeleraX70,018,031 - 70,078,673 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,486,322 - 63,547,144 (+)NCBIHuRef
CHM1_1X69,558,605 - 69,619,214 (+)NCBICHM1_1
T2T-CHM13v2.0X68,878,160 - 68,938,810 (+)NCBIT2T-CHM13v2.0
Dlg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,811,200 - 99,862,016 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,811,328 - 99,862,016 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X100,767,411 - 100,818,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,767,722 - 100,818,410 (+)Ensemblmm10GRCm38
MGSCv37X97,963,062 - 98,013,749 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X96,970,466 - 97,021,127 (+)NCBIMGSCv36mm8
CeleraX87,686,891 - 87,737,556 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.72NCBI
Dlg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,992,215 - 10,056,348 (+)Ensembl
ChiLan1.0NW_0049554759,992,888 - 10,056,197 (+)NCBIChiLan1.0ChiLan1.0
DLG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X70,121,582 - 70,181,058 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X70,125,184 - 70,184,660 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,712,755 - 59,773,372 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,771,482 - 69,831,376 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,771,477 - 69,831,369 (+)EnsemblpanPan2panpan1.1
DLG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,886,700 - 54,941,502 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,886,389 - 54,939,675 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX45,713,141 - 45,768,580 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,853,333 - 55,908,759 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX55,853,116 - 55,908,756 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X53,822,238 - 53,877,672 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,153,323 - 55,208,774 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,080,264 - 55,135,709 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dlg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,220,157 - 47,276,307 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762982,258 - 1,038,492 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936762982,331 - 1,038,486 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,472,307 - 56,527,983 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X56,471,941 - 56,531,481 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,666,759 - 63,724,414 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,290,280 - 60,346,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,290,630 - 60,346,953 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660652,134,119 - 2,191,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624903409,709 - 473,659 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624903409,721 - 473,422 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dlg3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X58,653,084 - 58,704,771 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dlg3
157 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:149
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000003741, ENSRNOT00000045082
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
BE119338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X65,872,920 - 65,873,090 (+)MAPPERmRatBN7.2
Rnor_6.0X70,609,544 - 70,609,713NCBIRnor6.0
Rnor_5.0X71,481,301 - 71,481,470UniSTSRnor5.0
RGSC_v3.4X88,790,552 - 88,790,721UniSTSRGSC3.4
CeleraX66,231,196 - 66,231,365UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003741   ⟹   ENSRNOP00000003741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX69,900,003 - 69,950,696 (+)Ensembl
mRatBN7.2 EnsemblX65,860,172 - 65,910,322 (+)Ensembl
Rnor_6.0 EnsemblX70,596,577 - 70,647,298 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045082   ⟹   ENSRNOP00000047310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX69,900,003 - 69,950,696 (+)Ensembl
mRatBN7.2 EnsemblX65,860,172 - 65,910,322 (+)Ensembl
Rnor_6.0 EnsemblX70,596,576 - 70,648,527 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,644,361 - 70,646,372 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076079   ⟹   ENSRNOP00000067983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX69,900,003 - 69,950,696 (+)Ensembl
mRatBN7.2 EnsemblX65,860,289 - 65,910,322 (+)Ensembl
Rnor_6.0 EnsemblX70,596,580 - 70,648,532 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX69,900,003 - 69,950,696 (+)Ensembl
mRatBN7.2 EnsemblX65,860,172 - 65,910,322 (+)Ensembl
Rnor_6.0 EnsemblX70,596,848 - 70,648,532 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076456   ⟹   ENSRNOP00000068233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,645,270 - 70,648,532 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX69,906,877 - 69,950,696 (+)Ensembl
mRatBN7.2 EnsemblX65,866,695 - 65,910,322 (+)Ensembl
Rnor_6.0 EnsemblX70,603,582 - 70,648,527 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088114   ⟹   ENSRNOP00000071634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX69,900,181 - 69,950,696 (+)Ensembl
mRatBN7.2 EnsemblX65,860,172 - 65,910,322 (+)Ensembl
Rnor_6.0 EnsemblX70,596,901 - 70,646,921 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099103   ⟹   ENSRNOP00000096478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX69,900,149 - 69,950,696 (+)Ensembl
mRatBN7.2 EnsemblX65,860,289 - 65,910,322 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105108   ⟹   ENSRNOP00000087105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX69,900,003 - 69,950,696 (+)Ensembl
mRatBN7.2 EnsemblX65,860,172 - 65,910,322 (+)Ensembl
RefSeq Acc Id: NM_031639   ⟹   NP_113827
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,900,003 - 69,950,696 (+)NCBI
mRatBN7.2X65,859,947 - 65,910,655 (+)NCBI
Rnor_6.0X70,596,577 - 70,647,298 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
RGSC_v3.4X88,777,585 - 88,828,504 (+)RGD
CeleraX66,218,231 - 66,268,819 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257080   ⟹   XP_006257142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,899,736 - 69,951,928 (+)NCBI
mRatBN7.2X65,859,698 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,251 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257081   ⟹   XP_006257143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,899,738 - 69,951,928 (+)NCBI
mRatBN7.2X65,859,700 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,253 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257082   ⟹   XP_006257144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,899,739 - 69,951,928 (+)NCBI
mRatBN7.2X65,859,701 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,246 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257083   ⟹   XP_006257145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,899,740 - 69,951,928 (+)NCBI
mRatBN7.2X65,859,703 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,249 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257084   ⟹   XP_006257146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,906,719 - 69,951,928 (+)NCBI
mRatBN7.2X65,866,946 - 65,911,887 (+)NCBI
Rnor_6.0X70,603,571 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257085   ⟹   XP_006257147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,909,455 - 69,951,928 (+)NCBI
mRatBN7.2X65,869,471 - 65,911,887 (+)NCBI
Rnor_6.0X70,605,385 - 70,648,529 (+)NCBI
Rnor_5.0X71,468,290 - 71,520,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773267   ⟹   XP_008771489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,899,735 - 69,951,928 (+)NCBI
mRatBN7.2X65,859,697 - 65,911,887 (+)NCBI
Rnor_6.0X70,596,249 - 70,648,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773268   ⟹   XP_008771490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,906,748 - 69,951,928 (+)NCBI
mRatBN7.2X65,866,828 - 65,911,887 (+)NCBI
Rnor_6.0X70,603,436 - 70,648,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063280267   ⟹   XP_063136337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,899,740 - 69,951,928 (+)NCBI
RefSeq Acc Id: XM_063280268   ⟹   XP_063136338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,899,694 - 69,945,862 (+)NCBI
RefSeq Acc Id: XM_063280269   ⟹   XP_063136339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,907,000 - 69,951,928 (+)NCBI
RefSeq Acc Id: XM_063280270   ⟹   XP_063136340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,909,520 - 69,951,928 (+)NCBI
RefSeq Acc Id: XM_063280271   ⟹   XP_063136341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,909,520 - 69,951,928 (+)NCBI
RefSeq Acc Id: NP_113827   ⟸   NM_031639
- UniProtKB: P70547 (UniProtKB/Swiss-Prot),   Q62936 (UniProtKB/Swiss-Prot),   A6IQ92 (UniProtKB/TrEMBL),   A0A8I6A7U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257142   ⟸   XM_006257080
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0Y9 (UniProtKB/TrEMBL),   A0A8I5Y1U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257143   ⟸   XM_006257081
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y1U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257144   ⟸   XM_006257082
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A7U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257145   ⟸   XM_006257083
- Peptide Label: isoform X6
- UniProtKB: A0A096MJ42 (UniProtKB/TrEMBL),   A0A8I6ATE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257146   ⟸   XM_006257084
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZLU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257147   ⟸   XM_006257085
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_008771489   ⟸   XM_008773267
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y1U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771490   ⟸   XM_008773268
- Peptide Label: isoform X10
- Sequence:
Ensembl Acc Id: ENSRNOP00000047310   ⟸   ENSRNOT00000045082
Ensembl Acc Id: ENSRNOP00000071634   ⟸   ENSRNOT00000088114
Ensembl Acc Id: ENSRNOP00000067983   ⟸   ENSRNOT00000076079
Ensembl Acc Id: ENSRNOP00000003741   ⟸   ENSRNOT00000003741
Ensembl Acc Id: ENSRNOP00000068233   ⟸   ENSRNOT00000076456
Ensembl Acc Id: ENSRNOP00000096478   ⟸   ENSRNOT00000099103
Ensembl Acc Id: ENSRNOP00000087105   ⟸   ENSRNOT00000105108
RefSeq Acc Id: XP_063136338   ⟸   XM_063280268
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063136337   ⟸   XM_063280267
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ATE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136339   ⟸   XM_063280269
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063136340   ⟸   XM_063280270
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063136341   ⟸   XM_063280271
- Peptide Label: isoform X12
Protein Domains
Guanylate kinase-like   PDZ   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62936-F1-model_v2 AlphaFold Q62936 1-849 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701870
Promoter ID:EPDNEW_R12392
Type:multiple initiation site
Name:Dlg3_1
Description:discs large MAGUK scaffold protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X70,596,588 - 70,596,648EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68423 AgrOrtholog
BioCyc Gene G2FUF-2122 BioCyc
Ensembl Genes ENSRNOG00000002767 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003741 ENTREZGENE
  ENSRNOT00000003741.7 UniProtKB/Swiss-Prot
  ENSRNOT00000045082 ENTREZGENE
  ENSRNOT00000045082.7 UniProtKB/Swiss-Prot
  ENSRNOT00000076079 ENTREZGENE
  ENSRNOT00000076450 ENTREZGENE
  ENSRNOT00000076503 ENTREZGENE
  ENSRNOT00000088114 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  Guanylate Kinase phosphate binding domain UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro DLG1-like UniProtKB/Swiss-Prot
  DLG1_PEST_dom UniProtKB/Swiss-Prot
  DLG3_SH3 UniProtKB/Swiss-Prot
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot
  Guanylate_kinase_CS UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_assoc UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Synaptic_Scaffolding_LAP-MAGUK UniProtKB/Swiss-Prot
KEGG Report rno:58948 UniProtKB/Swiss-Prot
NCBI Gene 58948 ENTREZGENE
PANTHER DISCS LARGE UniProtKB/Swiss-Prot
  DISKS LARGE HOMOLOG 3 UniProtKB/Swiss-Prot
Pfam Guanylate_kin UniProtKB/Swiss-Prot
  MAGUK_N_PEST UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_assoc UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Dlg3 PhenoGen
PIRSF MAGUK_DLGH UniProtKB/Swiss-Prot
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002767 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot
  MAGUK_N_PEST UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
TIGR TC218155
UniProt A0A096MJ42 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K0Y9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y1U1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLU7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7U5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATE5 ENTREZGENE, UniProtKB/TrEMBL
  A6IQ92 ENTREZGENE, UniProtKB/TrEMBL
  DLG3_RAT UniProtKB/Swiss-Prot
  P70547 ENTREZGENE
  Q62936 ENTREZGENE
UniProt Secondary P70547 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Dlg3  discs large MAGUK scaffold protein 3  Dlg3  discs large homolog 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Dlg3  discs large homolog 3  Dlg3  discs, large homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Dlg3  discs, large homolog 3 (Drosophila)  Dlgh3  discs, large homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dlgh3  discs, large homolog 3 (Drosophila)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference