Dpp6 (dipeptidyl peptidase like 6) - Rat Genome Database

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Pathways
Gene: Dpp6 (dipeptidyl peptidase like 6) Rattus norvegicus
Analyze
Symbol: Dpp6
Name: dipeptidyl peptidase like 6
RGD ID: 68402
Description: Predicted to enable potassium channel regulator activity. Involved in positive regulation of potassium ion transport and positive regulation of protein localization to plasma membrane. Located in cell surface and neuronal cell body. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6); INTERACTS WITH alpha-Zearalanol; atrazine; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A-type potassium channel modulatory protein DPP6; dipeptidyl aminopeptidase-like protein 6; dipeptidyl aminopeptidase-related protein; dipeptidyl peptidase IV-like protein; dipeptidyl peptidase VI; dipeptidylpeptidase 6; dipeptidylpeptidase VI; DPP VI; DPPX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr848,323,220 - 9,242,694 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl48,324,843 - 9,242,209 (-)EnsemblGRCr8
mRatBN7.247,589,386 - 8,508,666 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl47,591,009 - 8,508,532 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx412,601,019 - 13,257,605 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.048,415,266 - 9,071,862 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.046,761,456 - 7,425,308 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.044,021,021 - 4,943,675 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl44,021,008 - 4,473,307 (-)Ensemblrn6Rnor6.0
Rnor_5.044,060,496 - 4,970,129 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.442,853,479 - 3,565,666 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera42,039,300 - 2,691,360 (+)NCBICelera
RGSC_v3.142,853,478 - 3,565,666 (-)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. Alders M, etal., Am J Hum Genet. 2009 Apr;84(4):468-76. Epub 2009 Mar 12.
2. DPP6 gene variability confers increased risk of developing sporadic amyotrophic lateral sclerosis in Italian patients. Del Bo R, etal., J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1085.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein. Kin Y, etal., J Biochem. 2001 Feb;129(2):289-95.
5. Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients. Li XG, etal., Chin Med J (Engl). 2009 Dec 20;122(24):2989-92.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. Nadal MS, etal., Neuron. 2003 Feb 6;37(3):449-61.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Dpp6 is associated with susceptibility to progressive spinal muscular atrophy. van Es MA, etal., Neurology. 2009 Mar 31;72(13):1184-5.
14. Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. Wada K, etal., Proc Natl Acad Sci U S A 1992 Jan 1;89(1):197-201.
15. DPP10 modulates Kv4-mediated A-type potassium channels. Zagha E, etal., J Biol Chem. 2005 May 13;280(19):18853-61. Epub 2005 Jan 25.
Additional References at PubMed
PMID:8103397   PMID:18364354   PMID:19713751   PMID:20573902   PMID:21700703   PMID:21943606   PMID:22311982   PMID:22675523   PMID:23376485   PMID:23912628   PMID:24225951  


Genomics

Comparative Map Data
Dpp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr848,323,220 - 9,242,694 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl48,324,843 - 9,242,209 (-)EnsemblGRCr8
mRatBN7.247,589,386 - 8,508,666 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl47,591,009 - 8,508,532 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx412,601,019 - 13,257,605 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.048,415,266 - 9,071,862 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.046,761,456 - 7,425,308 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.044,021,021 - 4,943,675 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl44,021,008 - 4,473,307 (-)Ensemblrn6Rnor6.0
Rnor_5.044,060,496 - 4,970,129 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.442,853,479 - 3,565,666 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera42,039,300 - 2,691,360 (+)NCBICelera
RGSC_v3.142,853,478 - 3,565,666 (-)NCBI
Cytogenetic Map4q11NCBI
DPP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387153,748,133 - 154,894,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7153,748,133 - 154,894,285 (+)Ensemblhg38GRCh38
GRCh377153,445,218 - 154,685,995 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367153,380,710 - 153,894,933 (+)NCBIBuild 36Build 36hg18NCBI36
Build 367154,060,464 - 154,316,928 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347153,867,178 - 154,122,809NCBI
Celera7148,318,756 - 148,319,129 (-)NCBICelera
Celera7148,524,570 - 149,103,154 (+)NCBICelera
Cytogenetic Map7q36.2NCBI
HuRef7148,164,313 - 148,419,023 (+)NCBIHuRef
HuRef7147,843,601 - 148,104,076 (+)NCBIHuRef
HuRef7147,386,496 - 147,386,897 (+)NCBIHuRef
CHM1_17154,437,907 - 154,692,518 (+)NCBICHM1_1
CHM1_17153,592,891 - 154,272,396 (+)NCBICHM1_1
T2T-CHM13v2.07154,922,684 - 156,069,555 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27152,913,032 - 153,914,021 (+)NCBI
Dpp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39527,022,355 - 27,932,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl527,022,201 - 27,932,503 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38526,817,357 - 27,727,500 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl526,817,203 - 27,727,505 (+)Ensemblmm10GRCm38
MGSCv37527,143,897 - 28,054,040 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36527,148,144 - 28,057,245 (+)NCBIMGSCv36mm8
Celera524,366,865 - 25,273,913 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map512.92NCBI
Dpp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554917,326,138 - 8,168,270 (+)Ensembl
ChiLan1.0NW_0049554917,325,720 - 8,167,949 (+)NCBIChiLan1.0ChiLan1.0
DPP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26190,320,559 - 191,318,987 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1742,330,825 - 43,329,253 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07145,356,340 - 146,492,773 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17157,635,454 - 158,220,345 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7157,635,828 - 158,220,345 (+)EnsemblpanPan2panpan1.1
DPP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11617,357,461 - 18,043,547 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1617,357,522 - 18,041,822 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1617,836,985 - 18,676,560 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01618,946,820 - 19,772,122 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1618,947,086 - 19,772,116 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11617,458,435 - 18,143,487 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01617,898,790 - 18,723,713 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01617,951,354 - 18,776,429 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dpp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051183,479,982 - 4,328,689 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365278,574,849 - 9,421,763 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365278,574,455 - 9,423,445 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl183,148,483 - 4,054,118 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1183,148,479 - 3,905,845 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2183,287,948 - 3,570,413 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DPP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121121,882,842 - 123,035,787 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21122,441,548 - 123,035,792 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607218,290,133 - 19,155,278 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248002,725,253 - 3,585,409 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248002,725,353 - 3,585,987 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dpp6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16155,723,156 - 156,600,570 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dpp6
8579 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:64
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000045773
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat

Markers in Region
D4Rat4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr848,669,431 - 8,669,604 (+)Marker Load Pipeline
mRatBN7.247,935,610 - 7,935,781 (+)MAPPERmRatBN7.2
Rnor_6.044,364,715 - 4,364,885NCBIRnor6.0
Rnor_5.044,400,414 - 4,400,584UniSTSRnor5.0
RGSC_v3.443,237,191 - 3,237,361UniSTSRGSC3.4
RGSC_v3.443,237,190 - 3,237,361RGDRGSC3.4
Celera42,359,289 - 2,359,459UniSTS
RGSC_v3.143,237,190 - 3,237,361RGD
RH 2.0 Map40.0RGD
SHRSP x BN Map40.04RGD
FHH x ACI Map41.1801RGD
Cytogenetic Map4q11UniSTS
D4Rat139  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr848,495,818 - 8,495,955 (+)Marker Load Pipeline
mRatBN7.247,761,995 - 7,762,132 (+)MAPPERmRatBN7.2
Rnor_6.044,193,723 - 4,193,859NCBIRnor6.0
Rnor_5.044,230,992 - 4,231,128UniSTSRnor5.0
RGSC_v3.443,037,683 - 3,037,822RGDRGSC3.4
RGSC_v3.443,037,684 - 3,037,822UniSTSRGSC3.4
Celera42,523,609 - 2,523,747UniSTS
RGSC_v3.143,037,683 - 3,037,822RGD
RH 2.0 Map40.0RGD
SHRSP x BN Map40.0RGD
FHH x ACI Map41.3201RGD
Cytogenetic Map4q11UniSTS
D4Arb13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr848,606,734 - 8,606,887 (+)Marker Load Pipeline
mRatBN7.247,872,913 - 7,873,066 (+)MAPPERmRatBN7.2
Rnor_6.044,303,215 - 4,303,367NCBIRnor6.0
Rnor_5.044,338,454 - 4,338,606UniSTSRnor5.0
RGSC_v3.443,171,646 - 3,171,798UniSTSRGSC3.4
RGSC_v3.443,171,645 - 3,171,798RGDRGSC3.4
RGSC_v3.143,171,645 - 3,171,798RGD
RH 2.0 Map40.0RGD
SHRSP x BN Map40.08RGD
FHH x ACI Map41.3201RGD
Cytogenetic Map4q11UniSTS
D4Rat249  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr848,410,602 - 8,410,838 (+)Marker Load Pipeline
mRatBN7.247,676,771 - 7,677,007 (+)MAPPERmRatBN7.2
Rnor_6.044,108,269 - 4,108,504NCBIRnor6.0
Rnor_5.044,146,198 - 4,146,433UniSTSRnor5.0
RGSC_v3.442,938,590 - 2,938,825UniSTSRGSC3.4
RGSC_v3.442,938,589 - 2,938,825RGDRGSC3.4
Celera42,607,516 - 2,607,741UniSTS
RGSC_v3.142,938,247 - 2,938,852RGD
SHRSP x BN Map40.08RGD
SHRSP x BN Map40.08UniSTS
Cytogenetic Map4q11UniSTS
D4Got1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,949,085 - 7,949,208 (+)MAPPERmRatBN7.2
Rnor_6.044,377,736 - 4,377,858NCBIRnor6.0
Rnor_5.044,413,435 - 4,413,557UniSTSRnor5.0
RGSC_v3.443,250,662 - 3,250,785RGDRGSC3.4
RGSC_v3.443,250,663 - 3,250,785UniSTSRGSC3.4
Celera42,345,864 - 2,345,986UniSTS
RGSC_v3.143,250,662 - 3,250,785RGD
RH 2.0 Map40.0RGD
Cytogenetic Map4q11UniSTS
D4Got2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,810,244 - 7,810,377 (+)MAPPERmRatBN7.2
Rnor_6.044,241,885 - 4,242,017NCBIRnor6.0
Rnor_5.044,278,372 - 4,278,504UniSTSRnor5.0
RGSC_v3.443,086,917 - 3,087,050RGDRGSC3.4
RGSC_v3.443,086,918 - 3,087,050UniSTSRGSC3.4
Celera42,480,994 - 2,481,116UniSTS
RGSC_v3.143,086,917 - 3,087,050RGD
Cytogenetic Map4q11UniSTS
D4Got5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.248,253,041 - 8,253,170 (+)MAPPERmRatBN7.2
Rnor_6.044,682,158 - 4,682,284NCBIRnor6.0
Rnor_5.044,715,990 - 4,716,116UniSTSRnor5.0
RGSC_v3.443,557,260 - 3,557,387RGDRGSC3.4
RGSC_v3.443,557,261 - 3,557,387UniSTSRGSC3.4
Celera42,047,591 - 2,047,717UniSTS
RGSC_v3.143,557,260 - 3,557,387RGD
Cytogenetic Map4q11UniSTS
D4Got200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.248,203,532 - 8,203,701 (+)MAPPERmRatBN7.2
Rnor_6.044,632,646 - 4,632,814NCBIRnor6.0
Rnor_5.044,666,478 - 4,666,646UniSTSRnor5.0
RGSC_v3.443,507,913 - 3,508,081UniSTSRGSC3.4
Celera42,097,062 - 2,097,230UniSTS
Cytogenetic Map4q11UniSTS
D5Jcs89  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.248,259,413 - 8,259,550 (+)MAPPERmRatBN7.2
Rnor_6.044,688,524 - 4,688,660NCBIRnor6.0
Rnor_5.044,722,356 - 4,722,492UniSTSRnor5.0
RGSC_v3.443,563,627 - 3,563,763UniSTSRGSC3.4
Cytogenetic Map4q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 13 63 208 77 76 45 55 45 6 310 159 20 175 85 110 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000045773   ⟹   ENSRNOP00000043113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl48,324,843 - 8,777,073 (-)Ensembl
mRatBN7.2 Ensembl47,591,009 - 8,043,248 (-)Ensembl
Rnor_6.0 Ensembl44,021,008 - 4,473,307 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093848   ⟹   ENSRNOP00000080741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl48,324,843 - 9,138,504 (-)Ensembl
mRatBN7.2 Ensembl47,591,009 - 8,508,532 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108476   ⟹   ENSRNOP00000084952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl48,324,843 - 8,995,073 (-)Ensembl
mRatBN7.2 Ensembl47,591,009 - 8,261,470 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117212   ⟹   ENSRNOP00000080650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl48,324,843 - 9,242,209 (-)Ensembl
mRatBN7.2 Ensembl47,591,009 - 8,508,532 (-)Ensembl
RefSeq Acc Id: NM_022850   ⟹   NP_074041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr848,324,843 - 8,995,269 (-)NCBI
mRatBN7.247,591,009 - 8,261,452 (-)NCBI
Rnor_6.044,022,644 - 4,690,562 (-)NCBI
Rnor_5.044,060,496 - 4,970,129 (-)NCBI
RGSC_v3.442,853,479 - 3,565,666 (-)RGD
Celera42,039,300 - 2,691,360 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235880   ⟹   XP_006235942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr848,323,220 - 8,777,737 (-)NCBI
mRatBN7.247,589,386 - 8,043,973 (-)NCBI
Rnor_6.044,021,021 - 4,475,326 (-)NCBI
Rnor_5.044,060,496 - 4,970,129 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592501   ⟹   XP_017447990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr848,323,220 - 9,242,694 (-)NCBI
mRatBN7.247,589,386 - 8,508,666 (-)NCBI
Rnor_6.044,021,021 - 4,943,675 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592503   ⟹   XP_017447992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr848,323,220 - 9,139,505 (-)NCBI
mRatBN7.247,589,386 - 8,405,388 (-)NCBI
Rnor_6.044,021,021 - 4,837,007 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592504   ⟹   XP_017447993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr848,323,220 - 8,834,503 (-)NCBI
mRatBN7.247,589,386 - 8,100,391 (-)NCBI
Rnor_6.044,021,021 - 4,529,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285681   ⟹   XP_063141751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr848,392,968 - 9,002,343 (-)NCBI
RefSeq Acc Id: XM_063285682   ⟹   XP_063141752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr848,392,968 - 8,777,781 (-)NCBI
RefSeq Acc Id: NP_074041   ⟸   NM_022850
- UniProtKB: P46101 (UniProtKB/Swiss-Prot),   A0A8I6A0E2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235942   ⟸   XM_006235880
- Peptide Label: isoform X2
- UniProtKB: F1LMR7 (UniProtKB/TrEMBL),   A6KJK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447990   ⟸   XM_017592501
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQR2 (UniProtKB/TrEMBL),   A6KJK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447992   ⟸   XM_017592503
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZR04 (UniProtKB/TrEMBL),   A6KJK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447993   ⟸   XM_017592504
- Peptide Label: isoform X4
- UniProtKB: A6KJK3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043113   ⟸   ENSRNOT00000045773
Ensembl Acc Id: ENSRNOP00000084952   ⟸   ENSRNOT00000108476
Ensembl Acc Id: ENSRNOP00000080741   ⟸   ENSRNOT00000093848
Ensembl Acc Id: ENSRNOP00000080650   ⟸   ENSRNOT00000117212
RefSeq Acc Id: XP_063141751   ⟸   XM_063285681
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063141752   ⟸   XM_063285682
- Peptide Label: isoform X6
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46101-F1-model_v2 AlphaFold P46101 1-859 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68402 AgrOrtholog
BioCyc Gene G2FUF-46123 BioCyc
Ensembl Genes ENSRNOG00000030547 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000045773 ENTREZGENE
  ENSRNOT00000093848 ENTREZGENE
  ENSRNOT00000108476 ENTREZGENE
  ENSRNOT00000117212 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
  Dipeptidylpeptidase IV, N-terminal domain UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Peptidase_S9 UniProtKB/Swiss-Prot
  Peptidase_S9B_N UniProtKB/Swiss-Prot
  Serine_Prot_S9B/DPPIV_sf UniProtKB/Swiss-Prot
KEGG Report rno:29272 UniProtKB/Swiss-Prot
NCBI Gene 29272 ENTREZGENE
PANTHER DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6 UniProtKB/Swiss-Prot
  PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED UniProtKB/Swiss-Prot
Pfam DPPIV_N UniProtKB/Swiss-Prot
  Peptidase_S9 UniProtKB/Swiss-Prot
PhenoGen Dpp6 PhenoGen
RatGTEx ENSRNOG00000030547 RatGTEx
Superfamily-SCOP DPP6 N-terminal domain-like UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
TIGR TC239089
UniProt A0A8I5ZQR2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZR04 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0E2 ENTREZGENE, UniProtKB/TrEMBL
  A6KJK2_RAT UniProtKB/TrEMBL
  A6KJK3 ENTREZGENE, UniProtKB/TrEMBL
  A6KJK4_RAT UniProtKB/TrEMBL
  A6KJK5_RAT UniProtKB/TrEMBL
  A6KJK6_RAT UniProtKB/TrEMBL
  DPP6_RAT UniProtKB/Swiss-Prot
  F1LMR7 ENTREZGENE, UniProtKB/TrEMBL
  P46101 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Dpp6  dipeptidyl peptidase like 6  Dpp6  dipeptidylpeptidase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Dpp6  dipeptidyl peptidase like 6  Dpp6  dipeptidyl peptidase like 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dpp6  dipeptidylpeptidase 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in brain 68240