Dpys (dihydropyrimidinase) - Rat Genome Database

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Gene: Dpys (dihydropyrimidinase) Rattus norvegicus
Analyze
Symbol: Dpys
Name: dihydropyrimidinase
RGD ID: 68376
Description: Enables several functions, including dihydropyrimidinase activity; pyrimidine nucleobase binding activity; and zinc ion binding activity. Involved in beta-alanine metabolic process and nucleobase-containing small molecule metabolic process. Part of protein-containing complex. Is active in cytosol. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase); PARTICIPATES IN pyrimidine metabolic pathway; beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DHP; DHPase; dihydropyrimidine amidohydrolase; hydantoinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8772,707,566 - 72,814,183 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl772,721,048 - 72,814,142 (-)EnsemblGRCr8
mRatBN7.2770,822,648 - 70,929,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl770,835,789 - 70,929,231 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx772,734,091 - 72,812,164 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0774,936,581 - 75,014,645 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0774,804,671 - 74,882,740 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0778,769,918 - 78,847,941 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl778,769,807 - 78,847,974 (-)Ensemblrn6Rnor6.0
Rnor_5.0778,796,405 - 78,873,615 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4775,368,238 - 75,446,160 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera767,904,867 - 67,982,691 (-)NCBICelera
RGSC_v3.1775,449,118 - 75,466,890 (-)NCBI
Cytogenetic Map7q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
allopurinol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (ISO)
diquat  (ISO)
endosulfan  (EXP)
glafenine  (EXP)
gliotoxin  (EXP)
graphite  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sulindac  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,IEA,ISO)
protein-containing complex  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene. Hamajima N, etal., Am J Hum Genet. 1998 Sep;63(3):717-26.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Purification, characterization and inhibition of dihydropyrimidinase from rat liver. Kikugawa M, etal., Eur J Biochem. 1994 Jan 15;219(1-2):393-9.
6. Molecular cloning and sequencing of a cDNA encoding dihydropyrimidinase from the rat liver. Matsuda K, etal., Biochim Biophys Acta 1996 Jun 7;1307(2):140-4.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC 3.5.2.2). Tamaki N, etal., Br J Nutr. 1995 May;73(5):711-22.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10410956   PMID:10956643   PMID:15489334   PMID:18075467   PMID:19056867   PMID:23376485  


Genomics

Comparative Map Data
Dpys
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8772,707,566 - 72,814,183 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl772,721,048 - 72,814,142 (-)EnsemblGRCr8
mRatBN7.2770,822,648 - 70,929,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl770,835,789 - 70,929,231 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx772,734,091 - 72,812,164 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0774,936,581 - 75,014,645 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0774,804,671 - 74,882,740 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0778,769,918 - 78,847,941 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl778,769,807 - 78,847,974 (-)Ensemblrn6Rnor6.0
Rnor_5.0778,796,405 - 78,873,615 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4775,368,238 - 75,446,160 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera767,904,867 - 67,982,691 (-)NCBICelera
RGSC_v3.1775,449,118 - 75,466,890 (-)NCBI
Cytogenetic Map7q31NCBI
DPYS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388104,379,431 - 104,467,055 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8104,329,333 - 104,467,111 (-)Ensemblhg38GRCh38
GRCh378105,391,659 - 105,479,283 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368105,460,829 - 105,548,453 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348105,460,828 - 105,548,453NCBI
Celera8101,578,319 - 101,665,933 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef8100,592,683 - 100,680,266 (-)NCBIHuRef
CHM1_18105,432,468 - 105,520,073 (-)NCBICHM1_1
T2T-CHM13v2.08105,506,922 - 105,594,550 (-)NCBIT2T-CHM13v2.0
Dpys
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391539,631,881 - 39,720,866 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1539,631,883 - 39,720,866 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381539,768,485 - 39,857,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,768,487 - 39,857,470 (-)Ensemblmm10GRCm38
MGSCv371539,600,031 - 39,689,016 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361539,598,559 - 39,687,541 (-)NCBIMGSCv36mm8
Celera1540,252,611 - 40,341,397 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.53NCBI
Dpys
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541728,185,407 - 28,244,307 (-)Ensembl
ChiLan1.0NW_00495541728,183,771 - 28,244,309 (-)NCBIChiLan1.0ChiLan1.0
DPYS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27121,730,892 - 121,819,525 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1897,202,305 - 97,342,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08101,008,090 - 101,096,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18103,160,922 - 103,248,303 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8103,160,922 - 103,248,303 (-)EnsemblpanPan2panpan1.1
DPYS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1135,583,795 - 5,659,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha135,591,294 - 5,668,125 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0135,831,073 - 5,907,171 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl135,831,081 - 5,907,175 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1135,599,335 - 5,675,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0135,718,958 - 5,795,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0135,740,684 - 5,816,800 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dpys
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530332,138,098 - 32,211,295 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647039,564,335 - 39,637,544 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647039,564,431 - 39,637,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl432,789,460 - 32,879,489 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1432,791,152 - 32,879,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2435,528,834 - 35,616,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1899,216,623 - 99,303,969 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl899,216,354 - 99,303,282 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603941,267,984 - 41,354,516 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpys
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476320,620,380 - 20,680,782 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476320,618,515 - 20,680,790 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dpys
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11213,109,739 - 213,184,517 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dpys
782 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:43
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000006004
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH137692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2770,851,376 - 70,851,545 (+)MAPPERmRatBN7.2
Rnor_6.0778,770,063 - 78,770,231NCBIRnor6.0
Rnor_5.0778,796,550 - 78,796,718UniSTSRnor5.0
RGSC_v3.4775,368,383 - 75,368,551UniSTSRGSC3.4
Celera767,905,012 - 67,905,180UniSTS
RH 3.4 Map7630.4UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 8 12 106 82 85 59 25 59 5 202 52 1 91 77 52 26 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000006004   ⟹   ENSRNOP00000006004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl772,736,150 - 72,814,142 (-)Ensembl
mRatBN7.2 Ensembl770,851,232 - 70,929,231 (-)Ensembl
Rnor_6.0 Ensembl778,769,807 - 78,847,974 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120199   ⟹   ENSRNOP00000093000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl772,721,048 - 72,814,142 (-)Ensembl
mRatBN7.2 Ensembl770,835,789 - 70,929,231 (-)Ensembl
RefSeq Acc Id: NM_031705   ⟹   NP_113893
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8772,736,150 - 72,814,136 (-)NCBI
mRatBN7.2770,851,232 - 70,929,225 (-)NCBI
Rnor_6.0778,769,918 - 78,847,941 (-)NCBI
Rnor_5.0778,796,405 - 78,873,615 (-)NCBI
RGSC_v3.4775,368,238 - 75,446,160 (-)RGD
Celera767,904,867 - 67,982,691 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079859   ⟹   XP_038935787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8772,736,149 - 72,814,183 (-)NCBI
mRatBN7.2770,851,223 - 70,929,255 (-)NCBI
RefSeq Acc Id: XM_039079861   ⟹   XP_038935789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8772,707,566 - 72,814,183 (-)NCBI
mRatBN7.2770,822,648 - 70,929,255 (-)NCBI
RefSeq Acc Id: XM_039079862   ⟹   XP_038935790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8772,707,566 - 72,814,183 (-)NCBI
mRatBN7.2770,822,650 - 70,929,255 (-)NCBI
RefSeq Acc Id: NP_113893   ⟸   NM_031705
- UniProtKB: Q63150 (UniProtKB/Swiss-Prot),   Q642F0 (UniProtKB/Swiss-Prot),   A6HR83 (UniProtKB/TrEMBL),   A0A8I6AEZ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006004   ⟸   ENSRNOT00000006004
RefSeq Acc Id: XP_038935789   ⟸   XM_039079861
- Peptide Label: isoform X1
- UniProtKB: Q63150 (UniProtKB/Swiss-Prot),   Q642F0 (UniProtKB/Swiss-Prot),   A6HR83 (UniProtKB/TrEMBL),   A0A8I6AEZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935790   ⟸   XM_039079862
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AEZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935787   ⟸   XM_039079859
- Peptide Label: isoform X1
- UniProtKB: Q63150 (UniProtKB/Swiss-Prot),   Q642F0 (UniProtKB/Swiss-Prot),   A6HR83 (UniProtKB/TrEMBL),   A0A8I6AEZ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093000   ⟸   ENSRNOT00000120199
Protein Domains
Amidohydrolase-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63150-F1-model_v2 AlphaFold Q63150 1-519 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695309
Promoter ID:EPDNEW_R5834
Type:multiple initiation site
Name:Dpys_1
Description:dihydropyrimidinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0778,847,962 - 78,848,022EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68376 AgrOrtholog
BioCyc Gene G2FUF-33568 BioCyc
BioCyc Pathway PWY-3982 [uracil degradation I (reductive)] BioCyc
  PWY-6430 [thymine degradation] BioCyc
BioCyc Pathway Image PWY-3982 BioCyc
  PWY-6430 BioCyc
Ensembl Genes ENSRNOG00000004298 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006004 ENTREZGENE
  ENSRNOT00000006004.4 UniProtKB/Swiss-Prot
  ENSRNOT00000120199 ENTREZGENE
Gene3D-CATH 2.30.40.10 UniProtKB/Swiss-Prot
  Metal-dependent hydrolases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107549 IMAGE-MGC_LOAD
InterPro Amidohydro-rel UniProtKB/Swiss-Prot
  Hydantoinase/dihydroPyrase UniProtKB/Swiss-Prot
  Metal-dep_hydrolase_composite UniProtKB/Swiss-Prot
  Metal_Hydrolase UniProtKB/Swiss-Prot
  Metallo-dep_Hydrolases_sf UniProtKB/Swiss-Prot
KEGG Report rno:65135 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93342 IMAGE-MGC_LOAD
NCBI Gene 65135 ENTREZGENE
PANTHER DIHYDROPYRIMIDINASE UniProtKB/Swiss-Prot
  HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam Amidohydro_1 UniProtKB/Swiss-Prot
PharmGKB DPYS RGD
PhenoGen Dpys PhenoGen
RatGTEx ENSRNOG00000004298 RatGTEx
Superfamily-SCOP SSF51338 UniProtKB/Swiss-Prot
  SSF51556 UniProtKB/Swiss-Prot
TIGR TC211118
UniProt A0A8I6AEZ1 ENTREZGENE, UniProtKB/TrEMBL
  A6HR83 ENTREZGENE, UniProtKB/TrEMBL
  DPYS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642F0 ENTREZGENE
UniProt Secondary Q642F0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dpys  dihydropyrimidinase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 519 amino acids; 56.8 kDa 68241