Sigmar1 (sigma non-opioid intracellular receptor 1) - Rat Genome Database

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Gene: Sigmar1 (sigma non-opioid intracellular receptor 1) Rattus norvegicus
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Symbol: Sigmar1
Name: sigma non-opioid intracellular receptor 1
RGD ID: 68364
Description: Enables G protein-coupled opioid receptor activity. Involved in several processes, including conditioned place preference; cyclooxygenase pathway; and negative regulation of nitric oxide biosynthetic process. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is active in glutamatergic synapse. Used to study post-traumatic stress disorder. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and autosomal recessive distal hereditary motor neuronopathy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: opioid receptor, sigma 1; Oprs1; sigma 1-type opioid receptor; sigma1-receptor; sigma1R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,700,021 - 61,702,799 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl561,700,021 - 61,702,855 (-)EnsemblGRCr8
mRatBN7.2556,904,155 - 56,907,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,904,159 - 56,907,017 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,883,693 - 58,886,471 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,702,523 - 60,705,301 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,688,434 - 60,691,212 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,121,824 - 58,124,687 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,121,786 - 58,124,681 (-)Ensemblrn6Rnor6.0
Rnor_5.0562,645,887 - 62,648,735 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4559,162,537 - 59,165,315 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera555,498,271 - 55,501,049 (-)NCBICelera
RGSC_v3.1559,162,715 - 59,165,489 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetylcholine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextromethorphan  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dimemorfan  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fentin chloride  (EXP)
ferrostatin-1  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
hydrogen cyanide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
linuron  (ISO)
manganese(II) chloride  (EXP)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
N-\{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl\}-N-propylpropan-1-amine hydrochloride  (EXP)
N-nitrosodiethylamine  (EXP)
ochratoxin A  (ISO)
okadaic acid  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
piperazines  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
SCH 23390  (ISO)
scopolamine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes. Alam S, etal., Biosci Rep. 2017 Jul 16;37(4):BSR20170898. doi: 10.1042/BSR20170898. Print 2017 Aug 31.
2. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Aydar E, etal., Neuron 2002 Apr 25;34(3):399-410.
3. Potent sigma1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine modulates basal and N-methyl-D-aspartate-evoked nitric oxide production in vivo. Bhardwaj A, etal., Stroke. 1998 Nov;29(11):2404-10; discussion 2411.
4. A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors. Bucolo C, etal., Eur J Pharmacol. 2006 Apr 24;536(1-2):200-3. doi: 10.1016/j.ejphar.2006.02.026. Epub 2006 Mar 6.
5. Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats. Feltmann K, etal., Alcohol Clin Exp Res. 2018 Feb;42(2):338-351. doi: 10.1111/acer.13568. Epub 2018 Jan 24.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Hayashi T and Su TP, Cell. 2007 Nov 2;131(3):596-610.
9. Sigma-1 receptor activation ameliorates anxiety-like behavior through NR2A-CREB-BDNF signaling pathway in a rat model submitted to single-prolonged stress. Ji LL, etal., Mol Med Rep. 2017 Oct;16(4):4987-4993. doi: 10.3892/mmr.2017.7185. Epub 2017 Aug 7.
10. Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Kourrich S, etal., Cell. 2013 Jan 17;152(1-2):236-47. doi: 10.1016/j.cell.2012.12.004.
11. Expression of sigma receptor 1 mRNA and protein in rat retina. Liu LL, etal., Neuroscience. 2010 Jun 2;167(4):1151-9. doi: 10.1016/j.neuroscience.2010.03.006. Epub 2010 Mar 9.
12. The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. Martin PM, etal., Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):66-75. doi: 10.1016/j.molbrainres.2003.12.019.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Functional polymorphisms in the sigma1 receptor gene associated with alcoholism. Miyatake R, etal., Biol Psychiatry. 2004 Jan 1;55(1):85-90. doi: 10.1016/j.biopsych.2003.07.008.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Cloning and functional characterization of a sigma receptor from rat brain. Seth P, etal., J Neurochem 1998 Mar;70(3):922-31.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants. Takebayashi M, etal., J Pharmacol Exp Ther 2002 Dec;303(3):1227-37.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway. Tsai SY, etal., Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22468-73. doi: 10.1073/pnas.0909089106. Epub 2009 Dec 11.
24. Effects of sub-chronic, in vivo administration of sigma non-opioid intracellular receptor 1 ligands on platelet and aortic arachidonate cascade in rats. Váczi S, etal., Eur J Pharmacol. 2022 Jun 15;925:174983. doi: 10.1016/j.ejphar.2022.174983. Epub 2022 Apr 27.
25. Cannabidiol attenuates methamphetamine-induced conditioned place preference via the Sigma1R/AKT/GSK-3β/CREB signaling pathway in rats. Yang G, etal., Toxicol Res (Camb). 2020 May 9;9(3):202-211. doi: 10.1093/toxres/tfaa021. eCollection 2020 Jun.
26. Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. Zhang H and Cuevas J, J Neurophysiol 2002 Jun;87(6):2867-79.
27. Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway. Zhang Y, etal., Pharm Biol. 2022 Dec;60(1):2145-2154. doi: 10.1080/13880209.2022.2136207.
Additional References at PubMed
PMID:9341151   PMID:10406945   PMID:10771347   PMID:11149946   PMID:11434908   PMID:11687279   PMID:11861817   PMID:12535781   PMID:14622179   PMID:15064136   PMID:15170821   PMID:15466698  
PMID:15489334   PMID:16522641   PMID:17545312   PMID:17964567   PMID:18641291   PMID:18723775   PMID:18946467   PMID:19213917   PMID:20167253   PMID:20404054   PMID:20732358   PMID:21314692  
PMID:21346735   PMID:21555866   PMID:21842496   PMID:21905129   PMID:22357973   PMID:22878224   PMID:23105111   PMID:23314020   PMID:23732704   PMID:23965801   PMID:24015960   PMID:24508523  
PMID:25273321   PMID:25848705   PMID:26031312   PMID:26234785   PMID:26792191   PMID:26860755   PMID:27042935   PMID:27339730   PMID:27373906   PMID:27735948   PMID:27761593   PMID:28286226  
PMID:28495886   PMID:28682953   PMID:28923416   PMID:29424796   PMID:29876881   PMID:29908082   PMID:30291362   PMID:31768847   PMID:32424233   PMID:33098515   PMID:33459966   PMID:34176868  
PMID:34767993   PMID:35922746   PMID:36707178   PMID:37922065   PMID:38141412   PMID:39138590  


Genomics

Comparative Map Data
Sigmar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,700,021 - 61,702,799 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl561,700,021 - 61,702,855 (-)EnsemblGRCr8
mRatBN7.2556,904,155 - 56,907,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,904,159 - 56,907,017 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,883,693 - 58,886,471 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,702,523 - 60,705,301 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,688,434 - 60,691,212 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,121,824 - 58,124,687 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,121,786 - 58,124,681 (-)Ensemblrn6Rnor6.0
Rnor_5.0562,645,887 - 62,648,735 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4559,162,537 - 59,165,315 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera555,498,271 - 55,501,049 (-)NCBICelera
RGSC_v3.1559,162,715 - 59,165,489 (-)NCBI
Cytogenetic Map5q22NCBI
SIGMAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,634,722 - 34,637,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,634,720 - 34,637,844 (-)Ensemblhg38GRCh38
GRCh37934,634,719 - 34,637,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,624,719 - 34,627,768 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34934,624,719 - 34,627,768NCBI
Celera934,566,222 - 34,569,271 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,589,001 - 34,592,050 (-)NCBIHuRef
CHM1_1934,634,494 - 34,637,538 (-)NCBICHM1_1
T2T-CHM13v2.0934,653,268 - 34,656,333 (-)NCBIT2T-CHM13v2.0
Sigmar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39441,738,493 - 41,741,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,738,493 - 41,756,157 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38441,738,493 - 41,741,359 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,738,493 - 41,756,157 (-)Ensemblmm10GRCm38
MGSCv37441,685,369 - 41,688,186 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36441,927,007 - 41,929,824 (-)NCBIMGSCv36mm8
Celera441,399,281 - 41,402,095 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.05NCBI
Sigmar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,493,896 - 1,496,377 (+)Ensembl
ChiLan1.0NW_0049554721,493,896 - 1,496,377 (+)NCBIChiLan1.0ChiLan1.0
SIGMAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,963,584 - 89,968,985 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,971,824 - 89,974,927 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,471,362 - 34,474,459 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,280,777 - 35,283,672 (-)NCBIPanPan1.1PanPan1.1panPan2
SIGMAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,310,672 - 51,313,426 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,311,085 - 51,313,400 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1149,939,025 - 49,941,785 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01152,251,407 - 52,254,167 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,251,413 - 52,311,364 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,914,114 - 50,916,874 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,782,279 - 50,785,039 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,547,030 - 51,549,790 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sigmar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,170,303 - 166,173,309 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,715,769 - 2,721,085 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,717,885 - 2,720,874 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIGMAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,160,822 - 32,164,718 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11032,160,767 - 32,163,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,303,067 - 36,305,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIGMAR1
(Chlorocebus sabaeus - green monkey)		 No map positions available.
Sigmar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473639,032,517 - 39,035,176 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473639,023,641 - 39,035,180 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sigmar1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v113,809,934 - 3,812,758 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sigmar1
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:182
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000019795
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH127340  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,904,340 - 56,904,520 (+)MAPPERmRatBN7.2
Rnor_6.0558,122,008 - 58,122,187NCBIRnor6.0
Rnor_5.0562,646,073 - 62,646,252UniSTSRnor5.0
RGSC_v3.4559,162,719 - 59,162,898UniSTSRGSC3.4
Celera555,498,453 - 55,498,632UniSTS
Cytogenetic Map5q22UniSTS
AF004927  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,904,493 - 56,904,582 (+)MAPPERmRatBN7.2
Rnor_6.0558,122,161 - 58,122,249NCBIRnor6.0
Rnor_5.0562,646,226 - 62,646,314UniSTSRnor5.0
RGSC_v3.4559,162,872 - 59,162,960UniSTSRGSC3.4
Celera555,498,606 - 55,498,694UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019795   ⟹   ENSRNOP00000019795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,700,021 - 61,702,799 (-)Ensembl
mRatBN7.2 Ensembl556,904,159 - 56,907,017 (-)Ensembl
Rnor_6.0 Ensembl558,121,786 - 58,124,681 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112379   ⟹   ENSRNOP00000094001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,700,870 - 61,702,855 (-)Ensembl
mRatBN7.2 Ensembl556,905,008 - 56,907,017 (-)Ensembl
RefSeq Acc Id: NM_030996   ⟹   NP_112258
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8561,700,021 - 61,702,799 (-)NCBI
mRatBN7.2556,904,159 - 56,906,937 (-)NCBI
Rnor_6.0558,121,826 - 58,124,604 (-)NCBI
Rnor_5.0562,645,887 - 62,648,735 (-)NCBI
RGSC_v3.4559,162,537 - 59,165,315 (-)RGD
Celera555,498,271 - 55,501,049 (-)RGD
Sequence:
RefSeq Acc Id: NP_112258   ⟸   NM_030996
- UniProtKB: Q9R1J7 (UniProtKB/Swiss-Prot),   Q9R0C9 (UniProtKB/Swiss-Prot),   Q9Z2W2 (UniProtKB/Swiss-Prot),   A6IIW9 (UniProtKB/TrEMBL),   A0A8I6AGV2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019795   ⟸   ENSRNOT00000019795
Ensembl Acc Id: ENSRNOP00000094001   ⟸   ENSRNOT00000112379

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0C9-F1-model_v2 AlphaFold Q9R0C9 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693657
Promoter ID:EPDNEW_R4182
Type:initiation region
Name:Sigmar1_1
Description:sigma non-opioid intracellular receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0558,124,610 - 58,124,670EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68364 AgrOrtholog
BioCyc Gene G2FUF-41543 BioCyc
Ensembl Genes ENSRNOG00000014604 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019795 ENTREZGENE
  ENSRNOT00000019795.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623693 IMAGE-MGC_LOAD
InterPro ERG2_sigma1_rcpt-like UniProtKB/Swiss-Prot
KEGG Report rno:29336 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72418 IMAGE-MGC_LOAD
NCBI Gene 29336 ENTREZGENE
PANTHER PTHR10868 UniProtKB/Swiss-Prot
  SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 UniProtKB/Swiss-Prot
Pfam ERG2_Sigma1R UniProtKB/Swiss-Prot
PhenoGen Sigmar1 PhenoGen
RatGTEx ENSRNOG00000014604 RatGTEx
TIGR TC217595
UniProt A0A8I6AGV2 ENTREZGENE, UniProtKB/TrEMBL
  A6IIW9 ENTREZGENE, UniProtKB/TrEMBL
  Q9R0C9 ENTREZGENE
  Q9R1J7 ENTREZGENE
  Q9Z2W2 ENTREZGENE
  SGMR1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9R1J7 UniProtKB/Swiss-Prot
  Q9Z2W2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Sigmar1  sigma non-opioid intracellular receptor 1  Oprs1  opioid receptor, sigma 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Oprs1  opioid receptor, sigma 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference