Pde1c (phosphodiesterase 1C) - Rat Genome Database

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Pathways
Gene: Pde1c (phosphodiesterase 1C) Rattus norvegicus
Analyze
Symbol: Pde1c
Name: phosphodiesterase 1C
RGD ID: 68332
Description: Enables cAMP binding activity; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within response to calcium ion. Located in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C); PARTICIPATES IN protein kinase A (PKA) signaling pathway; calcium/calcium-mediated signaling pathway; purine metabolic pathway; INTERACTS WITH alpha-Zearalanol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3',5'-cyclic-AMP phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; cam-PDE 1C; cyclic nucleotide phosphodiesterase 1 C; dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; phosphodiesterase 1C calmodulin-dependent (70kD)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8486,629,074 - 87,108,147 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl486,626,282 - 87,193,259 (-)EnsemblGRCr8
mRatBN7.2485,300,858 - 85,777,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl485,300,858 - 85,863,219 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx490,536,092 - 91,012,558 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0486,311,496 - 86,787,976 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0484,708,405 - 85,182,236 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0486,359,762 - 86,925,044 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl486,359,820 - 86,630,543 (-)Ensemblrn6Rnor6.0
Rnor_5.04151,012,195 - 151,485,775 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4484,936,642 - 85,448,339 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera480,156,679 - 80,622,825 (-)NCBICelera
RGSC_v3.1485,180,112 - 85,587,782 (-)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clothianidin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
Didecyldimethylammonium  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
fosinopril  (EXP)
genistein  (ISO)
glycidol  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Moniliformin  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
progesterone  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
testosterone enanthate  (EXP)
testosterone undecanoate  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. Santone R, etal., J Neurosci Res. 2006 Oct;84(5):1020-6.
10. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, etal., Biochem Pharmacol. 2008 Oct 1;76(7):884-93. Epub 2008 Jul 26.
11. Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Yan C, etal., Proc Natl Acad Sci U S A 1995 Oct 10;92(21):9677-81.
Additional References at PubMed
PMID:19305400   PMID:21148428   PMID:25608528   PMID:35538034  


Genomics

Comparative Map Data
Pde1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8486,629,074 - 87,108,147 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl486,626,282 - 87,193,259 (-)EnsemblGRCr8
mRatBN7.2485,300,858 - 85,777,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl485,300,858 - 85,863,219 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx490,536,092 - 91,012,558 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0486,311,496 - 86,787,976 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0484,708,405 - 85,182,236 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0486,359,762 - 86,925,044 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl486,359,820 - 86,630,543 (-)Ensemblrn6Rnor6.0
Rnor_5.04151,012,195 - 151,485,775 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4484,936,642 - 85,448,339 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera480,156,679 - 80,622,825 (-)NCBICelera
RGSC_v3.1485,180,112 - 85,587,782 (-)NCBI
Cytogenetic Map4q24NCBI
PDE1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38731,616,777 - 32,428,224 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl731,751,179 - 32,428,131 (-)Ensemblhg38GRCh38
GRCh37731,790,793 - 32,467,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36731,795,772 - 32,077,516 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34731,602,486 - 31,884,231NCBI
Celera731,779,557 - 32,325,238 (-)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef731,673,350 - 32,219,567 (-)NCBIHuRef
CHM1_1731,792,207 - 32,337,961 (-)NCBICHM1_1
T2T-CHM13v2.0731,754,475 - 32,567,499 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2731,840,922 - 32,386,609 (-)NCBI
Pde1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39656,046,783 - 56,629,590 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl656,046,789 - 56,629,472 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38656,069,798 - 56,652,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl656,069,804 - 56,652,487 (-)Ensemblmm10GRCm38
MGSCv37656,019,798 - 56,319,628 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36656,011,359 - 56,292,097 (-)NCBIMGSCv36mm8
Celera660,236,120 - 60,238,326 (-)NCBICelera
Celera656,847,453 - 57,126,888 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.65NCBI
Pde1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541032,792,649 - 33,257,291 (-)Ensembl
ChiLan1.0NW_00495541032,790,720 - 33,257,760 (-)NCBIChiLan1.0ChiLan1.0
PDE1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2636,436,114 - 37,235,708 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1784,760,632 - 85,560,321 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0732,225,293 - 33,037,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1732,477,361 - 33,030,078 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl732,343,701 - 33,029,405 (-)EnsemblpanPan2panpan1.1
PDE1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11444,250,612 - 44,543,818 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1444,145,534 - 44,644,937 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1443,683,659 - 44,165,857 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01444,194,159 - 44,675,717 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1444,193,155 - 44,675,842 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11444,315,468 - 44,607,684 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,982,193 - 44,460,807 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01444,346,723 - 44,834,997 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pde1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511888,688,701 - 89,286,505 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364787,900,432 - 8,393,631 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364787,900,432 - 8,499,300 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1840,820,644 - 41,409,087 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11840,818,316 - 41,410,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PDE1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12126,094,604 - 26,712,127 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2126,501,264 - 26,598,053 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604278,073,957 - 78,643,089 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247831,027,548 - 1,139,231 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247831,025,606 - 1,708,803 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pde1c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1684,886,516 - 84,978,783 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pde1c
5013 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:81
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000017531
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48279077797183061Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
D4Rat34  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8486,709,649 - 86,709,840 (+)Marker Load Pipeline
mRatBN7.2485,379,421 - 85,379,614 (+)MAPPERmRatBN7.2
Rnor_6.0486,438,317 - 86,438,507NCBIRnor6.0
Rnor_5.04151,090,671 - 151,090,861UniSTSRnor5.0
RGSC_v3.4485,014,031 - 85,014,222RGDRGSC3.4
RGSC_v3.4485,014,032 - 85,014,222UniSTSRGSC3.4
Celera480,234,809 - 80,234,999UniSTS
RGSC_v3.1485,257,503 - 85,257,693RGD
RH 3.4 Map4533.1UniSTS
RH 3.4 Map4533.1RGD
SHRSP x BN Map443.1UniSTS
SHRSP x BN Map443.1RGD
FHH x ACI Map453.55RGD
Cytogenetic Map4q24UniSTS
D4Got260  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2485,478,419 - 85,478,509 (+)MAPPERmRatBN7.2
Rnor_6.0486,536,950 - 86,537,039NCBIRnor6.0
Rnor_5.04151,189,304 - 151,189,393UniSTSRnor5.0
RGSC_v3.4485,140,162 - 85,140,251UniSTSRGSC3.4
Celera480,333,729 - 80,333,818UniSTS
Cytogenetic Map4q24UniSTS
BF410175  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2485,334,574 - 85,334,686 (+)MAPPERmRatBN7.2
Rnor_6.0486,393,783 - 86,393,894NCBIRnor6.0
Rnor_5.04151,046,137 - 151,046,248UniSTSRnor5.0
RGSC_v3.4484,969,981 - 84,970,092UniSTSRGSC3.4
Celera480,190,079 - 80,190,190UniSTS
RH 3.4 Map4536.8UniSTS
Cytogenetic Map4q24UniSTS
RH137601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2485,330,833 - 85,330,978 (+)MAPPERmRatBN7.2
Rnor_6.0486,390,042 - 86,390,186NCBIRnor6.0
Rnor_5.04151,042,396 - 151,042,540UniSTSRnor5.0
RGSC_v3.4484,966,240 - 84,966,384UniSTSRGSC3.4
Celera480,186,338 - 80,186,482UniSTS
RH 3.4 Map4538.82UniSTS
Cytogenetic Map4q24UniSTS
BF401579  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2485,310,840 - 85,310,991 (+)MAPPERmRatBN7.2
Rnor_6.0486,369,792 - 86,369,942NCBIRnor6.0
Rnor_5.04151,022,146 - 151,022,296UniSTSRnor5.0
RGSC_v3.4484,945,870 - 84,946,020UniSTSRGSC3.4
Celera480,166,345 - 80,166,495UniSTS
RH 3.4 Map4534.4UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 67 157 62 61 30 68 30 6 301 168 11 136 81 91 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_592091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF328797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF328798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF328799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF328800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF329856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017531   ⟹   ENSRNOP00000017531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,631,093 - 86,902,496 (-)Ensembl
mRatBN7.2 Ensembl485,300,858 - 85,572,273 (-)Ensembl
Rnor_6.0 Ensembl486,359,820 - 86,466,797 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081244   ⟹   ENSRNOP00000075405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl485,357,946 - 85,572,856 (-)Ensembl
Rnor_6.0 Ensembl486,396,215 - 86,630,543 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097934   ⟹   ENSRNOP00000084095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl485,301,353 - 85,579,773 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098034   ⟹   ENSRNOP00000077659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,666,430 - 86,902,297 (-)Ensembl
mRatBN7.2 Ensembl485,336,544 - 85,572,081 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098186   ⟹   ENSRNOP00000096395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,631,093 - 87,107,992 (-)Ensembl
mRatBN7.2 Ensembl485,300,858 - 85,778,022 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102583   ⟹   ENSRNOP00000095937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,626,282 - 86,902,496 (-)Ensembl
mRatBN7.2 Ensembl485,301,353 - 85,572,273 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105428   ⟹   ENSRNOP00000078829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,631,093 - 87,193,259 (-)Ensembl
mRatBN7.2 Ensembl485,300,858 - 85,863,219 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114533   ⟹   ENSRNOP00000078259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl485,336,544 - 85,579,773 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118567   ⟹   ENSRNOP00000089783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,666,430 - 87,107,992 (-)Ensembl
mRatBN7.2 Ensembl485,336,544 - 85,778,022 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000121103   ⟹   ENSRNOP00000110688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,666,430 - 87,193,259 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146532   ⟹   ENSRNOP00000099233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,639,183 - 87,107,992 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152371   ⟹   ENSRNOP00000105005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,666,430 - 86,909,989 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167670   ⟹   ENSRNOP00000099194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl486,639,424 - 86,902,496 (-)Ensembl
RefSeq Acc Id: NM_031078   ⟹   NP_112340
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,631,093 - 87,108,134 (-)NCBI
mRatBN7.2485,300,858 - 85,777,936 (-)NCBI
Rnor_6.0486,359,820 - 86,833,450 (-)NCBI
Rnor_5.04151,012,195 - 151,485,775 (-)NCBI
RGSC_v3.4484,936,642 - 85,448,339 (-)RGD
Celera480,156,679 - 80,622,825 (-)RGD
Sequence:
RefSeq Acc Id: XM_008762922   ⟹   XP_008761144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,629,074 - 86,903,087 (-)NCBI
mRatBN7.2485,300,869 - 85,572,854 (-)NCBI
Rnor_6.0486,359,766 - 86,630,559 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108432   ⟹   XP_038964360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,635,802 - 87,108,147 (-)NCBI
mRatBN7.2485,303,579 - 85,777,948 (-)NCBI
RefSeq Acc Id: XM_039108433   ⟹   XP_038964361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,631,665 - 87,108,147 (-)NCBI
mRatBN7.2485,300,868 - 85,777,948 (-)NCBI
RefSeq Acc Id: XM_039108434   ⟹   XP_038964362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,629,074 - 86,903,087 (-)NCBI
mRatBN7.2485,300,869 - 85,572,854 (-)NCBI
RefSeq Acc Id: XM_039108435   ⟹   XP_038964363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,660,981 - 87,108,147 (-)NCBI
mRatBN7.2485,330,758 - 85,777,947 (-)NCBI
RefSeq Acc Id: XM_063286751   ⟹   XP_063142821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,635,802 - 86,903,086 (-)NCBI
RefSeq Acc Id: XM_063286752   ⟹   XP_063142822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,660,981 - 86,903,085 (-)NCBI
RefSeq Acc Id: XM_063286753   ⟹   XP_063142823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8486,660,981 - 86,903,100 (-)NCBI
RefSeq Acc Id: NP_112340   ⟸   NM_031078
- UniProtKB: Q63421 (UniProtKB/Swiss-Prot),   A0A8I6AQQ1 (UniProtKB/TrEMBL),   A6K104 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761144   ⟸   XM_008762922
- Peptide Label: isoform X2
- UniProtKB: F1LMX4 (UniProtKB/TrEMBL),   A6K105 (UniProtKB/TrEMBL),   A0A8I5Y1F5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017531   ⟸   ENSRNOT00000017531
Ensembl Acc Id: ENSRNOP00000075405   ⟸   ENSRNOT00000081244
RefSeq Acc Id: XP_038964361   ⟸   XM_039108433
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQQ1 (UniProtKB/TrEMBL),   A6K104 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964362   ⟸   XM_039108434
- Peptide Label: isoform X2
- UniProtKB: F1LMX4 (UniProtKB/TrEMBL),   A6K105 (UniProtKB/TrEMBL),   A0A8I5Y1F5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964360   ⟸   XM_039108432
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQQ1 (UniProtKB/TrEMBL),   A6K104 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964363   ⟸   XM_039108435
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A8V6 (UniProtKB/TrEMBL),   A0A8I6AQQ1 (UniProtKB/TrEMBL),   A6K104 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077659   ⟸   ENSRNOT00000098034
Ensembl Acc Id: ENSRNOP00000096395   ⟸   ENSRNOT00000098186
Ensembl Acc Id: ENSRNOP00000078829   ⟸   ENSRNOT00000105428
Ensembl Acc Id: ENSRNOP00000078259   ⟸   ENSRNOT00000114533
Ensembl Acc Id: ENSRNOP00000089783   ⟸   ENSRNOT00000118567
Ensembl Acc Id: ENSRNOP00000095937   ⟸   ENSRNOT00000102583
Ensembl Acc Id: ENSRNOP00000084095   ⟸   ENSRNOT00000097934
RefSeq Acc Id: XP_063142821   ⟸   XM_063286751
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AMU0 (UniProtKB/TrEMBL),   A6K107 (UniProtKB/TrEMBL),   A0A8I5Y1F5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142823   ⟸   XM_063286753
- Peptide Label: isoform X5
- UniProtKB: A6K108 (UniProtKB/TrEMBL),   A0A8I5Y1F5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142822   ⟸   XM_063286752
- Peptide Label: isoform X5
- UniProtKB: A6K108 (UniProtKB/TrEMBL),   A0A8I5Y1F5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099233   ⟸   ENSRNOT00000146532
Ensembl Acc Id: ENSRNOP00000105005   ⟸   ENSRNOT00000152371
Ensembl Acc Id: ENSRNOP00000110688   ⟸   ENSRNOT00000121103
Ensembl Acc Id: ENSRNOP00000099194   ⟸   ENSRNOT00000167670
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63421-F1-model_v2 AlphaFold Q63421 1-768 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68332 AgrOrtholog
BioCyc Gene G2FUF-44723 BioCyc
Ensembl Genes ENSRNOG00000012337 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017531 ENTREZGENE
  ENSRNOT00000098034 ENTREZGENE
  ENSRNOT00000098186 ENTREZGENE
  ENSRNOT00000118567 ENTREZGENE
  ENSRNOT00000146532 ENTREZGENE
  ENSRNOT00000167670 ENTREZGENE
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot
  PDEase UniProtKB/Swiss-Prot
  PDEase_catalytic_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot
  PDEase_CS UniProtKB/Swiss-Prot
  PDEase_N UniProtKB/Swiss-Prot
KEGG Report rno:81742 UniProtKB/Swiss-Prot
NCBI Gene 81742 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot
Pfam PDEase_I UniProtKB/Swiss-Prot
  PDEase_I_N UniProtKB/Swiss-Prot
PhenoGen Pde1c PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot
  PDEASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012337 RatGTEx
SMART HDc UniProtKB/Swiss-Prot
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot
UniProt A0A8I5Y1F5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZM70_RAT UniProtKB/TrEMBL
  A0A8I6A8V6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQQ1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L4E5_RAT UniProtKB/TrEMBL
  A0ABK0L9K0_RAT UniProtKB/TrEMBL
  A0ABK0LW65_RAT UniProtKB/TrEMBL
  A0ABK0M2Y6_RAT UniProtKB/TrEMBL
  A6K104 ENTREZGENE, UniProtKB/TrEMBL
  A6K105 ENTREZGENE, UniProtKB/TrEMBL
  A6K107 ENTREZGENE, UniProtKB/TrEMBL
  A6K108 ENTREZGENE, UniProtKB/TrEMBL
  F1LMX4 ENTREZGENE, UniProtKB/TrEMBL
  PDE1C_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99J81_RAT UniProtKB/TrEMBL
  Q99MN2_RAT UniProtKB/TrEMBL
  Q99MN3_RAT UniProtKB/TrEMBL
  Q99P54_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pde1c  phosphodiesterase 1C      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in olfactory sensory neurons 68318