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Gene: Gabre (gamma-aminobutyric acid type A receptor subunit epsilon) Rattus norvegicus

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Symbol:

Gabre

Name:

gamma-aminobutyric acid type A receptor subunit epsilon

RGD ID:

68320

Description:

Enables GABA-A receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in gamma-aminobutyric acid signaling pathway and response to xenobiotic stimulus. Is active in GABA-ergic synapse and postsynaptic membrane. Orthologous to human GABRE (gamma-aminobutyric acid type A receptor subunit epsilon); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GABA(A) receptor subunit epsilon; GABAAR subunit epsilon; gamma-aminobutyric acid (GABA) A receptor, epsilon; gamma-aminobutyric acid (GABA-A) receptor subunit epsilon; gamma-aminobutyric acid (GABA-A) receptor, subunit epsilon; gamma-aminobutyric acid A receptor, epsilon; gamma-aminobutyric acid receptor subunit epsilon; gamma-aminobutyric acid type A receptor epsilon subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	155,102,078 - 155,120,821 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	155,102,083 - 155,120,735 (-)	Ensembl				GRCr8
mRatBN7.2	X	150,060,035 - 150,078,773 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	150,060,040 - 150,078,693 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	152,252,925 - 152,270,090 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	155,787,134 - 155,804,299 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	153,328,707 - 153,345,872 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	152,220,180 - 152,237,347 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	152,218,707 - 152,237,361 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	147,946,356 - 147,963,349 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	158,335,158 - 158,353,615 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	131,038,889 - 131,056,053 (-)	NCBI		Celera
RGSC_v3.1	X	158,408,590 - 158,427,048 (+)	NCBI
Cytogenetic Map	X	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Dwarfism (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3alpha-hydroxy-5beta-pregnan-20-one (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzodiazepine (EXP)

bisphenol A (EXP,ISO)

butanal (ISO)

chlordiazepoxide (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

diethylstilbestrol (EXP)

etomidate (ISO)

fulvestrant (ISO)

furan (EXP)

gamma-aminobutyric acid (EXP,ISO)

genistein (ISO)

indometacin (ISO)

ketoconazole (EXP)

methimazole (EXP)

midazolam (EXP)

mono(2-ethylhexyl) phthalate (ISO)

ozone (ISO)

pentobarbital (EXP,ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

propofol (EXP,ISO)

quercetin (ISO)

rac-lactic acid (ISO)

serpentine asbestos (ISO)

silver atom (ISO)

silver(0) (ISO)

testosterone (ISO)

titanium dioxide (ISO)

triptonide (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IBA,IEA)

chloride transport (IEA,TAS)

gamma-aminobutyric acid signaling pathway (IBA,IDA)

inhibitory synapse assembly (IBA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

negative regulation of chloride transport (ISO)

regulation of postsynaptic membrane potential (IEA)

response to xenobiotic stimulus (IEP)

synaptic transmission, GABAergic (IBA)

Cellular Component

chloride channel complex (IEA)

dendrite membrane (IBA)

GABA-A receptor complex (IBA,ISO)

GABA-ergic synapse (EXP,IDA)

membrane (IEA)

plasma membrane (IEA)

postsynapse (IBA)

postsynaptic membrane (IDA,IEA)

Molecular Function

benzodiazepine receptor activity (IBA)

chloride channel activity (IBA,IEA)

extracellular ligand-gated monoatomic ion channel activity (IEA)

GABA-A receptor activity (IDA,IEA,ISO)

GABA-gated chloride ion channel activity (IBA,ISO,ISS)

monoatomic ion channel activity (IEA)

transmembrane signaling receptor activity (IEA)

transmitter-gated monoatomic ion channel activity (IEA)

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (EXP,IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Inhibitory transmission in locus coeruleus neurons expressing GABAA receptor epsilon subunit has a number of unique properties.	Belujon P, etal., J Neurophysiol. 2009 Oct;102(4):2312-25. doi: 10.1152/jn.00227.2009. Epub 2009 Jul 22.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	GABA(A) receptor epsilon-subunit may confer benzodiazepine insensitivity to the caudal aspect of the nucleus tractus solitarii of the rat.	Kasparov S, etal., J Physiol 2001 Nov 1;536(Pt 3):785-96.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	cDNA cloning and expression of a gamma-aminobutyric acid A receptor epsilon-subunit in rat brain.	Moragues N, etal., Eur J Neurosci 2000 Dec;12(12):4318-30.
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus.	Sinkkonen ST, etal., J Neurosci 2000 May 15;20(10):3588-95.

Additional References at PubMed

PMID:9039914	PMID:12650990	PMID:15634770	PMID:19249336	PMID:22303446	PMID:25748028

Genomics

Comparative Map Data

Gabre
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	155,102,078 - 155,120,821 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	155,102,083 - 155,120,735 (-)	Ensembl				GRCr8
mRatBN7.2	X	150,060,035 - 150,078,773 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	150,060,040 - 150,078,693 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	152,252,925 - 152,270,090 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	155,787,134 - 155,804,299 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	153,328,707 - 153,345,872 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	152,220,180 - 152,237,347 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	152,218,707 - 152,237,361 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	147,946,356 - 147,963,349 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	158,335,158 - 158,353,615 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	131,038,889 - 131,056,053 (-)	NCBI		Celera
RGSC_v3.1	X	158,408,590 - 158,427,048 (+)	NCBI
Cytogenetic Map	X	q37	NCBI

GABRE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	151,953,124 - 151,974,676 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	151,953,124 - 151,974,680 (-)	Ensembl			hg38	GRCh38
GRCh37	X	151,121,596 - 151,143,148 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	150,872,252 - 150,893,807 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	150,792,164 - 150,813,719	NCBI
Celera	X	151,367,187 - 151,388,743 (-)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	139,975,891 - 139,997,374 (-)	NCBI		HuRef
CHM1_1	X	150,996,531 - 151,018,085 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	150,219,338 - 150,240,900 (-)	NCBI		T2T-CHM13v2.0

Gabre
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	71,300,532 - 71,318,433 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	71,299,605 - 71,318,409 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	72,256,926 - 72,274,828 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	72,255,999 - 72,274,803 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	69,502,771 - 69,520,060 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	68,510,152 - 68,527,441 (-)	NCBI		MGSCv36	mm8
Celera	X	63,225,872 - 63,243,163 (-)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.21	NCBI

Gabre
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955498	7,470,881 - 7,488,902 (-)	NCBI	ChiLan1.0	ChiLan1.0

GABRE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	152,021,492 - 152,043,243 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	152,025,097 - 152,046,839 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	141,531,677 - 141,553,411 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	151,490,134 - 151,511,790 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	151,490,134 - 151,511,844 (-)	Ensembl			panPan2	panpan1.1

GABRE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	119,913,867 - 119,937,867 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	119,913,867 - 119,937,909 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	105,296,408 - 105,320,418 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	122,134,693 - 122,158,708 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	122,134,701 - 122,158,647 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	118,854,681 - 118,878,691 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	121,345,396 - 121,369,410 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	121,220,043 - 121,244,059 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gabre
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	117,428,433 - 117,448,231 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936714	812,265 - 827,957 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936714	808,287 - 827,990 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GABRE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	123,278,949 - 123,296,091 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	123,278,459 - 123,296,070 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	140,855,628 - 140,872,669 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GABRE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	126,524,665 - 126,554,786 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	126,526,240 - 126,554,682 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666065	64,320,447 - 64,341,842 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gabre
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624883	3,278,737 - 3,294,198 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624883	3,278,786 - 3,297,417 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gabre
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	130,018,171 - 130,035,689 (+)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	158
Count of miRNA genes:	98
Interacting mature miRNAs:	106
Transcripts:	ENSRNOT00000022431, ENSRNOT00000039949
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	105359969	157758123	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	118973754	157758123	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	12	62	142	63	62	31	29	31	6	244	124	10	118	67	92	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_023091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005498058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF189262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF255385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF255386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF255387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF255612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U92284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077750 ⟹ ENSRNOP00000074745

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	155,102,083 - 155,117,841 (-)	Ensembl
mRatBN7.2 Ensembl	X	150,060,040 - 150,075,799 (-)	Ensembl
Rnor_6.0 Ensembl	X	152,218,707 - 152,237,361 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087138 ⟹ ENSRNOP00000075293

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	155,102,083 - 155,120,735 (-)	Ensembl
mRatBN7.2 Ensembl	X	150,060,040 - 150,078,693 (-)	Ensembl
Rnor_6.0 Ensembl	X	152,220,180 - 152,237,347 (-)	Ensembl

RefSeq Acc Id:

NM_023091 ⟹ NP_075579

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	155,103,556 - 155,120,721 (-)	NCBI
mRatBN7.2	X	150,061,514 - 150,078,679 (-)	NCBI
Rnor_6.0	X	152,220,180 - 152,237,347 (-)	NCBI
Rnor_5.0	1	147,946,356 - 147,963,349 (-)	NCBI
RGSC_v3.4	X	158,335,158 - 158,353,615 (+)	RGD
Celera	1	131,038,889 - 131,056,053 (-)	NCBI

Sequence:

show sequence

TCGTGCCAGGCACCGCTGAGATGTTGCCTAAAGTTCTCCTGATGCTCCTCAACATGTTCCTGGC
CCTCCAGTGGAGGGTTGGACCTCACATTAAACTGGAGAATAAACCCCCTGCCCAAGATAAGGTA
GTCTTTGGCCCTCAGCCTCAGCCTGTGCCACAACCTCTGATTCCGCCTGAATCTCCTGCTGGAG
ATGATGTAGTCTTCGACTCTCAGCCCCAGCCCCAGTCGGAATCCCCTGGCCATGATGATGTCTT
TAGCTCCCAGCCCCAGCCTCTGCCCCAGCCCCAGCCTCTGCCGGAGCCCCAGCCTCTGCCGGAG
CCTGAGCCACAGCCGCAGCCACAGCCACAGCCGCAGCCGCAGCCACAGCCCCTGGCTGGGCGCC
AGCCTCTGCCCCAGCCCCTGCCTTGGCCCCTGCCTCAGCCTCAGCCCGAACCGGAGCCCCAGCC
GGAGCCCCAGCCGGAGCCCCAGCCTGAGCCCCAGCCGGAGCCCCAGCCTGAGCCCCAACCAGAA
CCCCAGCCAGAACCCCAGCCTCAACCTCAGCCTCTGGCTGGGCGCCAGCCTTTGCCTTGGCCCC
TGCCACTGCCCCTGCCCGAGCCCCAACCTGATCCCCAGCCTGATCCCCAACCGGAGCCTCAGCC
AGAACCCCAACCTGAGCCCCAGCCTCAGCCCCAGACCCCAGGCCAGGTCCAGGCTGGGCGCCAA
CCCCGCCCCAAACCTCAGCCTGATCCCCATCCCCATCCGCAGCCTGAACCTCAGCCTGAGCCAC
GTCTCCATCCCTTTCACCGTCTCCGTCTCCGTCCCCATCCCTATCCTGAGCCCCATCCAGGACC
CCAGCCGGAGCCTGAGCCTGAGCCTGAGCCGGAGCCCCAGCCGGAGCCCCAGCCGGAGCCCCAG
CCGGAGCCCCAACCGGAGCCTGAGCCCCAGCCGGAGCCGGAGCCGGAGCCTGAGCCTGAGCCTG
AGCCTGAGCCTGAGCCCGAGCCCGAGCCCGAGCCCGAGCCTGAGCCTGAGCCTGAGCCTGAGCC
TGAGCCTGAGCCTGAGCCTGAGCCCCAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCCCGAA
CCTGAGCCCGAGCCCGAGCCCGAGCCCGAGCCTCAGCCAGAGCCCCAGCCAGAACCTGAGCCTG
AGCCCGAGCCCCAGCCCGAGCCCCAGCCCGAGCCCGAGCCCGAGCCCGAGCCCGAGCCCGAGCC
CGAGCCCGAACCTGAACCTGAGCCTCAGCCGGAGCCCCAGCCTGAGCCTGAGCCCCAGCCTGAG
CCCCAGCCAGATCCTGAGCCTCAGCCTGAGCCCGGACCTGAACCTGGACCTGAACCTGAACCTG
AGCCTCAGCTGGAGCCCCAGCCAGAGCCTGAGCCTGAGCCACAGCCGGAGCCTGAGTCGGAGCT
GGACCTGGAGCCGGAACCAGAGCCCCAGCCCCTGCCGGAGCCCCAGCCTGAGCCTGAGCCTGAG
CCTGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGGAGCCGG
AGCCTGAGCCAGAACCGGAGCCAGAGCTGGAACTGGAGCCCCAGTCCCAGCTGGAGCCTCAGCC
TAGTGGAAAGAAGCTTCCAGCAAGAGAAACAGAACTCACTGCTGATCATACAACTGAACGCCCA
CGTGGAAAACTGACAAGAGCTTCTCAAATCCTTAACACCATCCTGAGCAACTACGACCATAAAC
TGCGCCCTAGCATTGGAGAGAAGCCTACCGTGGTCACTGTTAAAGTCTTTGTCAACAGCCTCGG
ACCTATTTCCATCCTAGACATGGAATATTCCATTGACATCATCTTCTACCAGACCTGGTATGAT
GAGCGTCTTCGTTACAATGACACCTTTGAGACACTTATTCTACATGGCAACGTGGTGAGCCAGT
TGTGGATCCCGGATACTTTTTTTAGGAATTCTAAGAGGACCCAAGAGTATGATATCACCATACC
CAACCAGATGGCTCTCATCCATAAGGATGGAAAAGTGTTGTACACAGTTAGGATGACCATTGAT
GCAAGATGCTCACTCCACATGCTCAATTTTCCAATGGATTCTCACTCTTGCCCTCTGTCTTTCT
CTAGCTTTTCCTATGATGAGCATGAGATGATATACAAGTGGGAGAATTTCAAACTCAAAATCGA
TGCGAAGAACACTTGGAAGCTATTGGAGTTTGATTTTACAGGAGTGAACAACAAAACTGAAATC
ATCTCCACCCCAGTTGGTGACTTCATGGTCATGACATTCTTCTTCAATGTAAGCAGGAGGTTTG
GCTTCATTGTCTTTCAAAACTATATCCCTTCATCTGTTACCACAATGCTTTCCTGGGTGTCCTT
CTGGATCAAGATAGAAGCTGCTGCTGCCAGGGCCTCTGTAGGGGTCAGTTCTGTGCTCACCATG
GCCACACTGGGTACCTTTTCTCGTAAGAATTTCCCTCGTGTCTCCTATCTCACAGCTTTGGACT
TCTATATTGCAATTTGTTTCGTCTTGTGCTTCTGTACTCTACTAGAGTTCACTGTGCTCAACTT
CCTGACCTACAATAATATTGAACGACAGGCTTCTCCAAAGTTCTACCAATTTCCAACCAATAGC
CGTGCTAATGCACGTACTCGTGCTCGTGCCCGCACTCGTGCTCGTGCTCGTGCCCGTGCTCGTC
AGCAGCAGGAAGTGTTTGTGTGTGAGATTGTTACCTATGAGGAAAATGCTGAAGAGGGTTACCA
GTGGTCTCCAAGATCAAGAAGACCTCAGTGTCCCTGGAGGCGATGTGGCCGAAGCTATGTGTGC
TTCAGGGTTCTCAGGAAGTATTTCTGCATGGTTCCTGGTTGTGAGGGCAACAGCTGGCAGCGGG
GCCGCATCTGCATCCACGTTTATCGCCTGGATAACTACTCGCGGGTGCTTTTCCCCATTACATT
CTTCTTCTTTAATGTGGTCTACTGGGTGATTTGCCTTAACCTGTAGGCTCCAGCTG

hide sequence

RefSeq Acc Id:

XM_039100028 ⟹ XP_038955956

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	155,102,078 - 155,120,821 (-)	NCBI
mRatBN7.2	X	150,060,035 - 150,078,773 (-)	NCBI

RefSeq Acc Id:

XM_039100030 ⟹ XP_038955958

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	155,103,796 - 155,120,821 (-)	NCBI
mRatBN7.2	X	150,061,747 - 150,078,773 (-)	NCBI

RefSeq Acc Id:

XM_039100033 ⟹ XP_038955961

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	155,108,331 - 155,120,821 (-)	NCBI
mRatBN7.2	X	150,066,289 - 150,078,773 (-)	NCBI

RefSeq Acc Id:

XM_039100034 ⟹ XP_038955962

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	155,108,331 - 155,120,821 (-)	NCBI
mRatBN7.2	X	150,066,289 - 150,078,773 (-)	NCBI

RefSeq Acc Id:

XM_063280287 ⟹ XP_063136357

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	155,102,078 - 155,120,821 (-)	NCBI

RefSeq Acc Id:

XR_005498058

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	155,104,527 - 155,120,821 (-)	NCBI
mRatBN7.2	X	150,062,485 - 150,078,773 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_075579	(Get FASTA)	NCBI Sequence Viewer
	XP_038955956	(Get FASTA)	NCBI Sequence Viewer
	XP_038955958	(Get FASTA)	NCBI Sequence Viewer
	XP_038955961	(Get FASTA)	NCBI Sequence Viewer
	XP_038955962	(Get FASTA)	NCBI Sequence Viewer
	XP_063136357	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB93879	(Get FASTA)	NCBI Sequence Viewer
	AAF70383	(Get FASTA)	NCBI Sequence Viewer
	AAG17631	(Get FASTA)	NCBI Sequence Viewer
	AAG38961	(Get FASTA)	NCBI Sequence Viewer
	AAG38962	(Get FASTA)	NCBI Sequence Viewer
	AAG38963	(Get FASTA)	NCBI Sequence Viewer
	EDL82827	(Get FASTA)	NCBI Sequence Viewer
	EDL82828	(Get FASTA)	NCBI Sequence Viewer
	EDL82829	(Get FASTA)	NCBI Sequence Viewer
	EDL82830	(Get FASTA)	NCBI Sequence Viewer
	EDL82831	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075293
GenBank Protein	Q9ES14	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_075579 ⟸ NM_023091
- Peptide Label:	precursor
- UniProtKB:	Q9JLE9 (UniProtKB/TrEMBL), A0A0G2KA77 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPKVLLMLLNMFLALQWRVGPHIKLENKPPAQDKVVFGPQPQPVPQPLIPPESPAGDDVVFDS QPQPQSESPGHDDVFSSQPQPLPQPQPLPEPQPLPEPEPQPQPQPQPQPQPQPLAGRQPLPQPL PWPLPQPQPEPEPQPEPQPEPQPEPQPEPQPEPQPEPQPEPQPQPQPLAGRQPLPWPLPLPLPE PQPDPQPDPQPEPQPEPQPEPQPQPQTPGQVQAGRQPRPKPQPDPHPHPQPEPQPEPRLHPFHR LRLRPHPYPEPHPGPQPEPEPEPEPEPQPEPQPEPQPEPQPEPEPQPEPEPEPEPEPEPEPEPE PEPEPEPEPEPEPEPEPEPEPEPQPEPEPEPEPEPEPEPEPEPEPEPQPEPQPEPEPEPEPQPE PQPEPEPEPEPEPEPEPEPEPEPQPEPQPEPEPQPEPQPDPEPQPEPGPEPGPEPEPEPQLEPQ PEPEPEPQPEPESELDLEPEPEPQPLPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE PELELEPQSQLEPQPSGKKLPARETELTADHTTERPRGKLTRASQILNTILSNYDHKLRPSIGE KPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYDERLRYNDTFETLILHGNVVSQLWIPDTF FRNSKRTQEYDITIPNQMALIHKDGKVLYTVRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYDE HEMIYKWENFKLKIDAKNTWKLLEFDFTGVNNKTEIISTPVGDFMVMTFFFNVSRRFGFIVFQN YIPSSVTTMLSWVSFWIKIEAAAARASVGVSSVLTMATLGTFSRKNFPRVSYLTALDFYIAICF VLCFCTLLEFTVLNFLTYNNIERQASPKFYQFPTNSRANARTRARARTRARARARARQQQEVFV CEIVTYEENAEEGYQWSPRSRRPQCPWRRCGRSYVCFRVLRKYFCMVPGCEGNSWQRGRICIHV YRLDNYSRVLFPITFFFFNVVYWVICLNL hide sequence

Ensembl Acc Id:

ENSRNOP00000075293 ⟸ ENSRNOT00000087138

Ensembl Acc Id:

ENSRNOP00000074745 ⟸ ENSRNOT00000077750

RefSeq Acc Id:	XP_038955956 ⟸ XM_039100028
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038955958 ⟸ XM_039100030
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038955962 ⟸ XM_039100034
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038955961 ⟸ XM_039100033
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063136357 ⟸ XM_063280287
- Peptide Label:	isoform X2

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ES14-F1-model_v2	AlphaFold	Q9ES14	1-506	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13702028

Promoter ID:

EPDNEW_R12549

Type:

single initiation site

Name:

Gabre_1

Description:

gamma-aminobutyric acid type A receptor epsilon subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	152,237,377 - 152,237,437	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68320	AgrOrtholog
BioCyc Gene	G2FUF-709	BioCyc
Ensembl Genes	ENSRNOG00000061182	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000087138	ENTREZGENE
Gene3D-CATH	1.20.58.390	UniProtKB/Swiss-Prot
	2.70.170.10	UniProtKB/Swiss-Prot
InterPro	GABAA/Glycine_rcpt	UniProtKB/Swiss-Prot
	GABAAe_rcpt	UniProtKB/Swiss-Prot
	Neur_chan_lig-bd	UniProtKB/Swiss-Prot
	Neur_chan_lig-bd_sf	UniProtKB/Swiss-Prot
	Neur_channel	UniProtKB/Swiss-Prot
	Neuro-gated_channel_TM_sf	UniProtKB/Swiss-Prot
	Neuro_actylchol_rec	UniProtKB/Swiss-Prot
	Neurotrans-gated_channel_TM	UniProtKB/Swiss-Prot
	Neurotransmitter_ion_chnl_CS	UniProtKB/Swiss-Prot
NCBI Gene	65191	ENTREZGENE
PANTHER	PTHR18945	UniProtKB/Swiss-Prot
Pfam	Neur_chan_LBD	UniProtKB/Swiss-Prot
	Neur_chan_memb	UniProtKB/Swiss-Prot
PhenoGen	Gabre	PhenoGen
PRINTS	GABAARECEPTR	UniProtKB/Swiss-Prot
	GABAAREPSLON	UniProtKB/Swiss-Prot
	NRIONCHANNEL	UniProtKB/Swiss-Prot
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000061182	RatGTEx
Superfamily-SCOP	SSF63712	UniProtKB/Swiss-Prot
	SSF90112	UniProtKB/Swiss-Prot
UniProt	A0A0G2K8U9_RAT	UniProtKB/TrEMBL
	A0A0G2KA77	ENTREZGENE
	A6KSX4_RAT	UniProtKB/TrEMBL
	A6KSX5_RAT	UniProtKB/TrEMBL
	A6KSX7_RAT	UniProtKB/TrEMBL
	GBRE_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9JLE9	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	O55209	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-12-06	Gabre	gamma-aminobutyric acid type A receptor subunit epsilon	Gabre	gamma-aminobutyric acid type A receptor epsilon subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-11	Gabre	gamma-aminobutyric acid type A receptor epsilon subunit	Gabre	gamma-aminobutyric acid (GABA) A receptor, epsilon	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-04	Gabre	gamma-aminobutyric acid (GABA) A receptor, epsilon	Gabre	gamma-aminobutyric acid (GABA-A) receptor, subunit epsilon	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-11	Gabre	gamma-aminobutyric acid (GABA-A) receptor, subunit epsilon	Gabre	gamma-aminobutyric acid (GABA) A receptor, epsilon	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Gabre	gamma-aminobutyric acid (GABA) A receptor, epsilon	Gabre	gamma-aminobutyric acid A receptor, epsilon	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Gabre	gamma-aminobutyric acid A receptor, epsilon			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar