Gpbar1 (G protein-coupled bile acid receptor 1) - Rat Genome Database

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Gene: Gpbar1 (G protein-coupled bile acid receptor 1) Rattus norvegicus
Analyze
Symbol: Gpbar1
Name: G protein-coupled bile acid receptor 1
RGD ID: 631400
Description: Enables G protein-coupled receptor activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of cholangiocyte proliferation. Predicted to be located in cytoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of metabolic dysfunction-associated steatohepatitis and polycystic kidney disease. Orthologous to human GPBAR1 (G protein-coupled bile acid receptor 1); INTERACTS WITH ammonium chloride; beta-naphthoflavone; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor; G-protein coupled bile acid receptor 1; M-BAR; membrane-type receptor for bile acids; Tgr5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,309,895 - 83,312,397 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl983,311,246 - 83,315,608 (+)EnsemblGRCr8
mRatBN7.2975,860,758 - 75,863,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,860,677 - 75,863,168 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,307,687 - 84,308,676 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,436,608 - 89,437,597 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,822,824 - 87,823,813 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,555,914 - 81,560,931 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,559,605 - 81,560,594 (+)Ensemblrn6Rnor6.0
Rnor_5.0981,324,651 - 81,327,608 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4973,605,141 - 73,606,130 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera973,438,636 - 73,439,625 (+)NCBICelera
RGSC_v3.1973,752,122 - 73,753,112 (+)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)
receptor complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
3. A G protein-coupled receptor responsive to bile acids. Kawamata Y, etal., J Biol Chem 2003 Mar 14;278(11):9435-40.
4. Identification of membrane-type receptor for bile acids (M-BAR). Maruyama T, etal., Biochem Biophys Res Commun 2002 Nov 15;298(5):714-9.
5. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. Masyuk TV, etal., Hepatology. 2017 Oct;66(4):1197-1218. doi: 10.1002/hep.29284. Epub 2017 Aug 26.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:17326144   PMID:18468513   PMID:22046243   PMID:23613625   PMID:23634890   PMID:23849932   PMID:25540233   PMID:27317945   PMID:27470217   PMID:27987324   PMID:28034761  
PMID:28946907   PMID:31909787   PMID:32381096   PMID:32443832   PMID:32699194   PMID:33055426   PMID:33427060   PMID:33531049   PMID:38329942   PMID:39082696  


Genomics

Comparative Map Data
Gpbar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,309,895 - 83,312,397 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl983,311,246 - 83,315,608 (+)EnsemblGRCr8
mRatBN7.2975,860,758 - 75,863,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,860,677 - 75,863,168 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,307,687 - 84,308,676 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,436,608 - 89,437,597 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,822,824 - 87,823,813 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,555,914 - 81,560,931 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,559,605 - 81,560,594 (+)Ensemblrn6Rnor6.0
Rnor_5.0981,324,651 - 81,327,608 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4973,605,141 - 73,606,130 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera973,438,636 - 73,439,625 (+)NCBICelera
RGSC_v3.1973,752,122 - 73,753,112 (+)NCBI
Cytogenetic Map9q33NCBI
GPBAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,259,496 - 218,263,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,259,496 - 218,263,861 (+)Ensemblhg38GRCh38
GRCh372219,124,219 - 219,128,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,833,983 - 218,836,826 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342218,951,257 - 218,954,087NCBI
Celera2212,892,317 - 212,895,161 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2210,978,835 - 210,981,679 (+)NCBIHuRef
CHM1_12219,132,227 - 219,135,071 (+)NCBICHM1_1
T2T-CHM13v2.02218,745,197 - 218,749,562 (+)NCBIT2T-CHM13v2.0
Gpbar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,316,269 - 74,318,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,317,709 - 74,318,783 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38174,278,600 - 74,279,589 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,278,550 - 74,279,624 (+)Ensemblmm10GRCm38
MGSCv37174,325,174 - 74,326,163 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36174,211,807 - 74,212,796 (+)NCBIMGSCv36mm8
Celera174,839,953 - 74,840,942 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.53NCBI
Gpbar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545315,109,711 - 15,112,438 (-)Ensembl
ChiLan1.0NW_00495545315,109,711 - 15,112,438 (-)NCBIChiLan1.0ChiLan1.0
GPBAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213120,889,518 - 120,896,066 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B120,904,485 - 120,911,243 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,520,364 - 105,523,229 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,116,896 - 224,121,263 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,120,127 - 224,121,119 (+)EnsemblpanPan2panpan1.1
GPBAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13724,937,955 - 24,943,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3724,940,325 - 24,943,421 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3725,759,271 - 25,763,567 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03724,955,171 - 24,959,466 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3724,956,387 - 24,959,328 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,860,410 - 24,865,048 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,794,673 - 24,799,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,814,333 - 24,818,678 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpbar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,444,119 - 174,451,783 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936569793,426 - 794,421 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936569792,393 - 794,764 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPBAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,336,488 - 120,339,505 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115120,336,196 - 120,339,506 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,440,341 - 133,443,017 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPBAR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,141,177 - 104,145,557 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,144,421 - 104,145,413 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604095,256,259 - 95,260,625 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpbar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,766,816 - 6,769,473 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248236,766,816 - 6,769,490 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpbar1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14147,729,105 - 147,731,614 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpbar1
12 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
AI548141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2975,862,878 - 75,863,061 (+)MAPPERmRatBN7.2
Rnor_6.0981,560,333 - 81,560,515NCBIRnor6.0
Rnor_5.0981,326,880 - 81,327,062UniSTSRnor5.0
RGSC_v3.4973,605,869 - 73,606,051UniSTSRGSC3.4
Celera973,439,364 - 73,439,546UniSTS
RH 3.4 Map9759.7UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 7 30 56 71 73 47 71 47 3 228 115 2 46 47 76 26 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000089698   ⟹   ENSRNOP00000075574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl975,860,677 - 75,863,168 (+)Ensembl
Rnor_6.0 Ensembl981,559,605 - 81,560,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134597   ⟹   ENSRNOP00000110717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl983,311,246 - 83,315,608 (+)Ensembl
RefSeq Acc Id: NM_177936   ⟹   NP_808797
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,309,895 - 83,312,397 (+)NCBI
mRatBN7.2975,860,758 - 75,863,260 (+)NCBI
Rnor_6.0981,559,605 - 81,560,594 (+)NCBI
Rnor_5.0981,324,651 - 81,327,608 (+)NCBI
RGSC_v3.4973,605,141 - 73,606,130 (+)RGD
Celera973,438,636 - 73,439,625 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_808797 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AGJ50516 (Get FASTA)   NCBI Sequence Viewer  
  BAC55238 (Get FASTA)   NCBI Sequence Viewer  
  BAC65345 (Get FASTA)   NCBI Sequence Viewer  
  EDL75340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075574.1
  ENSRNOP00000110717
GenBank Protein Q80T02 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_808797   ⟸   NM_177936
- UniProtKB: Q80T02 (UniProtKB/Swiss-Prot),   U5JAP5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075574   ⟸   ENSRNOT00000089698
Ensembl Acc Id: ENSRNOP00000110717   ⟸   ENSRNOT00000134597
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80T02-F1-model_v2 AlphaFold Q80T02 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631400 AgrOrtholog
BioCyc Gene G2FUF-27144 BioCyc
Ensembl Genes ENSRNOG00000058260 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000087111 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000089698.2 UniProtKB/Swiss-Prot
  ENSRNOT00000134597 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:338443 UniProtKB/Swiss-Prot
NCBI Gene 338443 ENTREZGENE
PANTHER G-PROTEIN COUPLED BILE ACID RECEPTOR 1 UniProtKB/Swiss-Prot
  OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Gpbar1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058260 RatGTEx
  ENSRNOG00000087111 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt GPBAR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  U5JAP5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Gpbar1  G protein-coupled bile acid receptor 1  Tgr5  G protein-coupled receptor  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in the suppression of macrophage functions by bile acids 634463
gene_regulation receptor internalization is induced by bile acids 634463