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Gene: Stk16 (serine/threonine kinase 16) Rattus norvegicus

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Symbol:

Stk16

Name:

serine/threonine kinase 16

RGD ID:

629474

Description:

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase activity. Involved in cellular response to transforming growth factor beta stimulus and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi-associated vesicle. Predicted to be active in Golgi apparatus. Orthologous to human STK16 (serine/threonine kinase 16); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

F52; MPSK; myristoylated and palmitoylated serine/threonine-protein kinase; PKL12; protein kinase PKL12; serine/threonine-protein kinase 16; TGF-beta-stimulated factor 1; TSF-1; tyrosine-protein kinase STK16

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STK16 (serine/threonine kinase 16)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Stk16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Stk16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STK16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STK16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Stk16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STK16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STK16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Stk16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Stk16 (serine/threonine kinase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	STK16 (serine/threonine kinase 16)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Stk16 (serine/threonine kinase 16)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	stk16 (serine/threonine kinase 16)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1227	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	D2045.7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ENV7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ENV7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	stk16	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	84,154,285 - 84,157,521 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	84,148,623 - 84,157,521 (+)	Ensembl				GRCr8
mRatBN7.2	9	76,705,591 - 76,708,859 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	76,705,602 - 76,708,855 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	85,150,423 - 85,153,654 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	90,279,314 - 90,282,545 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	88,665,529 - 88,668,760 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	82,411,010 - 82,414,249 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	82,411,013 - 82,414,240 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	82,180,271 - 82,183,510 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	74,491,917 - 74,495,148 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	74,276,032 - 74,279,263 (+)	NCBI		Celera
RGSC_v3.1	9	74,638,898 - 74,642,126 (+)	NCBI
Cytogenetic Map	9	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebrotendinous xanthomatosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

acrolein (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

atrazine (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

clofibrate (ISO)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

diuron (EXP)

endosulfan (EXP)

epoxiconazole (ISO)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

GSK-J4 (ISO)

inulin (ISO)

L-methionine (ISO)

lead(0) (ISO)

methylmercury chloride (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

quercetin (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to transforming growth factor beta stimulus (IDA)

positive regulation of transcription by RNA polymerase II (IDA)

protein autophosphorylation (IDA,ISO)

protein phosphorylation (ISO)

Cellular Component

cytoplasm (IBA)

cytosol (IEA,ISO)

Golgi apparatus (IBA,IEA,ISO)

Golgi-associated vesicle (IEA,ISO)

membrane (IEA)

perinuclear region of cytoplasm (IEA)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

non-membrane spanning protein tyrosine kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IDA,IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA,ISO)

protein tyrosine kinase activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IDA)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway.	Ohta S, etal., Biochem J 2000 Sep 1;350 Pt 2:395-404.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9712705	PMID:16310770	PMID:18184589

Genomics

Comparative Map Data

Stk16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	84,154,285 - 84,157,521 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	84,148,623 - 84,157,521 (+)	Ensembl				GRCr8
mRatBN7.2	9	76,705,591 - 76,708,859 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	76,705,602 - 76,708,855 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	85,150,423 - 85,153,654 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	90,279,314 - 90,282,545 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	88,665,529 - 88,668,760 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	82,411,010 - 82,414,249 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	82,411,013 - 82,414,240 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	82,180,271 - 82,183,510 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	74,491,917 - 74,495,148 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	74,276,032 - 74,279,263 (+)	NCBI		Celera
RGSC_v3.1	9	74,638,898 - 74,642,126 (+)	NCBI
Cytogenetic Map	9	q33	NCBI

STK16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	219,245,479 - 219,250,337 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	219,245,455 - 219,250,339 (+)	Ensembl			hg38	GRCh38
GRCh37	2	220,110,201 - 220,115,059 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	219,818,436 - 219,821,873 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	219,935,728 - 219,939,133	NCBI
Celera	2	213,879,899 - 213,884,766 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	211,963,107 - 211,967,974 (+)	NCBI		HuRef
CHM1_1	2	220,116,035 - 220,120,902 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	219,730,246 - 219,735,104 (+)	NCBI		T2T-CHM13v2.0

Stk16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	75,187,463 - 75,192,250 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	75,187,482 - 75,192,250 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	75,210,819 - 75,215,606 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	75,210,838 - 75,215,606 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	75,207,404 - 75,212,181 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	75,094,003 - 75,098,754 (+)	NCBI		MGSCv36	mm8
Celera	1	75,701,740 - 75,706,517 (+)	NCBI		Celera
Cytogenetic Map	1	C4	NCBI
cM Map	1	38.63	NCBI

Stk16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	14,182,066 - 14,185,584 (-)	Ensembl
ChiLan1.0	NW_004955453	14,182,167 - 14,185,569 (-)	NCBI	ChiLan1.0	ChiLan1.0

STK16
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	121,875,829 - 121,879,346 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	121,890,795 - 121,894,317 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	106,502,953 - 106,506,470 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	225,093,621 - 225,098,504 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	225,093,645 - 225,098,504 (+)	Ensembl			panPan2	panpan1.1

STK16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	25,793,993 - 25,797,632 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	25,794,382 - 25,797,587 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	26,619,873 - 26,623,533 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	25,809,201 - 25,812,862 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	25,809,595 - 25,812,860 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	25,713,591 - 25,717,250 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	25,648,706 - 25,652,368 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	25,669,607 - 25,673,268 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Stk16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	175,321,165 - 175,324,867 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936569	1,663,634 - 1,668,521 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936569	1,664,031 - 1,667,648 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STK16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	121,284,920 - 121,288,473 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	121,285,065 - 121,288,475 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	134,319,991 - 134,323,453 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STK16
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	105,149,953 - 105,153,553 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	105,150,421 - 105,153,693 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	94,242,891 - 94,246,400 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stk16
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624823	5,763,171 - 5,770,587 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624823	5,765,284 - 5,770,778 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Stk16
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	148,568,261 - 148,571,509 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Stk16
47 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	160
Count of miRNA genes:	121
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000026194
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56047863	101047863	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	82168823	86720295	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	83161999	118999486	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	54506504	99506504	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat

Markers in Region

RH130189

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	76,708,639 - 76,708,830 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	82,414,034 - 82,414,224	NCBI	Rnor6.0
Rnor_5.0	9	82,183,295 - 82,183,485	UniSTS	Rnor5.0
RGSC_v3.4	9	74,494,938 - 74,495,128	UniSTS	RGSC3.4
Celera	9	74,279,053 - 74,279,243	UniSTS
RH 3.4 Map	9	757.89	UniSTS
Cytogenetic Map	9	q33	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D86220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026194 ⟹ ENSRNOP00000026194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	84,148,623 - 84,157,521 (+)	Ensembl
mRatBN7.2 Ensembl	9	76,705,602 - 76,708,855 (+)	Ensembl
Rnor_6.0 Ensembl	9	82,411,013 - 82,414,240 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111780 ⟹ ENSRNOP00000077839

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	84,154,277 - 84,157,512 (+)	Ensembl
mRatBN7.2 Ensembl	9	76,705,619 - 76,708,855 (+)	Ensembl

RefSeq Acc Id:

NM_173142 ⟹ NP_775165

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	84,154,285 - 84,157,516 (+)	NCBI
mRatBN7.2	9	76,705,619 - 76,708,850 (+)	NCBI
Rnor_6.0	9	82,411,013 - 82,414,244 (+)	NCBI
Rnor_5.0	9	82,180,271 - 82,183,510 (+)	NCBI
RGSC_v3.4	9	74,491,917 - 74,495,148 (+)	RGD
Celera	9	74,276,032 - 74,279,263 (+)	RGD

Sequence:

show sequence

CTGGCCCTTTGCACAGGCAGGAGCCAGGTCACTGAAGAGTTTGTATTGGCAGATCCTGTGCTCG
GTCCTCAGCGACGGAGGGTGGACTCGGCCAGAGGTGGGCTCGAGTCCCGCACCTACTGCGCCAC
CCCATGCCTCACGGGTGTGAGAGCTGGACCTGGCCGAAGGTGGGCCGGGGTTGAAGGAAGCGGC
CTGCATGATCCGCCGGGACCCCAACCCATCGTCTGGAAGAGCCCACTCTCCCTGGAAGAAAGAC
CATCCTTGAAGAGGATGACTGAGACGCTATGGGCCATGCACTGTGTGTCTGTTCCCGGGGAACT
GTCATCATTGACAATAAGCGTTACCTCTTCGTCCAGAAATTGGGGGAGGGTGGGTTCAGCTACG
TGGACCTAGTGGAGGGCTTACATGATGGACACTTCTACGCCCTGAAGCGAATCCTGTGTCATGA
GCAGCAGGACCAGGAAGAGGCCCAACGAGAGGCAGACATGCATCGCCTCTTCCAGCATCCAAAC
ATCCTTCGCCTCATGGCTTACTCTTTGAAAGAACGAGGTGCTAAGCATGAAGCCTGGCTGCTGC
TACCCTTCTTCAAGAGAGGTACACTGTGGAATGAGATAGAAAGGCTGAAGGACCAAGGCAACTT
CCTGACTGAAGACCAAATCCTTCCGTTGTTGCTGGGTATCTGCAGAGGCCTTGAGGCCATTCAT
GCCAAAGGTTATGCACACAGGGACCTGAAGCCCACCAATATTTTGCTTGGTGATGAGGGGCAGC
CGGTTTTAATGGACTTGGGTTCTATGAATCAAGCATGCATCCAAGTGGAGGGATCTCGCCAGGC
CCTAGCTCTACAGGACTGGGCAGCCCAGCGGTGCACCATCTCCTACCGGGCACCTGAACTTTTT
TCTGTGCAAAGCCACTGTGTCATCGATGAGCGGACTGATGTCTGGTCCCTAGGCTGTGTGCTTT
ATGCAATGATGTTTGGGGAAGGCCCTTATGATATGGTGTTCCAGAAAGGTGACAGTGTGGCCCT
TGCTGTGCAGAATGACCTCAGCATCCCACAAAGCCCCAGGCATTCTTCAGCATTGCGACAGCTG
TTGGCCTCTATGATGACTGTGGACCCCCAGCAACGCCCTCACATCCCTGTCCTCCTCAGTCAAT
TGGAGGCATTGCAGCCACCAGCTCCTGGCCAGCACACCACCCAAATCTGATCAAATCAGTGAGC
ATATTGGGAAGATGACCTTGAATCAGCTCTCATGCCTCATTGGAACTTCTGATCTACACAAGAT
GGGTCTCACCATTAGGGGCAAGGATGGTGGGTCCTTGTATATTCTGCTCTTATCCCAATACCTG
GGCAAGGAGCCTAGGGTGAGTTGGGGGTGGGGGGGATGAAACAGAAAATATGGCTCAAAGCTGG
GCTGCTGGGCGCACATCATGTTCTGCCTCCAGATCTGGCAGCAGGAGAATACATAAAAAGTAGA
ATAAAGTGAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063266747 ⟹ XP_063122817

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	84,154,700 - 84,157,521 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_775165	(Get FASTA)	NCBI Sequence Viewer
	XP_063122817	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB16310	(Get FASTA)	NCBI Sequence Viewer
	EDL75402	(Get FASTA)	NCBI Sequence Viewer
	EDL75403	(Get FASTA)	NCBI Sequence Viewer
	EDL75404	(Get FASTA)	NCBI Sequence Viewer
	EDL75405	(Get FASTA)	NCBI Sequence Viewer
	EDL75406	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026194
	ENSRNOP00000026194.3
GenBank Protein	P57760	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_775165 ⟸ NM_173142

- UniProtKB:

P57760 (UniProtKB/Swiss-Prot), A6JVZ5 (UniProtKB/TrEMBL), A0A8I5Y7Y0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGHALCVCSRGTVIIDNKRYLFVQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDQEEAQR
EADMHRLFQHPNILRLMAYSLKERGAKHEAWLLLPFFKRGTLWNEIERLKDQGNFLTEDQILPL
LLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIQVEGSRQALALQDWAAQ
RCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNDLSIP
QSPRHSSALRQLLASMMTVDPQQRPHIPVLLSQLEALQPPAPGQHTTQI

hide sequence

Ensembl Acc Id:

ENSRNOP00000026194 ⟸ ENSRNOT00000026194

Ensembl Acc Id:

ENSRNOP00000077839 ⟸ ENSRNOT00000111780

RefSeq Acc Id:	XP_063122817 ⟸ XM_063266747
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5Y7Y0 (UniProtKB/TrEMBL)

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P57760-F1-model_v2	AlphaFold	P57760	1-305	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696774

Promoter ID:

EPDNEW_R7298

Type:

initiation region

Name:

Stk16_1

Description:

serine/threonine kinase 16

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	82,411,018 - 82,411,078	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:629474	AgrOrtholog
BioCyc Gene	G2FUF-27089	BioCyc
Ensembl Genes	ENSRNOG00000019294	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000026194	ENTREZGENE
	ENSRNOT00000026194.4	UniProtKB/Swiss-Prot
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Ser/Thr-specific_kinases	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
KEGG Report	rno:286927	UniProtKB/Swiss-Prot
NCBI Gene	286927	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE 16	UniProtKB/Swiss-Prot
	SERINE/THREONINE-PROTEIN KINASE 16	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Stk16	PhenoGen
PIRSF	Integrin-linked_kinase	UniProtKB/Swiss-Prot
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019294	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A8I5Y7Y0	ENTREZGENE, UniProtKB/TrEMBL
	A6JVZ5	ENTREZGENE, UniProtKB/TrEMBL
	A6JVZ7_RAT	UniProtKB/TrEMBL
	A6JVZ8_RAT	UniProtKB/TrEMBL
	P57760	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Stk16	serine/threonine kinase 16			Symbol and Name status set to approved	1299863	APPROVED
2003-04-06	Stk16	serine/threonine kinase 16			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_process	activates the promoter for transforming growth factor-beta (Tgfb)	727297
gene_process	may function in both transcriptional regulation and protein phosphorylation	727297

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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