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Gene: Gimap5 (GTPase, IMAP family member 5) Rattus norvegicus

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Symbol:

Gimap5

Name:

GTPase, IMAP family member 5

RGD ID:

628871

Description:

Predicted to enable GTPase activity. Involved in several processes, including negative regulation of metabolic process; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Predicted to be located in lysosomal membrane; mitochondrion; and multivesicular body membrane. Used to study lymphopenia and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to human GIMAP5 (GTPase, IMAP family member 5); INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GTPase IMAP family member 5; IAN-4; IAN4; Ian4l1; IAN5; immune associated nucleotide 4 like 1; immune associated nucleotide 4 like 1 (mouse); immunity-associated nucleotide 4 protein; immunity-associated nucleotide 4-like 1 protein; lymphopenia; lymphopenia gene; lyp

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Is Marker For:

Strains: BB.SHR-(D4Got41-Gimap5)/K ; BBDP.BBDR-Gimap5/Sunn ; BBDP.BBDR-Gimap5, WF-(D13Rat124-D13Mgh5)/Sunn

Candidate Gene For:

Bw52 Bw53 Iddm39

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	79,025,151 - 79,031,917 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	79,024,304 - 79,039,030 (+)	Ensembl				GRCr8
mRatBN7.2	4	77,693,417 - 77,701,025 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	77,687,564 - 77,703,086 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	82,902,037 - 82,908,725 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	78,677,516 - 78,684,204 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	77,117,807 - 77,124,495 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	78,377,228 - 78,386,683 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	78,378,144 - 78,385,577 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	143,066,311 - 143,073,003 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	76,836,521 - 76,843,214 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	72,631,351 - 72,638,043 (+)	NCBI		Celera
RGSC_v3.1	4	77,112,650 - 77,119,327 (+)	NCBI
Cytogenetic Map	4	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

lymphopenia (IAGP)

Noncirrhotic Portal Hypertension 2 (ISO)

type 1 diabetes mellitus (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-amphetamine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

7,12-dimethyltetraphene (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

CGP 52608 (ISO)

clozapine (EXP)

cocaine (EXP)

gentamycin (EXP)

haloperidol (EXP)

lipopolysaccharide (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

perfluorooctanoic acid (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

Soman (EXP)

topotecan (EXP)

triphenyl phosphate (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

myeloid dendritic cell differentiation (IMP)

negative regulation of apoptotic process (IMP)

negative regulation of lipid catabolic process (IMP)

negative regulation of nitric oxide biosynthetic process (IMP)

negative regulation of T cell activation (IMP)

negative regulation of type II interferon production (IMP)

positive regulation of calcium ion transport into cytosol (IMP)

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (IMP)

positive regulation of gamma-delta T cell differentiation (IMP)

positive regulation of humoral immune response mediated by circulating immunoglobulin (IMP)

positive regulation of membrane potential (IMP)

positive regulation of natural killer cell cytokine production (IMP)

positive regulation of natural killer cell mediated cytotoxicity (IMP)

regulation of mitochondrial membrane permeability (IMP)

T cell differentiation (IEP)

T cell homeostasis (IMP)

temperature homeostasis (IMP)

Cellular Component

endosome membrane (IEA)

lysosomal membrane (IEA)

mitochondrion (IEA)

multivesicular body membrane (IEA)

Molecular Function

GTP binding (IEA)

GTPase activity (IBA)

nucleotide binding (IEA)

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body temperature (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Decreased core temperature and increased beta(3)-adrenergic sensitivity in diabetes-prone BB rats.	Akesson L, etal., Diabetes Technol Ther. 2007 Aug;9(4):354-62.
2.	Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats.	Akesson L, etal., Exp Clin Endocrinol Diabetes. 2008 May 9;.
3.	The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats.	Bieg S, etal., Diabetologia 1997 Jul;40(7):786-92.
4.	The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.	Clark L, etal., FEMS Immunol Med Microbiol. 2002 Feb 18;32(3):205-9.
5.	Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs.	Dion C, etal., Int Immunol. 2005 Sep;17(9):1257-68. Epub 2005 Aug 15.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.	Hornum L, etal., Diabetes 2002 Jun;51(6):1972-9.
8.	Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes.	Ilangumaran S, etal., Mol Immunol. 2008 Nov 11.
9.	GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment.	Keita M, etal., Biochem Biophys Res Commun. 2007 Sep 21;361(2):481-6. Epub 2007 Jul 23.
10.	Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway.	Kupfer R, etal., Mol Immunol. 2007 Jan;44(4):479-87. Epub 2006 Apr 11.
11.	Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals.	Lau A, etal., Diabetes. 1998 Feb;47(2):197-205.
12.	Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related Gene.	MacMurray AJ, etal., Genome Res 2002 Jul;12(7):1029-39.
13.	Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.	Michalkiewicz M, etal., Physiol Genomics 2004 Oct 4;19(2):228-32. Epub 2004 Aug 24.
14.	A diabetogenic gene prevents T cells from receiving costimulatory signals.	Moore JK, etal., Cell Immunol. 1999 May 25;194(1):90-7.
15.	Ian4 is required for mitochondrial integrity and T cell survival.	Pandarpurkar M, etal., Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10382-7. Epub 2003 Aug 20.
16.	Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats.	Poussier P, etal., J Immunol. 2005 Apr 1;174(7):4081-9.
17.	Evidence for the extrathymic origin of intestinal TCRgammadelta(+) T cells in normal rats and for an impairment of this differentiation pathway in BB rats.	Ramanathan S, etal., J Immunol 2002 Mar 1;168(5):2182-7.
18.	GOA pipeline	RGD automated data pipeline
19.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
21.	Comprehensive gene review and curation	RGD comprehensive gene curation
22.	Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.	Sommandas V, etal., J Autoimmun. 2005 Aug;25(1):46-56.
23.	Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat.	Sommandas V, etal., J Leukoc Biol. 2007 Oct;82(4):869-76. Epub 2007 Jun 28.
24.	Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.	Todd DJ, etal., J Immunol. 2004 May 1;172(9):5356-62.

Additional References at PubMed

PMID:12477932	PMID:14624755	PMID:15307172	PMID:15474297	PMID:15489334	PMID:19351909	PMID:19424493	PMID:19996157	PMID:21925515	PMID:23098229	PMID:26740263	PMID:27023180

Genomics

Comparative Map Data

Gimap5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	79,025,151 - 79,031,917 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	79,024,304 - 79,039,030 (+)	Ensembl				GRCr8
mRatBN7.2	4	77,693,417 - 77,701,025 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	77,687,564 - 77,703,086 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	82,902,037 - 82,908,725 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	78,677,516 - 78,684,204 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	77,117,807 - 77,124,495 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	78,377,228 - 78,386,683 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	78,378,144 - 78,385,577 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	143,066,311 - 143,073,003 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	76,836,521 - 76,843,214 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	72,631,351 - 72,638,043 (+)	NCBI		Celera
RGSC_v3.1	4	77,112,650 - 77,119,327 (+)	NCBI
Cytogenetic Map	4	q24	NCBI

GIMAP5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	150,737,418 - 150,743,646 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	150,722,253 - 150,750,033 (+)	Ensembl			hg38	GRCh38
GRCh37	7	150,434,506 - 150,440,734 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	150,065,384 - 150,071,669 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	149,872,098 - 149,878,384	NCBI
Celera	7	144,991,531 - 144,997,796 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	144,246,520 - 144,252,822 (+)	NCBI		HuRef
CHM1_1	7	150,442,821 - 150,449,122 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	151,910,326 - 151,916,554 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	149,763,721 - 149,770,022 (+)	NCBI

Gimap5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	48,723,131 - 48,731,134 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	48,723,131 - 48,731,144 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	48,746,197 - 48,754,200 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	48,746,197 - 48,754,210 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	48,696,196 - 48,704,199 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	48,675,783 - 48,683,786 (+)	NCBI		MGSCv36	mm8
Celera	6	49,257,051 - 49,265,008 (+)	NCBI		Celera
Cytogenetic Map	6	B2.3	NCBI
cM Map	6	23.71	NCBI

GIMAP5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,152,549 - 187,161,746 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,162,808 - 39,172,010 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	142,319,479 - 142,326,035 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	154,471,995 - 154,478,298 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

LOC100687459
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	14,887,308 - 14,895,522 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	15,495,620 - 15,503,788 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	16,602,613 - 16,610,785 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	16,602,557 - 16,610,761 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	14,981,879 - 14,990,048 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	15,563,361 - 15,571,546 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	15,613,881 - 15,622,077 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

GIMAP5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	18	6,363,443 - 6,371,725 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,671,945 - 6,676,690 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GIMAP5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	118,919,988 - 118,927,294 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	118,920,051 - 118,927,211 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666072	14,892,700 - 14,899,113 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Gimap5
43 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	17
Count of miRNA genes:	17
Interacting mature miRNAs:	17
Transcripts:	ENSRNOT00000059156
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	59753119	104753119	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	41400577	86400577	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	44425024	89425024	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1357342	Bw40	Body weight QTL 40		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	4	74233320	119233320	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	58817672	103817672	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
70167	Bw22	Body weight QTL 22	3.1		body mass (VT:0001259)	body weight (CMO:0000012)	4	74233320	119233320	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58080146	80212111	Rat
1549839	Bw52	Body weight QTL 52		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	71647492	116647492	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	41400603	86400603	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	75939858	140508796	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	65060960	127749483	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	51085655	113588029	Rat
2317588	Eae27	Experimental allergic encephalomyelitis QTL 27			nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	4	69036742	114036742	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	40490442	117737312	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	57613242	102613242	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	57613242	102613242	Rat
6478684	Anxrr30	Anxiety related response QTL 30		0.00087	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	35113290	80113290	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	57613242	102613242	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	58079875	82597589	Rat
2306547	Iddm38	Insulin dependent diabetes mellitus QTL 38			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	68353567	113353567	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
2306545	Iddm39	Insulin dependent diabetes mellitus QTL 39			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	78687630	123687630	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
6478772	Anxrr49	Anxiety related response QTL 49		0.15488	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	74169813	134199155	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	59836842	104836842	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	37269577	82269577	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	75939858	140508796	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
634344	Hcar7	Hepatocarcinoma resistance QTL 7	7.8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	4	61041057	94638356	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
631651	Bp124	Blood pressure QTL 124	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	64209744	109209744	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	41400577	86400577	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58079875	92690793	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
6478743	Anxrr40	Anxiety related response QTL 40		0.83076	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
61434	Cia3	Collagen induced arthritis QTL 3	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63224393	108224393	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	63900458	88813920	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	59603319	80216952	Rat

Markers in Region

RH141689

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	77,700,690 - 77,700,902 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	78,384,502 - 78,384,713	NCBI	Rnor6.0
Rnor_5.0	4	143,072,669 - 143,072,880	UniSTS	Rnor5.0
RGSC_v3.4	4	76,842,880 - 76,843,091	UniSTS	RGSC3.4
Celera	4	72,637,709 - 72,637,920	UniSTS
RH 3.4 Map	4	499.81	UniSTS
Cytogenetic Map	4	q24	UniSTS

PMC186618P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	77,699,887 - 77,700,387 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	78,383,699 - 78,384,198	NCBI	Rnor6.0
Rnor_5.0	4	143,071,866 - 143,072,365	UniSTS	Rnor5.0
RGSC_v3.4	4	76,842,077 - 76,842,576	UniSTS	RGSC3.4
Celera	4	72,636,906 - 72,637,405	UniSTS
Cytogenetic Map	4	q24	UniSTS

PMC186618P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	77,700,048 - 77,700,387 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	78,383,860 - 78,384,198	NCBI	Rnor6.0
Rnor_5.0	4	143,072,027 - 143,072,365	UniSTS	Rnor5.0
RGSC_v3.4	4	76,842,238 - 76,842,576	UniSTS	RGSC3.4
Celera	4	72,637,067 - 72,637,405	UniSTS
Cytogenetic Map	4	q24	UniSTS

PMC186618P3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	77,700,048 - 77,700,433 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	78,383,860 - 78,384,244	NCBI	Rnor6.0
Rnor_5.0	4	143,072,027 - 143,072,411	UniSTS	Rnor5.0
RGSC_v3.4	4	76,842,238 - 76,842,622	UniSTS	RGSC3.4
Celera	4	72,637,067 - 72,637,451	UniSTS
Cytogenetic Map	4	q24	UniSTS

Related Rat Strains

The following Strains have been annotated to Gimap5

BB.SHR-(D4Got41-Gimap5)/K BBDP.BBDR-Gimap5/Sunn BBDP.BBDR-Gimap5, WF-(D13Rat124-D13Mgh5)/Sunn

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
17	12	79	175	91	90	59	152	59	6	457	273	20	138	100	111	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_145680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH011733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH011734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY055776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY055777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY550018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY550021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY550022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY550023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC092561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ125352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ125353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000059156 ⟹ ENSRNOP00000055929

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	79,024,304 - 79,031,896 (+)	Ensembl
mRatBN7.2 Ensembl	4	77,687,564 - 77,701,004 (+)	Ensembl
Rnor_6.0 Ensembl	4	78,378,144 - 78,384,827 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083891 ⟹ ENSRNOP00000071587

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	78,378,313 - 78,384,783 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084927 ⟹ ENSRNOP00000072663

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	79,024,646 - 79,039,030 (+)	Ensembl
mRatBN7.2 Ensembl	4	77,694,097 - 77,703,086 (+)	Ensembl
Rnor_6.0 Ensembl	4	78,382,287 - 78,385,577 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115571 ⟹ ENSRNOP00000078457

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	77,694,262 - 77,703,086 (+)	Ensembl

RefSeq Acc Id:

NM_001033913 ⟹ NP_001029085

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,025,225 - 79,031,917 (+)	NCBI
mRatBN7.2	4	77,694,333 - 77,701,025 (+)	NCBI
Rnor_6.0	4	78,378,144 - 78,384,836 (+)	NCBI
Rnor_5.0	4	143,066,311 - 143,073,003 (+)	NCBI
RGSC_v3.4	4	76,836,521 - 76,843,214 (+)	RGD
Celera	4	72,631,351 - 72,638,043 (+)	RGD

Sequence:

show sequence

TGGTCATTTACTAAGGCAGTTCTGCTGTGTTCTGGCGGATGTTCATGGCCTCTCCACCTACCTG
AAGGGAAACAGTCTGCAGGGCAGTGTGTGTTCTGTCACCATGGGTTTTTTTTCCTGCCTTCGGA
CTCAGGGTTTACAGCTCTGCGAGTAGCTGCTCCGTGACAGCATCGCTCTGCAGTCACAGGCCCA
CCGCCTGCCTGTAAGGAACCCCATCTGGGAGACGGGAAGCTGCGGTGCACTCAGAAGAGAATGG
AAGGCCTTCAGAAGAGCACATATGGAACTATAGTTGAAGGGACTCTGTGAAAGTCAAAAGTCAC
CTAAATTTATAGCCAAACAGTTAGGAGCATGGAGTTATGCCTGTTTTCCTGGGATGGAGGACCA
TGGCTTTGAGGAACTATCCACAAGGACCCATGACCTCAACGTCAGAAGACTCACTAAGGGAAAC
ATAAACTTTCTCTTGTCTACAGGACAAGAAACCTACAGTGTAGAAGACTCTGGCCTCCTGAGGA
TCCTCCTGGTGGGTAAATCTGGCTGCGGAAAAAGTGCCACAGGGAACAGCATTCTCCGCAGACC
AGCGTTCGAGTCCAGGCTCAGAGGCCAGTCTGTGACCAGGACCAGTCAGGCAGAGATGGGCACA
TGGGAGGGAAGGAGCTTCCTAGTGGTGGACACGCCCCCCATCTTCGAGTCAAAGATCCAGAACC
AAGACATGGACAAGGACATTGGGAACTGCTACCTGATGTGTGCCCCAGGACCCCATGTGTTGTT
GCTGGTGACCCAACTGGGACGCTACACAGTCGAAGATGCCATGGCTGTGAGGATGGTGAAGCAG
ATCTTTGGGGTAGGGGTCATGAGGTACATGATTGTCCTCTTCACCCACAAGGAAGACCTGGCAG
ATGAGTCCTTGGAAGAGTTTGTGACCCACACAGGCAACCTCGACCTGCACAGACTGGTTCAGGA
GTGTGGGAGGAGGTACTGTGCCTTTAATAACAAGGCTTCTGGGGAGGAGCAGCAGGGGCAGCTG
GCAGAGCTCATGGCCCTGGTGAGAAGACTGGAACAGGAGCATGAGGGCTCCTTCCACAGCAATG
ACCTCTTCGTTTATACTCAGGTGTTCCTTAGAGGTGGCTACAGTGAACACCAGGAGCCATACAA
GTTCTACCTGACCAAGGTGAGGCAGGAGGTAGAGAAGCAGAAGAGGGAGCTGGAGGAGCAGGAG
GGCAGCTGGATGGCTAAAATGCTTTGCAGAGTCACGTCCTGCTTGGACTGGCACATTGCAGTGT
CTGTTCTTCTTATTGTTCTTGGTCTGACCCTTCTCATCACTTTAATTAATATGTACATTGGCAG
GTGGAAATGAGTCTCTTTGGGTGAATCCTGCCATTATCCCTGTCCACCAAATTTCCCCATCTCC
ATGTTAGGGAAGCTCAGTCTTCAAATAATTTCACTATCATTTGACTCCTGTGCATGAGACACAG
TAGAACCCTTCTAAATACCGTTAAGTAAATAAAATATGAAAGAAGAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_145680 ⟹ NP_663713

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,025,225 - 79,031,917 (+)	NCBI
mRatBN7.2	4	77,694,333 - 77,701,025 (+)	NCBI
Rnor_6.0	4	78,378,144 - 78,384,836 (+)	NCBI
Rnor_5.0	4	143,066,311 - 143,073,003 (+)	NCBI
RGSC_v3.4	4	76,836,521 - 76,843,214 (+)	RGD
Celera	4	72,631,351 - 72,638,043 (+)	RGD

Sequence:

show sequence

TGGTCATTTACTAAGGCAGTTCTGCTGTGTTCTGGCGGATGTTCATGGCCTCTCCACCTACCTG
AAGGGAAACAGTCTGCAGGGCAGTGTGTGTTCTGTCACCATGGGTTTTTTTTCCTGCCTTCGGA
CTCAGGGTTTACAGCTCTGCGAGTAGCTGCTCCGTGACAGCATCGCTCTGCAGTCACAGGCCCA
CCGCCTGCCTGTAAGGAACCCCATCTGGGAGACGGGAAGCTGCGGTGCACTCAGAAGAGAATGG
AAGGCCTTCAGAAGAGCACATATGGAACTATAGTTGAAGGACAAGAAACCTACAGTGTAGAAGA
CTCTGGCCTCCTGAGGATCCTCCTGGTGGGTAAATCTGGCTGCGGAAAAAGTGCCACAGGGAAC
AGCATTCTCCGCAGACCAGCGTTCGAGTCCAGGCTCAGAGGCCAGTCTGTGACCAGGACCAGTC
AGGCAGAGATGGGCACATGGGAGGGAAGGAGCTTCCTAGTGGTGGACACGCCCCCCATCTTCGA
GTCAAAGATCCAGAACCAAGACATGGACAAGGACATTGGGAACTGCTACCTGATGTGTGCCCCA
GGACCCCATGTGTTGTTGCTGGTGACCCAACTGGGACGCTACACAGTCGAAGATGCCATGGCTG
TGAGGATGGTGAAGCAGATCTTTGGGGTAGGGGTCATGAGGTACATGATTGTCCTCTTCACCCA
CAAGGAAGACCTGGCAGATGAGTCCTTGGAAGAGTTTGTGACCCACACAGGCAACCTCGACCTG
CACAGACTGGTTCAGGAGTGTGGGAGGAGGTACTGTGCCTTTAATAACAAGGCTTCTGGGGAGG
AGCAGCAGGGGCAGCTGGCAGAGCTCATGGCCCTGGTGAGAAGACTGGAACAGGAGCATGAGGG
CTCCTTCCACAGCAATGACCTCTTCGTTTATACTCAGGTGTTCCTTAGAGGTGGCTACAGTGAA
CACCAGGAGCCATACAAGTTCTACCTGACCAAGGTGAGGCAGGAGGTAGAGAAGCAGAAGAGGG
AGCTGGAGGAGCAGGAGGGCAGCTGGATGGCTAAAATGCTTTGCAGAGTCACGTCCTGCTTGGA
CTGGCACATTGCAGTGTCTGTTCTTCTTATTGTTCTTGGTCTGACCCTTCTCATCACTTTAATT
AATATGTACATTGGCAGGTGGAAATGAGTCTCTTTGGGTGAATCCTGCCATTATCCCTGTCCAC
CAAATTTCCCCATCTCCATGTTAGGGAAGCTCAGTCTTCAAATAATTTCACTATCATTTGACTC
CTGTGCATGAGACACAGTAGAACCCTTCTAAATACCGTTAAGTAAATAAAATATGAAAGAAGAA
AAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236458 ⟹ XP_006236520

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,025,151 - 79,031,917 (+)	NCBI
mRatBN7.2	4	77,694,440 - 77,701,025 (+)	NCBI
Rnor_6.0	4	78,377,843 - 78,386,683 (+)	NCBI
Rnor_5.0	4	143,066,311 - 143,073,003 (+)	NCBI

Sequence:

show sequence

GTCAAATAGTAAAGAAGGGGTAACCAGCATGAGGTAACAGCTTAGCTGTCCTTTGAGAGGGGGC
AGTCTATGTTCTCTGGGACCAGAGATGCTTTTCTGACATGGGGCCCAGGGGCTTGGGAGTACAG
ATTCTCACCTTGGGTGCTGATGTAGAACCTGGGGCTCAGCACTTTCTAGCCACAAGAGGGCTTT
CATGAAAAGGGGACTGTCTTCCATTTCTCAGCGTCAGGCTCCCAGAACTATGCACTCAACACCT
CCCTGAAGGGGAAATGAGTAGAGCAGGGAGGCTTTCCACAGGAAGTGGTCATTTACTAAGGCAG
TTCTGCTGTGTTCTGGCGGATGTTCATGGCCTCTCCACCTACCTGAAGGGAAACAGTCTGCAGG
GCAGTGTGTGTTCTGTCACCATGGGTTTTTTTTCCTGCCTTCGGACTCAGGGTTTACAGCTCTG
CGAGTAGCTGCTCCGTGACAGCATCGCTCTGCAGTCACAGGCCCACCGCCTGCCTGTAAGGAAC
CCCATCTGGGAGACGGGAAGCTGCGGTGCACTCAGAGAATGGAAGGCCTTCAGAAGAGCACATA
TGGAACTATAGTTGAAGGACAAGAAACCTACAGTGTAGAAGACTCTGGCCTCCTGAGGATCCTC
CTGGTGGGTAAATCTGGCTGCGGAAAAAGTGCCACAGGGAACAGCATTCTCCGCAGACCAGCGT
TCGAGTCCAGGCTCAGAGGCCAGTCTGTGACCAGGACCAGTCAGGCAGAGATGGGCACATGGGA
GGGAAGGAGCTTCCTAGTGGTGGACACGCCCCCCATCTTCGAGTCAAAGATCCAGAACCAAGAC
ATGGACAAGGACATTGGGAACTGCTACCTGATGTGTGCCCCAGGACCCCATGTGTTGTTGCTGG
TGACCCAACTGGGACGCTACACAGTCGAAGATGCCATGGCTGTGAGGATGGTGAAGCAGATCTT
TGGGGTAGGGGTCATGAGGTACATGATTGTCCTCTTCACCCACAAGGAAGACCTGGCAGATGAG
TCCTTGGAAGAGTTTGTGACCCACACAGGCAACCTCGACCTGCACAGACTGGTTCAGGAGTGTG
GGAGGAGGTACTGTGCCTTTAATAACAAGGCTTCTGGGGAGGAGCAGCAGGGGCAGCTGGCAGA
GCTCATGGCCCTGGTGAGAAGACTGGAACAGGAGCATGAGGGCTCCTTCCACAGCAATGACCTC
TTCGTTTATACTCAGGTGTTCCTTAGAGGTGGCTACAGTGAACACCAGGAGCCATACAAGTTCT
ACCTGACCAAGGTGAGGCAGGAGGTAGAGAAGCAGAAGAGGGAGCTGGAGGAGCAGGAGGGCAG
CTGGATGGCTAAAATGCTTTGCAGAGTCACGTCCTGCTTGGACTGGCACATTGCAGTGTCTGTT
CTTCTTATTGTTCTTGGTCTGACCCTTCTCATCACTTTAATTAATATGTACATTGGCAGGTGGA
AATGAGTCTCTTTGGGTGAATCCTGCCATTATCCCTGTCCACCAAATTTCCCCATCTCCATGTT
AGGGAAGCTCAGTCTTCAAATAATTTCACTATCATTTGACTCCTGTGCATGAGACACAGTAGAA
CCCTTCTAAATACCGTTAAGTAAATAAAATATGAAAGAAGAATGTGTTTCTCTCTTTGTTGAAG
TTGTCAGGATAGATGATGGAGCAAGAAGCTACCATCATAAAGGTCTGGGGGCTTGCACAAAGGA
GGACTCAGGAACTGTGCAGCAGTGGGTGTGTCTCACCTAGAGCCCCACTTCCTACAGATGTGAT
ATTAAGAGGAGAAATGCAGAGCTTAGAGCAGAGTTATATTTTAGTCATAAGTTCACCCTGACCT
CACGGTACCTATAAAGTCAGAACTCCATCATCACTCCACCCCTGAGAAAGATAAAGATGGTGTG
CAGGAAGCAGAGGACTCTGAAGGTACAGAAGAGACTGAGGTTAGAGGCTGGGACGTGAGTGGGG
ACTGAGTGAAGAGGTTACAGGATCAGGGTGGGTCTTACACTAGAAAAAGCCGGGTCAGCAGTCA
AGAAACACAGGAGCCAGAATGTCTATGATCAGAGATACAAAGGGCTTGGAAGACTGTGTAGGAG
GTATAGGCCCTCGGCAGCACAGGCGGGCACAAGCCACTATGGTCAAGAGGCCATGCATTGACAA
ACCGGATGAGCAACAAATTTTGAGTTACATGTAATTTTCATGTATGAAGCTAGAACATTGTTCT
CCTGAGTCAGGCGTTTAAAAAAAAAAGGTGAAGATAGGTTGGAGAACGAGTGCAGGAATTAAGA
TTATATACTGCTGTGATCTCATGCACAGGCACTGCACTCACATGTGCACAACCCCATACAGACA
CACACACACACACACACACACACACACACACATATGTGTGTGTGTGTGTATGTATAGATTATAG
ATATAGATATAGATATAATTATTTTTTAAATGTGAAAATCAGGTTGGAAAAATGGCTCAGAGGT
TAAAGTACCAAACTAGTGTCCACATACAATTCAAGCTCAGTAGCATATATCTCTAACTCTAGAA
CTAGACAGAAAGGGAGACAGGTGGATCGCAGGGGCTCTCTGACCAGTCAGTCTAGTGGAAAATG
TGAGCTTTCCAGGCTTGGTGAGAGAAATATTGTGAAATAAGGTTATCCAAGAAAGTGAAAGAAT
TTTACAGTGGAAATTGTGAAACAGAGAAAGAAATGGAAGAAAACAGCAGAAGATGAAAGGGTTG
ATCATGGTCAAGAATCAATATTGTGAAAATAGCAATATCGTTGAAACCAGCCTACAAATTCAAT
GCAATATTTGTCAAAATGTCAGTGTTATTCTTCAAAGAAATTAAAAAAAAATAAACAGAAAAGA
AACCCTAACATTCCTTTGGAAGCTCCTGGGAACAGCTTGAGATCCCAGAGAGTTAAAAGAGAAA
TCTTGAGCAAAAGAACAATGCTGGGGGTATCACTAACCTGATATTACAGAGACATTGTAATGAC
ATCGACAACAATATCAGGAACACAGATAAATAGAATAGAGGCCCAGACACTAATCCATGCACGT
GAAGCCATGAGACTTTTGACAAAGATGCAAAAAAATATATATCAGAAAAAAAGACAACATGGGC
AGGTCCTTTGCTAGGTCTCTGAGAGCAGGCCAGCTGAATCATTGTACAACTAACAGTCGCCTGT
TAACAATATAGACAATATGCTAACAATATAGACAAATAAAAATCATACATCTATTCATATGTAT
ATATGAATGGTATGGAAAGAGAAGTGAAATTGTCCAGGGGAATAAAAGGACTAACGAGAGGAGA
AAGATTGGTAGGGAATGTAGGGGATACGGGAAAGTACAGGGTAGACTTACATAAAAATATTCTC
TCCGACCCCAGTTCTATGTACAATAAATTTACAGAAACTTTAGATGTCATTTTCAAAAACTGAC
TGAAATAAAGGCGATATGAAGACTTCTTTATTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001029085	(Get FASTA)	NCBI Sequence Viewer
	NP_663713	(Get FASTA)	NCBI Sequence Viewer
	XP_006236520	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH92561	(Get FASTA)	NCBI Sequence Viewer
	AAL17698	(Get FASTA)	NCBI Sequence Viewer
	AAL17699	(Get FASTA)	NCBI Sequence Viewer
	AAS56933	(Get FASTA)	NCBI Sequence Viewer
	AAS56936	(Get FASTA)	NCBI Sequence Viewer
	AAS56937	(Get FASTA)	NCBI Sequence Viewer
	AAS56938	(Get FASTA)	NCBI Sequence Viewer
	ABB03709	(Get FASTA)	NCBI Sequence Viewer
	ABB03710	(Get FASTA)	NCBI Sequence Viewer
	EDL88237	(Get FASTA)	NCBI Sequence Viewer
	EDL88238	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000055929.3
	ENSRNOP00000072663
	ENSRNOP00000072663.2
	ENSRNOP00000078457.1
GenBank Protein	Q8K3L6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_663713 ⟸ NM_145680
- Peptide Label:	isoform 2
- UniProtKB:	Q0R3W7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEGLQKSTYGTIVEGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRT SQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAM AVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASG EEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQK RELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK hide sequence

RefSeq Acc Id:	NP_001029085 ⟸ NM_001033913
- Peptide Label:	isoform 1
- UniProtKB:	Q5YEJ3 (UniProtKB/Swiss-Prot), Q5YEJ2 (UniProtKB/Swiss-Prot), Q8K3L7 (UniProtKB/Swiss-Prot), Q8K3L6 (UniProtKB/Swiss-Prot), A6K0I1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEDHGFEELSTRTHDLNVRRLTKGNINFLLSTGQETYSVEDSGLLRILLVGKSGCGKSATGNSI LRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGP HVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHR LVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQ EPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINM YIGRWK hide sequence

RefSeq Acc Id:	XP_006236520 ⟸ XM_006236458
- Peptide Label:	isoform X1
- UniProtKB:	Q0R3W7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEGLQKSTYGTIVEGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRT SQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAM AVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASG EEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQK RELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK hide sequence

Ensembl Acc Id:

ENSRNOP00000072663 ⟸ ENSRNOT00000084927

Ensembl Acc Id:

ENSRNOP00000071587 ⟸ ENSRNOT00000083891

Ensembl Acc Id:

ENSRNOP00000055929 ⟸ ENSRNOT00000059156

Ensembl Acc Id:

ENSRNOP00000078457 ⟸ ENSRNOT00000115571

Protein Domains

AIG1-type G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8K3L6-F1-model_v2	AlphaFold	Q8K3L6	1-326	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693032

Promoter ID:

EPDNEW_R3555

Type:

initiation region

Name:

Gimap5_1

Description:

GTPase, IMAP family member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	78,378,191 - 78,378,251	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628871	AgrOrtholog
BioCyc Gene	G2FUF-44941	BioCyc
Ensembl Genes	ENSRNOG00000008416	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000059156.3	UniProtKB/Swiss-Prot
	ENSRNOT00000084927	ENTREZGENE
	ENSRNOT00000084927.2	UniProtKB/Swiss-Prot
	ENSRNOT00000115571.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7106699	IMAGE-MGC_LOAD
	IMAGE:7130634	IMAGE-MGC_LOAD
InterPro	G_AIG1	UniProtKB/Swiss-Prot
	GIMA/IAN/Toc	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:246774	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108516	IMAGE-MGC_LOAD
	MGC:93145	IMAGE-MGC_LOAD
NCBI Gene	246774	ENTREZGENE
PANTHER	GTPASE IMAP FAMILY MEMBER 5	UniProtKB/Swiss-Prot
	PTHR10903	UniProtKB/Swiss-Prot
Pfam	AIG1	UniProtKB/Swiss-Prot
PhenoGen	Gimap5	PhenoGen
PROSITE	G_AIG1	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008416	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A6K0I1	ENTREZGENE, UniProtKB/TrEMBL
	GIMA5_RAT	UniProtKB/Swiss-Prot
	Q0R3W6_RAT	UniProtKB/TrEMBL
	Q0R3W7	ENTREZGENE, UniProtKB/TrEMBL
	Q5YEJ2	ENTREZGENE
	Q5YEJ3	ENTREZGENE
	Q8K3L6	ENTREZGENE
	Q8K3L7	ENTREZGENE
UniProt Secondary	Q5YEJ2	UniProtKB/Swiss-Prot
	Q5YEJ3	UniProtKB/Swiss-Prot
	Q8K3L7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Gimap5	GTPase, IMAP family member 5			Symbol and Name status set to approved	1299863	APPROVED
2004-12-08	Gimap5	GTPase, IMAP family member 5	Ian4l1	immune associated nucleotide 4 like 1 (mouse)	Symbol and Name updated	1299863	PROVISIONAL
2003-02-27	Ian4l1	immune associated nucleotide 4 like 1 (mouse)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	frameshift mutation which resulted in a truncated protein was found in lymphopenic rats	633092
gene_expression	mRNA expressed in spleen, thymus and lymph nodes	619544

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Mammalian Phenotype