Soat2 (sterol O-acyltransferase 2) - Rat Genome Database

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Gene: Soat2 (sterol O-acyltransferase 2) Rattus norvegicus
Analyze
Symbol: Soat2
Name: sterol O-acyltransferase 2
RGD ID: 628865
Description: Enables sterol O-acyltransferase activity. Involved in cholesterol metabolic process and response to nutrient. Predicted to be located in brush border; endoplasmic reticulum; and membrane. Predicted to be active in endoplasmic reticulum membrane. Used to study end stage renal disease. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in coronary artery disease and hepatocellular carcinoma. Orthologous to human SOAT2 (sterol O-acyltransferase 2); PARTICIPATES IN kidney failure pathway; steroid biosynthetic pathway; INTERACTS WITH 17beta-estradiol; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acat-2; acyl coenzyme A:cholesterol acyltransferase 2; acyl-CoA:cholesterol acyltransferase 2; acyl-coenzyme A:cholesterol acyltransferase 2; cholesterol acyltransferase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,160,424 - 135,173,521 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7135,160,402 - 135,173,513 (+)EnsemblGRCr8
mRatBN7.27133,281,818 - 133,294,915 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,281,818 - 133,294,915 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7135,043,192 - 135,056,256 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,272,559 - 137,285,623 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,257,195 - 137,270,297 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,754,892 - 143,767,989 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,754,892 - 143,767,989 (+)Ensemblrn6Rnor6.0
Rnor_5.07141,552,394 - 141,565,491 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,890,902 - 140,903,999 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,716,600 - 129,729,697 (+)NCBICelera
RGSC_v3.17140,967,338 - 140,980,436 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caesium atom  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
Ethyl icosapentate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
fructose  (EXP)
graphite  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
kojic acid  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium cholate  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
brush border  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
endoplasmic reticulum membrane  (IBA,IEA,ISO)
membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice. Bell TA 3rd, etal., Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1396-402. Epub 2007 Apr 12.
2. The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: modulation by cellular oxidative state. Botham KM, etal., Exp Biol Med (Maywood). 2003 Feb;228(2):143-51.
3. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Buhman KK, etal., Nat Med 2000 Dec;6(12):1341-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks. He X, etal., Hum Genet. 2005 Dec;118(3-4):393-403. Epub 2005 Sep 30.
7. Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats. Hori M, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1689-95. Epub 2004 Jul 8.
8. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential. Lee RG, etal., Circ Res. 2004 Nov 12;95(10):998-1004. Epub 2004 Oct 14.
9. Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells. Liang JJ, etal., J Biol Chem 2004 Oct 22;279(43):44938-44. Epub 2004 Aug 11.
10. Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure. Liang K and Vaziri ND, Am J Physiol Endocrinol Metab 2002 Oct;283(4):E676-81.
11. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. McCarthy JJ, etal., Hum Genet. 2003 Dec;114(1):87-98. Epub 2003 Oct 14.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma. Song BL, etal., Biochem J. 2006 Mar 15;394(Pt 3):617-26.
17. Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome. Vaziri ND and Liang K, Kidney Int 2002 May;61(5):1769-75.
Additional References at PubMed
PMID:9756919   PMID:11294643   PMID:12077311   PMID:12808042   PMID:14615411   PMID:15451793   PMID:16647063   PMID:16675724   PMID:16876788   PMID:22045928   PMID:31647302  


Genomics

Comparative Map Data
Soat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,160,424 - 135,173,521 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7135,160,402 - 135,173,513 (+)EnsemblGRCr8
mRatBN7.27133,281,818 - 133,294,915 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,281,818 - 133,294,915 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7135,043,192 - 135,056,256 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,272,559 - 137,285,623 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,257,195 - 137,270,297 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,754,892 - 143,767,989 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,754,892 - 143,767,989 (+)Ensemblrn6Rnor6.0
Rnor_5.07141,552,394 - 141,565,491 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,890,902 - 140,903,999 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,716,600 - 129,729,697 (+)NCBICelera
RGSC_v3.17140,967,338 - 140,980,436 (+)NCBI
Cytogenetic Map7q36NCBI
SOAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,103,486 - 53,124,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,103,461 - 53,124,538 (+)Ensemblhg38GRCh38
GRCh371253,497,270 - 53,518,319 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,783,541 - 51,804,590 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341251,783,581 - 51,804,589NCBI
Celera1253,145,169 - 53,166,217 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,540,306 - 50,561,441 (+)NCBIHuRef
CHM1_11253,463,699 - 53,484,782 (+)NCBICHM1_1
T2T-CHM13v2.01253,067,863 - 53,088,913 (+)NCBIT2T-CHM13v2.0
Soat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,058,853 - 102,071,871 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,058,961 - 102,071,904 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815102,150,415 - 102,163,469 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,150,526 - 102,163,469 (+)Ensemblmm10GRCm38
MGSCv3715101,981,006 - 101,993,867 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,978,609 - 101,991,470 (+)NCBIMGSCv36mm8
Celera15104,305,508 - 104,318,364 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.33NCBI
Soat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458382,892 - 394,749 (+)Ensembl
ChiLan1.0NW_004955458383,123 - 394,003 (+)NCBIChiLan1.0ChiLan1.0
SOAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,063,981 - 41,085,825 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,060,746 - 41,082,590 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,632,018 - 35,653,227 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,413,954 - 36,434,074 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,413,954 - 36,434,074 (-)EnsemblpanPan2panpan1.1
SOAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,053,063 - 2,062,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,053,067 - 2,062,329 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2744,186,356 - 44,196,074 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,057,164 - 2,066,887 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,057,174 - 2,066,374 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,074,438 - 2,083,937 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,060,773 - 2,070,480 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,585,437 - 44,595,161 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Soat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,733,617 - 62,745,065 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,420,804 - 10,430,881 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,420,847 - 10,430,813 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,358,673 - 18,371,264 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1518,358,941 - 18,371,262 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,773,838 - 18,786,099 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,214,295 - 49,228,268 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,215,034 - 49,228,244 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037196,837,935 - 196,852,282 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Soat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,160,203 - 1,170,935 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249041,160,275 - 1,170,249 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Soat2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11260,911,898 - 260,925,068 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:130
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000015368
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Rat93  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,294,921 - 133,295,037 (+)MAPPERmRatBN7.2
Rnor_6.07143,767,996 - 143,768,109NCBIRnor6.0
Rnor_5.07141,565,498 - 141,565,611UniSTSRnor5.0
RGSC_v3.47140,904,006 - 140,904,119UniSTSRGSC3.4
RGSC_v3.47140,904,005 - 140,904,119RGDRGSC3.4
Celera7129,729,704 - 129,729,817UniSTS
RGSC_v3.17140,980,443 - 140,980,556RGD
RH 3.4 Map71064.6RGD
RH 3.4 Map71064.6UniSTS
SHRSP x BN Map787.4099RGD
SHRSP x BN Map787.4099UniSTS
Cytogenetic Map7q36UniSTS
RH131180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,280,727 - 133,280,912 (+)MAPPERmRatBN7.2
Rnor_6.07143,753,802 - 143,753,986NCBIRnor6.0
Rnor_5.07141,550,827 - 141,551,011UniSTSRnor5.0
RGSC_v3.47140,889,812 - 140,889,996UniSTSRGSC3.4
Celera7129,715,510 - 129,715,694UniSTS
RH 3.4 Map71062.1UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 6 53 70 91 90 59 71 59 6 299 148 4 46 70 83 31 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000085896   ⟹   ENSRNOP00000071253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7135,160,402 - 135,173,513 (+)Ensembl
mRatBN7.2 Ensembl7133,281,818 - 133,294,915 (+)Ensembl
Rnor_6.0 Ensembl7143,754,892 - 143,767,989 (+)Ensembl
RefSeq Acc Id: NM_153728   ⟹   NP_714950
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,160,424 - 135,173,521 (+)NCBI
mRatBN7.27133,281,818 - 133,294,915 (+)NCBI
Rnor_6.07143,754,892 - 143,767,989 (+)NCBI
Rnor_5.07141,552,394 - 141,565,491 (+)NCBI
RGSC_v3.47140,890,902 - 140,903,999 (+)RGD
Celera7129,716,600 - 129,729,697 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_714950 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC00846 (Get FASTA)   NCBI Sequence Viewer  
  BAC78210 (Get FASTA)   NCBI Sequence Viewer  
  EDL86862 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071253
GenBank Protein Q7TQM4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_714950   ⟸   NM_153728
- UniProtKB: Q7TQM4 (UniProtKB/Swiss-Prot),   G3V7I6 (UniProtKB/TrEMBL),   A6KCT0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071253   ⟸   ENSRNOT00000085896

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQM4-F1-model_v2 AlphaFold Q7TQM4 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695691
Promoter ID:EPDNEW_R6216
Type:initiation region
Name:Soat2_1
Description:sterol O-acyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,754,850 - 143,754,910EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628865 AgrOrtholog
BioCyc Gene G2FUF-31948 BioCyc
BioCyc Pathway PWY-7424 [sterol:steryl ester interconversion (yeast)] BioCyc
BioCyc Pathway Image PWY-7424 BioCyc
Ensembl Genes ENSRNOG00000053769 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000085896 ENTREZGENE
InterPro MBOAT_fam UniProtKB/Swiss-Prot
  Oat_ACAT_DAG_ARE UniProtKB/Swiss-Prot
  Sterol_acyltranf_meta UniProtKB/Swiss-Prot
KEGG Report rno:266770 UniProtKB/Swiss-Prot
NCBI Gene 266770 ENTREZGENE
PANTHER PTHR10408 UniProtKB/Swiss-Prot
  STEROL O-ACYLTRANSFERASE 2 UniProtKB/Swiss-Prot
Pfam MBOAT UniProtKB/Swiss-Prot
PhenoGen Soat2 PhenoGen
PIRSF Oat_ACAT_DAG_ARE UniProtKB/Swiss-Prot
  Sterol_acyltranf_ACAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053769 RatGTEx
UniProt A6KCT0 ENTREZGENE, UniProtKB/TrEMBL
  G3V7I6 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQM4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Soat2  sterol O-acyltransferase 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Soat2  sterol O-acyltransferase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization membrane-associated in the endoplasmic reticulum 625687
gene_function catalyzes esterification of free cholesterol to cholesterol ester 625687
gene_process mediates cholesterol transport within the liver and intestinal mucosa 625687
gene_regulation chronic renal failure (CRF) increases the expression and enzymatic activity in the liver 625687