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Gene: Tor1a (torsin family 1, member A) Rattus norvegicus

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Symbol:

Tor1a

Name:

torsin family 1, member A

RGD ID:

628863

Description:

Enables kinesin binding activity. Involved in response to oxidative stress. Located in growth cone; secretory granule; and synaptic vesicle. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-5 and torsion dystonia 1. Orthologous to human TOR1A (torsin family 1 member A); INTERACTS WITH 2,4-dinitrotoluene; acrylamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dystonia 1; dystonia 1, torsion (autosomal dominant; dystonia 1, torsion (autosomal dominant); dystonia 1, torsion (autosomal dominant, torsin A); Dyt1; torsin A; torsin ATPase 1; torsin-1A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TOR1A (torsin family 1 member A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tor1a (torsin family 1, member A (torsin A))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tor1a (torsin family 1 member A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TOR1A (torsin family 1 member A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TOR1A (torsin family 1 member A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tor1a (torsin family 1 member A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TOR1A (torsin family 1 member A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TOR1A (torsin family 1 member A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tor1a (torsin family 1 member A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tor1a (torsin family 1 member A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TOR1B (torsin family 1 member B)	HGNC	OrthoDB
Homo sapiens (human):	PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TOR1A (torsin family 1 member A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tor1a (torsin family 1, member A (torsin A))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tor1l3 (torsin family 1 like 3)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	tor1l1 (torsin family 1 like 1)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	tor1 (torsin family 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ooc-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Torsin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tor-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tor-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tor1a	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	tor1a	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	tor1b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	34,648,421 - 34,655,453 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	34,648,422 - 34,655,417 (-)	Ensembl				GRCr8
mRatBN7.2	3	14,250,667 - 14,257,704 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	14,250,676 - 14,257,691 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	17,323,234 - 17,330,209 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	25,908,229 - 25,915,204 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	24,155,533 - 24,162,536 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	9,800,322 - 9,807,318 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	9,800,322 - 9,807,328 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	15,158,994 - 15,165,990 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	10,026,129 - 10,033,125 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	9,009,184 - 9,016,180 (-)	NCBI		Celera
RGSC_v3.1	3	9,921,497 - 9,928,493 (-)	NCBI
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arthrogryposis multiplex congenita-5 (ISO)

autosomal dominant intellectual developmental disorder 43 (ISO)

Contracture (ISO)

dystonia (ISO)

Dystonia Musculorum Deformans (TAS)

Familial Prostate Cancer (ISO)

focal dystonia (ISS)

genetic disease (ISO)

torsion dystonia 1 (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-colchicine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

adenine (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

captan (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

Dibutyl phosphate (ISO)

dinophysistoxin 1 (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

etoposide (ISO)

finasteride (EXP)

folic acid (ISO)

folpet (ISO)

gentamycin (EXP)

glycidyl methacrylate (ISO)

GSK-J4 (ISO)

haloperidol (ISO)

hydroxyurea (ISO)

ivermectin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

mitomycin C (ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

Nonylphenol (EXP)

okadaic acid (ISO)

oxidopamine (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

selenium atom (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sulindac (EXP)

sunitinib (ISO)

temozolomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA,ISO,ISS)

ERAD pathway (IEA,ISO,ISS)

intermediate filament cytoskeleton organization (IEA,ISO,ISS)

neuron projection development (IEA,ISO,ISS)

nuclear envelope organization (ISO,ISS)

nuclear membrane organization (IBA,ISO,ISS)

positive regulation of synaptic vesicle endocytosis (IEA,ISO,ISS)

protein deneddylation (IEA,ISO,ISS)

protein folding (IEA,ISO,ISS)

protein localization to nucleus (IBA,IEA,ISO,ISS)

regulation of dopamine uptake involved in synaptic transmission (IEA,ISO,ISS)

regulation of protein localization to cell surface (ISO,ISS)

response to oxidative stress (IDA)

synaptic vesicle membrane organization (IEA,ISO,ISS)

synaptic vesicle transport (IEA,ISO,ISS)

wound healing, spreading of cells (IEA,ISO,ISS)

Cellular Component

cytoplasm (IEA,ISO)

cytoplasmic vesicle (IEA)

cytoplasmic vesicle membrane (IEA)

endomembrane system (IEA)

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum lumen (IBA,IEA,ISO,ISS)

endoplasmic reticulum membrane (IEA,ISO,ISS)

growth cone (IDA,IEA)

membrane (IEA,ISO)

nuclear envelope (IBA,IEA,ISO,ISS)

nuclear inner membrane (IEA)

nuclear membrane (IEA,ISO)

nucleus (IEA,ISO)

secretory granule (IDA)

synaptic vesicle (IDA,IEA,ISO)

transport vesicle (IEA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA,ISO,ISS)

ATP-dependent protein folding chaperone (IEA,ISO,ISS)

cytoskeletal protein binding (IEA,ISO)

hydrolase activity (IEA)

identical protein binding (IEA,ISO,ISS)

kinesin binding (IBA,IDA,IEA,IPI,ISO)

misfolded protein binding (IEA,ISO)

protein binding (IPI,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.	Granata A, etal., EMBO J. 2011 Jan 5;30(1):181-93. doi: 10.1038/emboj.2010.285. Epub 2010 Nov 19.
3.	The dystonia-associated protein torsinA modulates synaptic vesicle recycling.	Granata A, etal., J Biol Chem. 2008 Mar 21;283(12):7568-79. doi: 10.1074/jbc.M704097200. Epub 2007 Dec 31.
4.	TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress.	Hewett J, etal., J Neurosci Res 2003 Apr 15;72(2):158-68.
5.	The early onset dystonia protein torsinA interacts with kinesin light chain 1.	Kamm C, etal., J Biol Chem 2004 May 7;279(19):19882-92. Epub 2004 Feb 17.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11730696	PMID:15505207	PMID:15767459	PMID:16325337	PMID:16361107	PMID:16364897	PMID:17037984	PMID:17200151	PMID:18538941	PMID:18827015	PMID:18971629	PMID:19199708
PMID:19535332	PMID:20015956	PMID:20080676	PMID:20169475	PMID:20457914	PMID:22472189	PMID:23376485	PMID:23569223	PMID:29289717

Genomics

Comparative Map Data

Tor1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	34,648,421 - 34,655,453 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	34,648,422 - 34,655,417 (-)	Ensembl				GRCr8
mRatBN7.2	3	14,250,667 - 14,257,704 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	14,250,676 - 14,257,691 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	17,323,234 - 17,330,209 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	25,908,229 - 25,915,204 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	24,155,533 - 24,162,536 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	9,800,322 - 9,807,318 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	9,800,322 - 9,807,328 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	15,158,994 - 15,165,990 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	10,026,129 - 10,033,125 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	9,009,184 - 9,016,180 (-)	NCBI		Celera
RGSC_v3.1	3	9,921,497 - 9,928,493 (-)	NCBI
Cytogenetic Map	3	p12	NCBI

TOR1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	129,812,942 - 129,824,136 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	129,812,942 - 129,824,244 (-)	Ensembl			hg38	GRCh38
GRCh37	9	132,575,221 - 132,586,415 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	131,615,042 - 131,626,262 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	129,654,775 - 129,665,995	NCBI
Celera	9	103,226,256 - 103,237,469 (-)	NCBI		Celera
Cytogenetic Map	9	q34.11	NCBI
HuRef	9	102,174,061 - 102,185,267 (-)	NCBI		HuRef
CHM1_1	9	132,724,350 - 132,735,481 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	142,017,521 - 142,028,703 (-)	NCBI		T2T-CHM13v2.0

Tor1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	30,850,573 - 30,857,930 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	30,850,639 - 30,857,945 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	30,960,561 - 30,967,918 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	30,960,627 - 30,967,933 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	30,816,081 - 30,823,438 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	30,782,636 - 30,789,900 (-)	NCBI		MGSCv36	mm8
Celera	2	30,666,353 - 30,673,710 (-)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	21.77	NCBI

Tor1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	30,655 - 36,360 (-)	Ensembl
ChiLan1.0	NW_004955513	30,655 - 36,299 (-)	NCBI	ChiLan1.0	ChiLan1.0

TOR1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	9,524,953 - 9,536,107 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	9,527,299 - 9,538,451 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	100,940,554 - 100,951,726 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	129,607,415 - 129,609,026 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

TOR1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	54,017,895 - 54,027,049 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	54,017,952 - 54,026,680 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	53,214,766 - 53,223,920 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	54,915,201 - 54,922,578 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	54,915,244 - 54,923,111 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	53,692,450 - 53,701,608 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	54,014,547 - 54,021,928 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	54,107,684 - 54,115,290 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tor1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	197,244,134 - 197,252,139 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	17,011,670 - 17,020,699 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	17,012,661 - 17,020,657 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOR1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	269,974,935 - 269,985,523 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	269,975,919 - 269,985,478 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	303,873,219 - 303,882,784 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOR1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	8,312,652 - 8,323,932 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	8,312,650 - 8,322,907 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666079	7,116,639 - 7,128,036 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tor1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	5,601,943 - 5,606,162 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624760	5,602,011 - 5,606,784 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tor1a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	4,649,817 - 4,656,552 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tor1a
62 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	61
Count of miRNA genes:	51
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000064660
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	29056275	47904329	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10450811	Scl73	Serum cholesterol level QTL 73	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat
10450808	Scl72	Serum cholesterol level QTL 72	4.4	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
10450806	Scl71	Serum cholesterol level QTL 71	5.8	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	28625339	67641995	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	6125437	51125437	Rat
8693641	Alc30	Alcohol consumption QTL 30	2	0.739	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	3	30832384	44921701	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	36721849	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	6556347	51556347	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	3e-08	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	15272348	60272348	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	29056275	47904329	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat

Markers in Region

Tor1a

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	14,250,707 - 14,251,075 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	9,800,358 - 9,800,725	NCBI	Rnor6.0
Rnor_5.0	3	15,159,030 - 15,159,397	UniSTS	Rnor5.0
RGSC_v3.4	3	10,026,165 - 10,026,532	UniSTS	RGSC3.4
Celera	3	9,009,220 - 9,009,587	UniSTS
Cytogenetic Map	3	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_153303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC125306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY054303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000064660 ⟹ ENSRNOP00000063691

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	34,648,422 - 34,655,417 (-)	Ensembl
mRatBN7.2 Ensembl	3	14,250,676 - 14,257,691 (-)	Ensembl
Rnor_6.0 Ensembl	3	9,800,322 - 9,807,328 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	9,800,330 - 9,801,050 (-)	Ensembl

RefSeq Acc Id:

NM_153303 ⟹ NP_695215

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	34,648,421 - 34,655,417 (-)	NCBI
mRatBN7.2	3	14,250,672 - 14,257,668 (-)	NCBI
Rnor_6.0	3	9,800,322 - 9,807,318 (-)	NCBI
Rnor_5.0	3	15,158,994 - 15,165,990 (-)	NCBI
RGSC_v3.4	3	10,026,129 - 10,033,125 (-)	RGD
Celera	3	9,009,184 - 9,016,180 (-)	RGD

Sequence:

show sequence

GGTGGGCGCTGAGACGCGCAAGGTGCGCGGGTCCGGGCATGAAGCTGGGCCGGGCCACTCTGGC
CCTGCTGCTGCTGGTGCCGTGCGTGGTTCGTGCGGTGGAGCCCATCAGCCTGGGTCTGGCCCTA
GCCGGCGTACTCACCGGCTATATCTCCTATCCTCGCCTCTACTGCCTCTTCGCCGAGTGCTGCG
GCCAGAAGCGGAGCCTCAGCCGTGAGGCGCTGCAGAAGGATCTGGATAACAAGCTCTTTGGACA
ACACCTTGCCAAAAGAGTCATCTTAAACGCCGTGTCTGGTTTCCTAAGCAACCCGAAGCCCAAG
AAGCCCCTCACCCTCTCCCTGCACGGGTGGACAGGCACCGGCAAAAACTTCGCTAGCAAGATCA
TCGCAGAGAATATTTACGAGGGTGGACTGAACAGTGACTATGTACACCTGTTTGTGGCCACGCT
ACACTTCCCCCACGCCTCTAACATCACCCTGTATAAGGACCAATTACAGATGTGGATTCGAGGC
AACGTGAGCGCCTGTGCTCGGTCCATCTTCATCTTTGACGAGATGGACAAGATGCACGCCGGCC
TCATCGACGCCATCAAGCCTTTCCTAGACTATTACGACGTGGTAGATGAGGTCTCCTATCAGAA
GGCCATCTTCATCTTCCTCAGCAATGCAGGGGCAGAAAGGATCACAGACGTGGCTCTGGATTTC
TGGAGAAGTGGGAAGCAGAGAGAGGAGATCAAGCTCAGAGACATGGAGCACGCCCTGGCCGTGT
CGGTCTTCAATAACAAGAACAGTGGCTTCTGGCACAGCAGCCTCATTGACCGGAACCTCATAGA
CTATTTTGTCCCCTTCCTGCCCCTGGAGTACAAGCACCTGAAAATGTGCATCAGAGTTGAGATG
CAGTCCCGTGGCTATGAAGAAGATGAGGACATAATCAATAAGGTAGCTGAAGAGATGACGTTCT
TCCCCAAGGAGGAGAAGGTCTTCTCTGACAAGGGCTGCAAGACTGTGTTCACCAAGCTGGACTA
CTACCTGGATGACTGAGCCCTGCTGCCAGGTGCTCTGTAGTCCGCTCCTCTCCCCACAAGAGGC
TTGGACACTTCCTGCTGAGGCTAGCGGGGATCCCATCAGGGGCGGTTTCTGCTCTTTGGAGCCT
GCAGGTGGCCATGATGTAGGGACCACAGATGCAACATGGACCTAAAGCTCCTGGAGCCTCCAAA
GGACGAAACCAGCTTCCAGCCTGCCCATTCTGGGCTCATGATTTTTTTAAAATTATGTTTTAAT
TTCAAGTGTTTCTGTTTTGAGGCAGGACAAGTGAGTTTTACTGCAAATGTGATAACTTTATTTA
AAATGGTTTTTAATACTATGAGAAGCCTTTCAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039104396 ⟹ XP_038960324

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	34,648,992 - 34,655,453 (-)	NCBI
mRatBN7.2	3	14,250,667 - 14,257,704 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_695215	(Get FASTA)	NCBI Sequence Viewer
	XP_038960324	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78714	(Get FASTA)	NCBI Sequence Viewer
	AAL05259	(Get FASTA)	NCBI Sequence Viewer
	EDL93286	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000063691
	ENSRNOP00000063691.1
GenBank Protein	Q68G38	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_695215 ⟸ NM_153303
- Peptide Label:	precursor
- UniProtKB:	Q8K3L8 (UniProtKB/Swiss-Prot), Q68G38 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MKLGRATLALLLLVPCVVRAVEPISLGLALAGVLTGYISYPRLYCLFAECCGQKRSLSREALQK DLDNKLFGQHLAKRVILNAVSGFLSNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSD YVHLFVATLHFPHASNITLYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYD VVDEVSYQKAIFIFLSNAGAERITDVALDFWRSGKQREEIKLRDMEHALAVSVFNNKNSGFWHS SLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEEDEDIINKVAEEMTFFPKEEKVFSDKGC KTVFTKLDYYLDD hide sequence

Ensembl Acc Id:

ENSRNOP00000063691 ⟸ ENSRNOT00000064660

RefSeq Acc Id:	XP_038960324 ⟸ XM_039104396
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68G38-F1-model_v2	AlphaFold	Q68G38	1-333	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691970

Promoter ID:

EPDNEW_R2495

Type:

initiation region

Name:

Tor1a_1

Description:

torsin family 1, member A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	9,807,341 - 9,807,401	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628863	AgrOrtholog
BioCyc Gene	G2FUF-50190	BioCyc
Ensembl Genes	ENSRNOG00000006894	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000064660	ENTREZGENE
	ENSRNOT00000064660.4	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7134604	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot
	TOR1A_C	UniProtKB/Swiss-Prot
	Torsin	UniProtKB/Swiss-Prot
	Torsin_1/2	UniProtKB/Swiss-Prot
KEGG Report	rno:266606	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93134	IMAGE-MGC_LOAD
NCBI Gene	266606	ENTREZGENE
PANTHER	PTHR10760	UniProtKB/Swiss-Prot
	PTHR10760:SF15	UniProtKB/Swiss-Prot
Pfam	TOR1A_C	UniProtKB/Swiss-Prot
	Torsin	UniProtKB/Swiss-Prot
PhenoGen	Tor1a	PhenoGen
PIRSF	Torsin_2A	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000006894	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	Q68G38	ENTREZGENE
	Q8K3L8	ENTREZGENE
	TOR1A_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q8K3L8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-07-09	Tor1a	torsin family 1, member A	Dyt1	dystonia 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Dyt1	dystonia 1		dystonia 1, torsion (autosomal dominant; torsin A)	Name updated	1299863	APPROVED
2003-02-27	Dyt1	dystonia 1, torsion (autosomal dominant; torsin A)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	colocalizes with the lumenal ER protein protein disulfide isomerase (PDI) and extends throughout neurites	634735
gene_protein	37 kDA	634735
gene_regulation	oxidative stress causes an increase in the apparent molecular weight and redistribution to protrusions from the cell surface	634735

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

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