Tor1aip1 (torsin 1A interacting protein 1) - Rat Genome Database

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Gene: Tor1aip1 (torsin 1A interacting protein 1) Rattus norvegicus
Analyze
Symbol: Tor1aip1
Name: torsin 1A interacting protein 1
RGD ID: 628851
Description: Enables lamin binding activity. Predicted to be involved in nuclear membrane organization; positive regulation of ATP-dependent activity; and protein localization to nucleus. Predicted to act upstream of or within protein localization to nuclear envelope. Located in nuclear envelope. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Y. Orthologous to human TOR1AIP1 (torsin 1A interacting protein 1); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lamina-associated polypeptide 1B; lamina-associated polypeptide 1C; Lap1b; Lap1c; MGC93149; torsin A interacting protein 1; torsin-1A-interacting protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,746,941 - 70,776,382 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1370,746,941 - 70,776,123 (-)EnsemblGRCr8
mRatBN7.21368,196,681 - 68,226,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,196,681 - 68,225,862 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1370,776,432 - 70,805,603 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,097,134 - 72,126,168 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,358,610 - 69,387,653 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01373,670,649 - 73,704,668 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,670,141 - 73,704,678 (-)Ensemblrn6Rnor6.0
Rnor_5.01378,593,998 - 78,629,999 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41371,042,848 - 71,072,766 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1368,060,269 - 68,088,483 (-)NCBICelera
RGSC_v3.11371,057,068 - 71,086,822 (-)NCBI
Cytogenetic Map13q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
coumarin  (ISO)
dexamethasone  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
N(4)-hydroxycytidine  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nuclear envelope  (IDA,IEA,ISO)
nuclear inner membrane  (IEA)
nuclear membrane  (IBA,IEA,ISO)
nucleus  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane. Martin L, etal., J Biol Chem 1995 Apr 14;270(15):8822-8.
3. Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals. Pestov NB, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11215-20. Epub 2007 Jun 25.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. Santos M, etal., PLoS One. 2013 Oct 7;8(10):e76788. doi: 10.1371/journal.pone.0076788. eCollection 2013.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:15767459   PMID:16128803   PMID:16361107   PMID:20457914   PMID:23569223   PMID:24275647  


Genomics

Comparative Map Data
Tor1aip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,746,941 - 70,776,382 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1370,746,941 - 70,776,123 (-)EnsemblGRCr8
mRatBN7.21368,196,681 - 68,226,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,196,681 - 68,225,862 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1370,776,432 - 70,805,603 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,097,134 - 72,126,168 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,358,610 - 69,387,653 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01373,670,649 - 73,704,668 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,670,141 - 73,704,678 (-)Ensemblrn6Rnor6.0
Rnor_5.01378,593,998 - 78,629,999 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41371,042,848 - 71,072,766 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1368,060,269 - 68,088,483 (-)NCBICelera
RGSC_v3.11371,057,068 - 71,086,822 (-)NCBI
Cytogenetic Map13q22NCBI
TOR1AIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381179,882,285 - 179,920,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1179,882,042 - 179,920,077 (+)Ensemblhg38GRCh38
GRCh371179,851,420 - 179,889,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361178,118,043 - 178,155,834 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1152,959,025 - 152,996,742 (+)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1151,083,015 - 151,120,943 (+)NCBIHuRef
CHM1_11181,274,983 - 181,312,965 (+)NCBICHM1_1
T2T-CHM13v2.01179,238,027 - 179,275,744 (+)NCBIT2T-CHM13v2.0
Tor1aip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,880,328 - 155,912,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,880,345 - 155,912,226 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381156,004,599 - 156,036,480 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1156,004,599 - 156,036,480 (-)Ensemblmm10GRCm38
MGSCv371157,851,729 - 157,883,610 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361157,768,999 - 157,798,513 (-)NCBIMGSCv36mm8
Celera1158,442,340 - 158,474,394 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.69NCBI
Tor1aip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540619,122,926 - 19,151,522 (+)Ensembl
ChiLan1.0NW_00495540619,122,906 - 19,152,458 (+)NCBIChiLan1.0ChiLan1.0
TOR1AIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2169,847,349 - 69,886,436 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1169,505,625 - 69,544,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01155,362,806 - 155,401,185 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,042,982 - 159,081,408 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,043,072 - 159,081,408 (+)EnsemblpanPan2panpan1.1
TOR1AIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1713,452,808 - 13,501,392 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl713,452,949 - 13,501,307 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha713,031,899 - 13,080,621 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0713,179,822 - 13,228,560 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl713,179,965 - 13,266,838 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1713,091,335 - 13,140,041 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0713,197,272 - 13,245,962 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0713,322,123 - 13,370,847 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tor1aip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,387,630 - 91,415,014 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364819,232,588 - 9,262,563 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364819,234,379 - 9,261,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOR1AIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9121,515,570 - 121,566,796 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19121,515,691 - 121,566,799 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29133,362,871 - 133,391,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOR1AIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12549,454,642 - 49,492,903 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2549,452,289 - 49,491,525 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605550,849,688 - 50,887,405 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tor1aip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624771172,666 - 200,893 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624771172,429 - 202,427 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tor1aip1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11035,428,646 - 35,457,858 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tor1aip1
147 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:86
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000005280, ENSRNOT00000005296
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH129301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21368,196,722 - 68,196,916 (+)MAPPERmRatBN7.2
Rnor_6.01373,670,691 - 73,670,884NCBIRnor6.0
Rnor_5.01378,595,740 - 78,595,933UniSTSRnor5.0
RGSC_v3.41371,042,890 - 71,043,083UniSTSRGSC3.4
Celera1368,060,311 - 68,060,504UniSTS
RH 3.4 Map81192.4UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 173 91 90 59 92 59 6 357 192 11 152 82 92 31 25 25

Sequence


Ensembl Acc Id: ENSRNOT00000005280   ⟹   ENSRNOP00000005280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1370,746,941 - 70,776,123 (-)Ensembl
mRatBN7.2 Ensembl1368,196,681 - 68,225,862 (-)Ensembl
Rnor_6.0 Ensembl1373,670,141 - 73,704,678 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000005296   ⟹   ENSRNOP00000005296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1370,747,704 - 70,776,123 (-)Ensembl
mRatBN7.2 Ensembl1368,197,444 - 68,225,862 (-)Ensembl
Rnor_6.0 Ensembl1373,671,412 - 73,704,480 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098741   ⟹   ENSRNOP00000085745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1370,746,941 - 70,776,123 (-)Ensembl
mRatBN7.2 Ensembl1368,196,681 - 68,225,862 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107683   ⟹   ENSRNOP00000087328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1370,746,941 - 70,776,123 (-)Ensembl
mRatBN7.2 Ensembl1368,196,681 - 68,225,862 (-)Ensembl
RefSeq Acc Id: NM_145092   ⟹   NP_659560
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,746,941 - 70,776,123 (-)NCBI
mRatBN7.21368,196,681 - 68,225,862 (-)NCBI
Rnor_6.01373,670,649 - 73,704,668 (-)NCBI
Rnor_5.01378,593,998 - 78,629,999 (-)NCBI
RGSC_v3.41371,042,848 - 71,072,766 (-)RGD
Celera1368,060,269 - 68,088,483 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250027   ⟹   XP_006250089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,746,946 - 70,774,560 (-)NCBI
mRatBN7.21368,197,301 - 68,224,299 (-)NCBI
Rnor_6.01373,670,650 - 73,703,162 (-)NCBI
Rnor_5.01378,593,998 - 78,629,999 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250028   ⟹   XP_006250090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,746,946 - 70,775,002 (-)NCBI
mRatBN7.21368,197,301 - 68,224,977 (-)NCBI
Rnor_6.01373,670,650 - 73,703,973 (-)NCBI
Rnor_5.01378,593,998 - 78,629,999 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090334   ⟹   XP_038946262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,746,946 - 70,776,382 (-)NCBI
mRatBN7.21368,197,317 - 68,226,121 (-)NCBI
RefSeq Acc Id: NP_659560   ⟸   NM_145092
- UniProtKB: Q62741 (UniProtKB/Swiss-Prot),   Q62754 (UniProtKB/Swiss-Prot),   Q5PQX1 (UniProtKB/Swiss-Prot),   A6ICZ9 (UniProtKB/TrEMBL),   A0A8I6AGC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250090   ⟸   XM_006250028
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006250089   ⟸   XM_006250027
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000005296   ⟸   ENSRNOT00000005296
Ensembl Acc Id: ENSRNOP00000005280   ⟸   ENSRNOT00000005280
RefSeq Acc Id: XP_038946262   ⟸   XM_039090334
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2B4 (UniProtKB/TrEMBL),   A0A8I6AGC6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087328   ⟸   ENSRNOT00000107683
Ensembl Acc Id: ENSRNOP00000085745   ⟸   ENSRNOT00000098741
Protein Domains
Torsin-1A-interacting protein 1/2 AAA+ activator   Torsin-1A-interacting protein 1/2 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQX1-F1-model_v2 AlphaFold Q5PQX1 1-583 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698912
Promoter ID:EPDNEW_R9437
Type:initiation region
Name:Tor1aip1_1
Description:torsin 1A interacting protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01373,704,689 - 73,704,749EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628851 AgrOrtholog
BioCyc Gene G2FUF-17826 BioCyc
Ensembl Genes ENSRNOG00000003946 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005280 ENTREZGENE
  ENSRNOT00000005280.7 UniProtKB/Swiss-Prot
  ENSRNOT00000098741 ENTREZGENE
Gene3D-CATH 3.40.50.12190 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7129718 IMAGE-MGC_LOAD
InterPro Lamina-ass_polypeptide_CLAP1C UniProtKB/Swiss-Prot
  LAP1C-like_C_sf UniProtKB/Swiss-Prot
  TOIP1/2_C UniProtKB/Swiss-Prot
  TOIP1/2_N UniProtKB/Swiss-Prot
KEGG Report rno:246314 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93149 IMAGE-MGC_LOAD
NCBI Gene 246314 ENTREZGENE
PANTHER PTHR18843 UniProtKB/Swiss-Prot
  TORSIN-1A-INTERACTING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam LAP1_N UniProtKB/Swiss-Prot
  LAP1C UniProtKB/Swiss-Prot
PhenoGen Tor1aip1 PhenoGen
RatGTEx ENSRNOG00000003946 RatGTEx
UniProt A0A8I6A2B4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q1H0_RAT UniProtKB/TrEMBL
  A6ICZ8_RAT UniProtKB/TrEMBL
  A6ICZ9 ENTREZGENE, UniProtKB/TrEMBL
  A6ID00_RAT UniProtKB/TrEMBL
  Q5PQX1 ENTREZGENE
  Q62741 ENTREZGENE
  Q62754 ENTREZGENE
  TOIP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q62741 UniProtKB/Swiss-Prot
  Q62754 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Tor1aip1  torsin 1A interacting protein 1  Tor1aip1  torsin A interacting protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tor1aip1  torsin A interacting protein 1  Lap1b  lamina-associated polypeptide 1B  Symbol and Name updated 1299863 APPROVED
2005-01-20 Lap1b  lamina-associated polypeptide 1B  Lap1c  lamina-associated polypeptide 1C  Symbol and Name updated 1299863 APPROVED
2003-02-27 Lap1c  lamina-associated polypeptide 1C      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the inner nuclear membrane 633106
gene_protein 506-amino acid protein 633106