Zbtb14 (zinc finger and BTB domain containing 14)

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Gene: Zbtb14 (zinc finger and BTB domain containing 14) Rattus norvegicus

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Symbol:

Zbtb14 (Ensembl: Zfp161)

Name:

zinc finger and BTB domain containing 14 (Ensembl:zinc finger protein 161)

RGD ID:

628712

Description:

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within heart development and kidney development. Predicted to be located in aggresome; cytosol; and nucleolus. Predicted to be active in nucleoplasm. Orthologous to human ZBTB14 (zinc finger and BTB domain containing 14); INTERACTS WITH amitrole; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Zf5; Zfp161; zinc finger and BTB domain-containing protein 14; zinc finger protein 161; zinc finger protein 161 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	116,780,100 - 116,785,306 (+)	NCBI		GRCr8
mRatBN7.2	9	109,333,440 - 109,338,646 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	109,331,028 - 109,338,632 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	117,721,347 - 117,726,535 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	122,847,609 - 122,852,815 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	121,187,236 - 121,192,424 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	117,739,067 - 117,744,273 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	117,737,611 - 117,744,300 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	117,205,246 - 117,206,593 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	108,512,808 - 108,514,157 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	108,722,289 - 108,723,637 (+)	NCBI
Celera	9	106,479,395 - 106,484,601 (+)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 18p deletion syndrome (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

carbon nanotube (ISO)

choline (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (ISO)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gentamycin (EXP)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

irinotecan (ISO)

iron dichloride (ISO)

L-methionine (ISO)

oxaliplatin (EXP)

pirinixic acid (ISO)

potassium cyanide (ISO)

quercetin (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cardiac septum development (ISO)

coronary vasculature development (ISO)

heart valve development (ISO)

kidney development (ISO)

negative regulation of DNA-templated transcription (IBA,ISO)

negative regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

aggresome (IEA,ISO)

cytosol (IEA,ISO)

nucleolus (IEA,ISO)

nucleoplasm (IBA,ISO)

nucleus (ISO)

Molecular Function

DNA-binding transcription factor activity (ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IBA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Cloning and characterization of zinc finger protein 161 in Rattus norvegicus.	Lee KH and Lee YS, DNA Seq 2004 Aug;15(4):310-3.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus.	Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
8.	The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr)	Sobek-Klocke I, etal., Genomics 1997 Jul 15;43(2):156-64.

Additional References at PubMed

PMID:8367294	PMID:15629158	PMID:17714511	PMID:25807483

Genomics

Comparative Map Data

Zbtb14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	116,780,100 - 116,785,306 (+)	NCBI		GRCr8
mRatBN7.2	9	109,333,440 - 109,338,646 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	109,331,028 - 109,338,632 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	117,721,347 - 117,726,535 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	122,847,609 - 122,852,815 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	121,187,236 - 121,192,424 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	117,739,067 - 117,744,273 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	117,737,611 - 117,744,300 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	117,205,246 - 117,206,593 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	108,512,808 - 108,514,157 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	108,722,289 - 108,723,637 (+)	NCBI
Celera	9	106,479,395 - 106,484,601 (+)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

ZBTB14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	5,289,022 - 5,297,053 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	5,289,019 - 5,297,053 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	5,289,021 - 5,297,052 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	5,279,379 - 5,283,313 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	5,279,378 - 5,283,313	NCBI
Celera	18	5,173,448 - 5,180,808 (-)	NCBI		Celera
Cytogenetic Map	18	p11.31	NCBI
HuRef	18	5,254,774 - 5,262,912 (-)	NCBI		HuRef
CHM1_1	18	5,288,930 - 5,296,891 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	5,451,292 - 5,459,322 (-)	NCBI		T2T-CHM13v2.0

Zbtb14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	69,690,170 - 69,697,747 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	69,690,045 - 69,698,194 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	69,383,175 - 69,390,752 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	69,383,050 - 69,391,199 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	69,733,318 - 69,739,884 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	69,288,880 - 69,295,446 (+)	NCBI		MGSCv36	mm8
Celera	17	73,673,040 - 73,679,603 (+)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	40.42	NCBI

Zbtb14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	5,750,877 - 5,757,370 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	5,750,877 - 5,757,370 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZBTB14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	33,153,728 - 33,160,711 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	18,846,321 - 18,853,304 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	8,986,957 - 8,996,065 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	11,303,640 - 11,309,749 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	11,303,612 - 11,309,749 (+)	Ensembl	panpan1.1		panPan2

ZBTB14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	71,680,692 - 71,687,651 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	71,682,578 - 71,687,703 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	71,136,728 - 71,143,682 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	71,738,166 - 71,745,177 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	71,738,166 - 71,745,276 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	71,440,837 - 71,447,786 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	71,468,973 - 71,475,935 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	71,760,581 - 71,767,581 (-)	NCBI		UU_Cfam_GSD_1.0

Zbtb14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	67,892,571 - 68,014,817 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936779	1,199,490 - 1,207,934 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936779	1,198,469 - 1,205,671 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZBTB14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	101,758,014 - 101,764,531 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	101,757,067 - 101,764,531 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ZBTB14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	64,388,984 - 64,398,969 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	64,389,055 - 64,394,938 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	39,261,736 - 39,268,709 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Zbtb14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	15,012,887 - 15,019,805 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	15,016,689 - 15,021,000 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Zbtb14
29 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	137
Count of miRNA genes:	119
Interacting mature miRNAs:	130
Transcripts:	ENSRNOT00000022396
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	77813894	111552878	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat

Markers in Region

Zfp161

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	109,336,409 - 109,337,215 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	117,742,037 - 117,742,842	NCBI	Rnor6.0
Rnor_5.0	9	117,206,288 - 117,207,093	UniSTS	Rnor5.0
RGSC_v3.4	9	108,513,852 - 108,514,657	UniSTS	RGSC3.4
Celera	9	106,482,365 - 106,483,170	UniSTS
Cytogenetic Map	9	q38	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_172325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY157624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022396 ⟹ ENSRNOP00000022396

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	109,331,028 - 109,338,632 (+)	Ensembl
Rnor_6.0 Ensembl	9	117,737,611 - 117,744,300 (+)	Ensembl

RefSeq Acc Id:

NM_172325 ⟹ NP_758828

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	116,780,100 - 116,785,306 (+)	NCBI
mRatBN7.2	9	109,333,440 - 109,338,646 (+)	NCBI
Rnor_6.0	9	117,739,067 - 117,744,273 (+)	NCBI
Rnor_5.0	9	117,205,246 - 117,206,593 (+)	NCBI
RGSC_v3.4	9	108,512,808 - 108,514,157 (+)	RGD
Celera	9	106,479,395 - 106,484,601 (+)	NCBI

Sequence:

show sequence

ATCTGGCTTGCCCCTGATCAGACTTACTCTGATCTGAAGATTTTGTTGTTTAAGGCATTAAGAA
AATAGCCTGAATTGTTCATGGAGTTTTTCATCAGTATGTCTGAAACTATAAAATACAATGACGA
TGATCATAAGACGCTGTTTCTGAAAACGCTGAACGAACAGCGCCTGGAAGGAGAGTTCTGTGAC
ATCGCCATCGTGGTGGAAGATGTGAAGTTCAGAGCCCACCGCTGTGTCCTCGCCGCCTGCAGCA
CGTACTTTAAGAAGCTGTTTAAGAAGCTGGAAGTGGATAGCTCTTCTGTCATAGAGATAGATTT
CCTCCGTTCCGACATATTTGAAGAGGTGCTGAACTACATGTACACAGCAAAGATTTCCGTGAAG
AAGGAGGACGTCAACCTGATGATGTCGTCCGGTCAGATTCTTGGCATCCGCTTTTTGGATAAAC
TGTGTTCCCAGAAGCGCGACGTGTCCAGCCCGGATGAAAGTAACGGCCAGTCCAAGAGTAAGTA
TTGCCTCAAGTTAAACCGCCCCATTGGAGACGCTGCCGATGCTCAGGACGATGATGTGGAAGAA
ATCGGGGACCAGGATGACAGCCCTTCTGACGACACGGTGGAGGGCACTCCCCCAAGCCAGGAGG
ACGGCAAGTCTCCCACGACCACTCTCAGGGTTCAGGAAGCGATTTTGAAAGAGCTGGGGAGTGA
AGAGGTTCGGAAAGTGAACTGCTACGGCCAGGAGGTGGAATCCATGGAGACTCCCGAGTCCAAA
GATCTGGGGTCTCAGACCCCCCAAGCCTTAACCTTTAACGACGGGATGAGCGAGGTGAAAGACG
AACAGACTCCTGGCTGGACGACAGCAGCCAGTGACATGAAGTTTGAGTACCTGCTCTACGGTCA
CCACCGGGAGCAGATCGCCTGCCAGGCGTGCGGGAAGACGTTTTCTGACGAAGGCAGGTTGAGG
AAGCATGAAAAGCTCCACACGGCAGACAGGCCATTTGTCTGTGAGATGTGTACAAAGGGTTTCA
CCACCCAGGCCCATCTGAAGGAACACCTAAAGATCCACACGGGGTATAAACCATACAGCTGTGA
GGTGTGCGGGAAGTCGTTTATCCGCGCCCCAGACCTGAAGAAGCACGAGAGAGTTCACAGCAAC
GAGAGACCGTTCGCCTGTCACATGTGCGACAAAGCCTTCAAACACAAGTCTCACCTCAAGGACC
ACGAGAGAAGACACAGAGGGGAGAAGCCTTTTGTGTGCGGCTCCTGCACCAAGGCCTTTGCCAA
GGCCTCGGATCTGAAGAGGCACGAGAACAATATGCACAGTGAAAGGAAACAGGTCACCCCCAGT
GCCATCCAGAGCGAGACGGAACAGTTGCAGGCCGCAGCGATGGCCGCTGAGGCGGAACAGCAGC
TAGAGACAATTGCCTGTAGCTAGAGGTGGTGGGTCAGGAACACTCGGCCCGGGAGGTGGTCGCT
TGAACACTTCTGTGCTGGCAGGACCTAAGGCAGTGTGCACTCCGGTTAGGTAATTCTCAGATTT
CTCAAGGCAGTTATGTTCCTACGTTCTGACCAAACAGTTTGAGGTTTTTTTTGTTTGTTTGTTT
GGTTGTTTTTTTTTTGTTTTGTTTTGTTTTGTTTTTTGTGATGTCTAAAGTTCATATTCTCAAT
AAGTTCCTCTACCCTTCTTTATGGTTTTAGTTCGAAATCTCCTTTGTCTAGTTTAAAATGGATG
GCTTCTGTCCCGTCCAGAATCCCTCAAGTCTTACCAAGCTGGTGAGTGCACTGCGGAGAGTCAC
TGAAATAAATTGATTTCCCCAATCATCCCAGTGTATGTGACTACTCATGGTCAAAACAGCAGTT
TTAATAACTGGATACAAGAACTTTATATATAGGGTGCAGACAGTGTTGGCACGCGCTGACCCAG
AACACTGCAGAAGTACAAAACCAAATGTGGAAAAATGGAATGGTGTTGAGTTTTATATTTGGTT
TGTGATTTCTCTCTCTCTCACATACACACACACACACACACACACACACACACACACACACACG
TTTTTCACTGTTCCTGTGGACAAACAGTGGTTGCTTTCCTGAAGTGTTTCTTCATCCATTGTAA
TGGCCCCTGTACCCACCCATGCTGCGGGTCATGTGGTACCTCAGGGTGAGCGAGATCACCAGGA
GGCTGGTGGTGTTGAAACCGAGTTCCTCTTTTGTCCAGTGTGGCCATACTGTCTGTGTGTGTCT
GTGCGGTGGACCAGTATCGACTGGAGGAGAAGAGTCTAAGACAAGGTTTTTACAGATTAAAACA
AAACAAAAAAAAAACAAAAAAAAAAGCCCTAAGGTTTCCTAGGTCTTGAAATTGTGACTGGTTT
TGTATTTAAGATCAAAATTAGGACAAGGAACAGAGATGTTTCTTCAGATGTTTGTGTAGCTTGC
AGGTCGTCAAGCTTGGGGTGGGGGCATCTCTGCAGCACTCAGGTTCCCGTGAAGAAGACGCTCG
CTTACGTGAATGTGAAATCCTTTAAGTGTGTAAATAGTAGTGTTGGTCTCATGCATTTCGAGAA
AAAGGACAGCTGCAATGTTTTTTCCTTTCCTTTTTTTTTTTTCTTCTTCTTTTTTTTACGCAGT
GGATTAAAGTACCTTTCACTGGCAACAAGTCTCAGACCCCTTCAACCAACGTTAGAGACCATCA
GACGAACCGTCCATGTTCTCCAAATGTGTTTTATCATTGGTGGTTGCAGTTTTCGATGGAAGCT
GATTGCCTTGTCATAGCCATAAATCAGAATTATGAACTTTGTTACAGATTGGGCGTACTAAATG
CTCTTTTGACTGTTTCCTTAGGAATATATTGAAATGCCAACGGAGTTCGGATTATGTTCTGTAA
GAAAGTGTAGACCATTGTTTTAGGATGTGTACAGTTGTAGAAGGTGCCAGCTTTAAGAGTTCAT
GTTTTGGTTCTTAAGGTTTTTCTTTTTTCTTTTTTGTTTATAAATGCATCAAAGTAATTTCATT
ACATGGCTTGCCGTACTAACATCTGTTATTACTGTTGTGAGAAAATTTTTTACTTTCAAAACCG
GTGTACATGTTTATGCCCGAGATTGTCGGATGGAGAAGCTACCGTTAAGATTTTTTTTTAATTT
ATTTTTAAAATGTATTGGCTTAAATTAATTTTTCCCTGAGCGGTTTGTTCTGTTTCGAAGGCAA
TCCCGTCAGTTCGACTATGCTGTTAGTAGGGGGGGGCCAACTGGTGATCCTGGGCTGTGTTAAC
CAAAGCAAATGTGAGATCAGCTGGCATCCTGTTAATAGCTATTTCAACAAACCATATTTTGGGC
CTTTGTTTTTGTATATAAAGATAATGATACACTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_758828	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAN75191	(Get FASTA)	NCBI Sequence Viewer
	EDL90928	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022396.4

RefSeq Acc Id:

NP_758828 ⟸ NM_172325

- UniProtKB:

F1LMU5 (UniProtKB/TrEMBL), A6KF76 (UniProtKB/TrEMBL), Q8CGQ6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKL
FKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKR
DVSSPDESNGQSKSKYCLKLNRPIGDAADAQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPT
TTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGW
TTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHL
KEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHR
GEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIAC
S

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Ensembl Acc Id:

ENSRNOP00000022396 ⟸ ENSRNOT00000022396

Protein Domains

BTB C2H2-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LMU5-F1-model_v2	AlphaFold	F1LMU5	1-449	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628712	AgrOrtholog
BioCyc Gene	G2FUF-26369	BioCyc
Ensembl Genes	ENSRNOG00000016719	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000022396.7	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	BTB/POZ-like	UniProtKB/TrEMBL
	BTB/POZ_fold	UniProtKB/TrEMBL
	Znf_C2H2/integrase_DNA-bd	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
KEGG Report	rno:282825	UniProtKB/TrEMBL
NCBI Gene	282825	ENTREZGENE
PANTHER	ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7A	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN	UniProtKB/TrEMBL
Pfam	BTB	UniProtKB/TrEMBL
	zf-C2H2	UniProtKB/TrEMBL
PhenoGen	Zbtb14	PhenoGen
PROSITE	BTB	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016719	RatGTEx
SMART	BTB	UniProtKB/TrEMBL
	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	BTB/POZ_fold	UniProtKB/TrEMBL
	SSF57667	UniProtKB/TrEMBL
UniProt	A6KF76	ENTREZGENE, UniProtKB/TrEMBL
	F1LMU5	ENTREZGENE, UniProtKB/TrEMBL
	Q8CGQ6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-07-13	Zbtb14	zinc finger and BTB domain containing 14	Zfp161	zinc finger protein 161	Name and Symbol changed	629549	APPROVED
2005-11-17	Zfp161	zinc finger protein 161			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Zfp161	zinc finger protein 161			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	human homolog is a candidate gene for holoprosencephaly type 4 (HPE4)	727770

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar