Gpsm1 (G-protein signaling modulator 1) - Rat Genome Database

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Gene: Gpsm1 (G-protein signaling modulator 1) Rattus norvegicus
Analyze
Symbol: Gpsm1
Name: G-protein signaling modulator 1
RGD ID: 628682
Description: Enables G-protein alpha-subunit binding activity. Involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cell cortex. Used to study alcohol dependence. Orthologous to human GPSM1 (G protein signaling modulator 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activator of G-protein signaling 3; Ags3; G-protein signaling modulator 1 (AGS3-like, C. elegans); G-protein signalling modulator 1 (AGS3-like, C. elegans); G-protein-signaling modulator 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,538,929 - 29,565,921 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl329,526,802 - 29,565,920 (+)EnsemblGRCr8
mRatBN7.239,140,816 - 9,167,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,128,636 - 9,167,827 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx312,194,280 - 12,221,191 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,777,510 - 20,804,421 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,032,845 - 19,059,758 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,767,394 - 3,794,360 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,767,394 - 3,794,359 (+)Ensemblrn6Rnor6.0
Rnor_5.039,127,874 - 9,155,507 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.434,493,828 - 4,520,795 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,960,926 - 3,987,743 (+)NCBICelera
RGSC_v3.134,500,900 - 4,519,959 (+)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. An N, etal., J Biol Chem. 2008 Sep 5;283(36):24718-28. Epub 2008 Jun 19.
2. Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis. Blumer JB, etal., J Biol Chem 2002 May 3;277(18):15897-903.
3. Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha. Blumer JB, etal., J Biol Chem 2003 Jun 27;278(26):23217-20. Epub 2003 Apr 28.
4. Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Bowers MS, etal., Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12533-8. doi: 10.1073/pnas.0706999105. Epub 2008 Aug 21.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation. Ghosh M, etal., J Biol Chem 2003 Sep 12;278(37):34747-50. Epub 2003 Jul 24.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3. Peterson YK, etal., J Biol Chem 2000 Oct 27;275(43):33193-6.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Receptor-independent activators of heterotrimeric G-protein signaling pathways. Takesono A, etal., J Biol Chem 1999 Nov 19;274(47):33202-5.
Additional References at PubMed
PMID:8889548   PMID:11024022   PMID:11042168   PMID:11121039   PMID:11278352   PMID:12477932   PMID:12642577   PMID:12834360   PMID:14530282   PMID:14726514   PMID:15091342   PMID:15489334  
PMID:15937104   PMID:16009138   PMID:16154268   PMID:16458856   PMID:18541531   PMID:20065032   PMID:20305814   PMID:21343176   PMID:22074847   PMID:23404409   PMID:23504261  


Genomics

Comparative Map Data
Gpsm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,538,929 - 29,565,921 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl329,526,802 - 29,565,920 (+)EnsemblGRCr8
mRatBN7.239,140,816 - 9,167,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,128,636 - 9,167,827 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx312,194,280 - 12,221,191 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,777,510 - 20,804,421 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,032,845 - 19,059,758 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,767,394 - 3,794,360 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,767,394 - 3,794,359 (+)Ensemblrn6Rnor6.0
Rnor_5.039,127,874 - 9,155,507 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.434,493,828 - 4,520,795 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,960,926 - 3,987,743 (+)NCBICelera
RGSC_v3.134,500,900 - 4,519,959 (+)NCBI
Cytogenetic Map3p13NCBI
GPSM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,327,539 - 136,359,601 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,327,476 - 136,359,605 (+)Ensemblhg38GRCh38
GRCh379139,221,995 - 139,254,053 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,348,726 - 138,372,493 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349136,504,741 - 136,528,509NCBI
Celera9109,736,118 - 109,768,993 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,681,506 - 108,713,413 (+)NCBIHuRef
CHM1_19139,370,654 - 139,402,253 (+)NCBICHM1_1
T2T-CHM13v2.09148,556,955 - 148,588,936 (+)NCBIT2T-CHM13v2.0
Gpsm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,204,623 - 26,238,249 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,205,527 - 26,238,249 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38226,314,611 - 26,348,237 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,315,515 - 26,348,237 (+)Ensemblmm10GRCm38
MGSCv37226,171,060 - 26,203,755 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36226,137,549 - 26,170,244 (+)NCBIMGSCv36mm8
Celera226,038,151 - 26,065,930 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.73NCBI
Gpsm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,361,139 - 4,387,356 (-)Ensembl
ChiLan1.0NW_0049555134,363,534 - 4,387,356 (-)NCBIChiLan1.0ChiLan1.0
GPSM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,026,987 - 3,058,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,029,322 - 3,060,608 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,400,819 - 107,432,165 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,387,430 - 136,411,951 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,383,929 - 136,410,561 (+)EnsemblpanPan2panpan1.1
GPSM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,124,828 - 49,152,079 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,118,627 - 49,152,208 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha948,375,389 - 48,402,483 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0950,001,466 - 50,028,600 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,001,472 - 50,028,791 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,781,935 - 48,809,055 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,076,267 - 49,103,397 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,123,796 - 49,150,891 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpsm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,905,770 - 201,932,514 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,440,902 - 1,463,944 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,442,550 - 1,469,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPSM1
(Sus scrofa - pig)		 No map positions available.
GPSM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,845,882 - 1,877,400 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,847,233 - 1,877,265 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660583,338,671 - 3,370,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpsm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,507,242 - 1,529,163 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247601,507,255 - 1,529,170 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpsm1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1510,740,404 - 10,767,067 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpsm1
156 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:125
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000067840
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH130608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,167,608 - 9,167,792 (+)MAPPERmRatBN7.2
Rnor_6.033,794,141 - 3,794,324NCBIRnor6.0
Rnor_5.039,155,288 - 9,155,471UniSTSRnor5.0
RGSC_v3.434,520,576 - 4,520,759UniSTSRGSC3.4
Celera33,987,524 - 3,987,707UniSTS
Cytogenetic Map3p13UniSTS
RH140521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,167,731 - 9,167,977 (+)MAPPERmRatBN7.2
Rnor_6.033,794,264 - 3,794,509NCBIRnor6.0
Rnor_5.039,155,411 - 9,155,656UniSTSRnor5.0
RGSC_v3.434,520,699 - 4,520,944UniSTSRGSC3.4
Celera33,987,647 - 3,987,892UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY136742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF408282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB615566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB743977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067840   ⟹   ENSRNOP00000062075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,538,911 - 29,565,918 (+)Ensembl
mRatBN7.2 Ensembl39,140,864 - 9,167,827 (+)Ensembl
Rnor_6.0 Ensembl33,767,394 - 3,794,359 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084567   ⟹   ENSRNOP00000070079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,553,218 - 29,565,918 (+)Ensembl
mRatBN7.2 Ensembl39,155,125 - 9,167,827 (+)Ensembl
Rnor_6.0 Ensembl33,788,583 - 3,794,359 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097564   ⟹   ENSRNOP00000079739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,535,951 - 29,565,920 (+)Ensembl
mRatBN7.2 Ensembl39,137,147 - 9,167,827 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102548   ⟹   ENSRNOP00000089684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,543,609 - 29,565,920 (+)Ensembl
mRatBN7.2 Ensembl39,145,516 - 9,167,827 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111577   ⟹   ENSRNOP00000094743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,538,911 - 29,565,918 (+)Ensembl
mRatBN7.2 Ensembl39,140,864 - 9,167,827 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118478   ⟹   ENSRNOP00000084484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl329,526,802 - 29,565,920 (+)Ensembl
mRatBN7.2 Ensembl39,128,636 - 9,167,827 (+)Ensembl
RefSeq Acc Id: NM_001145469   ⟹   NP_001138941
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,560,144 - 29,565,921 (+)NCBI
mRatBN7.239,162,051 - 9,167,828 (+)NCBI
Rnor_6.033,788,583 - 3,794,360 (+)NCBI
Rnor_5.039,127,874 - 9,155,507 (+)NCBI
RGSC_v3.434,493,828 - 4,520,795 (+)RGD
Celera33,981,980 - 3,987,743 (+)NCBI
Sequence:
RefSeq Acc Id: NM_144745   ⟹   NP_653346
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,538,953 - 29,565,921 (+)NCBI
mRatBN7.239,140,864 - 9,167,828 (+)NCBI
Rnor_6.033,767,394 - 3,794,360 (+)NCBI
Rnor_5.039,127,874 - 9,155,507 (+)NCBI
RGSC_v3.434,493,828 - 4,520,795 (+)RGD
Celera33,960,926 - 3,987,743 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233670   ⟹   XP_006233732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,543,547 - 29,565,919 (+)NCBI
mRatBN7.239,144,692 - 9,167,828 (+)NCBI
Rnor_6.033,771,938 - 3,794,358 (+)NCBI
Rnor_5.039,127,874 - 9,155,507 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761620   ⟹   XP_008759842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,553,391 - 29,565,919 (+)NCBI
mRatBN7.239,155,290 - 9,167,828 (+)NCBI
Rnor_6.033,781,786 - 3,794,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591463   ⟹   XP_017446952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,551,363 - 29,565,919 (+)NCBI
mRatBN7.239,153,262 - 9,167,828 (+)NCBI
Rnor_6.033,780,409 - 3,794,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104257   ⟹   XP_038960185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,538,929 - 29,564,440 (+)NCBI
mRatBN7.239,140,816 - 9,166,347 (+)NCBI
RefSeq Acc Id: XM_039104258   ⟹   XP_038960186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,547,452 - 29,565,919 (+)NCBI
mRatBN7.239,149,359 - 9,167,828 (+)NCBI
RefSeq Acc Id: XM_063283082   ⟹   XP_063139152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,560,277 - 29,565,919 (+)NCBI
RefSeq Acc Id: NP_653346   ⟸   NM_144745
- Peptide Label: isoform a
- UniProtKB: Q8K3E2 (UniProtKB/Swiss-Prot),   Q9R080 (UniProtKB/Swiss-Prot),   G3V9X2 (UniProtKB/TrEMBL),   A6JTD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138941   ⟸   NM_001145469
- Peptide Label: isoform b
- UniProtKB: A6JTD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233732   ⟸   XM_006233670
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AC91 (UniProtKB/TrEMBL),   A6JTD2 (UniProtKB/TrEMBL),   A6JTD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759842   ⟸   XM_008761620
- Peptide Label: isoform X3
- UniProtKB: A0A8L2R2Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446952   ⟸   XM_017591463
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000062075   ⟸   ENSRNOT00000067840
Ensembl Acc Id: ENSRNOP00000070079   ⟸   ENSRNOT00000084567
RefSeq Acc Id: XP_038960185   ⟸   XM_039104257
- Peptide Label: isoform X1
- UniProtKB: Q9R080 (UniProtKB/Swiss-Prot),   Q8K3E2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038960186   ⟸   XM_039104258
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000079739   ⟸   ENSRNOT00000097564
Ensembl Acc Id: ENSRNOP00000084484   ⟸   ENSRNOT00000118478
Ensembl Acc Id: ENSRNOP00000089684   ⟸   ENSRNOT00000102548
Ensembl Acc Id: ENSRNOP00000094743   ⟸   ENSRNOT00000111577
RefSeq Acc Id: XP_063139152   ⟸   XM_063283082
- Peptide Label: isoform X4
- UniProtKB: A6JTD5 (UniProtKB/TrEMBL)
Protein Domains
GoLoco

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R080-F1-model_v2 AlphaFold Q9R080 1-673 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691900
Promoter ID:EPDNEW_R2425
Type:single initiation site
Name:Gpsm1_1
Description:G-protein signaling modulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.033,788,566 - 3,788,626EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628682 AgrOrtholog
BioCyc Gene G2FUF-50388 BioCyc
Ensembl Genes ENSRNOG00000018666 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000067840 ENTREZGENE
  ENSRNOT00000102548 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
InterPro GoLoco_motif UniProtKB/Swiss-Prot
  GPSM UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:246254 UniProtKB/Swiss-Prot
NCBI Gene 246254 ENTREZGENE
PANTHER G-PROTEIN-SIGNALING MODULATOR 1 UniProtKB/Swiss-Prot
  LD33695P UniProtKB/Swiss-Prot
Pfam GoLoco UniProtKB/Swiss-Prot
  TPR_10 UniProtKB/Swiss-Prot
  TPR_12 UniProtKB/Swiss-Prot
PhenoGen Gpsm1 PhenoGen
PROSITE GOLOCO UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018666 RatGTEx
SMART GoLoco UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniProt A0A8I5ZNN7_RAT UniProtKB/TrEMBL
  A0A8I5ZZF6_RAT UniProtKB/TrEMBL
  A0A8I6AC91 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMW5_RAT UniProtKB/TrEMBL
  A0A8L2R2Q0 ENTREZGENE, UniProtKB/TrEMBL
  A6JTD0 ENTREZGENE, UniProtKB/TrEMBL
  A6JTD1_RAT UniProtKB/TrEMBL
  A6JTD2 ENTREZGENE, UniProtKB/TrEMBL
  A6JTD3_RAT UniProtKB/TrEMBL
  A6JTD4 ENTREZGENE, UniProtKB/TrEMBL
  A6JTD5 ENTREZGENE, UniProtKB/TrEMBL
  G3V9X2 ENTREZGENE, UniProtKB/TrEMBL
  GPSM1_RAT UniProtKB/Swiss-Prot
  Q8K3E2 ENTREZGENE
  Q9R080 ENTREZGENE
UniProt Secondary Q8K3E2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Gpsm1  G-protein signaling modulator 1  Gpsm1  G-protein signaling modulator 1 (AGS3-like, C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Gpsm1  G-protein signaling modulator 1 (AGS3-like, C. elegans)  Gpsm1  G-protein signalling modulator 1 (AGS3-like, C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gpsm1  G-protein signalling modulator 1 (AGS3-like, C. elegans)  Ags3  activator of G-protein signaling 3  Symbol and Name updated 1299863 APPROVED
2003-02-27 Ags3  activator of G-protein signaling 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains four G-protein regulatory motifs that may bind G-protein alpha subunits 631949
gene_physical_interaction binds to Galpha and showed a preference for GalphaGDP versus GalphaGTPgammaS 631950