Abo3 (histo-blood group ABO system transferase 3) - Rat Genome Database

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Gene: Abo3 (histo-blood group ABO system transferase 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Abo3
Name: histo-blood group ABO system transferase 3
RGD ID: 628609
Description: Enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in defense response to bacterium. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase); INTERACTS WITH 17beta-estradiol; alpha-Zearalanol; fenvalerate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a transferase; Abo; ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase); ABO blood group (transferase B, alpha 1-3-galactosyltransferase); ABO blood group-like 1; Abol1; alpha 1-3-N-acetylgalactosaminyltransferase-like 1; B blood group galactosyltransferase; b transferase; blood group A glycosyltransferase 1; cis-AB transferase 1; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Gbgt1; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; histo-blood group A transferase; histo-blood group ABO system transferase 1; histo-blood group B transferase; N-acetylgalactosaminyltransferase A blood group-like enzyme; NAGAT 1; transferase B, alpha 1-3-galactosyltransferase)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Is Marker For: Strains:   W-Tg(CAG-ABO*A)32Jmsk ; W-Tg(CAG-ABO*B)13Jmsk ; W-Tg(CAG-ABO*B)2Jmsk
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,141,941 - 30,159,129 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl330,139,289 - 30,159,129 (+)EnsemblGRCr8
mRatBN7.239,743,861 - 9,761,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,646,515 - 9,761,043 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd327,698,644 - 27,715,834 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive334,647,541 - 34,664,731 (+)NCBILyon_Normotensive
Lyon_Hypertensive326,547,023 - 26,564,213 (+)NCBILyon_Hypertensive
F344_StmMcwi37,754,938 - 7,772,128 (+)NCBIF344_StmMcwi
Rnor_6.035,109,880 - 5,127,376 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,118,956 - 5,126,901 (+)Ensemblrn6Rnor6.0
Rnor_5.0310,462,400 - 10,479,896 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.435,253,147 - 5,269,783 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera34,553,035 - 4,569,671 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning of a rat gene encoding the histo-blood group A enzyme. Tissue expression of the gene and of the A and B antigens. Cailleau-Thomas A, etal., Eur J Biochem 2002 Aug;269(16):4040-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat encodes the paralogous gene equivalent of the human histo-blood group ABO gene. Association with antigen expression by overexpression of human ABO transferase. Iwamoto S, etal., J Biol Chem 2002 Nov 29;277(48):46463-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection. Olson FJ, etal., J Biol Chem 2002 Apr 26;277(17):15044-52.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12799344  


Genomics

Variants

.
Variants in Abo3
166 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:80
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000006553, ENSRNOT00000074271
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Related Rat Strains
The following Strains have been annotated to Abo3
W-Tg(CAG-ABO*A)32Jmsk     W-Tg(CAG-ABO*B)13Jmsk     W-Tg(CAG-ABO*B)2Jmsk    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
15 6 22 39 36 22 8 22 6 95 26 10 32 44 14

Sequence


Ensembl Acc Id: ENSRNOT00000006553   ⟹   ENSRNOP00000006553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,141,941 - 30,159,129 (+)Ensembl
mRatBN7.2 Ensembl39,743,869 - 9,761,043 (+)Ensembl
Rnor_6.0 Ensembl35,118,956 - 5,126,901 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074271   ⟹   ENSRNOP00000065701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,150,880 - 30,159,129 (+)Ensembl
mRatBN7.2 Ensembl39,687,102 - 9,761,043 (+)Ensembl
Rnor_6.0 Ensembl35,118,962 - 5,126,901 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108913   ⟹   ENSRNOP00000077013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,752,800 - 9,761,043 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113251   ⟹   ENSRNOP00000087139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,752,315 - 9,761,043 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116703   ⟹   ENSRNOP00000084937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,139,289 - 30,159,129 (+)Ensembl
mRatBN7.2 Ensembl39,646,515 - 9,761,043 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126673   ⟹   ENSRNOP00000111156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,150,395 - 30,159,129 (+)Ensembl
RefSeq Acc Id: NM_023094   ⟹   NP_075582
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,141,941 - 30,159,129 (+)NCBI
mRatBN7.239,743,861 - 9,761,049 (+)NCBI
Dahl_SR_JrHsd327,698,644 - 27,715,834 (+)NCBI
Lyon_Normotensive334,647,541 - 34,664,731 (+)NCBI
Lyon_Hypertensive326,547,023 - 26,564,213 (+)NCBI
F344_StmMcwi37,754,938 - 7,772,128 (+)NCBI
Rnor_6.035,109,880 - 5,126,901 (+)NCBI
Rnor_5.0310,462,400 - 10,479,896 (+)NCBI
RGSC_v3.435,253,147 - 5,269,783 (+)RGD
Celera34,553,035 - 4,569,671 (+)RGD
Sequence:
RefSeq Acc Id: NP_075582   ⟸   NM_023094
- UniProtKB: Q8R4Y3 (UniProtKB/Swiss-Prot),   Q8R005 (UniProtKB/Swiss-Prot),   Q8CFC6 (UniProtKB/Swiss-Prot),   Q8CFC5 (UniProtKB/Swiss-Prot),   Q8R552 (UniProtKB/Swiss-Prot),   Q9ET32 (UniProtKB/Swiss-Prot),   A0A0H2UI32 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006553   ⟸   ENSRNOT00000006553
Ensembl Acc Id: ENSRNOP00000065701   ⟸   ENSRNOT00000074271
Ensembl Acc Id: ENSRNOP00000087139   ⟸   ENSRNOT00000113251
Ensembl Acc Id: ENSRNOP00000077013   ⟸   ENSRNOT00000108913
Ensembl Acc Id: ENSRNOP00000084937   ⟸   ENSRNOT00000116703
Ensembl Acc Id: ENSRNOP00000111156   ⟸   ENSRNOT00000126673

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ET32-F1-model_v2 AlphaFold Q9ET32 1-348 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628609 AgrOrtholog
BioCyc Gene G2FUF-50340 BioCyc
Ensembl Genes ENSRNOG00000039906 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006553 ENTREZGENE
  ENSRNOT00000006553.8 UniProtKB/Swiss-Prot
  ENSRNOT00000074271.4 UniProtKB/Swiss-Prot
Gene3D-CATH Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A UniProtKB/Swiss-Prot
InterPro Glyco_trans_6 UniProtKB/Swiss-Prot
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot
KEGG Report rno:65270 UniProtKB/Swiss-Prot
NCBI Gene 65270 ENTREZGENE
PANTHER HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE 1 UniProtKB/Swiss-Prot
  PTHR10462 UniProtKB/Swiss-Prot
Pfam Glyco_transf_6 UniProtKB/Swiss-Prot
PhenoGen Abo3 PhenoGen
RatGTEx ENSRNOG00000039906 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot
UniProt A0A0H2UHD6_RAT UniProtKB/TrEMBL
  A0A0H2UI32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A083_RAT UniProtKB/TrEMBL
  A0ABK0LXJ1_RAT UniProtKB/TrEMBL
  BGAT1_RAT UniProtKB/Swiss-Prot
  Q8CFC5 ENTREZGENE
  Q8CFC6 ENTREZGENE
  Q8R005 ENTREZGENE
  Q8R4Y3 ENTREZGENE
  Q8R552 ENTREZGENE
  Q9ET32 ENTREZGENE
UniProt Secondary Q8CFC5 UniProtKB/Swiss-Prot
  Q8CFC6 UniProtKB/Swiss-Prot
  Q8R005 UniProtKB/Swiss-Prot
  Q8R4Y3 UniProtKB/Swiss-Prot
  Q8R552 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-17 Abol1  alpha 1-3-N-acetylgalactosaminyltransferase-like 1  Gbgt1l  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1-like  Name and Symbol changed 629549 APPROVED
2015-12-17 Gbgt1l  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1-like  Gbgt1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1  Name and Symbol changed 629549 APPROVED
2015-12-17 Abo3  histo-blood group ABO system transferase 3  Abol1  alpha 1-3-N-acetylgalactosaminyltransferase-like 1  Name and Symbol changed 629549 APPROVED
2013-12-11 Gbgt1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1  Abol1  ABO blood group-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-04-21 Abol1  ABO blood group-like 1  Abo  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Abo  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Abo  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a short N-terminal intracytoplasmic domain, a transmembrane domain followed by a stem region and a catalytic domain 625720
gene_expression A antigen expressesd in tongue, oesophagus, large intestine, pancreas, parotid gland, submaxillary gland stomach, seminal vesicle, parathyroid gland, and thymus 625720
gene_function showed histo-blood group A-transferase activity 631948
gene_homology amino acid sequence is 70, 71 and 77% identity with the human, pig and mouse sequences, respectively 625720
gene_mapping mapped to rat chromosome 3 (q11-q12), a region homologous to human 9q34 625720
gene_process demonstrated a small UDP-Gal:Fucalpha1,2GalalphaGal transferase (B transferase) activity 625720
gene_regulation induced during infection with the parasite Nipponstrongylus brasiliensis