Laptm5 (lysosomal protein transmembrane 5) - Rat Genome Database

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Gene: Laptm5 (lysosomal protein transmembrane 5) Rattus norvegicus
Analyze
Symbol: Laptm5
Name: lysosomal protein transmembrane 5
RGD ID: 621838
Description: Predicted to enable protein sequestering activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including lysosomal transport; regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in lysosome. Orthologous to human LAPTM5 (lysosomal protein transmembrane 5); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gcd-10; granule cell death-10; lysosomal multispanning membrane protein 5; lysosomal-associated protein transmembrane 5; lysosomal-associated transmembrane protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85148,371,880 - 148,393,927 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5148,339,435 - 148,393,927 (+)EnsemblGRCr8
mRatBN7.25143,087,759 - 143,109,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5143,087,759 - 143,109,807 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5145,787,261 - 145,809,419 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05147,557,078 - 147,579,236 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05147,552,786 - 147,574,739 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05149,015,793 - 149,069,719 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5149,047,681 - 149,069,719 (+)Ensemblrn6Rnor6.0
Rnor_5.05152,749,594 - 152,771,632 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45149,775,904 - 149,797,951 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5141,549,551 - 141,571,574 (+)NCBICelera
RGSC_v3.15149,785,942 - 149,807,990 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
esketamine  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
fonofos  (ISO)
formaldehyde  (EXP,ISO)
furan  (EXP)
Genipin  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
methylparaben  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
streptozocin  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trametinib  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
triticonazole  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to leukemia inhibitory factor  (ISO)
defense response to tumor cell  (ISO)
Golgi to lysosome transport  (ISO)
induction of programmed cell death  (ISO)
intracellular protein transport  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of autophagic cell death  (ISO)
negative regulation of B cell activation  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of pre-B cell receptor expression  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of type II interferon production  (ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of lysosomal membrane permeability  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of proteolysis involved in protein catabolic process  (ISO)
positive regulation of receptor catabolic process  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
protein localization to lysosome  (ISO)
protein targeting to lysosome  (ISO)
regulation of lysosomal membrane permeability  (IBA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. Adra CN, etal., Genomics. 1996 Jul 15;35(2):328-37. doi: 10.1006/geno.1996.0364.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Activation of a novel microglial gene encoding a lysosomal membrane protein in response to neuronal apoptosis. Origasa M, etal., Brain Res Mol Brain Res 2001 Mar 31;88(1-2):1-13.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:20439489  


Genomics

Comparative Map Data
Laptm5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85148,371,880 - 148,393,927 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5148,339,435 - 148,393,927 (+)EnsemblGRCr8
mRatBN7.25143,087,759 - 143,109,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5143,087,759 - 143,109,807 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5145,787,261 - 145,809,419 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05147,557,078 - 147,579,236 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05147,552,786 - 147,574,739 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05149,015,793 - 149,069,719 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5149,047,681 - 149,069,719 (+)Ensemblrn6Rnor6.0
Rnor_5.05152,749,594 - 152,771,632 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45149,775,904 - 149,797,951 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5141,549,551 - 141,571,574 (+)NCBICelera
RGSC_v3.15149,785,942 - 149,807,990 (+)NCBI
Cytogenetic Map5q36NCBI
LAPTM5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38130,732,469 - 30,757,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl130,732,465 - 30,757,855 (-)Ensemblhg38GRCh38
GRCh37131,205,316 - 31,230,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36130,977,903 - 31,003,254 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34130,874,408 - 30,899,760NCBI
Celera129,461,191 - 29,486,564 (-)NCBICelera
Cytogenetic Map1p35.2NCBI
HuRef129,311,671 - 29,337,045 (-)NCBIHuRef
CHM1_1131,321,732 - 31,347,104 (-)NCBICHM1_1
T2T-CHM13v2.0130,584,986 - 30,610,292 (-)NCBIT2T-CHM13v2.0
Laptm5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394130,640,627 - 130,663,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4130,640,436 - 130,663,452 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384130,912,890 - 130,936,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4130,913,125 - 130,936,141 (+)Ensemblmm10GRCm38
MGSCv374130,469,249 - 130,492,063 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364130,183,341 - 130,208,215 (+)NCBIMGSCv36mm8
Celera4129,075,831 - 129,099,969 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map464.0NCBI
Laptm5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554529,334,587 - 9,358,444 (-)Ensembl
ChiLan1.0NW_0049554529,335,481 - 9,358,177 (-)NCBIChiLan1.0ChiLan1.0
LAPTM5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21196,082,383 - 196,107,824 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11195,199,639 - 195,225,059 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0130,005,941 - 30,031,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1131,032,963 - 31,058,385 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl131,032,963 - 31,058,385 (-)EnsemblpanPan2panpan1.1
LAPTM5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1270,188,382 - 70,215,361 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl270,152,739 - 70,333,073 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha266,763,871 - 66,790,833 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0270,748,385 - 70,775,429 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl270,748,388 - 70,775,427 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1267,583,493 - 67,610,219 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,582,446 - 68,609,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,580,796 - 69,607,573 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Laptm5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505848,277,298 - 48,295,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647414,102,423 - 14,119,558 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647414,102,080 - 14,119,592 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAPTM5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl687,363,911 - 87,390,347 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1687,363,911 - 87,390,371 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2681,068,830 - 81,095,229 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAPTM5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120102,080,500 - 102,106,649 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20102,080,508 - 102,106,729 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603314,543,899 - 14,569,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Laptm5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476414,207,094 - 14,228,135 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476414,208,144 - 14,277,208 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Laptm5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1127,387,558 - 27,409,795 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Laptm5
170 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:180
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000015198
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH131904  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25143,108,767 - 143,108,980 (+)MAPPERmRatBN7.2
Rnor_6.05149,068,680 - 149,068,892NCBIRnor6.0
Rnor_5.05152,770,593 - 152,770,805UniSTSRnor5.0
RGSC_v3.45149,796,912 - 149,797,124UniSTSRGSC3.4
Celera5141,570,535 - 141,570,747UniSTS
RH 3.4 Map5989.6UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 92 59 6 356 192 11 138 81 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000015198   ⟹   ENSRNOP00000015198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5148,377,839 - 148,393,927 (+)Ensembl
mRatBN7.2 Ensembl5143,087,759 - 143,109,807 (+)Ensembl
Rnor_6.0 Ensembl5149,047,681 - 149,069,719 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083028   ⟹   ENSRNOP00000071739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5148,371,656 - 148,393,927 (+)Ensembl
mRatBN7.2 Ensembl5143,095,524 - 143,109,807 (+)Ensembl
Rnor_6.0 Ensembl5149,056,078 - 149,068,932 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156522   ⟹   ENSRNOP00000110759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5148,339,435 - 148,393,140 (+)Ensembl
RefSeq Acc Id: NM_053538   ⟹   NP_445990
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85148,371,880 - 148,393,927 (+)NCBI
mRatBN7.25143,087,759 - 143,109,807 (+)NCBI
Rnor_6.05149,047,681 - 149,069,719 (+)NCBI
Rnor_5.05152,749,594 - 152,771,632 (+)NCBI
RGSC_v3.45149,775,904 - 149,797,951 (+)RGD
Celera5141,549,551 - 141,571,574 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445990 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60517 (Get FASTA)   NCBI Sequence Viewer  
  BAB03459 (Get FASTA)   NCBI Sequence Viewer  
  EDL80601 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015198.5
  ENSRNOP00000071739
  ENSRNOP00000071739.2
  ENSRNOP00000110759.1
RefSeq Acc Id: NP_445990   ⟸   NM_053538
- UniProtKB: Q6P9Z7 (UniProtKB/TrEMBL),   F1LN25 (UniProtKB/TrEMBL),   A0A9K3Y751 (UniProtKB/TrEMBL),   Q9JJ55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071739   ⟸   ENSRNOT00000083028
Ensembl Acc Id: ENSRNOP00000015198   ⟸   ENSRNOT00000015198
Ensembl Acc Id: ENSRNOP00000110759   ⟸   ENSRNOT00000156522

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P9Z7-F1-model_v2 AlphaFold Q6P9Z7 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694087
Promoter ID:EPDNEW_R4611
Type:initiation region
Name:Laptm5_1
Description:lysosomal protein transmembrane 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05149,047,621 - 149,047,681EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621838 AgrOrtholog
BioCyc Gene G2FUF-39732 BioCyc
Ensembl Genes ENSRNOG00000011054 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015198.8 UniProtKB/TrEMBL
  ENSRNOT00000083028 ENTREZGENE
  ENSRNOT00000083028.3 UniProtKB/TrEMBL
  ENSRNOT00000156522.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5597893 IMAGE-MGC_LOAD
InterPro LAPTM4/5 UniProtKB/TrEMBL
  LAPTM_4A/5 UniProtKB/TrEMBL
  LAPTM_transporter UniProtKB/TrEMBL
KEGG Report rno:89783 UniProtKB/TrEMBL
MGC_CLONE MGC:72357 IMAGE-MGC_LOAD
NCBI Gene 89783 ENTREZGENE
PANTHER LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN UniProtKB/TrEMBL
  PTHR12479:SF2 UniProtKB/TrEMBL
Pfam Mtp UniProtKB/TrEMBL
PhenoGen Laptm5 PhenoGen
RatGTEx ENSRNOG00000011054 RatGTEx
UniProt A0A0G2K184_RAT UniProtKB/TrEMBL
  A0A9K3Y751 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M1F0_RAT UniProtKB/TrEMBL
  F1LN25 ENTREZGENE
  Q6P9Z7 ENTREZGENE, UniProtKB/TrEMBL
  Q9JJ55 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LN25 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-10-22 Laptm5  lysosomal protein transmembrane 5  Laptm5  lysosomal multispanning membrane protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Laptm5  lysosomal multispanning membrane protein 5  Laptm5  lysosomal-associated protein transmembrane 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Laptm5  lysosomal-associated protein transmembrane 5      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Laptm5  lysosomal-associated protein transmembrane 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the perinuclear area of cultured microglia 633121