Oas1a (2'-5' oligoadenylate synthetase 1A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Oas1a (2'-5' oligoadenylate synthetase 1A) Rattus norvegicus
Analyze
Symbol: Oas1a
Name: 2'-5' oligoadenylate synthetase 1A
RGD ID: 621760
Description: Enables 2'-5'-oligoadenylate synthetase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of cytokine production; and regulation of innate immune response. Located in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 100. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1G; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthase 1A; 2-5A synthetase 1; 25 oligoadenylate synthetase; MGC93097; Oas1; Oas1g
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,330,423 - 41,341,130 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1241,285,211 - 41,341,128 (+)EnsemblGRCr8
mRatBN7.21235,669,798 - 35,680,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,669,801 - 35,680,517 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,848,682 - 36,859,311 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,459,883 - 37,470,514 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,512,331 - 36,522,962 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,200,680 - 41,211,393 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,200,718 - 41,211,909 (+)Ensemblrn6Rnor6.0
Rnor_5.01243,064,691 - 43,075,400 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41236,806,061 - 36,816,722 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1237,333,307 - 37,343,967 (+)NCBICelera
RGSC_v3.11236,669,448 - 36,680,110 (+)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
Actein  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
ATP  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carnosic acid  (ISO)
chenodeoxycholic acid  (ISO)
chlorophyllin  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
isotretinoin  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ribavirin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium fluoride  (EXP)
sotorasib  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tofacitinib  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,ISO)
endoplasmic reticulum  (IEA)
membrane  (IBA)
mitochondrion  (IEA,ISO)
nucleoplasm  (IBA,ISO)
nucleus  (IDA,IEA,ISO)
ribosome  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: effects of 17beta-estradiol on the regulation of OAS1g in both tissues. Maia CJ, etal., Mol Cell Biochem. 2008 Jul;314(1-2):113-21. doi: 10.1007/s11010-008-9771-z. Epub 2008 Apr 18.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. Perelygin AA, etal., J Mol Evol. 2006 Oct;63(4):562-76. Epub 2006 Oct 5.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions. Truve E, etal., Biotechnology (N Y) 1993 Sep;11(9):1048-52.
Additional References at PubMed
PMID:3753689   PMID:3754863   PMID:6654863   PMID:11682059   PMID:12477932   PMID:12799444   PMID:12892903   PMID:18931074   PMID:19923450   PMID:20844035   PMID:21245038   PMID:23319625  
PMID:23575436   PMID:25930096   PMID:28146100   PMID:30822544  


Genomics

Comparative Map Data
Oas1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,330,423 - 41,341,130 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1241,285,211 - 41,341,128 (+)EnsemblGRCr8
mRatBN7.21235,669,798 - 35,680,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,669,801 - 35,680,517 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,848,682 - 36,859,311 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,459,883 - 37,470,514 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,512,331 - 36,522,962 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,200,680 - 41,211,393 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,200,718 - 41,211,909 (+)Ensemblrn6Rnor6.0
Rnor_5.01243,064,691 - 43,075,400 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41236,806,061 - 36,816,722 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1237,333,307 - 37,343,967 (+)NCBICelera
RGSC_v3.11236,669,448 - 36,680,110 (+)NCBI
Cytogenetic Map12q16NCBI
OAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,906,962 - 112,933,219 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12112,905,856 - 112,933,219 (+)Ensemblhg38GRCh38
GRCh3712113,344,767 - 113,371,024 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,829,122 - 111,842,095 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412111,807,531 - 111,820,427NCBI
Celera12112,971,828 - 112,984,801 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,357,341 - 110,370,314 (+)NCBIHuRef
CHM1_112113,313,139 - 113,326,112 (+)NCBICHM1_1
T2T-CHM13v2.012112,883,649 - 112,909,905 (+)NCBIT2T-CHM13v2.0
Oas1g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,014,205 - 121,025,676 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,014,205 - 121,025,676 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385120,876,142 - 120,887,613 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,876,142 - 120,887,613 (-)Ensemblmm10GRCm38
MGSCv375121,326,151 - 121,337,607 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365121,136,759 - 121,148,215 (-)NCBIMGSCv36mm8
Celera5117,962,394 - 117,973,852 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.65NCBI
OAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210120,996,177 - 121,009,992 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112120,992,579 - 121,006,388 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,511,984 - 110,525,343 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112113,896,687 - 113,922,082 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12113,896,760 - 113,921,814 (+)EnsemblpanPan2panpan1.1
OAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,385,393 - 10,396,734 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2610,385,447 - 10,396,733 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2610,503,053 - 10,513,130 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02610,624,806 - 10,636,143 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,624,845 - 10,638,025 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,598,606 - 10,608,681 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,661,801 - 10,671,881 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,710,236 - 10,720,322 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
OAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,851,918 - 38,859,409 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11438,851,083 - 38,867,427 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,260,747 - 41,268,627 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,163,203 - 108,176,191 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,163,299 - 108,176,193 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037136,898,457 - 136,923,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,428,833 - 19,434,550 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474719,428,994 - 19,434,512 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Oas1a
68 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:363
Count of miRNA genes:168
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000038426, ENSRNOT00000048450, ENSRNOT00000057279, ENSRNOT00000067176
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH129983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,680,351 - 35,680,501 (+)MAPPERmRatBN7.2
mRatBN7.21235,680,351 - 35,680,501 (-)MAPPERmRatBN7.2
Rnor_6.01241,293,807 - 41,293,956NCBIRnor6.0
Rnor_6.01241,211,240 - 41,211,389NCBIRnor6.0
Rnor_5.01243,152,978 - 43,153,127UniSTSRnor5.0
Rnor_5.01243,075,247 - 43,075,396UniSTSRnor5.0
RGSC_v3.41236,896,820 - 36,896,969UniSTSRGSC3.4
RGSC_v3.41236,816,573 - 36,816,722UniSTSRGSC3.4
Celera1237,343,818 - 37,343,967UniSTS
Celera1237,425,280 - 37,425,429UniSTS
RH 3.4 Map12621.5UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 154 91 90 59 92 59 6 354 190 11 133 81 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000038426   ⟹   ENSRNOP00000036734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,285,226 - 41,341,128 (+)Ensembl
mRatBN7.2 Ensembl1235,669,801 - 35,680,501 (+)Ensembl
Rnor_6.0 Ensembl1241,200,718 - 41,211,909 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000041741   ⟹   ENSRNOP00000048411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,330,457 - 41,340,663 (+)Ensembl
mRatBN7.2 Ensembl1235,669,801 - 35,680,517 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000043279   ⟹   ENSRNOP00000048340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,285,211 - 41,341,128 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000048450   ⟹   ENSRNOP00000040841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,285,230 - 41,341,128 (+)Ensembl
mRatBN7.2 Ensembl1235,669,835 - 35,680,501 (+)Ensembl
Rnor_6.0 Ensembl1241,200,729 - 41,211,389 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067176   ⟹   ENSRNOP00000059183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,330,432 - 41,340,282 (+)Ensembl
mRatBN7.2 Ensembl1235,669,801 - 35,679,657 (+)Ensembl
Rnor_6.0 Ensembl1241,200,776 - 41,210,449 (+)Ensembl
RefSeq Acc Id: NM_138913   ⟹   NP_620268
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,330,466 - 41,341,126 (+)NCBI
mRatBN7.21235,669,835 - 35,680,501 (+)NCBI
Rnor_6.01241,200,729 - 41,211,389 (+)NCBI
Rnor_5.01243,064,691 - 43,075,400 (+)NCBI
RGSC_v3.41236,806,061 - 36,816,722 (+)RGD
Celera1237,333,307 - 37,343,967 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249382   ⟹   XP_006249444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,330,423 - 41,341,130 (+)NCBI
mRatBN7.21235,669,798 - 35,680,505 (+)NCBI
Rnor_6.01241,200,680 - 41,211,393 (+)NCBI
Rnor_5.01243,064,691 - 43,075,400 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271037   ⟹   XP_063127107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,330,461 - 41,341,130 (+)NCBI
RefSeq Acc Id: NP_620268   ⟸   NM_138913
- UniProtKB: Q05961 (UniProtKB/Swiss-Prot),   G3V9A4 (UniProtKB/TrEMBL),   A6J1H0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249444   ⟸   XM_006249382
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000059183   ⟸   ENSRNOT00000067176
Ensembl Acc Id: ENSRNOP00000040841   ⟸   ENSRNOT00000048450
Ensembl Acc Id: ENSRNOP00000036734   ⟸   ENSRNOT00000038426
Ensembl Acc Id: ENSRNOP00000048411   ⟸   ENSRNOT00000041741
RefSeq Acc Id: XP_063127107   ⟸   XM_063271037
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000048340   ⟸   ENSRNOT00000043279
Protein Domains
2'-5'-oligoadenylate synthetase   Polymerase nucleotidyl transferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05961-F1-model_v2 AlphaFold Q05961 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698663
Promoter ID:EPDNEW_R9186
Type:initiation region
Name:Oas1a_1
Description:2'-5' oligoadenylate synthetase 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01241,200,720 - 41,200,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621760 AgrOrtholog
BioCyc Gene G2FUF-19196 BioCyc
Ensembl Genes ENSRNOG00000001369 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041741 ENTREZGENE
  ENSRNOT00000048450 ENTREZGENE
Gene3D-CATH 2'-5'-oligoadenylate synthetase 1, domain 2 UniProtKB/Swiss-Prot
  3.30.460.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191865 IMAGE-MGC_LOAD
InterPro 2-5-oligoadenylate_synth_CS UniProtKB/Swiss-Prot
  2-5-oligoadenylate_synth_N UniProtKB/Swiss-Prot
  2-5-oligoAdlate_synth_1_dom2/C UniProtKB/Swiss-Prot
  2-5OAS_N_CS UniProtKB/Swiss-Prot
  NT_sf UniProtKB/Swiss-Prot
  Polymerase_NTP_transf_dom UniProtKB/Swiss-Prot
KEGG Report rno:192281 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93097 IMAGE-MGC_LOAD
NCBI Gene 192281 ENTREZGENE
PANTHER 2'-5'-OLIGOADENYLATE SYNTHASE 1 UniProtKB/Swiss-Prot
  PTHR11258 UniProtKB/Swiss-Prot
Pfam NTP_transf_2 UniProtKB/Swiss-Prot
  OAS1_C UniProtKB/Swiss-Prot
PhenoGen Oas1a PhenoGen
PROSITE 25A_SYNTH_1 UniProtKB/Swiss-Prot
  25A_SYNTH_2 UniProtKB/Swiss-Prot
  25A_SYNTH_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001369 RatGTEx
Superfamily-SCOP PAP/OAS1 substrate-binding domain UniProtKB/Swiss-Prot
  SSF81301 UniProtKB/Swiss-Prot
UniProt A0A8J8XSI7_RAT UniProtKB/TrEMBL
  A0ABZ3NNB8_RAT UniProtKB/TrEMBL
  A6J1H0 ENTREZGENE, UniProtKB/TrEMBL
  D4A5A2_RAT UniProtKB/TrEMBL
  F7EEP6 ENTREZGENE
  G3V9A4 ENTREZGENE, UniProtKB/TrEMBL
  OAS1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5MYW5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Oas1a  2'-5' oligoadenylate synthetase 1A  Oas1  2',5'-oligoadenylate synthetase 1, 40/46kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Oas1  2',5'-oligoadenylate synthetase 1, 40/46kDa    25 oligoadenylate synthetase  Name updated 1299863 APPROVED
2002-08-07 Oas1  25 oligoadenylate synthetase      Symbol and Name status set to provisional 70820 PROVISIONAL