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Gene: Pggt1b (protein geranylgeranyltransferase type I subunit beta) Rattus norvegicus

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Symbol:

Pggt1b

Name:

protein geranylgeranyltransferase type I subunit beta

RGD ID:

621754

Description:

Enables heterocyclic compound binding activity. Contributes to CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and zinc ion binding activity. Involved in positive regulation of cell cycle; positive regulation of cell population proliferation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta); INTERACTS WITH (+)-schisandrin B; ammonium chloride; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

geranylgeranyl transferase type I subunit beta; geranylgeranyl transferase type-1 subunit beta; geranylgeranyltransferase type 1 beta; geranylgeranyltransferase type I (GGTase-I); GGTase-I-beta; protein geranylgeranyltransferase type 1 subunit beta; protein geranylgeranyltransferase type I, beta subunit; type I protein geranyl-geranyltransferase subunit beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	41,138,536 - 41,182,145 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	41,139,965 - 41,182,139 (-)	Ensembl				GRCr8
mRatBN7.2	18	38,952,147 - 38,995,656 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	38,952,914 - 38,995,503 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	40,986,574 - 41,028,748 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	41,688,793 - 41,730,969 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	39,481,904 - 39,524,080 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	40,173,236 - 40,218,225 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	40,175,951 - 40,218,225 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	39,826,667 - 39,871,483 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	40,410,055 - 40,452,883 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	37,212,291 - 37,254,465 (-)	NCBI		Celera
RGSC_v3.1	18	40,447,595 - 40,490,419 (-)	NCBI
Cytogenetic Map	18	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Lung Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

fenthion (ISO)

gentamycin (EXP)

glyphosate (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

lipopolysaccharide (ISO)

menadione (ISO)

methidathion (ISO)

methylmercury chloride (ISO)

miconazole (ISO)

ochratoxin A (ISO)

phenobarbital (ISO)

potassium dichromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CAAX-box protein maturation (IEA,ISO)

positive regulation of cell cycle (IMP)

positive regulation of cell population proliferation (IMP)

protein geranylgeranylation (IDA,ISO,ISS,TAS)

Cellular Component

CAAX-protein geranylgeranyltransferase complex (IBA,IDA,IEA,ISO,TAS)

Molecular Function

CAAX-protein geranylgeranyltransferase activity (IBA,IDA,IEA,ISO,TAS)

catalytic activity (IEA)

heterocyclic compound binding (IDA)

metal ion binding (IEA)

peptide binding (IDA)

prenyltransferase activity (IEA)

protein binding (IPI,ISO)

protein geranylgeranyltransferase activity (IEA,ISO,ISS)

protein prenyltransferase activity (IEA)

small molecule binding (IDA)

transferase activity (IEA)

zinc ion binding (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.	Finder JD, etal., J Biol Chem. 1997 May 23;272(21):13484-8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells.	Mazet JL, etal., FEBS Lett. 1999 Oct 29;460(2):235-40.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes.	Reid TS, etal., Biochemistry. 2004 Jul 20;43(28):9000-8.
9.	Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.	Reid TS, etal., J Mol Biol. 2004 Oct 15;343(2):417-33.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Role of the carboxyterminal residue in peptide binding to protein farnesyltransferase and protein geranylgeranyltransferase.	Roskoski R Jr and Ritchie P, Arch Biochem Biophys. 1998 Aug 15;356(2):167-76.
14.	Structure of mammalian protein geranylgeranyltransferase type-I.	Taylor JS, etal., EMBO J. 2003 Nov 17;22(22):5963-74.
15.	cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.	Zhang FL, etal., J Biol Chem 1994 Feb 4;269(5):3175-80.
16.	Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I.	Zhang FL, etal., J Biol Chem. 1994 Sep 23;269(38):23465-70.
17.	TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis.	Zhou XP, etal., Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17181-6. Epub 2008 Oct 28.

Additional References at PubMed

PMID:15131129	PMID:16893176	PMID:20540740

Genomics

Comparative Map Data

Pggt1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	41,138,536 - 41,182,145 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	41,139,965 - 41,182,139 (-)	Ensembl				GRCr8
mRatBN7.2	18	38,952,147 - 38,995,656 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	38,952,914 - 38,995,503 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	40,986,574 - 41,028,748 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	41,688,793 - 41,730,969 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	39,481,904 - 39,524,080 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	40,173,236 - 40,218,225 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	40,175,951 - 40,218,225 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	39,826,667 - 39,871,483 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	40,410,055 - 40,452,883 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	37,212,291 - 37,254,465 (-)	NCBI		Celera
RGSC_v3.1	18	40,447,595 - 40,490,419 (-)	NCBI
Cytogenetic Map	18	q11	NCBI

PGGT1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	115,204,012 - 115,262,877 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	115,204,012 - 115,262,877 (-)	Ensembl			hg38	GRCh38
GRCh37	5	114,539,709 - 114,598,574 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	114,575,476 - 114,626,449 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	114,575,475 - 114,626,449	NCBI
Celera	5	110,494,046 - 110,546,088 (-)	NCBI		Celera
Cytogenetic Map	5	q22.3	NCBI
HuRef	5	109,728,848 - 109,780,942 (-)	NCBI		HuRef
CHM1_1	5	113,979,258 - 114,031,277 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	115,713,562 - 115,776,201 (-)	NCBI		T2T-CHM13v2.0

Pggt1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	46,368,411 - 46,414,173 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	46,368,418 - 46,414,060 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	46,235,344 - 46,281,089 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	46,235,351 - 46,280,993 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	46,399,603 - 46,440,504 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	46,365,280 - 46,406,181 (-)	NCBI		MGSCv36	mm8
Celera	18	47,599,910 - 47,646,046 (-)	NCBI		Celera
Cytogenetic Map	18	C	NCBI
cM Map	18	24.45	NCBI

Pggt1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	34,994,545 - 35,049,037 (-)	Ensembl
ChiLan1.0	NW_004955408	34,994,545 - 35,049,037 (-)	NCBI	ChiLan1.0	ChiLan1.0

PGGT1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	110,459,853 - 110,511,951 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	108,613,523 - 108,665,713 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	110,558,684 - 110,622,175 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	116,360,149 - 116,419,069 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	116,366,984 - 116,419,069 (-)	Ensembl			panPan2	panpan1.1

PGGT1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	4,967,504 - 5,020,491 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	4,880,404 - 5,020,473 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	5,099,400 - 5,171,320 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	4,940,644 - 5,012,576 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	4,953,486 - 5,012,560 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	4,896,291 - 4,968,192 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	4,977,938 - 5,037,052 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	5,218,691 - 5,290,606 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pggt1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	127,692,328 - 127,749,907 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936742	395,073 - 450,860 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936742	394,061 - 450,717 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PGGT1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	119,383,387 - 119,440,322 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	119,386,692 - 119,440,834 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	124,200,641 - 124,235,373 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PGGT1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	18,462,750 - 18,517,193 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	18,464,827 - 18,517,176 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	59,882,912 - 59,945,051 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pggt1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	6,683,080 - 6,761,038 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	6,682,123 - 6,766,359 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pggt1b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	40,776,288 - 40,819,678 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pggt1b
449 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	244
Count of miRNA genes:	171
Interacting mature miRNAs:	199
Transcripts:	ENSRNOT00000004723
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	22015562	61600538	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
631834	Sach3	Saccharin preference QTL 3	3.9	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	18	38575919	83575919	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	63968306	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	40462383	85462383	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	36121626	81121626	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	15226101	42690662	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L24116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004723 ⟹ ENSRNOP00000004723

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	41,139,965 - 41,182,139 (-)	Ensembl
mRatBN7.2 Ensembl	18	38,952,917 - 38,995,503 (-)	Ensembl
Rnor_6.0 Ensembl	18	40,175,951 - 40,218,225 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097524 ⟹ ENSRNOP00000087553

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	41,139,965 - 41,182,139 (-)	Ensembl
mRatBN7.2 Ensembl	18	38,952,917 - 38,995,503 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103699 ⟹ ENSRNOP00000095779

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	41,139,965 - 41,177,653 (-)	Ensembl
mRatBN7.2 Ensembl	18	38,952,914 - 38,995,491 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116864 ⟹ ENSRNOP00000087099

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	38,952,917 - 38,995,281 (-)	Ensembl

RefSeq Acc Id:

NM_031082 ⟹ NP_112344

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	41,139,965 - 41,182,139 (-)	NCBI
mRatBN7.2	18	38,953,329 - 38,995,507 (-)	NCBI
Rnor_6.0	18	40,175,951 - 40,218,225 (-)	NCBI
Rnor_5.0	18	39,826,667 - 39,871,483 (-)	NCBI
RGSC_v3.4	18	40,410,055 - 40,452,883 (-)	RGD
Celera	18	37,212,291 - 37,254,465 (-)	RGD

Sequence:

show sequence

GGACAGCGCATGGCGGCCACAGAGGATGACAGACTGGCGGGGAGCGGAGAAGGAGAACGGCTGG
ATTTCCTGCGGGACCGACACGTGCGGTTCTTCCAGCGCTGCCTCCAGGTCTTGCCGGAGCGGTA
TTCTTCGCTGGAGACCAGCAGGCTGACAATTGCATTTTTTGCACTCTCTGGGCTGGATATGTTG
GACTCCTTGGATGTGGTGAACAAAGACGATATAATAGAGTGGATTTATTCCTTGCAGGTTCTTC
CCACAGAAGACAGGTCAAATCTGGATCGCTGTGGTTTCCGAGGTTCTTCATATTTGGGTATTCC
ATTCAACCCATCAAAGAATCCAGGCACAGCTCATCCTTATGACAGTGGACACATAGCGATGACT
TACACTGGTCTTTCCTGTTTAATTATTCTTGGAGATGATTTAAGCCGAGTAGATAAAGAAGCTT
GCTTAGCAGGCTTGAGAGCACTTCAGCTGGAAGATGGGAGCTTCTGTGCTGTTCCTGAAGGCAG
TGAGAATGACATGAGGTTTGTGTACTGTGCTTCCTGCATTTGCTATATGCTCAACAACTGGTCA
GGCATGGATATGAAGAAAGCCATCAGCTACATTAGAAGAAGTATGTCCTATGACAATGGCCTGG
CACAGGGGGCAGGACTTGAGTCTCATGGAGGATCCACCTTTTGTGGCATTGCGTCACTGTGCCT
GATGGGTAAACTGGAAGAAGTTTTTTCAGAGAAAGAACTGAACCGGATAAAGAGGTGGTGCATA
ATGAGGCAGCAGAACGGGTACCACGGAAGACCTAACAAGCCTGTCGACACCTGTTACTCTTTCT
GGGTGGGAGCAACACTAAAGCTTTTGAAAATTTTCCAGTACACTAACTTTGAGAAGAATAGGAA
TTACATCTTATCAACTCAGGATCGCCTTGTTGGGGGATTTGCTAAATGGCCAGACAGTCATCCA
GATGCTTTGCATGCGTACTTCGGGATCTGTGGCCTGTCACTAATGGAGGAGAGTGGAATTTGTA
AAGTTCATCCTGCTCTGAATGTAAGCACACGAACTTCTGAGCGCCTCCGAGATCTCCATCAAAG
CTGGAAGACCAAGGACTCTAAACAGTGCTCAGACAATGTCCATATTTCCAGTTGACTAACCCTG
GGGTAAAGGGTGTGTAGCATACGTGTAGCTCAAGGTTAAAAGCCATGTGTAACCAAGTGTGCTC
TTCTTTAAGGGTTAGTCGTAAAAGTCAGAAGCGTGTACTGCTAGTTCTTCAGGATATGCTCTTA
GGCCAGTGACCACTGTCATGGATTTCAAGAAAATCCTTGTTGACGTGTGGACATCAGCAGAACT
CTGGTATGGTTCTTAACTGTTACACTGTGTTTCTGAGACCTTTCATGGGGCAGATATGTTTGTA
GGTTATCTTCTTAAAACCCTCAGTACAAGTTCTGGCTTACAAAATGTACGTAAACCTTCAAAAC
AAGTTTACACTCCATATGGCATTGATAATCTTCAGGTGAGCATTTAACGATCACTTAAAAATCG
CTACTGCTGATGGGAAGAAATTTGTTTATCCG

hide sequence

RefSeq Acc Id:

XM_008772177 ⟹ XP_008770399

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	41,138,536 - 41,182,046 (-)	NCBI
mRatBN7.2	18	38,953,360 - 38,995,498 (-)	NCBI
Rnor_6.0	18	40,173,236 - 40,218,167 (-)	NCBI

Sequence:

show sequence

CTGGATTTCCTGCGGGACCGACACGTGCGGTTCTTCCAGCGCTGCCTCCAGGTCTTGCCGGAGC
GGTATTCTTCGCTGGAGACCAGCAGGACAGCATTGCACTAGAACCTGTGGTGGCAGCTGCCATA
TACAAGGCATTAACAAGCCTTGTCAAGCAATGTGAGGCTGACAATTGCATTTTTTGCACTCTCT
GGGCTGGATATGTTGGACTCCTTGGATGTGGTGAACAAAGACGATATAATAGAGTGGATTTATT
CCTTGCAGGTTCTTCCCACAGAAGACAGGTCAAATCTGGATCGCTGTGGTTTCCGAGGTTCTTC
ATATTTGGGTATTCCATTCAACCCATCAAAGAATCCAGGCACAGCTCATCCTTATGACAGTGGA
CACATAGCGATGACTTACACTGGTCTTTCCTGTTTAATTATTCTTGGAGATGATTTAAGCCGAG
TAGATAAAGAAGCTTGCTTAGCAGGCTTGAGAGCACTTCAGCTGGAAGATGGGAGCTTCTGTGC
TGTTCCTGAAGGCAGTGAGAATGACATGAGGTTTGTGTACTGTGCTTCCTGCATTTGCTATATG
CTCAACAACTGGTCAGGCATGGATATGAAGAAAGCCATCAGCTACATTAGAAGAAGTATGTCCT
ATGACAATGGCCTGGCACAGGGGGCAGGACTTGAGTCTCATGGAGGATCCACCTTTTGTGGCAT
TGCGTCACTGTGCCTGATGGGTAAACTGGAAGAAGTTTTTTCAGAGAAAGAACTGAACCGGATA
AAGAGGTGGTGCATAATGAGGCAGCAGAACGGGTACCACGGAAGACCTAACAAGCCTGTCGACA
CCTGTTACTCTTTCTGGGTGGGAGCAACACTAAAGCTTTTGAAAATTTTCCAGTACACTAACTT
TGAGAAGAATAGGAATTACATCTTATCAACTCAGGATCGCCTTGTTGGGGGATTTGCTAAATGG
CCAGACAGTCATCCAGATGCTTTGCATGCGTACTTCGGGATCTGTGGCCTGTCACTAATGGAGG
AGAGTGGAATTTGTAAAGTTCATCCTGCTCTGAATGTAAGCACACGAACTTCTGAGCGCCTCCG
AGATCTCCATCAAAGCTGGAAGACCAAGGACTCTAAACAGTGCTCAGACAATGTCCATATTTCC
AGTTGACTAACCCTGGGGTAAAGGGTGTGTAGCATACGTGTAGCTCAAGGTTAAAAGCCATGTG
TAACCAAGTGTGCTCTTCTTTAAGGGTTAGTCGTAAAAGTCAGAAGCGTGTACTGCTAGTTCTT
CAGGATATGCTCTTAGGCCAGTGACCACTGTCATGGATTTCAAGAAAATCCTTGTTGACGTGTG
GACATCAGCAGAACTCTGGTATGGTTCTTAACTGTTACACTGTGTTTCTGAGACCTTTCATGGG
GCAGATATGTTTGTAGGTTATCTTCTTAAAACCCTCAGTACAAGTTCTGGCTTACAAAATGTAC
GTAAACCTTCAAAACAAGTTTACACTCCATATGGCATTGATAATCTTCAGGTGAGCATTTAACG
ATCACTTAAAAATCGCTACTGCTGATGGGAAGAAATTTGTTTATTGAATTAAGTATCTGGGATT
ATTCTTTAAAAATTGATAGTCTCATAATTCTCTTAAAGAATAACGTATTTTGCGTTATTCTTAA
GGTGTGCCAACTAGACTTGTGTAACCTATACAGATAAAAATTAAAAGTTCATATAAGAAAAATG
TAGGCTTAACTAGTACTATAGTTTTGTAAAGGGAGAGTATTACCTAATTGAGGGAGAAGTAATT
GAACTGTTTAATTATGAATGAAAAAGTTATGTGTCTTTATTATAGATTCCTTAGGGGAATACCT
GATGTGTTTTGTTTTAATCCCAAATCATTGACTGCCATTTGTCTGGGGCAAAGGAAGAAACAAT
CTTTGCTAACTAGAGAAAAGACATTCAGTGTTTTATTCTTCTGAGAAACTATAAATTATACTTG
TATGACTATCACCAAGTTCTTTTTAGTTGCTTAGATTTTTTTTTTCCGGTGTTTTGTGGTTACT
ATAGTTAATGGCTTTATCTTCCACCTACCAGGTTGAGCATCCTTAATCCAAAATCCACTCTCTG
GGTCAGGCATAGTGGCACATGCCTTTAGTCCCGTACTCAGGAGGCAGAGGCAACCAGATCTCTT
TGAGATCAAAGCCAGTCTGGTCTAAGAGTGAGCCAGTCAGAGCTATATGATAAAACCCAGTCTC
AAAAAACAAAACAAAACAACAACAAAAATAATAATAAAATCGAGTATCTGAAATGCCCTGGAAT
CTAAATTTTTTAACCGACAGCATGACACAATTGGAAAATCTCACTCTTTATGTTGAAGGTCACA
GGTAAATTTCAGAGACACTGTAAATAGTGTATAAAACCACTTGAAACTACTGAAGAAAGTGTAT
GAAATAATGCATTCTGTATTTAGACCAGGTCGAACCCCAGTCACAAGGTAAAGTGTATATGCAA
AATCTGAAAGCAAAATCTAAAACTGGAAACATTACTTTTGATCCCAAGCATTTTGGATAATGAT
ACTCAACCTGTAAATACTTTTCTAATGTTTTTAAGTTTGGTAAATCTTAAACAGAACCACTGAA
GTATAAATAGTCATTTATATTTTTATATTTTTGGCTAAGCGGGAGGGAAATACATTCATTTAGA
GGGATAAACTAGGGTTTTACTTACTTGTCATCTTGTTTTATTGTCTTAATTCTATGAACTAACA
ACCAAATGGAGATGGTGTAAGAATCCTTTGTTAGCAATCAACATGCTACATTAAATTACATCTA
TGACTTGGTGACAAGAAGGACATTTCTTCAGTAGAGGAAACGGGTGTGTTAGTTTTGGTAGTAA
TAAGAGTTGTATTATTAATCAACAGGCATCATTGTAAAAGCTAAATTACTAGTGTCCCTCGATA
GACAATAGCATTTTCATTTATTTTCTGAATTAAAGATTCCTACATAACAGTTCTTCTAAAGGAA
ACCCGGCATATGATTACTACATCTCTTATCAGCAGACTTGGCTTTAGACTTGAATTTGTACTGC
TGGGAGTCTAGCTCACTGCCTGATGTGCACAAGGCCCTGGGATCCCTGGCTTTGATCCTTGGCC
CTCAAGCTAACAAATGAACCAAATCCTATTTAGAAATAAGTCTTCTGGTGGTGGAGAGAAAGCT
TTACCAAGAAATGTTATCCTCTCACAAGTTTTTCCAGTTGCTTCTATTTAAATAACAAATAACA
TTCCTGTTTTAACCTGAGTTATCTCCTAGATGTTAAGAGCGGAAGTAGCATGTTGAAAATGTTA
AAGGGGTATTTCAAGGCCAGTACTTTTCCTGAGTTGCCATTAGTTGTTAAAAAGTAAGAAACAT
GGTTTTTGCCAGGAGGTGGTGGCTCACATCTTTAATCCCAGCACCCAGGAGACAGAGGCAGGTA
GATCTATGAGTTCAAGGCCAGTCTGGTCTAGAGTGACAGCCAGGGCTACACAGAGAAATTTTAT
CTCAAAAAATAACAAAAAGTGATTACAAAATAGATTTATAACATAAAAGTAATTTATATTTTCA
CACTTCTTGAATAAATTACTGCAAAGGCATTTTAATGACAGAATGATTCTAATATATCCAAGAG
ATAAGGTTCTGTGTGATACTTTATGGATCAGTGAATGTTCATATTTCTTAGAAACCAACCAAAA
AATACTGACTTGTTATGAAGTATGAAAAAAATTGTTTCTAGCTTTTCCTAAATACTATAAGGAA
AGTATTTATTAATAAATTATAAGCAACATATATAATCTTTTTTCTAGAAGTAGTGACATAGTAA
GAGGAAAAACACATAGTTCAGATGTCTAGCACCATTCACTCCTCACCAGCCTCTCTCCTCTTTC
TGTATTTTCTGAAGAATAATAGCAAGAAACATTTATTTATCACCTACATTTTTAAGTTTGACCT
ATAATATTTGTTTTTATTAGGCTTTAAAATATGTAGTTGTAAGTAATTAAATTCAAAATTTTGC
TGACAATGGTCATAATTTAAGAAGCGATAACTGAGAAGGAGGTCGTCTGAAGCTAGATGGTTTG
CAGTTTATCTGCCCATTGAGCAGCATGGTCTCGGACCCAGTTCTGCCACTGGTAAGGTGAAGTA
GGGTTTAAACTGAAGGCAGACACTGCCAATGGTATAGTTCTTTTTAACTGTCCCCATAAGTAAC
AGAAGGAGTAGCAAGTGTAGCCATGGTCACTATAGAACTACATGACAGGTGGATCCCTATGAGC
CTCAGAA

hide sequence

RefSeq Acc Id:

XM_039097140 ⟹ XP_038953068

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	41,138,536 - 41,177,311 (-)	NCBI
mRatBN7.2	18	38,952,147 - 38,995,520 (-)	NCBI

RefSeq Acc Id:

XM_039097141 ⟹ XP_038953069

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	41,147,688 - 41,182,145 (-)	NCBI
mRatBN7.2	18	38,961,058 - 38,995,656 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_112344	(Get FASTA)	NCBI Sequence Viewer
	XP_008770399	(Get FASTA)	NCBI Sequence Viewer
	XP_038953068	(Get FASTA)	NCBI Sequence Viewer
	XP_038953069	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA17756	(Get FASTA)	NCBI Sequence Viewer
	EDM14382	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004723
	ENSRNOP00000004723.1
	ENSRNOP00000095779
GenBank Protein	P53610	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112344 ⟸ NM_031082

- UniProtKB:

P53610 (UniProtKB/Swiss-Prot), A6IWV1 (UniProtKB/TrEMBL), A0A8I6A578 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAATEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSL
DVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTG
LSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMD
MKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ
QNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDAL
HAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHISS

hide sequence

RefSeq Acc Id:	XP_008770399 ⟸ XM_008772177
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A578 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIA MTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNN WSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRW CIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDS HPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHISS hide sequence

Ensembl Acc Id:

ENSRNOP00000004723 ⟸ ENSRNOT00000004723

RefSeq Acc Id:	XP_038953068 ⟸ XM_039097140
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038953069 ⟸ XM_039097141
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000095779 ⟸ ENSRNOT00000103699

Ensembl Acc Id:

ENSRNOP00000087099 ⟸ ENSRNOT00000116864

Ensembl Acc Id:

ENSRNOP00000087553 ⟸ ENSRNOT00000097524

Protein Domains

Prenyltransferase alpha-alpha toroid

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P53610-F1-model_v2	AlphaFold	P53610	1-377	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700760

Promoter ID:

EPDNEW_R11284

Type:

multiple initiation site

Name:

Pggt1b_1

Description:

protein geranylgeranyltransferase type 1 subunit beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	40,218,228 - 40,218,288	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621754	AgrOrtholog
BioCyc Gene	G2FUF-7635	BioCyc
Ensembl Genes	ENSRNOG00000003541	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000004723	ENTREZGENE
	ENSRNOT00000004723.4	UniProtKB/Swiss-Prot
	ENSRNOT00000103699	ENTREZGENE
Gene3D-CATH	1.50.10.20	UniProtKB/Swiss-Prot
InterPro	GGTase_I_beta	UniProtKB/Swiss-Prot
	PFTB_repeat	UniProtKB/Swiss-Prot
	PGGT1B-like	UniProtKB/Swiss-Prot
	Terpenoid_cyclase/PrenylTrfase	UniProtKB/Swiss-Prot
KEGG Report	rno:81746	UniProtKB/Swiss-Prot
NCBI Gene	81746	ENTREZGENE
PANTHER	GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA	UniProtKB/Swiss-Prot
	PTHR11774	UniProtKB/Swiss-Prot
Pfam	Prenyltrans	UniProtKB/Swiss-Prot
PhenoGen	Pggt1b	PhenoGen
RatGTEx	ENSRNOG00000003541	RatGTEx
Superfamily-SCOP	SSF48239	UniProtKB/Swiss-Prot
UniProt	A0A8I6A578	ENTREZGENE
	A0A8I6AGS5_RAT	UniProtKB/TrEMBL
	A0A8I6GLB2_RAT	UniProtKB/TrEMBL
	A6IWV1	ENTREZGENE, UniProtKB/TrEMBL
	P53610	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-08	Pggt1b	protein geranylgeranyltransferase type I subunit beta	Pggt1b	protein geranylgeranyltransferase type 1 subunit beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-03	Pggt1b	protein geranylgeranyltransferase type 1 subunit beta	Pggt1b	protein geranylgeranyltransferase type I, beta subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Pggt1b	protein geranylgeranyltransferase type I, beta subunit		geranylgeranyltransferase type I (GGTase-I)	Name updated	1299863	APPROVED
2002-08-07	Pggt1b	geranylgeranyltransferase type I (GGTase-I)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_product	beta subunit of geranylgeranyltransferase type I	729447

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD