Grin3a (glutamate ionotropic receptor NMDA type subunit 3A) - Rat Genome Database

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Gene: Grin3a (glutamate ionotropic receptor NMDA type subunit 3A) Rattus norvegicus
Analyze
Symbol: Grin3a
Name: glutamate ionotropic receptor NMDA type subunit 3A
RGD ID: 621704
Description: Enables carboxylic acid binding activity; glutamate-gated receptor activity; and protein phosphatase 2A binding activity. Contributes to NMDA glutamate receptor activity. Involved in several processes, including ionotropic glutamate receptor signaling pathway; monoatomic cation transport; and negative regulation of dendritic spine development. Located in cytoplasm and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A); PARTICIPATES IN excitatory synaptic transmission pathway; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chi-1; GluN3A; glutamate [NMDA] receptor subunit 3A; glutamate receptor chi-1; glutamate receptor ionotropic, NMDA 3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR-L; NMDAR-L1; NMDAR3A; NR3; NR3 ,chi-1; NR3 chi-1; NR3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8568,802,333 - 69,001,880 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl568,804,970 - 69,001,558 (-)EnsemblGRCr8
mRatBN7.2564,006,847 - 64,206,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl564,009,980 - 64,206,085 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx565,943,276 - 66,142,503 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0567,762,618 - 67,961,860 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0567,731,985 - 67,931,195 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0564,928,620 - 65,073,012 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,928,620 - 65,073,012 (-)Ensemblrn6Rnor6.0
Rnor_5.0569,420,058 - 69,564,696 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4566,406,451 - 66,602,353 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera563,404,358 - 63,599,048 (+)NCBICelera
RGSC_v3.1566,411,563 - 66,607,247 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (IDA)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. An NMDA receptor signaling complex with protein phosphatase 2A. Chan SF and Sucher NJ, J Neurosci. 2001 Oct 15;21(20):7985-92.
2. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Chatterton JE, etal., Nature 2002 Feb 14;415(6873):793-8.
3. Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. Ciabarra AM, etal., J Neurosci 1995 Oct;15(10):6498-508.
4. The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain. Eriksson M, etal., Biochem Biophys Res Commun. 2007 Sep 14;361(1):127-32. Epub 2007 Jul 16.
5. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Fiuza M, etal., Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12. doi: 10.1073/pnas.1312211110. Epub 2013 Dec 2.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Prenatal development of NMDA receptor composition and function in trigeminal neurons. Ishihama K, etal., Arch Histol Cytol. 2005 Dec;68(4):321-35.
8. GluN3A promotes dendritic spine pruning and destabilization during postnatal development. Kehoe LA, etal., J Neurosci. 2014 Jul 9;34(28):9213-21. doi: 10.1523/JNEUROSCI.5183-13.2014.
9. Molecular interaction of NMDA receptor subunit NR3A with protein phosphatase 2A. Ma OK and Sucher NJ, Neuroreport. 2004 Jun 28;15(9):1447-50.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Pérez-Otaño I, etal., Nat Neurosci. 2006 May;9(5):611-21. doi: 10.1038/nn1680. Epub 2006 Apr 16.
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. Sucher NJ, etal., J Neurosci 1995 Oct;15(10):6509-20.
18. Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain. Sun L, etal., FEBS Lett 1998 Dec 28;441(3):392-6.
19. NR3A modulates the outer vestibule of the "NMDA" receptor channel. Wada A, etal., J Neurosci. 2006 Dec 20;26(51):13156-66.
20. Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. Yao Y, etal., EMBO J. 2008 Aug 6;27(15):2158-70. doi: 10.1038/emboj.2008.140. Epub 2008 Jul 17.
Additional References at PubMed
PMID:8889548   PMID:9620802   PMID:11160393   PMID:11929923   PMID:12391275   PMID:14499953   PMID:14507892   PMID:14760703   PMID:15866554   PMID:17320117   PMID:17502428   PMID:17997397  
PMID:18445116   PMID:19361480   PMID:19452450   PMID:20813147   PMID:21697368   PMID:21697378   PMID:22870318   PMID:23285183   PMID:23883441   PMID:23972471   PMID:24183704   PMID:24663672  
PMID:25144876   PMID:25231980   PMID:31444392   PMID:32393578   PMID:35475675  


Genomics

Comparative Map Data
Grin3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8568,802,333 - 69,001,880 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl568,804,970 - 69,001,558 (-)EnsemblGRCr8
mRatBN7.2564,006,847 - 64,206,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl564,009,980 - 64,206,085 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx565,943,276 - 66,142,503 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0567,762,618 - 67,961,860 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0567,731,985 - 67,931,195 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0564,928,620 - 65,073,012 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,928,620 - 65,073,012 (-)Ensemblrn6Rnor6.0
Rnor_5.0569,420,058 - 69,564,696 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4566,406,451 - 66,602,353 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera563,404,358 - 63,599,048 (+)NCBICelera
RGSC_v3.1566,411,563 - 66,607,247 (-)NCBI
Cytogenetic Map5q22NCBI
GRIN3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389101,569,352 - 101,738,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9101,569,352 - 101,738,647 (-)Ensemblhg38GRCh38
GRCh379104,331,634 - 104,500,929 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369103,371,456 - 103,540,683 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349101,411,189 - 101,580,417NCBI
Celera974,845,889 - 75,014,334 (-)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef973,932,382 - 74,100,688 (-)NCBIHuRef
CHM1_19104,478,039 - 104,647,164 (-)NCBICHM1_1
T2T-CHM13v2.09113,744,124 - 113,912,649 (-)NCBIT2T-CHM13v2.0
Grin3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39449,661,611 - 49,846,023 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl449,661,611 - 49,845,744 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38449,661,611 - 49,846,023 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl449,661,611 - 49,845,744 (-)Ensemblmm10GRCm38
MGSCv37449,678,098 - 49,857,953 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera449,693,525 - 49,874,264 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.72NCBI
Grin3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541924,104,820 - 24,273,113 (+)Ensembl
ChiLan1.0NW_00495541924,105,360 - 24,272,533 (+)NCBIChiLan1.0ChiLan1.0
GRIN3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,628,485 - 37,797,704 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1937,630,856 - 37,800,076 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0972,773,866 - 72,943,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19100,767,715 - 100,936,352 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9100,767,715 - 100,941,323 (-)EnsemblpanPan2panpan1.1
GRIN3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11158,271,808 - 58,421,887 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1158,273,377 - 58,421,761 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1156,716,312 - 56,866,073 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01159,411,203 - 59,557,777 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1159,411,203 - 59,557,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11157,917,161 - 58,067,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01157,930,109 - 58,080,617 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01158,627,851 - 58,778,332 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grin3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947173,173,201 - 173,337,402 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365249,720,767 - 9,885,120 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365249,720,777 - 9,884,984 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1243,259,495 - 243,415,590 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11243,263,202 - 243,416,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21271,873,962 - 272,030,759 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11237,700,311 - 37,865,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1237,701,039 - 37,867,041 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660354,693,852 - 4,858,752 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247589,579,752 - 9,756,525 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247589,579,750 - 9,756,396 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grin3a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1757,041,420 - 57,234,313 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grin3a
995 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:110
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000007957
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
D5Rat140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2564,168,599 - 64,168,813 (+)MAPPERmRatBN7.2
mRatBN7.2564,168,538 - 64,168,813 (+)MAPPERmRatBN7.2
Rnor_6.0565,089,516 - 65,089,791NCBIRnor6.0
Rnor_6.0565,089,575 - 65,089,791NCBIRnor6.0
Rnor_5.0569,578,856 - 69,579,072UniSTSRnor5.0
Rnor_5.0569,578,797 - 69,579,072UniSTSRnor5.0
RGSC_v3.4566,564,857 - 66,565,073UniSTSRGSC3.4
RGSC_v3.4566,564,798 - 66,565,073RGDRGSC3.4
RGSC_v3.4566,564,799 - 66,565,073UniSTSRGSC3.4
Celera563,440,142 - 63,440,422UniSTS
Celera563,440,142 - 63,440,364UniSTS
RGSC_v3.1566,569,911 - 66,570,186RGD
SHRSP x BN Map538.7199RGD
SHRSP x BN Map538.7199UniSTS
AW530893  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8568,822,454 - 68,822,880 (+)Marker Load Pipeline
mRatBN7.2564,026,970 - 64,027,396 (+)MAPPERmRatBN7.2
Rnor_6.0564,945,651 - 64,946,076NCBIRnor6.0
Rnor_5.0569,437,089 - 69,437,514UniSTSRnor5.0
RGSC_v3.4566,423,442 - 66,423,867UniSTSRGSC3.4
Celera563,581,627 - 63,582,052UniSTS
RH 3.4 Map5434.7UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 12 57 142 40 43 16 56 16 6 223 142 11 125 49 89 27 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000007957   ⟹   ENSRNOP00000007957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl568,804,970 - 69,001,558 (-)Ensembl
mRatBN7.2 Ensembl564,009,980 - 64,206,085 (-)Ensembl
Rnor_6.0 Ensembl564,928,620 - 65,073,012 (-)Ensembl
RefSeq Acc Id: NM_001198583   ⟹   NP_001185512
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8568,805,466 - 69,001,558 (-)NCBI
mRatBN7.2564,009,980 - 64,206,085 (-)NCBI
Rnor_6.0564,928,620 - 65,073,012 (-)NCBI
Rnor_5.0569,420,058 - 69,564,696 (-)NCBI
Celera563,404,358 - 63,599,048 (+)NCBI
Sequence:
RefSeq Acc Id: NM_138546   ⟹   NP_612555
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8568,805,466 - 69,001,558 (-)NCBI
mRatBN7.2564,009,980 - 64,206,085 (-)NCBI
Rnor_6.0564,928,620 - 65,073,012 (-)NCBI
Rnor_5.0569,420,058 - 69,564,696 (-)NCBI
Celera563,404,358 - 63,599,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109241   ⟹   XP_038965169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8568,802,333 - 69,001,880 (-)NCBI
mRatBN7.2564,006,847 - 64,206,408 (-)NCBI
RefSeq Acc Id: NP_001185512   ⟸   NM_001198583
- Peptide Label: isoform 2 precursor
- UniProtKB: A6KJD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_612555   ⟸   NM_138546
- Peptide Label: isoform 1 precursor
- UniProtKB: Q63268 (UniProtKB/Swiss-Prot),   Q62800 (UniProtKB/Swiss-Prot),   O09155 (UniProtKB/Swiss-Prot),   O09098 (UniProtKB/Swiss-Prot),   Q9Z2H0 (UniProtKB/Swiss-Prot),   Q9R1M7 (UniProtKB/Swiss-Prot),   A6KJD3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007957   ⟸   ENSRNOT00000007957
RefSeq Acc Id: XP_038965169   ⟸   XM_039109241
- Peptide Label: isoform X1
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1M7-F1-model_v2 AlphaFold Q9R1M7 1-1135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621704 AgrOrtholog
BioCyc Gene G2FUF-41323 BioCyc
Ensembl Genes ENSRNOG00000005723 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007957 ENTREZGENE
  ENSRNOT00000007957.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:191573 UniProtKB/Swiss-Prot
NCBI Gene 191573 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
PhenoGen Grin3a PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005723 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
UniProt A0A096MIS4_RAT UniProtKB/TrEMBL
  A6KJD3 ENTREZGENE, UniProtKB/TrEMBL
  A6KJD4 ENTREZGENE, UniProtKB/TrEMBL
  NMD3A_RAT UniProtKB/Swiss-Prot
  O09098 ENTREZGENE
  O09155 ENTREZGENE
  Q62800 ENTREZGENE
  Q63268 ENTREZGENE
  Q9R1M7 ENTREZGENE
  Q9Z2H0 ENTREZGENE
UniProt Secondary O09098 UniProtKB/Swiss-Prot
  O09155 UniProtKB/Swiss-Prot
  Q62800 UniProtKB/Swiss-Prot
  Q63268 UniProtKB/Swiss-Prot
  Q9Z2H0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin3a  glutamate ionotropic receptor NMDA type subunit 3A  Grin3a  glutamate receptor, ionotropic, N-methyl-D-aspartate 3A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Grin3a  glutamate receptor, ionotropic, N-methyl-D-aspartate 3A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Grin3a  glutamate receptor, ionotropic, N-methyl-D-aspartate 3A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the spinal cord, brainstem, hypothalamus, thalamus, CA1 field of the hippocampus, and amygdala 632839