Akp3 (alkaline phosphatase 3, intestine, not Mn requiring) - Rat Genome Database

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Gene: Akp3 (alkaline phosphatase 3, intestine, not Mn requiring) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
RGD ID: 621650
Description: Enables alkaline phosphatase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in response to nutrient levels. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell) and ALPI (alkaline phosphatase, intestinal); PARTICIPATES IN folate metabolic pathway; INTERACTS WITH ammonium chloride; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Alpi2; IAP-2; IAP-II; Intestinal alkaline phosphatase 2; Intestinal alkaline phosphatase II; intestinal alkaline phosphatase-II (IAP-II); intestinal alkaline phosphatase-II (IAP-II) gene; intestinal-type alkaline phosphatase; Intestinal-type alkaline phosphatase 2; putative alkaline phosphatase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,252,581 - 95,256,616 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl995,248,840 - 95,256,616 (+)EnsemblGRCr8
mRatBN7.2987,804,680 - 87,808,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,804,749 - 87,807,913 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx996,229,049 - 96,233,083 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09101,364,679 - 101,368,710 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,732,935 - 99,736,974 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,228,960 - 94,232,001 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,228,960 - 94,232,001 (+)Ensemblrn6Rnor6.0
Rnor_5.0993,954,155 - 93,957,145 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4985,924,232 - 85,927,327 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera985,218,441 - 85,221,576 (+)NCBICelera
RGSC_v3.1986,107,650 - 86,110,746 (+)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ammonium chloride  (EXP)
bisphenol A  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
DDT  (EXP)
furan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Impaired mucosal barrier function in the small intestine of the cystic fibrosis mouse. De Lisle RC, etal., J Pediatr Gastroenterol Nutr. 2011 Oct;53(4):371-9. doi: 10.1097/MPG.0b013e318219c397.
2. Two rat intestinal alkaline phosphatase isoforms with different carboxyl-terminal peptides are both membrane-bound by a glycan phosphatidylinositol linkage. Engle MJ, etal., J Biol Chem. 1995 May 19;270(20):11935-40.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Expression of mRNA encoding intestinal type alkaline phosphatase in rat liver and its increase by fat-feeding. Goseki-Sone M, etal., Liver. 1996 Dec;16(6):358-64.
5. Characterization of structural and catalytic differences in rat intestinal alkaline phosphatase isozymes. Harada T, etal., FEBS J. 2005 May;272(10):2477-86.
6. Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Kaliannan K, etal., Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7003-8. doi: 10.1073/pnas.1220180110. Epub 2013 Apr 8.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis. Nakano T, etal., Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1439-49. doi: 10.1152/ajpgi.00331.2006. Epub 2007 Mar 1.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The two isozymes of rat intestinal alkaline phosphatase are products of two distinct genes. Xie Q and Alpers DH, Physiol Genomics 2000 Jun 29;3(1):1-8.
Additional References at PubMed
PMID:1458592   PMID:1654110   PMID:1954251  


Genomics

Variants

.
Variants in Akp3
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:93
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000026294, ENSRNOT00000073454
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2987,807,644 - 87,807,855 (+)MAPPERmRatBN7.2
Rnor_6.0994,231,780 - 94,231,990NCBIRnor6.0
Rnor_5.0993,956,919 - 93,957,134UniSTSRnor5.0
RGSC_v3.4985,927,106 - 85,927,316UniSTSRGSC3.4
Celera985,221,355 - 85,221,565UniSTS
Cytogenetic Map9q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 1 3 57 13 11 3 12 3 32 20 1 54 2 44 8 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000080897   ⟹   ENSRNOP00000071091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,252,581 - 95,256,616 (+)Ensembl
mRatBN7.2 Ensembl987,804,749 - 87,807,913 (+)Ensembl
Rnor_6.0 Ensembl994,228,960 - 94,232,001 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083137   ⟹   ENSRNOP00000070046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl994,228,960 - 94,231,966 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000152279   ⟹   ENSRNOP00000101317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,248,904 - 95,256,616 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163587   ⟹   ENSRNOP00000106844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,248,840 - 95,256,616 (+)Ensembl
RefSeq Acc Id: NM_022680   ⟹   NP_073171
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,252,581 - 95,256,616 (+)NCBI
mRatBN7.2987,804,680 - 87,808,715 (+)NCBI
Rnor_6.0994,228,960 - 94,232,001 (+)NCBI
Rnor_5.0993,954,155 - 93,957,145 (+)NCBI
RGSC_v3.4985,924,232 - 85,927,327 (+)RGD
Celera985,218,441 - 85,221,576 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_073171 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB20378 (Get FASTA)   NCBI Sequence Viewer  
  AAF36718 (Get FASTA)   NCBI Sequence Viewer  
  EDL75615 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071091
GenBank Protein P51740 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_073171   ⟸   NM_022680
- Peptide Label: precursor
- UniProtKB: A0A0G2JZL2 (UniProtKB/TrEMBL),   A6JWK7 (UniProtKB/TrEMBL),   Q9JKS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071091   ⟸   ENSRNOT00000080897
Ensembl Acc Id: ENSRNOP00000070046   ⟸   ENSRNOT00000083137
Ensembl Acc Id: ENSRNOP00000101317   ⟸   ENSRNOT00000152279
Ensembl Acc Id: ENSRNOP00000106844   ⟸   ENSRNOT00000163587

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51740-F1-model_v2 AlphaFold P51740 1-551 view protein structure
AF-A0A0G2JZL2-F1-model_v2 AlphaFold A0A0G2JZL2 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696830
Promoter ID:EPDNEW_R7355
Type:multiple initiation site
Name:Akp3_1
Description:alkaline phosphatase 3, intestine, not Mn requiring
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0994,228,905 - 94,228,965EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621650 AgrOrtholog
BioCyc Gene G2FUF-26853 BioCyc
Ensembl Genes ENSRNOG00000058652 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080897 ENTREZGENE
Gene3D-CATH 3.40.720.10 UniProtKB/Swiss-Prot
InterPro Alkaline_phosphatase UniProtKB/Swiss-Prot
  Alkaline_phosphatase_AS UniProtKB/Swiss-Prot
  Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot
NCBI Gene 64621 ENTREZGENE
PANTHER INTESTINAL-TYPE ALKALINE PHOSPHATASE UniProtKB/Swiss-Prot
  PTHR11596 UniProtKB/Swiss-Prot
Pfam Alk_phosphatase UniProtKB/Swiss-Prot
PhenoGen Akp3 PhenoGen
PRINTS ALKPHPHTASE UniProtKB/Swiss-Prot
PROSITE ALKALINE_PHOSPHATASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058652 RatGTEx
SMART alkPPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot
UniProt A0A0G2JZL2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L8R7_RAT UniProtKB/TrEMBL
  A0ABK0M0K9_RAT UniProtKB/TrEMBL
  A6JWK7 ENTREZGENE, UniProtKB/TrEMBL
  P51740 ENTREZGENE, UniProtKB/Swiss-Prot
  Q9JKS8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Akp3  alkaline phosphatase 3, intestine, not Mn requiring  Alpi2  intestinal alkaline phosphatase-II (IAP-II) gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Alpi2  intestinal alkaline phosphatase-II (IAP-II) gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression increased by incubation with oleic acid when transfection of the promoter region (linked to luciferase as a reporter gene) into COS-7 632197
gene_transcript 5' region contains Sp1 and gut-enriched Kruppel-like factor (GKLF) binding sites and a TATA-box 55 bp upstream from the transcriptional start site 632197