Soat1 (sterol O-acyltransferase 1) - Rat Genome Database

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Gene: Soat1 (sterol O-acyltransferase 1) Rattus norvegicus
Analyze
Symbol: Soat1
Name: sterol O-acyltransferase 1
RGD ID: 621641
Description: Enables sterol O-acyltransferase activity. Predicted to be involved in several processes, including cholesterol efflux; cholesterol homeostasis; and macrophage derived foam cell differentiation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human SOAT1 (sterol O-acyltransferase 1); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acat-1; acyl coenzyme A:cholesterol acyltransferase 1; acyl-coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase 1; cholesterol acyltransferase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81371,105,178 - 71,147,776 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1371,105,178 - 71,147,672 (-)EnsemblGRCr8
mRatBN7.21368,552,274 - 68,597,529 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,552,317 - 68,597,494 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1371,134,597 - 71,176,925 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,454,344 - 72,496,807 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,715,839 - 69,758,305 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01374,035,258 - 74,077,759 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1374,035,080 - 74,077,783 (-)Ensemblrn6Rnor6.0
Rnor_5.01378,956,528 - 78,999,029 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41371,420,862 - 71,463,365 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1368,416,482 - 68,458,206 (-)NCBICelera
RGSC_v3.11371,435,049 - 71,477,553 (-)NCBI
Cytogenetic Map13q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
griseofulvin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
omega-6 fatty acid  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
troglitazone  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ACAT-1 gene rs1044925 SNP and its relation with different clinical forms of chronic Chagas disease. Carvalho TB, etal., Parasitol Res. 2019 Aug;118(8):2343-2351. doi: 10.1007/s00436-019-06377-9. Epub 2019 Jun 24.
2. ACBP and cholesterol differentially alter fatty acyl CoA utilization by microsomal ACAT. Chao H, etal., J Lipid Res 2003 Jan;44(1):72-83.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure. Liang K and Vaziri ND, Am J Physiol Endocrinol Metab 2002 Oct;283(4):E676-81.
7. Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia. Lu Z, etal., PLoS One. 2011;6(10):e25344. doi: 10.1371/journal.pone.0025344. Epub 2011 Oct 14.
8. Molecular cloning, functional expression and tissue distribution of rat acyl-coenzyme A:cholesterol acyltransferase. Matsuda H, etal., Biochim Biophys Acta 1998 Mar 30;1391(2):193-203.
9. Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions. Melton EM, etal., J Biol Chem. 2019 Oct 25;294(43):15836-15849. doi: 10.1074/jbc.RA119.010564. Epub 2019 Sep 8.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Amelioration of Hyperglycemia with a Sodium-Glucose Cotransporter 2 Inhibitor Prevents Macrophage-Driven Atherosclerosis through Macrophage Foam Cell Formation Suppression in Type 1 and Type 2 Diabetic Mice. Terasaki M, etal., PLoS One. 2015 Nov 25;10(11):e0143396. doi: 10.1371/journal.pone.0143396. eCollection 2015.
18. Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome. Vaziri ND and Liang K, Kidney Int 2002 May;61(5):1769-75.
19. Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow. Wakabayashi T, etal., Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2576-2589. doi: 10.1161/ATVBAHA.118.311648.
20. Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells. Yamazaki H, etal., J Atheroscler Thromb. 2019 Mar 1;26(3):246-259. doi: 10.5551/jat.44040. Epub 2018 Oct 4.
Additional References at PubMed
PMID:8407899   PMID:9020103   PMID:9756919   PMID:10623671   PMID:15308631   PMID:15353128   PMID:15845870   PMID:16647063   PMID:17412327  


Genomics

Comparative Map Data
Soat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81371,105,178 - 71,147,776 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1371,105,178 - 71,147,672 (-)EnsemblGRCr8
mRatBN7.21368,552,274 - 68,597,529 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,552,317 - 68,597,494 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1371,134,597 - 71,176,925 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,454,344 - 72,496,807 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,715,839 - 69,758,305 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01374,035,258 - 74,077,759 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1374,035,080 - 74,077,783 (-)Ensemblrn6Rnor6.0
Rnor_5.01378,956,528 - 78,999,029 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41371,420,862 - 71,463,365 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1368,416,482 - 68,458,206 (-)NCBICelera
RGSC_v3.11371,435,049 - 71,477,553 (-)NCBI
Cytogenetic Map13q22NCBI
SOAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381179,293,797 - 179,358,680 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1179,293,440 - 179,358,680 (+)Ensemblhg38GRCh38
GRCh371179,262,932 - 179,327,815 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,529,640 - 177,591,076 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341175,994,673 - 176,056,109NCBI
Celera1152,371,279 - 152,432,730 (+)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1150,490,026 - 150,555,022 (+)NCBIHuRef
CHM1_11180,686,373 - 180,751,320 (+)NCBICHM1_1
T2T-CHM13v2.01178,648,799 - 178,713,729 (+)NCBIT2T-CHM13v2.0
Soat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,255,678 - 156,301,898 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1156,252,095 - 156,301,901 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381156,428,108 - 156,474,328 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1156,424,525 - 156,474,331 (-)Ensemblmm10GRCm38
MGSCv371158,358,239 - 158,404,459 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361158,265,149 - 158,310,920 (-)NCBIMGSCv36mm8
Celera1158,822,751 - 158,868,673 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.71NCBI
Soat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540618,655,894 - 18,706,891 (+)Ensembl
ChiLan1.0NW_00495540618,644,351 - 18,708,666 (+)NCBIChiLan1.0ChiLan1.0
SOAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2170,405,471 - 70,466,287 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1170,065,689 - 70,130,644 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01154,776,305 - 154,840,594 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,464,886 - 158,529,952 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,464,886 - 158,524,909 (+)EnsemblpanPan2panpan1.1
SOAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1720,481,386 - 20,556,706 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl720,486,069 - 20,546,055 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha720,005,887 - 20,081,197 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0720,217,662 - 20,292,968 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl720,220,698 - 20,293,045 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1720,126,140 - 20,201,100 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0720,232,924 - 20,307,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0720,368,010 - 20,443,005 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Soat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,767,856 - 91,822,797 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364819,616,850 - 9,669,705 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364819,614,605 - 9,669,705 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9121,045,234 - 121,113,692 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19121,045,211 - 121,112,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29132,895,468 - 132,952,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12549,998,197 - 50,061,433 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2550,001,910 - 50,061,173 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605551,485,709 - 51,549,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Soat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247712,994,696 - 3,055,916 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247712,992,752 - 3,055,842 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Soat1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11035,786,750 - 35,831,851 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Soat1
130 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000005677
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
SOAT1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81371,105,891 - 71,106,474 (+)Marker Load Pipeline
mRatBN7.21368,555,666 - 68,556,249 (+)MAPPERmRatBN7.2
Rnor_6.01374,035,972 - 74,036,554NCBIRnor6.0
Rnor_5.01378,957,242 - 78,957,824UniSTSRnor5.0
RGSC_v3.41371,421,576 - 71,422,158UniSTSRGSC3.4
Celera1368,417,196 - 68,417,778UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005677   ⟹   ENSRNOP00000005677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1371,105,178 - 71,147,672 (-)Ensembl
mRatBN7.2 Ensembl1368,552,317 - 68,597,494 (-)Ensembl
Rnor_6.0 Ensembl1374,035,080 - 74,077,783 (-)Ensembl
RefSeq Acc Id: NM_031118   ⟹   NP_112380
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,105,178 - 71,147,672 (-)NCBI
mRatBN7.21368,554,953 - 68,597,455 (-)NCBI
Rnor_6.01374,035,258 - 74,077,759 (-)NCBI
Rnor_5.01378,956,528 - 78,999,029 (-)NCBI
RGSC_v3.41371,420,862 - 71,463,365 (-)RGD
Celera1368,416,482 - 68,458,206 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272637   ⟹   XP_063128707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81371,105,872 - 71,147,776 (-)NCBI
Protein Sequences
Protein RefSeqs NP_112380 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128707 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA25372 (Get FASTA)   NCBI Sequence Viewer  
  EDM09484 (Get FASTA)   NCBI Sequence Viewer  
  EDM09485 (Get FASTA)   NCBI Sequence Viewer  
  EDM09486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005677
GenBank Protein O70536 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112380   ⟸   NM_031118
- UniProtKB: O70536 (UniProtKB/Swiss-Prot),   A6ID11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005677   ⟸   ENSRNOT00000005677
RefSeq Acc Id: XP_063128707   ⟸   XM_063272637
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70536-F1-model_v2 AlphaFold O70536 1-545 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698915
Promoter ID:EPDNEW_R9440
Type:initiation region
Name:Soat1_1
Description:sterol O-acyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01374,077,770 - 74,077,830EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621641 AgrOrtholog
BioCyc Gene G2FUF-17811 BioCyc
BioCyc Pathway PWY-7424 [sterol:steryl ester interconversion (yeast)] BioCyc
BioCyc Pathway Image PWY-7424 BioCyc
Ensembl Genes ENSRNOG00000004111 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005677 ENTREZGENE
InterPro MBOAT_fam UniProtKB/Swiss-Prot
  Oat_ACAT_DAG_ARE UniProtKB/Swiss-Prot
  Sterol_acyltranf_meta UniProtKB/Swiss-Prot
KEGG Report rno:81782 UniProtKB/Swiss-Prot
NCBI Gene 81782 ENTREZGENE
PANTHER PTHR10408 UniProtKB/Swiss-Prot
  STEROL O-ACYLTRANSFERASE 1 UniProtKB/Swiss-Prot
Pfam MBOAT UniProtKB/Swiss-Prot
PhenoGen Soat1 PhenoGen
PIRSF Oat_ACAT_DAG_ARE UniProtKB/Swiss-Prot
  Sterol_acyltranf_ACAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004111 RatGTEx
UniProt A6ID11 ENTREZGENE, UniProtKB/TrEMBL
  A6ID13_RAT UniProtKB/TrEMBL
  G3V6J2_RAT UniProtKB/TrEMBL
  O70536 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Soat1  sterol O-acyltransferase 1    acyl-coenzyme A:cholesterol acyltransferase  Name updated 1299863 APPROVED
2002-08-07 Soat1  acyl-coenzyme A:cholesterol acyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization membrane-associated in the endoplasmic reticulum 625687
gene_disease mRNA expression is increased in a puromycin-induced model of nephrotic syndrome 730139
gene_function catalyzes esterification of free cholesterol to cholesterol ester 625687
gene_process mediates cholesterol transport within the liver and intestinal mucosa 625687
gene_regulation chronic renal failure (CRF) has no effect on the level of mRNA and protein 625687