Slc22a12 (solute carrier family 22 member 12) - Rat Genome Database

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Gene: Slc22a12 (solute carrier family 22 member 12) Rattus norvegicus
Analyze
Symbol: Slc22a12
Name: solute carrier family 22 member 12
RGD ID: 621628
Description: Predicted to enable PDZ domain binding activity and urate transmembrane transporter activity. Involved in cellular response to insulin stimulus; renal urate salt excretion; and urate transport. Located in apical plasma membrane. Biomarker of diabetes mellitus. Orthologous to human SLC22A12 (solute carrier family 22 member 12); INTERACTS WITH 2-hydroxypropanoic acid; 6-propyl-2-thiouracil; 7,9-dihydro-1H-purine-2,6,8(3H)-trione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC365398; MGC124974; Rst; Slc22al2; solute carrier family 22 (organic anion/cation transporter), member 12; solute carrier family 22 (organic anion/urate transporter), member 12; solute carrier family 22 (organic cation transporter)-like 2; URAT1; urate anion exchanger 1; urate:anion antiporter SLC22A12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,274,266 - 213,282,793 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1213,274,275 - 213,281,380 (-)EnsemblGRCr8
mRatBN7.21203,845,039 - 203,852,496 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,845,048 - 203,853,555 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1212,194,211 - 212,201,339 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,290,324 - 219,297,440 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,981,381 - 211,988,497 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,910,787 - 221,919,277 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,910,767 - 221,919,301 (-)Ensemblrn6Rnor6.0
Rnor_5.01228,902,080 - 228,910,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41209,320,804 - 209,327,918 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1201,379,795 - 201,386,875 (-)NCBICelera
RGSC_v3.11209,479,477 - 209,480,301 (-)NCBI
Cytogenetic Map1q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-D  (ISO)
2-hydroxypropanoic acid  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azaorotic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
acrylamide  (EXP,ISO)
allopurinol  (EXP,ISO)
alloxanthine  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
barium(0)  (ISO)
benzarone  (ISO)
benzbromarone  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
D-gluconic acid  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone sulfate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
diethyl pyrocarbonate  (ISO)
disodium cromoglycate  (EXP)
E3040  (ISO)
enalapril  (ISO)
estrone 3-sulfate  (ISO)
eugenol  (EXP)
fructose  (EXP)
gentamycin  (EXP)
Honokiol  (ISO)
hypoxanthine  (ISO)
imperatorin  (ISO)
indometacin  (ISO)
isoimperatorin  (ISO)
losartan  (ISO)
mangiferin  (ISO)
methylmercury chloride  (ISO)
ochratoxin A  (EXP)
ouabain  (ISO)
p-aminohippuric acid  (ISO)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylbutazone  (ISO)
pirinixic acid  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium atom  (ISO)
probenecid  (ISO)
psoralen  (ISO)
pterostilbene  (ISO)
purines  (EXP)
pyrazine-2-carboxylic acid  (EXP,ISO)
pyrazinecarboxamide  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP,ISO)
rutin  (EXP)
salicylates  (ISO)
Salinomycin  (ISO)
sodium arsenite  (ISO)
stilben-4-ol  (ISO)
streptozocin  (ISO)
sulfinpyrazone  (ISO)
thallium atom  (EXP)
thallium sulfate  (EXP)
trans-piceid  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IDA,IEA,ISO,ISS)
brush border membrane  (ISO,ISS)
membrane  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2. null
2. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Enomoto A, etal., Nature. 2002 May 23;417(6887):447-52. Epub 2002 Apr 14.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rapid isolation of tissue-specific genes from rat kidney. Hu E, etal., Exp Nephrol 2001 Mar-Apr;9(2):156-64.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. Sato M, etal., Biochim Biophys Acta. 2011 Jun;1808(6):1441-7. doi: 10.1016/j.bbamem.2010.11.002. Epub 2010 Nov 11.
14. Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia. Wakida N, etal., J Clin Endocrinol Metab. 2005 Apr;90(4):2169-74. Epub 2005 Jan 5.
Additional References at PubMed
PMID:12477932   PMID:14694169   PMID:14747372   PMID:15304510   PMID:16775029   PMID:19056867   PMID:19503597   PMID:25773064   PMID:28499081   PMID:33132325  


Genomics

Comparative Map Data
Slc22a12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,274,266 - 213,282,793 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1213,274,275 - 213,281,380 (-)EnsemblGRCr8
mRatBN7.21203,845,039 - 203,852,496 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,845,048 - 203,853,555 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1212,194,211 - 212,201,339 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,290,324 - 219,297,440 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,981,381 - 211,988,497 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,910,787 - 221,919,277 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,910,767 - 221,919,301 (-)Ensemblrn6Rnor6.0
Rnor_5.01228,902,080 - 228,910,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41209,320,804 - 209,327,918 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1201,379,795 - 201,386,875 (-)NCBICelera
RGSC_v3.11209,479,477 - 209,480,301 (-)NCBI
Cytogenetic Map1q43NCBI
SLC22A12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,591,220 - 64,602,344 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,590,641 - 64,602,353 (+)Ensemblhg38GRCh38
GRCh371164,358,692 - 64,369,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,114,858 - 64,126,396 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341164,114,857 - 64,126,396NCBI
Celera1161,684,540 - 61,696,078 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,685,738 - 60,696,371 (+)NCBIHuRef
CHM1_11164,241,496 - 64,253,033 (+)NCBICHM1_1
T2T-CHM13v2.01164,583,895 - 64,595,327 (+)NCBIT2T-CHM13v2.0
Slc22a12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,585,884 - 6,593,100 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,585,875 - 6,593,062 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38196,535,854 - 6,543,070 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,535,845 - 6,543,032 (-)Ensemblmm10GRCm38
MGSCv37196,535,854 - 6,543,070 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36196,535,854 - 6,543,006 (-)NCBIMGSCv36mm8
Celera196,408,578 - 6,415,794 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.05NCBI
Slc22a12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,556,098 - 20,596,012 (-)Ensembl
ChiLan1.0NW_00495542220,555,458 - 20,561,818 (-)NCBIChiLan1.0ChiLan1.0
SLC22A12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,815,712 - 65,826,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,861,088 - 66,871,842 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,944,311 - 59,956,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,289,393 - 63,300,742 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,290,329 - 63,299,047 (+)EnsemblpanPan2panpan1.1
SLC22A12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,541,820 - 52,550,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,542,497 - 52,549,655 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1851,149,805 - 51,156,963 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01853,587,392 - 53,595,590 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,587,387 - 53,595,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,678,526 - 52,685,694 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,264,797 - 52,271,967 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,048,889 - 53,056,060 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc22a12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,250,573 - 8,258,303 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,693,352 - 4,698,721 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,693,493 - 4,698,556 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,558,535 - 7,565,751 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.127,557,822 - 7,565,801 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,688,333 - 6,696,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,633,589 - 9,644,519 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,632,645 - 9,643,664 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038107,023,694 - 107,035,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,772,744 - 21,779,230 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476721,771,137 - 21,780,305 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc22a12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v121,139,141 - 1,146,225 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc22a12
137 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:53
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000028665
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
RH134217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,850,309 - 203,850,489 (+)MAPPERmRatBN7.2
mRatBN7.21203,850,309 - 203,850,522 (+)MAPPERmRatBN7.2
Rnor_6.01221,916,058 - 221,916,270NCBIRnor6.0
Rnor_6.01221,916,058 - 221,916,237NCBIRnor6.0
Rnor_5.01228,907,351 - 228,907,563UniSTSRnor5.0
Rnor_5.01228,907,351 - 228,907,530UniSTSRnor5.0
RGSC_v3.41209,326,075 - 209,326,254UniSTSRGSC3.4
RGSC_v3.41209,326,075 - 209,326,287UniSTSRGSC3.4
Celera1201,385,032 - 201,385,244UniSTS
Celera1201,385,032 - 201,385,211UniSTS
RH 3.4 Map11536.3UniSTS
Cytogenetic Map1q43UniSTS
RH142462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,845,494 - 203,845,642 (+)MAPPERmRatBN7.2
Rnor_6.01221,911,243 - 221,911,390NCBIRnor6.0
Rnor_5.01228,902,536 - 228,902,683UniSTSRnor5.0
RGSC_v3.41209,321,260 - 209,321,407UniSTSRGSC3.4
Celera1201,380,222 - 201,380,369UniSTS
RH 3.4 Map11522.9UniSTS
Cytogenetic Map1q43UniSTS
AI987855  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,845,917 - 203,845,997 (+)MAPPERmRatBN7.2
Rnor_6.01221,911,666 - 221,911,745NCBIRnor6.0
Rnor_5.01228,902,959 - 228,903,038UniSTSRnor5.0
RGSC_v3.41209,321,683 - 209,321,762UniSTSRGSC3.4
Celera1201,380,645 - 201,380,724UniSTS
Cytogenetic Map1q43UniSTS
Slc22a12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,846,010 - 203,846,979 (+)MAPPERmRatBN7.2
Rnor_6.01221,911,759 - 221,912,727NCBIRnor6.0
Rnor_5.01228,903,052 - 228,904,020UniSTSRnor5.0
RGSC_v3.41209,321,776 - 209,322,744UniSTSRGSC3.4
Celera1201,380,738 - 201,381,706UniSTS
Cytogenetic Map1q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 37 110 59 58 28 34 28 6 222 93 90 81 67 30 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000028665   ⟹   ENSRNOP00000028665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,845,048 - 203,853,555 (-)Ensembl
Rnor_6.0 Ensembl1221,910,785 - 221,919,301 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092270   ⟹   ENSRNOP00000075925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1213,274,275 - 213,281,380 (-)Ensembl
mRatBN7.2 Ensembl1203,845,048 - 203,852,153 (-)Ensembl
Rnor_6.0 Ensembl1221,910,767 - 221,917,901 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,849,453 - 203,853,555 (-)Ensembl
Rnor_6.0 Ensembl1221,915,201 - 221,919,182 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092580   ⟹   ENSRNOP00000075914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1221,915,167 - 221,919,210 (-)Ensembl
RefSeq Acc Id: NM_001034943   ⟹   NP_001030115
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,274,266 - 213,281,380 (-)NCBI
mRatBN7.21203,845,039 - 203,852,153 (-)NCBI
Rnor_6.01221,910,787 - 221,917,901 (-)NCBI
Rnor_5.01228,902,080 - 228,910,569 (-)NCBI
RGSC_v3.41209,320,804 - 209,327,918 (-)RGD
Celera1201,379,795 - 201,386,875 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085569   ⟹   XP_038941497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,274,266 - 213,281,723 (-)NCBI
mRatBN7.21203,845,039 - 203,852,496 (-)NCBI
RefSeq Acc Id: XM_063269878   ⟹   XP_063125948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,274,266 - 213,282,793 (-)NCBI
RefSeq Acc Id: XM_063269880   ⟹   XP_063125950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,274,266 - 213,282,793 (-)NCBI
RefSeq Acc Id: XM_063269882   ⟹   XP_063125952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,274,266 - 213,282,793 (-)NCBI
RefSeq Acc Id: XM_063269883   ⟹   XP_063125953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,274,266 - 213,282,793 (-)NCBI
RefSeq Acc Id: NP_001030115   ⟸   NM_001034943
- UniProtKB: Q3ZAV1 (UniProtKB/Swiss-Prot),   A6HZI0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075925   ⟸   ENSRNOT00000092270
Ensembl Acc Id: ENSRNOP00000075914   ⟸   ENSRNOT00000092580
Ensembl Acc Id: ENSRNOP00000028665   ⟸   ENSRNOT00000028665
RefSeq Acc Id: XP_038941497   ⟸   XM_039085569
- Peptide Label: isoform X1
- UniProtKB: A6HZI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125953   ⟸   XM_063269883
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063125950   ⟸   XM_063269880
- Peptide Label: isoform X3
- UniProtKB: A6HZI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125952   ⟸   XM_063269882
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063125948   ⟸   XM_063269878
- Peptide Label: isoform X2
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3ZAV1-F1-model_v2 AlphaFold Q3ZAV1 1-553 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690702
Promoter ID:EPDNEW_R1226
Type:multiple initiation site
Name:Slc22a12_1
Description:solute carrier family 22 member 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1227  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01221,917,925 - 221,917,985EPDNEW
RGD ID:13690706
Promoter ID:EPDNEW_R1227
Type:multiple initiation site
Name:Slc22a12_2
Description:solute carrier family 22 member 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1226  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01221,919,230 - 221,919,290EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621628 AgrOrtholog
BioCyc Gene G2FUF-56588 BioCyc
Ensembl Genes ENSRNOG00000021108 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000092270 ENTREZGENE
  ENSRNOT00000092270.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109619 IMAGE-MGC_LOAD
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report rno:365398 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124974 IMAGE-MGC_LOAD
NCBI Gene Slc22a12 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Slc22a12 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021108 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A6HZI0 ENTREZGENE, UniProtKB/TrEMBL
  A6HZI1_RAT UniProtKB/TrEMBL
  Q3ZAV1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc22a12  solute carrier family 22 member 12  Slc22a12  solute carrier family 22 (organic anion/urate transporter), member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc22a12  solute carrier family 22 (organic anion/urate transporter), member 12  Slc22a12  solute carrier family 22 (organic anion/cation transporter), member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Slc22a12  solute carrier family 22 (organic anion/cation transporter), member 12  Slc22a12_predicted  solute carrier family 22 (organic anion/cation transporter), member 12 (predicted)  Data merged from RGD:1311864 1299863 APPROVED
2005-01-14 Slc22a12  solute carrier family 22 (organic anion/cation transporter), member 12  Slc22al2  solute carrier family 22 (organic cation transporter)-like 2  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Slc22a12_predicted  solute carrier family 22 (organic anion/cation transporter), member 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Slc22al2  solute carrier family 22 (organic cation transporter)-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL