Plekhb1 (pleckstrin homology domain containing B1) - Rat Genome Database

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Gene: Plekhb1 (pleckstrin homology domain containing B1) Rattus norvegicus
Analyze
Symbol: Plekhb1
Name: pleckstrin homology domain containing B1
RGD ID: 621614
Description: Predicted to enable protein homodimerization activity. Involved in regulation of cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in membrane. Orthologous to human PLEKHB1 (pleckstrin homology domain containing B1); INTERACTS WITH (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: evectin-1; Evt1; Kpl1; MGC93114; PH domain-containing family B member 1; pleckstrin homology domain containing, family B (evectins) member 1; pleckstrin homology domain-containing family B member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,410,901 - 164,425,216 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1164,410,903 - 164,428,568 (-)EnsemblGRCr8
mRatBN7.21154,998,798 - 155,013,094 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,998,800 - 155,016,142 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1162,990,805 - 163,005,137 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,170,911 - 170,185,243 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,048,211 - 163,062,477 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,665,905 - 165,683,753 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,665,909 - 165,680,206 (-)Ensemblrn6Rnor6.0
Rnor_5.01171,867,142 - 171,884,997 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41158,081,932 - 158,096,197 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1153,081,911 - 153,096,176 (-)NCBICelera
RGSC_v3.11158,160,918 - 158,175,184 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (EXP)
camptothecin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diethyl phthalate  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
ketamine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
Triptolide  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. KPL1, which encodes a novel PH domain-containing protein, is induced during ciliated cell differentiation of rat tracheal epithelial cells. Andrews KL, etal., Exp Lung Res 2000 Jun;26(4):257-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Krappa R, etal., Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4633-8.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10585447   PMID:15976448  


Genomics

Comparative Map Data
Plekhb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,410,901 - 164,425,216 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1164,410,903 - 164,428,568 (-)EnsemblGRCr8
mRatBN7.21154,998,798 - 155,013,094 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,998,800 - 155,016,142 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1162,990,805 - 163,005,137 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,170,911 - 170,185,243 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,048,211 - 163,062,477 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,665,905 - 165,683,753 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,665,909 - 165,680,206 (-)Ensemblrn6Rnor6.0
Rnor_5.01171,867,142 - 171,884,997 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41158,081,932 - 158,096,197 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1153,081,911 - 153,096,176 (-)NCBICelera
RGSC_v3.11158,160,918 - 158,175,184 (-)NCBI
Cytogenetic Map1q32NCBI
PLEKHB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,646,581 - 73,662,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,646,178 - 73,662,819 (+)Ensemblhg38GRCh38
GRCh371173,357,626 - 73,373,864 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,034,871 - 73,051,512 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341173,034,870 - 73,051,510NCBI
Celera1170,662,626 - 70,679,269 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1169,652,343 - 69,668,986 (+)NCBIHuRef
CHM1_11173,240,944 - 73,257,586 (+)NCBICHM1_1
T2T-CHM13v2.01173,575,709 - 73,591,948 (+)NCBIT2T-CHM13v2.0
Plekhb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,291,922 - 100,311,601 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,292,099 - 100,311,621 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387100,643,896 - 100,662,394 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,642,892 - 100,662,414 (-)Ensemblmm10GRCm38
MGSCv377107,792,410 - 107,810,908 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367100,517,985 - 100,536,452 (-)NCBIMGSCv36mm8
Celera7100,983,083 - 101,001,965 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.36NCBI
Plekhb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,826,812 - 17,841,195 (-)Ensembl
ChiLan1.0NW_00495541417,826,812 - 17,840,988 (-)NCBIChiLan1.0ChiLan1.0
PLEKHB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2974,592,764 - 74,608,025 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,636,908 - 75,652,187 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,724,168 - 68,739,450 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,035,823 - 72,052,130 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,035,823 - 72,052,130 (+)EnsemblpanPan2panpan1.1
PLEKHB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,592,081 - 24,608,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,593,030 - 24,608,035 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2124,357,746 - 24,373,756 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02124,798,480 - 24,814,492 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2124,779,529 - 24,814,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,592,702 - 24,608,711 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02124,793,195 - 24,809,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02124,708,636 - 24,724,649 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plekhb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494761,214,283 - 61,232,169 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364982,813,587 - 2,831,855 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364982,813,842 - 2,831,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,102,056 - 8,117,815 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.198,103,497 - 8,117,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.298,856,601 - 8,870,878 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,893,566 - 64,909,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,894,988 - 64,909,789 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604360,977,000 - 60,993,323 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,323,743 - 3,338,257 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248173,324,394 - 3,336,696 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Plekhb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1298,949,506 - 98,963,446 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plekhb1
60 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:110
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000025245
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH128964  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,998,867 - 154,999,067 (+)MAPPERmRatBN7.2
Rnor_6.01165,665,975 - 165,666,174NCBIRnor6.0
Rnor_5.01171,867,212 - 171,867,411UniSTSRnor5.0
RGSC_v3.41158,081,996 - 158,082,195UniSTSRGSC3.4
Celera1153,081,975 - 153,082,174UniSTS
RH 3.4 Map11258.1UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 354 191 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025245   ⟹   ENSRNOP00000025245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,410,905 - 164,425,172 (-)Ensembl
mRatBN7.2 Ensembl1154,998,802 - 155,013,069 (-)Ensembl
Rnor_6.0 Ensembl1165,665,911 - 165,680,176 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082697   ⟹   ENSRNOP00000071143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,410,905 - 164,428,568 (-)Ensembl
mRatBN7.2 Ensembl1154,998,802 - 155,013,099 (-)Ensembl
Rnor_6.0 Ensembl1165,665,909 - 165,680,206 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110726   ⟹   ENSRNOP00000080413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,410,905 - 164,425,202 (-)Ensembl
mRatBN7.2 Ensembl1154,998,802 - 155,013,099 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110941   ⟹   ENSRNOP00000097391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,410,903 - 164,428,568 (-)Ensembl
mRatBN7.2 Ensembl1154,998,800 - 155,016,142 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120073   ⟹   ENSRNOP00000087028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,410,903 - 164,422,018 (-)Ensembl
mRatBN7.2 Ensembl1154,998,800 - 155,009,915 (-)Ensembl
RefSeq Acc Id: NM_172033   ⟹   NP_742030
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,410,907 - 164,425,172 (-)NCBI
mRatBN7.21154,998,804 - 155,013,069 (-)NCBI
Rnor_6.01165,665,911 - 165,680,176 (-)NCBI
Rnor_5.01171,867,142 - 171,884,997 (-)NCBI
RGSC_v3.41158,081,932 - 158,096,197 (-)RGD
Celera1153,081,911 - 153,096,176 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229791   ⟹   XP_006229853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,410,901 - 164,425,216 (-)NCBI
mRatBN7.21154,998,798 - 155,013,094 (-)NCBI
Rnor_6.01165,665,905 - 165,680,201 (-)NCBI
Rnor_5.01171,867,142 - 171,884,997 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272775   ⟹   XP_063128845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,410,901 - 164,425,205 (-)NCBI
RefSeq Acc Id: NP_742030   ⟸   NM_172033
- UniProtKB: Q9WU68 (UniProtKB/Swiss-Prot),   A6I6R2 (UniProtKB/TrEMBL),   A0A8I6AWB1 (UniProtKB/TrEMBL),   A6I6Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229853   ⟸   XM_006229791
- Peptide Label: isoform X2
- UniProtKB: Q6AZ73 (UniProtKB/TrEMBL),   A6I6R1 (UniProtKB/TrEMBL),   A6I6Q7 (UniProtKB/TrEMBL),   A6I6R0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071143   ⟸   ENSRNOT00000082697
Ensembl Acc Id: ENSRNOP00000025245   ⟸   ENSRNOT00000025245
Ensembl Acc Id: ENSRNOP00000080413   ⟸   ENSRNOT00000110726
Ensembl Acc Id: ENSRNOP00000087028   ⟸   ENSRNOT00000120073
Ensembl Acc Id: ENSRNOP00000097391   ⟸   ENSRNOT00000110941
RefSeq Acc Id: XP_063128845   ⟸   XM_063272775
- Peptide Label: isoform X1
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WU68-F1-model_v2 AlphaFold Q9WU68 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690249
Promoter ID:EPDNEW_R773
Type:multiple initiation site
Name:Plekhb1_1
Description:pleckstrin homology domain containing B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,680,183 - 165,680,243EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621614 AgrOrtholog
BioCyc Gene G2FUF-58316 BioCyc
Ensembl Genes ENSRNOG00000018627 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025245 ENTREZGENE
  ENSRNOT00000025245.6 UniProtKB/Swiss-Prot
  ENSRNOT00000082697 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124581 IMAGE-MGC_LOAD
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PLEKHB1/2 UniProtKB/Swiss-Prot
KEGG Report rno:64471 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93114 IMAGE-MGC_LOAD
NCBI Gene 64471 ENTREZGENE
PANTHER PTHR14309 UniProtKB/Swiss-Prot
  PTHR14309:SF7 UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
PhenoGen Plekhb1 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018627 RatGTEx
SMART SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
UniProt A0A8I5ZT13_RAT UniProtKB/TrEMBL
  A0A8I6A714_RAT UniProtKB/TrEMBL
  A0A8I6AWB1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABZ3NN77_RAT UniProtKB/TrEMBL
  A6I6Q7 ENTREZGENE, UniProtKB/TrEMBL
  A6I6Q8 ENTREZGENE, UniProtKB/TrEMBL
  A6I6Q9_RAT UniProtKB/TrEMBL
  A6I6R0 ENTREZGENE, UniProtKB/TrEMBL
  A6I6R1 ENTREZGENE, UniProtKB/TrEMBL
  A6I6R2 ENTREZGENE, UniProtKB/TrEMBL
  PKHB1_RAT UniProtKB/Swiss-Prot
  Q6AZ73 ENTREZGENE
  Q9WU68 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Plekhb1  pleckstrin homology domain containing B1  Plekhb1  pleckstrin homology domain containing, family B (evectins) member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Plekhb1  pleckstrin homology domain containing, family B (evectins) member 1    evectin-1  Name updated 1299863 APPROVED
2004-09-10 Plekhb1  evectin-1  Evt1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Evt1  evectin-1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology 94% amino acid identity to human homolog 632808
gene_protein member of the family of PH domain-containing proteins 632808
gene_regulation induced during ciliated cell differentiation of tracheal epithelial cells 632808