Nts (neurotensin) - Rat Genome Database

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Gene: Nts (neurotensin) Rattus norvegicus
Analyze
Symbol: Nts
Name: neurotensin
RGD ID: 621612
Description: Predicted to enable neuropeptide receptor binding activity and receptor ligand activity. Involved in several processes, including cellular response to lithium ion; response to antipsychotic drug; and response to glucocorticoid. Located in axon terminus and neuronal cell body. Used to study nicotine dependence. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human NTS (neurotensin); INTERACTS WITH (S)-colchicine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299757; neuromedin N; neurotensin/neuromedin N; neurotensin/neuromedin N gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8739,451,484 - 39,460,888 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl739,451,073 - 39,460,961 (-)EnsemblGRCr8
mRatBN7.2737,564,944 - 37,574,350 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl737,564,533 - 37,574,423 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx739,491,733 - 39,501,228 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0741,694,804 - 41,704,299 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0741,469,771 - 41,479,266 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0744,111,594 - 44,120,998 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl744,111,151 - 44,121,130 (-)Ensemblrn6Rnor6.0
Rnor_5.0744,140,647 - 44,150,051 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4740,474,654 - 40,484,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera734,527,468 - 34,536,872 (-)NCBICelera
RGSC_v3.1740,494,497 - 40,495,295 (-)NCBI
Cytogenetic Map7q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(3-chlorostyryl)caffeine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (EXP)
amphetamine  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
batimastat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
chelerythrine  (ISO)
chlorpyrifos  (EXP)
chromium atom  (EXP)
clothianidin  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
D-mannitol  (EXP)
dehydroepiandrosterone  (ISO)
dexloxiglumide  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emamectin benzoate  (ISO)
ethanol  (EXP)
fentanyl  (EXP)
fragrance  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (ISO)
glucose  (EXP)
Goe 6976  (ISO)
haloperidol  (EXP,ISO)
Lasiocarpine  (ISO)
LY294002  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
nickel atom  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
orlistat  (ISO)
paracetamol  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramidon  (ISO)
phthalaldehyde  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
reserpine  (EXP)
Ro 31-8220  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Sodium oleate  (ISO)
staurosporine  (ISO)
sucrose  (ISO)
theophylline  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum. Adams DH, etal., Neuroscience. 2001;102(4):843-51.
2. Estrogen-inducible neurotensin immunoreactivity in the preoptic area of the female rat. Alexander MJ and Leeman SE, J Comp Neurol. 1994 Jul 22;345(4):496-509.
3. Cellular distribution of neurotensin receptors in rat brain: immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor. Boudin H, etal., J Comp Neurol. 1996 Sep 9;373(1):76-89.
4. Synergistic induction of neurotensin gene transcription in PC12 cells parallels changes in AP-1 activity. Bullock BP, etal., Brain Res Mol Brain Res. 1994 Dec;27(2):232-42.
5. Biosynthesis and posttranslational processing of the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line. Effect of dexamethasone. de Nadai F, etal., Endocrinology. 1993 Apr;132(4):1614-20.
6. Kinetics of neurotensin gene expression in the developing gut. Evers BM and Wang XF, Surgery. 1996 Feb;119(2):186-90.
7. Developmental expression of the neurotensin gene in the rat liver. Evers BM, etal., Ann Surg. 1993 Aug;218(2):183-8.
8. Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody. Fassio A, etal., Neuropharmacology. 2000 Jun 8;39(8):1430-42.
9. Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference. Felszeghy K, etal., Neuropsychopharmacology. 2007 Dec;32(12):2601-10. doi: 10.1038/sj.npp.1301382. Epub 2007 Mar 14.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences. Kislauskis E, etal., J Biol Chem 1988 Apr 5;263(10):4963-8.
12. Characterization of neurotensin receptors. Kitabgi P and Pelaprat D, Curr Protoc Pharmacol. 2004 May;Chapter 1:Unit 1.29. doi: 10.1002/0471141755.ph0129s24.
13. Effects of neurotensin in amygdaloid spatial learning mechanisms. Laszlo K, etal., Behav Brain Res. 2010 Jul 11;210(2):280-3. doi: 10.1016/j.bbr.2010.02.038. Epub 2010 Feb 26.
14. Effect of a novel neurotensin analog, NT69L, on nicotine-induced alterations in monoamine levels in rat brain. Liang Y, etal., Brain Res. 2008 Sep 22;1231:6-15. doi: 10.1016/j.brainres.2008.07.037. Epub 2008 Jul 19.
15. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
16. Coexpression of neurotensin and c-fos mRNAs in rat neostriatal neurons following acute haloperidol. Merchant KM and Miller MA, Brain Res Mol Brain Res. 1994 May;23(3):271-7.
17. Pro-Neurotensin as a Potential Novel Diagnostic Biomarker for Detection of Nonalcoholic Fatty Liver Disease. Mohamed AA, etal., Diabetes Metab Syndr Obes. 2022 Jun 22;15:1935-1943. doi: 10.2147/DMSO.S365147. eCollection 2022.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats. Prus AJ, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:78-84. doi: 10.1016/j.pnpbp.2013.11.011. Epub 2013 Nov 23.
20. Neurotensin antagonist acutely and robustly attenuates locomotion that accompanies stimulation of a neurotensin-containing pathway from rostrobasal forebrain to the ventral tegmental area. Reynolds SM, etal., Eur J Neurosci. 2006 Jul;24(1):188-96. doi: 10.1111/j.1460-9568.2006.04791.x.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Immunohistochemical evidence for the implication of PC1 in the processing of proneurotensin in rat brain. Villeneuve P, etal., Neuroreport. 2000 Nov 9;11(16):3443-7.
25. Physiological regulation of peptide messenger RNA colocalization in rat hypothalamic paraventricular medial parvicellular neurons. Watts AG and Sanchez-Watts G, J Comp Neurol. 1995 Feb 20;352(4):501-14.
26. Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone. Watts AG and Sanchez-Watts G, J Physiol. 1995 May 1;484 ( Pt 3):721-36.
27. Neuropeptides and thirst: the temporal response of corticotropin-releasing hormone and neurotensin/neuromedin N gene expression in rat limbic forebrain neurons to drinking hypertonic saline. Watts AG, etal., Behav Neurosci. 1995 Dec;109(6):1146-57.
28. Chronic pain increases brainstem proneurotensin/neuromedin-N mRNA expression: a hybridization-histochemical and immunohistochemical study using three different rat models for chronic nociception. Williams FG and Beitz AJ, Brain Res. 1993 May 14;611(1):87-102.
29. Post-translational processing of the neurotensin/neuromedin N precursor in the central nervous system of the rat--II. Immunohistochemical localization of maturation products. Woulfe J, etal., Neuroscience. 1994 May;60(1):167-81.
30. Heterogeneity of melanized neurons expressing neurotensin receptor messenger RNA in the substantia nigra and the nucleus paranigralis of control and Parkinson's disease brain. Yamada M, etal., Neuroscience. 1995 Jan;64(2):405-17.
31. Distinct and interactive effects of d-amphetamine and haloperidol on levels of neurotensin and its mRNA in subterritories in the dorsal and ventral striatum of the rat. Zahm DS, etal., J Comp Neurol. 1998 Nov 2;400(4):487-503.
32. Peripheral axotomy induces increased expression of neurotensin in large neurons in rat lumbar dorsal root ganglia. Zhang X, etal., Neurosci Res. 1996 Aug;25(4):359-69.
Additional References at PubMed
PMID:8471039   PMID:11294867   PMID:12074933   PMID:12080490   PMID:14552872   PMID:15193419   PMID:18155361   PMID:18182046   PMID:18252810   PMID:18456542   PMID:18556091   PMID:18607747  
PMID:18991855   PMID:18992283   PMID:19322170   PMID:19941912   PMID:20471454   PMID:20601081   PMID:21656844   PMID:21820035   PMID:22035146   PMID:24969625   PMID:27267684   PMID:27372546  
PMID:28522313   PMID:28877396   PMID:32327191   PMID:33682882  


Genomics

Comparative Map Data
Nts
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8739,451,484 - 39,460,888 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl739,451,073 - 39,460,961 (-)EnsemblGRCr8
mRatBN7.2737,564,944 - 37,574,350 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl737,564,533 - 37,574,423 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx739,491,733 - 39,501,228 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0741,694,804 - 41,704,299 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0741,469,771 - 41,479,266 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0744,111,594 - 44,120,998 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl744,111,151 - 44,121,130 (-)Ensemblrn6Rnor6.0
Rnor_5.0744,140,647 - 44,150,051 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4740,474,654 - 40,484,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera734,527,468 - 34,536,872 (-)NCBICelera
RGSC_v3.1740,494,497 - 40,495,295 (-)NCBI
Cytogenetic Map7q21NCBI
NTS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381285,874,295 - 85,882,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1285,874,162 - 85,882,992 (+)Ensemblhg38GRCh38
GRCh371286,268,073 - 86,276,770 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361284,792,206 - 84,800,898 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341284,770,542 - 84,779,231NCBI
Celera1285,930,823 - 85,939,559 (+)NCBICelera
Cytogenetic Map12q21.31NCBI
HuRef1283,324,584 - 83,333,603 (+)NCBIHuRef
CHM1_11286,233,027 - 86,241,361 (+)NCBICHM1_1
T2T-CHM13v2.01285,854,932 - 85,863,806 (+)NCBIT2T-CHM13v2.0
Nts
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910102,317,617 - 102,326,294 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10102,317,617 - 102,326,347 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810102,481,756 - 102,490,418 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10102,481,756 - 102,490,486 (-)Ensemblmm10GRCm38
MGSCv3710101,944,390 - 101,953,052 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610101,911,444 - 101,920,106 (-)NCBIMGSCv36mm8
Celera10104,415,989 - 104,424,662 (-)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1053.56NCBI
Nts
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540523,748,280 - 23,758,529 (+)Ensembl
ChiLan1.0NW_00495540523,696,258 - 23,758,487 (+)NCBIChiLan1.0ChiLan1.0
NTS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21093,932,967 - 93,940,591 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11293,929,364 - 93,936,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01283,402,313 - 83,410,356 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11286,640,722 - 86,648,708 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1286,640,720 - 86,648,745 (+)EnsemblpanPan2panpan1.1
NTS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11527,361,002 - 27,372,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1527,361,002 - 27,372,232 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1527,806,896 - 27,818,114 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01527,977,054 - 27,988,287 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1527,977,054 - 27,988,287 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11527,329,416 - 27,340,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01527,370,112 - 27,381,344 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01527,659,448 - 27,670,671 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nts
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494532,906,185 - 32,916,431 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365073,318,915 - 3,329,342 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365073,318,982 - 3,329,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl596,260,560 - 96,272,976 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1596,261,299 - 96,272,947 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25101,076,752 - 101,088,628 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NTS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11181,270,147 - 81,278,327 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1181,270,593 - 81,277,713 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037164,046,316 - 164,054,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nts
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248375,035,159 - 5,045,651 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248375,035,237 - 5,045,560 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nts
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11180,862,549 - 180,872,521 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nts
140 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:66
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000005706
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 1 30 116 65 71 46 12 46 2 134 49 108 26 49 25 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000005706   ⟹   ENSRNOP00000005706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl739,451,073 - 39,460,961 (-)Ensembl
mRatBN7.2 Ensembl737,564,533 - 37,574,423 (-)Ensembl
Rnor_6.0 Ensembl744,111,151 - 44,121,130 (-)Ensembl
RefSeq Acc Id: NM_001102381   ⟹   NP_001095851
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8739,451,484 - 39,460,888 (-)NCBI
mRatBN7.2737,564,944 - 37,574,350 (-)NCBI
Rnor_6.0744,111,594 - 44,120,998 (-)NCBI
Rnor_5.0744,140,647 - 44,150,051 (-)NCBI
RGSC_v3.4740,474,654 - 40,484,058 (-)RGD
Celera734,527,468 - 34,536,872 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001095851 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41712 (Get FASTA)   NCBI Sequence Viewer  
  EDM16790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005706
GenBank Protein P20068 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001095851   ⟸   NM_001102381
- Peptide Label: precursor
- UniProtKB: Q9QV80 (UniProtKB/Swiss-Prot),   P20068 (UniProtKB/Swiss-Prot),   A6IGA8 (UniProtKB/TrEMBL),   G3V6J4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005706   ⟸   ENSRNOT00000005706

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20068-F1-model_v2 AlphaFold P20068 1-169 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695176
Promoter ID:EPDNEW_R5701
Type:single initiation site
Name:Nts_1
Description:neurotensin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0744,121,018 - 44,121,078EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621612 AgrOrtholog
BioCyc Gene G2FUF-34223 BioCyc
Ensembl Genes ENSRNOG00000004179 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005706 ENTREZGENE
InterPro NeurotensiN UniProtKB/Swiss-Prot
NCBI Gene Nts ENTREZGENE
PANTHER NEUROTENSIN/NEUROMEDIN N UniProtKB/Swiss-Prot
  PTHR15356 UniProtKB/Swiss-Prot
Pfam Pro-NT_NN UniProtKB/Swiss-Prot
PhenoGen Nts PhenoGen
PRINTS NEUROTENSIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004179 RatGTEx
UniProt A6IGA8 ENTREZGENE, UniProtKB/TrEMBL
  G3V6J4 ENTREZGENE, UniProtKB/TrEMBL
  NEUT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QV80 ENTREZGENE
UniProt Secondary Q9QV80 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-10-18 Nts  neurotensin  Nts_predicted  neurotensin (predicted)  Data merged from RGD:1308997 737654 APPROVED
2005-01-20 Nts  neurotensin    neurotensin/neuromedin N gene  Name updated 1299863 APPROVED
2005-01-12 Nts_predicted  neurotensin (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Nts  neurotensin/neuromedin N gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript neurotensin and neuromedin N coding domains are tandemly positioned on exon 4 728959