Gak (cyclin G associated kinase) - Rat Genome Database

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Gene: Gak (cyclin G associated kinase) Rattus norvegicus
Analyze
Symbol: Gak
Name: cyclin G associated kinase
RGD ID: 621589
Description: Enables cyclin binding activity. Predicted to be involved in several processes, including Golgi to lysosome transport; clathrin coat disassembly; and regulation of clathrin coat assembly. Predicted to act upstream of or within several processes, including epithelial cell differentiation; establishment of skin barrier; and intrahepatic bile duct development. Predicted to be located in Golgi apparatus and clathrin-coated vesicle. Predicted to be active in cytoplasm and vesicle. Orthologous to human GAK (cyclin G associated kinase); INTERACTS WITH 3H-1,2-dithiole-3-thione; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclin G-associated kinase; cyclin-G-associated kinase; dnaJ homolog subfamily C member 26
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,234,272 - 1,308,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl141,234,266 - 1,323,974 (+)EnsemblGRCr8
mRatBN7.2141,089,853 - 1,164,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,089,866 - 1,216,398 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14989,603 - 1,063,129 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,291,381 - 2,364,893 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014988,076 - 1,061,600 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,100,104 - 2,174,332 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,100,106 - 2,174,318 (+)Ensemblrn6Rnor6.0
Rnor_5.0142,095,637 - 2,168,946 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4141,630,890 - 1,710,373 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera141,129,213 - 1,203,494 (+)NCBICelera
RGSC_v3.1141,630,889 - 1,710,373 (+)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
baricitinib  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
choline  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dimethylarsinic acid  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
Monobutylphthalate  (EXP)
nickel dichloride  (EXP)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. Kanaoka Y, etal., FEBS Lett 1997 Jan 27;402(1):73-80.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16155256   PMID:16262722   PMID:18434600   PMID:19946888   PMID:20160091   PMID:24510904   PMID:29476059  


Genomics

Comparative Map Data
Gak
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,234,272 - 1,308,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl141,234,266 - 1,323,974 (+)EnsemblGRCr8
mRatBN7.2141,089,853 - 1,164,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,089,866 - 1,216,398 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14989,603 - 1,063,129 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,291,381 - 2,364,893 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014988,076 - 1,061,600 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,100,104 - 2,174,332 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,100,106 - 2,174,318 (+)Ensemblrn6Rnor6.0
Rnor_5.0142,095,637 - 2,168,946 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4141,630,890 - 1,710,373 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera141,129,213 - 1,203,494 (+)NCBICelera
RGSC_v3.1141,630,889 - 1,710,373 (+)NCBI
Cytogenetic Map14p22NCBI
GAK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384849,277 - 932,316 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4849,275 - 932,411 (-)Ensemblhg38GRCh38
GRCh374843,065 - 926,104 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364833,065 - 916,174 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344832,895 - 915,805NCBI
Celera4750,124 - 863,080 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef4813,547 - 897,389 (-)NCBIHuRef
CHM1_14842,855 - 925,384 (-)NCBICHM1_1
T2T-CHM13v2.04847,030 - 930,388 (-)NCBIT2T-CHM13v2.0
Gak
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,716,973 - 108,777,643 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5108,717,277 - 108,777,621 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385108,569,107 - 108,629,777 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,569,411 - 108,629,755 (-)Ensemblmm10GRCm38
MGSCv375108,998,433 - 109,058,758 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365108,809,716 - 108,870,041 (-)NCBIMGSCv36mm8
Celera5105,690,922 - 105,751,237 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.2NCBI
Gak
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514387,179 - 434,077 (-)Ensembl
ChiLan1.0NW_004955514391,305 - 434,198 (-)NCBIChiLan1.0ChiLan1.0
GAK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v231,164,993 - 1,262,302 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan141,121,494 - 1,228,106 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04952,474 - 1,049,612 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14883,096 - 967,473 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4883,096 - 967,473 (-)EnsemblpanPan2panpan1.1
GAK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,575,537 - 91,630,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,574,751 - 91,630,663 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha394,040,859 - 94,095,630 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0392,574,135 - 92,629,637 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl392,573,478 - 92,631,424 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1391,745,453 - 91,800,982 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0391,799,161 - 91,854,620 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0392,183,004 - 92,238,533 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gak
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,552,411 - 68,599,133 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647722,253,471 - 22,300,932 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647722,254,109 - 22,300,827 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8240,822 - 296,956 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18240,818 - 296,989 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28322 - 23,682 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,852,548 - 47,935,691 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,852,588 - 47,935,874 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660514,214,320 - 4,318,135 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gak
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475526,208,334 - 26,250,533 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475526,208,207 - 26,250,937 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gak
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11118,350,869 - 18,415,409 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gak
215 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:160
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000000064
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
RH131491  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14p22UniSTS
GAK__6772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.294,087,257 - 4,087,688 (+)MAPPERmRatBN7.2
mRatBN7.2141,163,595 - 1,164,093 (+)MAPPERmRatBN7.2
mRatBN7.2132,121,542 - 2,122,041 (+)MAPPERmRatBN7.2
Rnor_6.0134,656,799 - 4,657,297NCBIRnor6.0
Rnor_6.0142,173,821 - 2,174,318NCBIRnor6.0
Rnor_5.0142,168,440 - 2,168,937UniSTSRnor5.0
Rnor_5.0134,633,864 - 4,634,362UniSTSRnor5.0
Celera141,202,997 - 1,203,494UniSTS
Celera133,084,268 - 3,084,766UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000064   ⟹   ENSRNOP00000000064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl141,234,276 - 1,308,526 (+)Ensembl
mRatBN7.2 Ensembl141,089,866 - 1,164,094 (+)Ensembl
Rnor_6.0 Ensembl142,100,106 - 2,174,318 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061720   ⟹   ENSRNOP00000058432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl141,234,272 - 1,323,974 (+)Ensembl
mRatBN7.2 Ensembl141,089,866 - 1,216,398 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105303   ⟹   ENSRNOP00000081704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl141,234,266 - 1,308,492 (+)Ensembl
mRatBN7.2 Ensembl141,089,866 - 1,164,094 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114393   ⟹   ENSRNOP00000081239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl141,234,376 - 1,308,526 (+)Ensembl
mRatBN7.2 Ensembl141,089,971 - 1,164,094 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134932   ⟹   ENSRNOP00000100598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl141,234,276 - 1,308,526 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000135400   ⟹   ENSRNOP00000111853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl141,234,276 - 1,308,526 (+)Ensembl
RefSeq Acc Id: NM_031030   ⟹   NP_112292
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,234,272 - 1,308,489 (+)NCBI
mRatBN7.2141,089,867 - 1,164,093 (+)NCBI
Rnor_6.0142,100,106 - 2,174,318 (+)NCBI
Rnor_5.0142,095,637 - 2,168,946 (+)NCBI
RGSC_v3.4141,630,890 - 1,710,373 (+)RGD
Celera141,129,213 - 1,203,494 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250583   ⟹   XP_006250645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,234,376 - 1,308,492 (+)NCBI
mRatBN7.2141,089,854 - 1,164,098 (+)NCBI
Rnor_6.0142,100,104 - 2,174,327 (+)NCBI
Rnor_5.0142,095,637 - 2,168,946 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250584   ⟹   XP_006250646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,234,376 - 1,308,492 (+)NCBI
mRatBN7.2141,089,854 - 1,164,098 (+)NCBI
Rnor_6.0142,100,104 - 2,174,327 (+)NCBI
Rnor_5.0142,095,637 - 2,168,946 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599389   ⟹   XP_017454878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,241,700 - 1,308,492 (+)NCBI
mRatBN7.2141,097,285 - 1,164,098 (+)NCBI
Rnor_6.0142,107,561 - 2,174,332 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092485   ⟹   XP_038948413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,267,163 - 1,308,492 (+)NCBI
mRatBN7.2141,122,771 - 1,164,098 (+)NCBI
RefSeq Acc Id: XM_063273665   ⟹   XP_063129735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,234,376 - 1,308,492 (+)NCBI
RefSeq Acc Id: XM_063273666   ⟹   XP_063129736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,234,376 - 1,308,492 (+)NCBI
RefSeq Acc Id: XM_063273667   ⟹   XP_063129737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,234,376 - 1,279,255 (+)NCBI
RefSeq Acc Id: NP_112292   ⟸   NM_031030
- UniProtKB: P97874 (UniProtKB/Swiss-Prot),   F1LMD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250645   ⟸   XM_006250583
- Peptide Label: isoform X2
- UniProtKB: F1LMD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250646   ⟸   XM_006250584
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZTC5 (UniProtKB/TrEMBL),   F1LMD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454878   ⟸   XM_017599389
- Peptide Label: isoform X5
- UniProtKB: A6KPE6 (UniProtKB/TrEMBL),   A6KPE7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000064   ⟸   ENSRNOT00000000064
RefSeq Acc Id: XP_038948413   ⟸   XM_039092485
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000058432   ⟸   ENSRNOT00000061720
Ensembl Acc Id: ENSRNOP00000081704   ⟸   ENSRNOT00000105303
Ensembl Acc Id: ENSRNOP00000081239   ⟸   ENSRNOT00000114393
RefSeq Acc Id: XP_063129735   ⟸   XM_063273665
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QS27 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129736   ⟸   XM_063273666
- Peptide Label: isoform X4
- UniProtKB: F1LMD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129737   ⟸   XM_063273667
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000111853   ⟸   ENSRNOT00000135400
Ensembl Acc Id: ENSRNOP00000100598   ⟸   ENSRNOT00000134932
Protein Domains
C2 tensin-type   J   Phosphatase tensin-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97874-F1-model_v2 AlphaFold P97874 1-1305 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699148
Promoter ID:EPDNEW_R9672
Type:initiation region
Name:Gak_1
Description:cyclin G associated kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0142,100,105 - 2,100,165EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621589 AgrOrtholog
BioCyc Gene G2FUF-16681 BioCyc
Ensembl Genes ENSRNOG00000000048 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000064 ENTREZGENE
  ENSRNOT00000105303 ENTREZGENE
Gene3D-CATH 1.10.287.110 UniProtKB/Swiss-Prot
  2.60.40.1110 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro C2_domain_sf UniProtKB/Swiss-Prot
  DnaJ_domain UniProtKB/Swiss-Prot
  J_dom_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Tensin_C2-dom UniProtKB/Swiss-Prot
  Tensin_phosphatase UniProtKB/Swiss-Prot
KEGG Report rno:81659 UniProtKB/Swiss-Prot
NCBI Gene 81659 ENTREZGENE
PANTHER AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED UniProtKB/Swiss-Prot
  CYCLIN-G-ASSOCIATED KINASE UniProtKB/Swiss-Prot
Pfam DnaJ UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  PTEN_C2 UniProtKB/Swiss-Prot
PhenoGen Gak PhenoGen
PROSITE C2_TENSIN UniProtKB/Swiss-Prot
  DNAJ_2 UniProtKB/Swiss-Prot
  PPASE_TENSIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000048 RatGTEx
SMART DnaJ UniProtKB/Swiss-Prot
  PTEN_C2 UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46565 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
  SSF52799 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZS37_RAT UniProtKB/TrEMBL
  A0A8I5ZTC5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QS27 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L7P3_RAT UniProtKB/TrEMBL
  A0ABK0M7C1_RAT UniProtKB/TrEMBL
  A6KPE6 ENTREZGENE, UniProtKB/TrEMBL
  A6KPE7 ENTREZGENE, UniProtKB/TrEMBL
  A6KPE8_RAT UniProtKB/TrEMBL
  A6KPE9_RAT UniProtKB/TrEMBL
  F1LMD9 ENTREZGENE, UniProtKB/TrEMBL
  GAK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gak  cyclin G associated kinase    cyclin G-associated kinase  Name updated 1299863 APPROVED
2002-08-07 Gak  cyclin G-associated kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a serine/threonine kinase-like catalytic domain at the N-terminal, and a leucine zipper region at the C-terminal 728630
gene_physical_interaction protein associates directly with cyclin G in vivo 728630